Table of Contents

Articles

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  Quantitative Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) in Limiting Brain and Testis Penetration of Xenobiotic Compounds

  Junichi Enokizono, Hiroyuki Kusuhara, Atsushi Ose, Alfred H. Schinkel and Yuichi Sugiyama

  Drug Metabolism and Disposition June 2008, 36 (6) 995-1002; DOI: https://doi.org/10.1124/dmd.107.019257
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  Identification of Human Liver Cytochrome P450 Isoforms Involved in Autoinduced Metabolism of the Antiangiogenic Agent (Z)-5-[(1,2-Dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2,4-dimethyl-1H-pyrrole-3-propanoic Acid (TSU-68)

  Ryuichi Kitamura, Hisae Asanoma, Sekio Nagayama and Masaki Otagiri

  Drug Metabolism and Disposition June 2008, 36 (6) 1003-1009; DOI: https://doi.org/10.1124/dmd.107.019877
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  Identification and Characterization of Potent CYP2B6 Inhibitors in Woohwangcheongsimwon Suspension, an Herbal Preparation Used in the Treatment and Prevention of Apoplexy in Korea and China

  Hyunmi Kim, Kwon-Bok Kim, Hei-Young Ku, Soo-Jin Park, Hoon Choi, Joon-Kwan Moon, Byeoung-Soo Park, Jeong-Han Kim, Sung Su Yea, Choong-Hwan Lee, Hye Suk Lee, Jae-Gook Shin and Kwang-Hyeon Liu

  Drug Metabolism and Disposition June 2008, 36 (6) 1010-1015; DOI: https://doi.org/10.1124/dmd.107.019612
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  Comparison of the Bioactivation Potential of the Antidepressant and Hepatotoxin Nefazodone with Aripiprazole, a Structural Analog and Marketed Drug

  Jonathan N. Bauman, Kosea S. Frederick, Aarti Sawant, Robert L. Walsky, Loretta M. Cox, Ronald S. Obach and Amit S. Kalgutkar

  Drug Metabolism and Disposition June 2008, 36 (6) 1016-1029; DOI: https://doi.org/10.1124/dmd.108.020545
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  Hepatic Uptake and Excretion of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans

  Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura

  Drug Metabolism and Disposition June 2008, 36 (6) 1030-1038; DOI: https://doi.org/10.1124/dmd.108.020669
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  Characterization of Cytochrome P450 Protein Expression along the Entire Length of the Intestine of Male and Female Rats

  Doreen Mitschke, Andreas Reichel, Gert Fricker and Ursula Moenning

  Drug Metabolism and Disposition June 2008, 36 (6) 1039-1045; DOI: https://doi.org/10.1124/dmd.107.019687
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  Comparison of Immortalized Fa2N-4 Cells and Human Hepatocytes as in Vitro Models for Cytochrome P450 Induction

  Niresh Hariparsad, Brian A. Carr, Raymond Evers and Xiaoyan Chu

  Drug Metabolism and Disposition June 2008, 36 (6) 1046-1055; DOI: https://doi.org/10.1124/dmd.108.020677
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  The “Albumin Effect” and Drug Glucuronidation: Bovine Serum Albumin and Fatty Acid-Free Human Serum Albumin Enhance the Glucuronidation of UDP-Glucuronosyltransferase (UGT) 1A9 Substrates but Not UGT1A1 and UGT1A6 Activities

  Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners

  Drug Metabolism and Disposition June 2008, 36 (6) 1056-1062; DOI: https://doi.org/10.1124/dmd.108.021105
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  ATF5 Is a Highly Abundant Liver-Enriched Transcription Factor that Cooperates with Constitutive Androstane Receptor in the Transactivation of CYP2B6: Implications in Hepatic Stress Responses

  Maya Pascual, M. José Gómez-Lechón, José V. Castell and Ramiro Jover

  Drug Metabolism and Disposition June 2008, 36 (6) 1063-1072; DOI: https://doi.org/10.1124/dmd.107.019380
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  P-Glycoprotein Contributes to the Blood-Brain, but Not Blood-Cerebrospinal Fluid, Barrier in a Spontaneous Canine P-Glycoprotein Knockout Model

  Katrina L. Mealey, Stephen Greene, Rodney Bagley, John Gay, Russ Tucker, Patrick Gavin, Kari Schmidt and Frederick Nelson

  Drug Metabolism and Disposition June 2008, 36 (6) 1073-1079; DOI: https://doi.org/10.1124/dmd.107.018978
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  Forkhead Box A2–Mediated Regulation of Female-Predominant Expression of the Mouse Cyp2b9 Gene

  Tadahiro Hashita, Tsutomu Sakuma, Mami Akada, Asuka Nakajima, Hirofumi Yamahara, Sumiyo Ito, Hidekazu Takesako and Nobuo Nemoto

  Drug Metabolism and Disposition June 2008, 36 (6) 1080-1087; DOI: https://doi.org/10.1124/dmd.107.019729
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  Involvement of Multidrug Resistance-Associated Protein 2 (Abcc2) in Molecular Weight-Dependent Biliary Excretion of β-Lactam Antibiotics

  Yukio Kato, Seiko Takahara, Sayaka Kato, Yoshiyuki Kubo, Yoshimichi Sai, Ikumi Tamai, Hikaru Yabuuchi and Akira Tsuji

  Drug Metabolism and Disposition June 2008, 36 (6) 1088-1096; DOI: https://doi.org/10.1124/dmd.107.019125
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  Hydroxyitraconazole, Formed During Intestinal First-Pass Metabolism of Itraconazole, Controls the Time Course of Hepatic CYP3A Inhibition and the Bioavailability of Itraconazole in Rats

  Sara K. Quinney, Raymond E. Galinsky, Vanida A. Jiyamapa-Serna, Yong Chen, Mitchell A. Hamman, Stephen D. Hall and Robert E. Kimura

  Drug Metabolism and Disposition June 2008, 36 (6) 1097-1101; DOI: https://doi.org/10.1124/dmd.108.020644
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  Role of P-Glycoprotein and the Intestine in the Excretion of DPC 333 [(2R)-2-{(3R)-3-Amino-3-[4-(2-methylquinolin-4-ylmethoxy)phenyl]-2-oxopyrrolidin-1-yl}-N-hydroxy-4-methylpentanamide] in Rodents

  C. Edwin Garner, Eric Solon, Chii-Ming Lai, Jianrong Lin, Gang Luo, Kevin Jones, Jingwu Duan, Carl P. Decicco, Thomas Maduskuie, Stephen E. Mercer, Lian-Shen Gan, Mingxin Qian, Shimoga Prakash, Huey-Shin Shen and Frank W. Lee

  Drug Metabolism and Disposition June 2008, 36 (6) 1102-1110; DOI: https://doi.org/10.1124/dmd.107.017038
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  Long-Term Functional Stability of Human HepaRG Hepatocytes and Use for Chronic Toxicity and Genotoxicity Studies

  Rozenn Jossé, Caroline Aninat, Denise Glaise, Julie Dumont, Valérie Fessard, Fabrice Morel, Jean-Michel Poul, Christiane Guguen-Guillouzo and André Guillouzo

  Drug Metabolism and Disposition June 2008, 36 (6) 1111-1118; DOI: https://doi.org/10.1124/dmd.107.019901
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  Role of Flavin-Containing Monooxygenase in Oxidative Metabolism of Voriconazole by Human Liver Microsomes

  Souzan B. Yanni, Pieter P. Annaert, Patrick Augustijns, Arlene Bridges, Yan Gao, Daniel K. Benjamin and Dhiren R. Thakker

  Drug Metabolism and Disposition June 2008, 36 (6) 1119-1125; DOI: https://doi.org/10.1124/dmd.107.019646
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  Integrated in Vitro Analysis for the in Vivo Prediction of Cytochrome P450-Mediated Drug-Drug Interactions

  Dermot F. McGinnity, Nigel J. Waters, James Tucker and Robert J. Riley

  Drug Metabolism and Disposition June 2008, 36 (6) 1126-1134; DOI: https://doi.org/10.1124/dmd.108.020446
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  Metabolism of Boswellic Acids in Vitro and in Vivo

  Phillip Krüger, Rambod Daneshfar, Gunter P. Eckert, Jochen Klein, Dietrich A. Volmer, Ute Bahr, Walter E. Müller, Michael Karas, Manfred Schubert-Zsilavecz and Mona Abdel-Tawab

  Drug Metabolism and Disposition June 2008, 36 (6) 1135-1142; DOI: https://doi.org/10.1124/dmd.107.018424
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  N-Demethylation Is a Major Route of 2-Amino-3-Methylimidazo[4,5-f]quinoline Metabolism in Mouse

  Vijaya M. Lakshmi, Fong Fu Hsu and Terry V. Zenser

  Drug Metabolism and Disposition June 2008, 36 (6) 1143-1152; DOI: https://doi.org/10.1124/dmd.107.019166
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  Predictive Physiologically Based Pharmacokinetic Model for Antibody-Directed Enzyme Prodrug Therapy

  Lanyan Fang and Duxin Sun

  Drug Metabolism and Disposition June 2008, 36 (6) 1153-1165; DOI: https://doi.org/10.1124/dmd.107.019182
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  Comparison of Two Immortalized Human Cell Lines to Study Nuclear Receptor-Mediated CYP3A4 Induction

  S. Harmsen, A. S. Koster, J. H. Beijnen, J. H. M. Schellens and I. Meijerman

  Drug Metabolism and Disposition June 2008, 36 (6) 1166-1171; DOI: https://doi.org/10.1124/dmd.107.017335
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  Intestinal Human Colon Adenocarcinoma Cell Line LS180 Is an Excellent Model to Study Pregnane X Receptor, but Not Constitutive Androstane Receptor, Mediated CYP3A4 and Multidrug Resistance Transporter 1 Induction: Studies with Anti-Human Immunodeficiency Virus Protease Inhibitors

  Anshul Gupta, Ganesh M. Mugundu, Pankaj B. Desai, Kenneth E. Thummel and Jashvant D. Unadkat

  Drug Metabolism and Disposition June 2008, 36 (6) 1172-1180; DOI: https://doi.org/10.1124/dmd.107.018689
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  PDZK1 Regulates Two Intestinal Solute Carriers (Slc15a1 and Slc22a5) in Mice

  Tomoko Sugiura, Yukio Kato, Tomohiko Wakayama, David L. Silver, Yoshiyuki Kubo, Shoichi Iseki and Akira Tsuji

  Drug Metabolism and Disposition June 2008, 36 (6) 1181-1188; DOI: https://doi.org/10.1124/dmd.107.020321