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Drug Metabolism & Disposition

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Table of Contents

June 01, 2008; Volume 36,Issue 6

CENTENNIAL PERSPECTIVE

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    The Development of Drug Metabolism Research as Expressed in the Publications of ASPET: Part 2, 1959–1983
    Patrick J. Murphy
    Drug Metabolism and Disposition June 2008, 36 (6) 981-985; DOI: https://doi.org/10.1124/dmd.108.021113

Short Communications

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    The Contributions of Cytochromes P450 3A4 and 3A5 to the Metabolism of the Phosphodiesterase Type 5 Inhibitors Sildenafil, Udenafil, and Vardenafil
    Hei-Young Ku, Hee-Jeong Ahn, Kyung-Ah Seo, Hyunmi Kim, Minkyung Oh, Soo Kyung Bae, Jae-Gook Shin, Ji-Hong Shon and Kwang-Hyeon Liu
    Drug Metabolism and Disposition June 2008, 36 (6) 986-990; DOI: https://doi.org/10.1124/dmd.107.020099
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    Aldo-Keto Reductase 1C2 Fails to Metabolize Doxorubicin and Daunorubicin in Vitro
    Ryan H. Takahashi, Onkar S. Bains, Tom A. Pfeifer, Thomas A. Grigliatti, Ronald E. Reid and K. Wayne Riggs
    Drug Metabolism and Disposition June 2008, 36 (6) 991-994; DOI: https://doi.org/10.1124/dmd.108.020388

Articles

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    Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting Brain and Testis Penetration of Xenobiotic Compounds
    Junichi Enokizono, Hiroyuki Kusuhara, Atsushi Ose, Alfred H. Schinkel and Yuichi Sugiyama
    Drug Metabolism and Disposition June 2008, 36 (6) 995-1002; DOI: https://doi.org/10.1124/dmd.107.019257
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    Identification of Human Liver Cytochrome P450 Isoforms Involved in Autoinduced Metabolism of the Antiangiogenic Agent (Z)-5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic Acid (TSU-68)
    Ryuichi Kitamura, Hisae Asanoma, Sekio Nagayama and Masaki Otagiri
    Drug Metabolism and Disposition June 2008, 36 (6) 1003-1009; DOI: https://doi.org/10.1124/dmd.107.019877
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    Identification and Characterization of Potent CYP2B6 Inhibitors in Woohwangcheongsimwon Suspension, an Herbal Preparation Used in the Treatment and Prevention of Apoplexy in Korea and China
    Hyunmi Kim, Kwon-Bok Kim, Hei-Young Ku, Soo-Jin Park, Hoon Choi, Joon-Kwan Moon, Byeoung-Soo Park, Jeong-Han Kim, Sung Su Yea, Choong-Hwan Lee, Hye Suk Lee, Jae-Gook Shin and Kwang-Hyeon Liu
    Drug Metabolism and Disposition June 2008, 36 (6) 1010-1015; DOI: https://doi.org/10.1124/dmd.107.019612
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    Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug
    Jonathan N. Bauman, Kosea S. Frederick, Aarti Sawant, Robert L. Walsky, Loretta M. Cox, Ronald S. Obach and Amit S. Kalgutkar
    Drug Metabolism and Disposition June 2008, 36 (6) 1016-1029; DOI: https://doi.org/10.1124/dmd.108.020545
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    Hepatic Uptake and Excretion of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans
    Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition June 2008, 36 (6) 1030-1038; DOI: https://doi.org/10.1124/dmd.108.020669
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    Characterization of Cytochrome P450 Protein Expression along the Entire Length of the Intestine of Male and Female Rats
    Doreen Mitschke, Andreas Reichel, Gert Fricker and Ursula Moenning
    Drug Metabolism and Disposition June 2008, 36 (6) 1039-1045; DOI: https://doi.org/10.1124/dmd.107.019687
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    Comparison of Immortalized Fa2N-4 Cells and Human Hepatocytes as in Vitro Models for Cytochrome P450 Induction
    Niresh Hariparsad, Brian A. Carr, Raymond Evers and Xiaoyan Chu
    Drug Metabolism and Disposition June 2008, 36 (6) 1046-1055; DOI: https://doi.org/10.1124/dmd.108.020677
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    The “Albumin Effect” and Drug Glucuronidation: Bovine Serum Albumin and Fatty Acid-Free Human Serum Albumin Enhance the Glucuronidation of UDP-Glucuronosyltransferase (UGT) 1A9 Substrates but Not UGT1A1 and UGT1A6 Activities
    Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
    Drug Metabolism and Disposition June 2008, 36 (6) 1056-1062; DOI: https://doi.org/10.1124/dmd.108.021105
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    ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses
    Maya Pascual, M. José Gómez-Lechón, José V. Castell and Ramiro Jover
    Drug Metabolism and Disposition June 2008, 36 (6) 1063-1072; DOI: https://doi.org/10.1124/dmd.107.019380
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    P-Glycoprotein Contributes to the Blood-Brain, but Not Blood-Cerebrospinal Fluid, Barrier in a Spontaneous Canine P-Glycoprotein Knockout Model
    Katrina L. Mealey, Stephen Greene, Rodney Bagley, John Gay, Russ Tucker, Patrick Gavin, Kari Schmidt and Frederick Nelson
    Drug Metabolism and Disposition June 2008, 36 (6) 1073-1079; DOI: https://doi.org/10.1124/dmd.107.018978
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    Forkhead Box A2–Mediated Regulation of Female-Predominant Expression of the Mouse Cyp2b9 Gene
    Tadahiro Hashita, Tsutomu Sakuma, Mami Akada, Asuka Nakajima, Hirofumi Yamahara, Sumiyo Ito, Hidekazu Takesako and Nobuo Nemoto
    Drug Metabolism and Disposition June 2008, 36 (6) 1080-1087; DOI: https://doi.org/10.1124/dmd.107.019729
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    Involvement of Multidrug Resistance-Associated Protein 2 (Abcc2) in Molecular Weight-Dependent Biliary Excretion of β-Lactam Antibiotics
    Yukio Kato, Seiko Takahara, Sayaka Kato, Yoshiyuki Kubo, Yoshimichi Sai, Ikumi Tamai, Hikaru Yabuuchi and Akira Tsuji
    Drug Metabolism and Disposition June 2008, 36 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.107.019125
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    Hydroxyitraconazole, Formed During Intestinal First-Pass Metabolism of Itraconazole, Controls the Time Course of Hepatic CYP3A Inhibition and the Bioavailability of Itraconazole in Rats
    Sara K. Quinney, Raymond E. Galinsky, Vanida A. Jiyamapa-Serna, Yong Chen, Mitchell A. Hamman, Stephen D. Hall and Robert E. Kimura
    Drug Metabolism and Disposition June 2008, 36 (6) 1097-1101; DOI: https://doi.org/10.1124/dmd.108.020644
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    Role of P-Glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents
    C. Edwin Garner, Eric Solon, Chii-Ming Lai, Jianrong Lin, Gang Luo, Kevin Jones, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Stephen E. Mercer, Lian-Shen Gan, Mingxin Qian, Shimoga Prakash, Huey-Shin Shen and Frank W. Lee
    Drug Metabolism and Disposition June 2008, 36 (6) 1102-1110; DOI: https://doi.org/10.1124/dmd.107.017038
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    Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies
    Rozenn Jossé, Caroline Aninat, Denise Glaise, Julie Dumont, Valérie Fessard, Fabrice Morel, Jean-Michel Poul, Christiane Guguen-Guillouzo and André Guillouzo
    Drug Metabolism and Disposition June 2008, 36 (6) 1111-1118; DOI: https://doi.org/10.1124/dmd.107.019901
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    Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes
    Souzan B. Yanni, Pieter P. Annaert, Patrick Augustijns, Arlene Bridges, Yan Gao, Daniel K. Benjamin and Dhiren R. Thakker
    Drug Metabolism and Disposition June 2008, 36 (6) 1119-1125; DOI: https://doi.org/10.1124/dmd.107.019646
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    Integrated in Vitro Analysis for the in Vivo Prediction of Cytochrome P450-Mediated Drug-Drug Interactions
    Dermot F. McGinnity, Nigel J. Waters, James Tucker and Robert J. Riley
    Drug Metabolism and Disposition June 2008, 36 (6) 1126-1134; DOI: https://doi.org/10.1124/dmd.108.020446
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    Metabolism of Boswellic Acids in Vitro and in Vivo
    Phillip Krüger, Rambod Daneshfar, Gunter P. Eckert, Jochen Klein, Dietrich A. Volmer, Ute Bahr, Walter E. Müller, Michael Karas, Manfred Schubert-Zsilavecz and Mona Abdel-Tawab
    Drug Metabolism and Disposition June 2008, 36 (6) 1135-1142; DOI: https://doi.org/10.1124/dmd.107.018424
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    N-Demethylation Is a Major Route of 2-Amino-3-Methylimidazo[4,5-f]quinoline Metabolism in Mouse
    Vijaya M. Lakshmi, Fong Fu Hsu and Terry V. Zenser
    Drug Metabolism and Disposition June 2008, 36 (6) 1143-1152; DOI: https://doi.org/10.1124/dmd.107.019166
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    Predictive Physiologically Based Pharmacokinetic Model for Antibody-Directed Enzyme Prodrug Therapy
    Lanyan Fang and Duxin Sun
    Drug Metabolism and Disposition June 2008, 36 (6) 1153-1165; DOI: https://doi.org/10.1124/dmd.107.019182
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    Comparison of Two Immortalized Human Cell Lines to Study Nuclear Receptor-Mediated CYP3A4 Induction
    S. Harmsen, A. S. Koster, J. H. Beijnen, J. H. M. Schellens and I. Meijerman
    Drug Metabolism and Disposition June 2008, 36 (6) 1166-1171; DOI: https://doi.org/10.1124/dmd.107.017335
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    Intestinal Human Colon Adenocarcinoma Cell Line LS180 Is an Excellent Model to Study Pregnane X Receptor, but Not Constitutive Androstane Receptor, Mediated CYP3A4 and Multidrug Resistance Transporter 1 Induction: Studies with Anti-Human Immunodeficiency Virus Protease Inhibitors
    Anshul Gupta, Ganesh M. Mugundu, Pankaj B. Desai, Kenneth E. Thummel and Jashvant D. Unadkat
    Drug Metabolism and Disposition June 2008, 36 (6) 1172-1180; DOI: https://doi.org/10.1124/dmd.107.018689
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    PDZK1 Regulates Two Intestinal Solute Carriers (Slc15a1 and Slc22a5) in Mice
    Tomoko Sugiura, Yukio Kato, Tomohiko Wakayama, David L. Silver, Yoshiyuki Kubo, Shoichi Iseki and Akira Tsuji
    Drug Metabolism and Disposition June 2008, 36 (6) 1181-1188; DOI: https://doi.org/10.1124/dmd.107.020321
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Drug Metabolism and Disposition: 36 (6)
Drug Metabolism and Disposition
Vol. 36, Issue 6
1 Jun 2008
  • Table of Contents
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  • CENTENNIAL PERSPECTIVE
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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