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Research ArticleArticle

Comparison of Immortalized Fa2N-4 Cells and Human Hepatocytes as in Vitro Models for Cytochrome P450 Induction

Niresh Hariparsad, Brian A. Carr, Raymond Evers and Xiaoyan Chu
Drug Metabolism and Disposition June 2008, 36 (6) 1046-1055; DOI: https://doi.org/10.1124/dmd.108.020677

Article Information

vol. 36 no. 6 1046-1055
DOI 
https://doi.org/10.1124/dmd.108.020677
PubMed 
18332078
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 29, 2008
  • Accepted March 5, 2008
  • Published online May 19, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Niresh Hariparsad,
  2. Brian A. Carr,
  3. Raymond Evers and
  4. Xiaoyan Chu
  1. Department of Drug Metabolism and Pharmacokinetics, Merck & Co., West Point, Pennsylvania (N.H., B.A.C.); and Department of Drug Metabolism and Pharmacokinetics, Merck & Co., Rahway, New Jersey (R.E., X.C.).
  1. Address correspondence to:
    Dr. Niresh Hariparsad, Merck and Co. Inc., 770 SumneytownPike, WP75A-235A, WestPoint, PA19486. E-mail:niresh_hariparsad{at}merck.com
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Research ArticleArticle

Comparison of Immortalized Fa2N-4 Cells and Human Hepatocytes as in Vitro Models for Cytochrome P450 Induction

Niresh Hariparsad, Brian A. Carr, Raymond Evers and Xiaoyan Chu
Drug Metabolism and Disposition June 1, 2008, 36 (6) 1046-1055; DOI: https://doi.org/10.1124/dmd.108.020677
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