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Research ArticleArticle

The “Albumin Effect” and Drug Glucuronidation: Bovine Serum Albumin and Fatty Acid-Free Human Serum Albumin Enhance the Glucuronidation of UDP-Glucuronosyltransferase (UGT) 1A9 Substrates but Not UGT1A1 and UGT1A6 Activities

Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
Drug Metabolism and Disposition June 2008, 36 (6) 1056-1062; DOI: https://doi.org/10.1124/dmd.108.021105

Article Information

vol. 36 no. 6 1056-1062
DOI 
https://doi.org/10.1124/dmd.108.021105
PubMed 
18362158
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 17, 2008
  • Accepted March 20, 2008
  • Published online May 19, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Andrew Rowland,
  2. Kathleen M. Knights,
  3. Peter I. Mackenzie and
  4. John O. Miners
  1. Department of Clinical Pharmacology, Flinders University and Flinders Medical Centre, Bedford Park, Adelaide, Australia
  1. Address correspondence to:
    Dr. John Miners, Department of Clinical Pharmacology, Flinders Medical Centre, Bedford Park, SA 5042, Australia. E-mail: john.miners{at}flinders.edu.au
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Research ArticleArticle

The “Albumin Effect” and Drug Glucuronidation: Bovine Serum Albumin and Fatty Acid-Free Human Serum Albumin Enhance the Glucuronidation of UDP-Glucuronosyltransferase (UGT) 1A9 Substrates but Not UGT1A1 and UGT1A6 Activities

Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
Drug Metabolism and Disposition June 1, 2008, 36 (6) 1056-1062; DOI: https://doi.org/10.1124/dmd.108.021105
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