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Drug Metabolism & Disposition

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Table of Contents

July 01, 2008; Volume 36,Issue 7

Short Communications

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    The Antiapoptotic Factor Growth Arrest and DNA-Damage-Inducible 45 β Regulates the Nuclear Receptor Constitutive Active/Androstane Receptor-Mediated Transcription
    Yukio Yamamoto and Masahiko Negishi
    Drug Metabolism and Disposition July 2008, 36 (7) 1189-1193; DOI: https://doi.org/10.1124/dmd.108.020628
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    Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data
    Peter J. Kilford, Michael Gertz, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition July 2008, 36 (7) 1194-1197; DOI: https://doi.org/10.1124/dmd.108.020834
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    An in Vitro Mechanistic Study to Elucidate the Desipramine/Bupropion Clinical Drug-Drug Interaction
    Melinda J. Reese, Robert M. Wurm, Keith T. Muir, Grant T. Generaux, Lisa St. John-Williams and Donavon J. Mcconn
    Drug Metabolism and Disposition July 2008, 36 (7) 1198-1201; DOI: https://doi.org/10.1124/dmd.107.020198
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    Aldehyde Oxidase-Catalyzed Metabolism of N1-Methylnicotinamide in Vivo and in Vitro in Chimeric Mice with Humanized Liver
    Shigeyuki Kitamura, Kayoko Nitta, Yoshitaka Tayama, Chiaki Tanoue, Kazumi Sugihara, Tae Inoue, Toru Horie and Shigeru Ohta
    Drug Metabolism and Disposition July 2008, 36 (7) 1202-1205; DOI: https://doi.org/10.1124/dmd.107.019075
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    Inhibitory Effects of Terpenoids on Multidrug Resistance-Associated Protein 2- and Breast Cancer Resistance Protein-Mediated Transport
    Naoko Yoshida, Tappei Takada, Yoshikazu Yamamura, Isao Adachi, Hiroshi Suzuki and Junichi Kawakami
    Drug Metabolism and Disposition July 2008, 36 (7) 1206-1211; DOI: https://doi.org/10.1124/dmd.107.019513

Articles

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    Osmotic Regulation of a Novel Flavin-Containing Monooxygenase in Primary Cultured Cells from Rainbow Trout (Oncorhynchus mykiss)
    Gabriela Rodríguez-Fuentes, Rosaura Aparicio-Fabre, Qi Li and Daniel Schlenk
    Drug Metabolism and Disposition July 2008, 36 (7) 1212-1217; DOI: https://doi.org/10.1124/dmd.107.019968
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    Disposition of Lasofoxifene, a Next-Generation Selective Estrogen Receptor Modulator, in Healthy Male Subjects
    Chandra Prakash, Kim A. Johnson and Mark J. Gardner
    Drug Metabolism and Disposition July 2008, 36 (7) 1218-1226; DOI: https://doi.org/10.1124/dmd.108.020404
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    The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2
    Eric T. Williams, Karen O. Jones, G. Douglas Ponsler, Shane M. Lowery, Everett J. Perkins, Steven A. Wrighton, Kenneth J. Ruterbories, Miho Kazui and Nagy A. Farid
    Drug Metabolism and Disposition July 2008, 36 (7) 1227-1232; DOI: https://doi.org/10.1124/dmd.107.020248
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    Pharmacokinetic Parameters of Chlorzoxazone and Its Main Metabolite, 6-Hydroxychlorzoxazone, after Intravenous and Oral Administration of Chlorzoxazone to Liver Cirrhotic Rats with Diabetes Mellitus
    Choong Y. Ahn, Soo K. Bae, Young S. Jung, Inchul Lee, Young C. Kim, Myung G. Lee and Wan G. Shin
    Drug Metabolism and Disposition July 2008, 36 (7) 1233-1241; DOI: https://doi.org/10.1124/dmd.107.017442
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    Differential Genotype Dependent Inhibition of CYP2C9 in Humans
    Vikas Kumar, Richard C. Brundage, William S. Oetting, Ilo E. Leppik and Timothy S. Tracy
    Drug Metabolism and Disposition July 2008, 36 (7) 1242-1248; DOI: https://doi.org/10.1124/dmd.108.020396
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    Closing the Gaps: A Full Scan of the Intestinal Expression of P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 in Male and Female Rats
    Caroline MacLean, Ulla Moenning, Andreas Reichel and Gert Fricker
    Drug Metabolism and Disposition July 2008, 36 (7) 1249-1254; DOI: https://doi.org/10.1124/dmd.108.020859
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    Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. II. In Vitro-in Vivo Correlation with Ketoconazole
    Chuang Lu, Panos Hatsis, Cicely Berg, Frank W. Lee and Suresh K. Balani
    Drug Metabolism and Disposition July 2008, 36 (7) 1255-1260; DOI: https://doi.org/10.1124/dmd.107.018796
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    Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. III. In Vitro-in Vivo Correlation with Fluconazole
    Chuang Lu, Cicely Berg, Shimoga R. Prakash, Frank W. Lee and Suresh K. Balani
    Drug Metabolism and Disposition July 2008, 36 (7) 1261-1266; DOI: https://doi.org/10.1124/dmd.107.019000
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    Pharmacokinetic-Pharmacodynamic Modeling of Biomarker Response and Tumor Growth Inhibition to an Orally Available cMet Kinase Inhibitor in Human Tumor Xenograft Mouse Models
    Shinji Yamazaki, Judith Skaptason, David Romero, Joseph H. Lee, Helen Y. Zou, James G. Christensen, Jeffrey R. Koup, Bill J. Smith and Tatiana Koudriakova
    Drug Metabolism and Disposition July 2008, 36 (7) 1267-1274; DOI: https://doi.org/10.1124/dmd.107.019711
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    Effect of Plasma Protein Binding on in Vitro-in Vivo Correlation of Biliary Excretion of Drugs Evaluated by Sandwich-Cultured Rat Hepatocytes
    Hajime Fukuda, Rikiya Ohashi, Minoru Tsuda-Tsukimoto and Ikumi Tamai
    Drug Metabolism and Disposition July 2008, 36 (7) 1275-1282; DOI: https://doi.org/10.1124/dmd.107.019026
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    Effects of Spice Constituents on P-Glycoprotein-Mediated Transport and CYP3A4-Mediated Metabolism in Vitro
    Wenxia Zhang and Lee-Yong Lim
    Drug Metabolism and Disposition July 2008, 36 (7) 1283-1290; DOI: https://doi.org/10.1124/dmd.107.019737
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    The Mibefradil Derivative NNC55-0396, a Specific T-Type Calcium Channel Antagonist, Exhibits Less CYP3A4 Inhibition than Mibefradil
    Peter H. Bui, Arnulfo Quesada, Adrian Handforth and Oliver Hankinson
    Drug Metabolism and Disposition July 2008, 36 (7) 1291-1299; DOI: https://doi.org/10.1124/dmd.107.020115
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    Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition
    Tao Zhang, Cathie D. Xiang, David Gale, Samantha Carreiro, Ellen Y. Wu and Eric Y. Zhang
    Drug Metabolism and Disposition July 2008, 36 (7) 1300-1307; DOI: https://doi.org/10.1124/dmd.108.021121
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    Inhibitory Effects of Seven Components of Danshen Extract on Catalytic Activity of Cytochrome P450 Enzyme in Human Liver Microsomes
    Furong Qiu, Rong Zhang, Jianguo Sun, Jiye A, Haiping Hao, Ying Peng, Hua Ai and Guangji Wang
    Drug Metabolism and Disposition July 2008, 36 (7) 1308-1314; DOI: https://doi.org/10.1124/dmd.108.021030
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    Cellular Accumulation of Cholyl-Glycylamido-Fluorescein in Sandwich-Cultured Rat Hepatocytes: Kinetic Characterization, Transport Mechanisms, and Effect of Human Immunodeficiency Virus Protease Inhibitors
    Zhi-wei Ye, Patrick Augustijns and Pieter Annaert
    Drug Metabolism and Disposition July 2008, 36 (7) 1315-1321; DOI: https://doi.org/10.1124/dmd.107.019398
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    Functional Expression and Comparative Characterization of Nine Murine Cytochromes P450 by Fluorescent Inhibition Screening
    Lesley A. McLaughlin, Leslie J. Dickmann, C. Roland Wolf and Colin J. Henderson
    Drug Metabolism and Disposition July 2008, 36 (7) 1322-1331; DOI: https://doi.org/10.1124/dmd.108.021261
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    Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications
    Jamie Henshall, Aleksandra Galetin, Anthony Harrison and J. Brian Houston
    Drug Metabolism and Disposition July 2008, 36 (7) 1332-1340; DOI: https://doi.org/10.1124/dmd.108.021279
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    Biotransformation of [14C]Dasatinib: In Vitro Studies in Rat, Monkey, and Human and Disposition after Administration to Rats and Monkeys
    Lisa J. Christopher, Donghui Cui, Wenying Li, Anthony Barros, Vinod K. Arora, Haiying Zhang, Lifei Wang, Donglu Zhang, James A. Manning, Kan He, Anthony M. Fletcher, Marc Ogan, Michael Lago, Samuel J. Bonacorsi, W. Griffith Humphreys and Ramaswamy A. Iyer
    Drug Metabolism and Disposition July 2008, 36 (7) 1341-1356; DOI: https://doi.org/10.1124/dmd.107.018234
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    Metabolism and Disposition of Dasatinib after Oral Administration to Humans
    Lisa J. Christopher, Donghui Cui, Chiyuan Wu, Roger Luo, James A. Manning, Samuel J. Bonacorsi, Michael Lago, Alban Allentoff, Francis Y. F. Lee, Betty McCann, Susan Galbraith, Donald P. Reitberg, Kan He, Anthony Barros, Anne Blackwood-Chirchir, W. Griffith Humphreys and Ramaswamy A. Iyer
    Drug Metabolism and Disposition July 2008, 36 (7) 1357-1364; DOI: https://doi.org/10.1124/dmd.107.018267
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    Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes
    Stuart W. Paine, Alison J. Parker, Philip Gardiner, Peter J. H. Webborn and Robert J. Riley
    Drug Metabolism and Disposition July 2008, 36 (7) 1365-1374; DOI: https://doi.org/10.1124/dmd.107.019455
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    Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir
    Alison J. Parker and J. Brian Houston
    Drug Metabolism and Disposition July 2008, 36 (7) 1375-1384; DOI: https://doi.org/10.1124/dmd.108.020917
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    Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds
    R. Scott Obach, Franco Lombardo and Nigel J. Waters
    Drug Metabolism and Disposition July 2008, 36 (7) 1385-1405; DOI: https://doi.org/10.1124/dmd.108.020479
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    Use of Online Microdialysis Sampling to Determine the in Vivo Rate of Phenol Glucuronidation in Rainbow Trout
    John W. Nichols, Alex D. Hoffman, Patrick N. Fitzsimmons, Gregory J. Lien and Correne T. Jenson
    Drug Metabolism and Disposition July 2008, 36 (7) 1406-1413; DOI: https://doi.org/10.1124/dmd.107.020123
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    In Silico Methods for Unraveling the Mechanistic Complexities of Intestinal Absorption: Metabolism-Efflux Transport Interactions
    Lana X. Garmire and C. Anthony Hunt
    Drug Metabolism and Disposition July 2008, 36 (7) 1414-1424; DOI: https://doi.org/10.1124/dmd.107.020164
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    Bioactivation of Flutamide Metabolites by Human Liver Microsomes
    Ping Kang, Deepak Dalvie, Evan Smith, Sue Zhou, Alan Deese and James A. Nieman
    Drug Metabolism and Disposition July 2008, 36 (7) 1425-1437; DOI: https://doi.org/10.1124/dmd.108.020370
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    Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury
    Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami
    Drug Metabolism and Disposition July 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089
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    Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies
    Kajsa P. Kanebratt and Tommy B. Andersson
    Drug Metabolism and Disposition July 2008, 36 (7) 1444-1452; DOI: https://doi.org/10.1124/dmd.107.020016
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Drug Metabolism and Disposition: 36 (7)
Drug Metabolism and Disposition
Vol. 36, Issue 7
1 Jul 2008
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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