Advertisement
Research ArticleArticle

Hepatic Uptake and Excretion of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans

Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
Drug Metabolism and Disposition June 2008, 36 (6) 1030-1038; DOI: https://doi.org/10.1124/dmd.108.020669

Article Information

vol. 36 no. 6 1030-1038
DOI 
https://doi.org/10.1124/dmd.108.020669
PubMed 
18332079
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 29, 2008
  • Accepted March 5, 2008
  • Published online May 19, 2008.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Ken-ichi Umehara,
  2. Megumi Iwai,
  3. Yasuhisa Adachi,
  4. Takafumi Iwatsubo,
  5. Takashi Usui and
  6. Hidetaka Kamimura
  1. Drug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., Tokyo, Japan (K.U., M.I., T.I., T.U., H.K.); and ADME/TOX Research Institute, Sekisui Medical Co., Ltd., Ibaraki, Japan (Y.A.)
  1. Address correspondence to:
    Ken-ichi Umehara, Drug Metabolism Research Laboratories, Drug Discovery Research, Astellas Pharma Inc., 1-8, Azusawa 1-chome, Itabashi-ku, Tokyo 174-8511, Japan. E-mail: kenichi.umehara{at}jp.astellas.com
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to May 2023

AbstractFullPdf
Aug 20171511
Sep 2017016610
Oct 201711176
Nov 20170139
Dec 20170132
Jan 20180206
Feb 20181166
Mar 2018093
Apr 20180176
May 20180133
Jun 20180114
Jul 20180116
Aug 20182155
Sep 2018243
Oct 2018164
Nov 2018072
Dec 2018621
Jan 2019300
Feb 2019621
Mar 2019711
Apr 2019735
May 20191112
Jun 2019504
Jul 20191201
Aug 20191111
Oct 20191300
Nov 20191621
Dec 20192402
Jan 20201100
Feb 2020600
Mar 2020600
May 2020211
Jun 20201612
Jul 20201000
Aug 2020600
Sep 2020901
Oct 20202024
Nov 2020601
Dec 20201000
Jan 20213232
Feb 20212841
Mar 20211840
Apr 20212021
May 20212421
Jun 20212860
Jul 20211913
Aug 20216161
Sep 2021520
Oct 20211641
Nov 20211513
Dec 20211710
Jan 2022711
Feb 20221011
Mar 2022511
Apr 20221841
May 2022610
Jun 20222111
Jul 20221618
Aug 20221311
Sep 20221310
Oct 20221320
Nov 20221626
Dec 20221813
Jan 20231341
Feb 20231222
Mar 2023710
Apr 2023616
May 20231934

Back to top

In this issue

Download PDF
Article Alerts
Email Article
Citation Tools

Research ArticleArticle

Hepatic Uptake and Excretion of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, in Rats and Humans

Ken-ichi Umehara, Megumi Iwai, Yasuhisa Adachi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
Drug Metabolism and Disposition June 1, 2008, 36 (6) 1030-1038; DOI: https://doi.org/10.1124/dmd.108.020669
Reddit logo Twitter logo Facebook logo Mendeley logo

Jump to section

Advertisement