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The Contributions of Cytochromes P450 3A4 and 3A5 to the Metabolism of the Phosphodiesterase Type 5 Inhibitors Sildenafil, Udenafil, and Vardenafil

Hei-Young Ku, Hee-Jeong Ahn, Kyung-Ah Seo, Hyunmi Kim, Minkyung Oh, Soo Kyung Bae, Jae-Gook Shin, Ji-Hong Shon and Kwang-Hyeon Liu
Drug Metabolism and Disposition June 2008, 36 (6) 986-990; DOI: https://doi.org/10.1124/dmd.107.020099
Hei-Young Ku
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Hee-Jeong Ahn
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Kyung-Ah Seo
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Hyunmi Kim
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Minkyung Oh
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Soo Kyung Bae
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Jae-Gook Shin
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Ji-Hong Shon
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Kwang-Hyeon Liu
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Article Information

vol. 36 no. 6 986-990
DOI 
https://doi.org/10.1124/dmd.107.020099
PubMed 
18308836

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 12, 2007
  • Accepted February 22, 2008
  • Published online May 19, 2008.

Article Versions

  • Earlier version (February 28, 2008 - 05:35).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hei-Young Ku,
  2. Hee-Jeong Ahn,
  3. Kyung-Ah Seo,
  4. Hyunmi Kim,
  5. Minkyung Oh,
  6. Soo Kyung Bae,
  7. Jae-Gook Shin,
  8. Ji-Hong Shon and
  9. Kwang-Hyeon Liu
  1. Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan, South Korea (H.-Y.K., H.-J.A., K.-A.S., H.K., J.-G.S., J.-H.S., K.-H.L.); Frontier Inje Research for Science and Technology, Inje University, Busan, Korea (J.-G.S., K.-H.L.); and Department of Clinical Pharmacology, Inje University Busan Paik Hospital, Busan, South Korea (M.O., S.K.B., J.-G.S., J.-H.S.)
  1. Address correspondence to:
    Kwang-Hyeon Liu, Department of Pharmacology and PharmacoGenomics Research Center, Inje University College of Medicine, Busan 614-735, South Korea. E-mail: dstlkh{at}inje.ac.kr
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Drug Metabolism and Disposition: 36 (6)
Drug Metabolism and Disposition
Vol. 36, Issue 6
1 Jun 2008
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OtherShort Communication

The Contributions of Cytochromes P450 3A4 and 3A5 to the Metabolism of the Phosphodiesterase Type 5 Inhibitors Sildenafil, Udenafil, and Vardenafil

Hei-Young Ku, Hee-Jeong Ahn, Kyung-Ah Seo, Hyunmi Kim, Minkyung Oh, Soo Kyung Bae, Jae-Gook Shin, Ji-Hong Shon and Kwang-Hyeon Liu
Drug Metabolism and Disposition June 1, 2008, 36 (6) 986-990; DOI: https://doi.org/10.1124/dmd.107.020099

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OtherShort Communication

The Contributions of Cytochromes P450 3A4 and 3A5 to the Metabolism of the Phosphodiesterase Type 5 Inhibitors Sildenafil, Udenafil, and Vardenafil

Hei-Young Ku, Hee-Jeong Ahn, Kyung-Ah Seo, Hyunmi Kim, Minkyung Oh, Soo Kyung Bae, Jae-Gook Shin, Ji-Hong Shon and Kwang-Hyeon Liu
Drug Metabolism and Disposition June 1, 2008, 36 (6) 986-990; DOI: https://doi.org/10.1124/dmd.107.020099
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