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Research ArticleArticle

Hepatic Uptake and Excretion of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans

Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
Drug Metabolism and Disposition June 2008, 36 (6) 1030-1038; DOI: https://doi.org/10.1124/dmd.108.020669
Ken-ichi Umehara
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Megumi Iwai
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Yasuhisa Adachi
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Takafumi Iwatsubo
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Takashi Usui
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Hidetaka Kamimura
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Article Information

vol. 36 no. 6 1030-1038
DOI 
https://doi.org/10.1124/dmd.108.020669
PubMed 
18332079

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 29, 2008
  • Accepted March 5, 2008
  • Published online May 19, 2008.

Article Versions

  • Earlier version (March 10, 2008 - 08:00).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ken-ichi Umehara,
  2. Megumi Iwai,
  3. Yasuhisa Adachi,
  4. Takafumi Iwatsubo,
  5. Takashi Usui and
  6. Hidetaka Kamimura
  1. Drug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tokyo, Japan (K.U., M.I., T.I., T.U., H.K.); and ADME/TOX Research Institute, Sekisui Medical Co., Ltd., Ibaraki, Japan (Y.A.)
  1. Address correspondence to:
    Ken-ichi Umehara, Drug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., 1-8, Azusawa 1-chome, Itabashi-ku, Tokyo 174-8511, Japan. E-mail: kenichi.umehara{at}jp.astellas.com
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Drug Metabolism and Disposition: 36 (6)
Drug Metabolism and Disposition
Vol. 36, Issue 6
1 Jun 2008
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Hepatic Uptake and Excretion of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans
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Research ArticleArticle

Hepatic Uptake and Excretion of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans

Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
Drug Metabolism and Disposition June 1, 2008, 36 (6) 1030-1038; DOI: https://doi.org/10.1124/dmd.108.020669

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Research ArticleArticle

Hepatic Uptake and Excretion of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans

Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
Drug Metabolism and Disposition June 1, 2008, 36 (6) 1030-1038; DOI: https://doi.org/10.1124/dmd.108.020669
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