Table of Contents

Articles

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  Osmotic Regulation of a Novel Flavin-Containing Monooxygenase in Primary Cultured Cells from Rainbow Trout (Oncorhynchus mykiss)

  Gabriela Rodríguez-Fuentes, Rosaura Aparicio-Fabre, Qi Li and Daniel Schlenk

  Drug Metabolism and Disposition July 2008, 36 (7) 1212-1217; DOI: https://doi.org/10.1124/dmd.107.019968
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  Disposition of Lasofoxifene, a Next-Generation Selective Estrogen Receptor Modulator, in Healthy Male Subjects

  Chandra Prakash, Kim A. Johnson and Mark J. Gardner

  Drug Metabolism and Disposition July 2008, 36 (7) 1218-1226; DOI: https://doi.org/10.1124/dmd.108.020404
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  The Biotransformation of Prasugrel, a New Thienopyridine Prodrug, by the Human Carboxylesterases 1 and 2

  Eric T. Williams, Karen O. Jones, G. Douglas Ponsler, Shane M. Lowery, Everett J. Perkins, Steven A. Wrighton, Kenneth J. Ruterbories, Miho Kazui and Nagy A. Farid

  Drug Metabolism and Disposition July 2008, 36 (7) 1227-1232; DOI: https://doi.org/10.1124/dmd.107.020248
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  Pharmacokinetic Parameters of Chlorzoxazone and Its Main Metabolite, 6-Hydroxychlorzoxazone, after Intravenous and Oral Administration of Chlorzoxazone to Liver Cirrhotic Rats with Diabetes Mellitus

  Choong Y. Ahn, Soo K. Bae, Young S. Jung, Inchul Lee, Young C. Kim, Myung G. Lee and Wan G. Shin

  Drug Metabolism and Disposition July 2008, 36 (7) 1233-1241; DOI: https://doi.org/10.1124/dmd.107.017442
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  Differential Genotype Dependent Inhibition of CYP2C9 in Humans

  Vikas Kumar, Richard C. Brundage, William S. Oetting, Ilo E. Leppik and Timothy S. Tracy

  Drug Metabolism and Disposition July 2008, 36 (7) 1242-1248; DOI: https://doi.org/10.1124/dmd.108.020396
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  Closing the Gaps: A Full Scan of the Intestinal Expression of P-Glycoprotein, Breast Cancer Resistance Protein, and Multidrug Resistance-Associated Protein 2 in Male and Female Rats

  Caroline MacLean, Ulla Moenning, Andreas Reichel and Gert Fricker

  Drug Metabolism and Disposition July 2008, 36 (7) 1249-1254; DOI: https://doi.org/10.1124/dmd.108.020859
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  Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. II. In Vitro-in Vivo Correlation with Ketoconazole

  Chuang Lu, Panos Hatsis, Cicely Berg, Frank W. Lee and Suresh K. Balani

  Drug Metabolism and Disposition July 2008, 36 (7) 1255-1260; DOI: https://doi.org/10.1124/dmd.107.018796
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  Prediction of Pharmacokinetic Drug-Drug Interactions Using Human Hepatocyte Suspension in Plasma and Cytochrome P450 Phenotypic Data. III. In Vitro-in Vivo Correlation with Fluconazole

  Chuang Lu, Cicely Berg, Shimoga R. Prakash, Frank W. Lee and Suresh K. Balani

  Drug Metabolism and Disposition July 2008, 36 (7) 1261-1266; DOI: https://doi.org/10.1124/dmd.107.019000
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  Pharmacokinetic-Pharmacodynamic Modeling of Biomarker Response and Tumor Growth Inhibition to an Orally Available cMet Kinase Inhibitor in Human Tumor Xenograft Mouse Models

  Shinji Yamazaki, Judith Skaptason, David Romero, Joseph H. Lee, Helen Y. Zou, James G. Christensen, Jeffrey R. Koup, Bill J. Smith and Tatiana Koudriakova

  Drug Metabolism and Disposition July 2008, 36 (7) 1267-1274; DOI: https://doi.org/10.1124/dmd.107.019711
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  Effect of Plasma Protein Binding on in Vitro-in Vivo Correlation of Biliary Excretion of Drugs Evaluated by Sandwich-Cultured Rat Hepatocytes

  Hajime Fukuda, Rikiya Ohashi, Minoru Tsuda-Tsukimoto and Ikumi Tamai

  Drug Metabolism and Disposition July 2008, 36 (7) 1275-1282; DOI: https://doi.org/10.1124/dmd.107.019026
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  Effects of Spice Constituents on P-Glycoprotein-Mediated Transport and CYP3A4-Mediated Metabolism in Vitro

  Wenxia Zhang and Lee-Yong Lim

  Drug Metabolism and Disposition July 2008, 36 (7) 1283-1290; DOI: https://doi.org/10.1124/dmd.107.019737
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  The Mibefradil Derivative NNC55-0396, a Specific T-Type Calcium Channel Antagonist, Exhibits Less CYP3A4 Inhibition than Mibefradil

  Peter H. Bui, Arnulfo Quesada, Adrian Handforth and Oliver Hankinson

  Drug Metabolism and Disposition July 2008, 36 (7) 1291-1299; DOI: https://doi.org/10.1124/dmd.107.020115
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  Drug Transporter and Cytochrome P450 mRNA Expression in Human Ocular Barriers: Implications for Ocular Drug Disposition

  Tao Zhang, Cathie D. Xiang, David Gale, Samantha Carreiro, Ellen Y. Wu and Eric Y. Zhang

  Drug Metabolism and Disposition July 2008, 36 (7) 1300-1307; DOI: https://doi.org/10.1124/dmd.108.021121
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  Inhibitory Effects of Seven Components of Danshen Extract on Catalytic Activity of Cytochrome P450 Enzyme in Human Liver Microsomes

  Furong Qiu, Rong Zhang, Jianguo Sun, Jiye A, Haiping Hao, Ying Peng, Hua Ai and Guangji Wang

  Drug Metabolism and Disposition July 2008, 36 (7) 1308-1314; DOI: https://doi.org/10.1124/dmd.108.021030
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  Cellular Accumulation of Cholyl-Glycylamido-Fluorescein in Sandwich-Cultured Rat Hepatocytes: Kinetic Characterization, Transport Mechanisms, and Effect of Human Immunodeficiency Virus Protease Inhibitors

  Zhi-wei Ye, Patrick Augustijns and Pieter Annaert

  Drug Metabolism and Disposition July 2008, 36 (7) 1315-1321; DOI: https://doi.org/10.1124/dmd.107.019398
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  Functional Expression and Comparative Characterization of Nine Murine Cytochromes P450 by Fluorescent Inhibition Screening

  Lesley A. McLaughlin, Leslie J. Dickmann, C. Roland Wolf and Colin J. Henderson

  Drug Metabolism and Disposition July 2008, 36 (7) 1322-1331; DOI: https://doi.org/10.1124/dmd.108.021261
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  Comparative Analysis of CYP3A Heteroactivation by Steroid Hormones and Flavonoids in Different in Vitro Systems and Potential in Vivo Implications

  Jamie Henshall, Aleksandra Galetin, Anthony Harrison and J. Brian Houston

  Drug Metabolism and Disposition July 2008, 36 (7) 1332-1340; DOI: https://doi.org/10.1124/dmd.108.021279
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  Biotransformation of [¹⁴C]Dasatinib: In Vitro Studies in Rat, Monkey, and Human and Disposition after Administration to Rats and Monkeys

  Lisa J. Christopher, Donghui Cui, Wenying Li, Anthony Barros, Vinod K. Arora, Haiying Zhang, Lifei Wang, Donglu Zhang, James A. Manning, Kan He, Anthony M. Fletcher, Marc Ogan, Michael Lago, Samuel J. Bonacorsi, W. Griffith Humphreys and Ramaswamy A. Iyer

  Drug Metabolism and Disposition July 2008, 36 (7) 1341-1356; DOI: https://doi.org/10.1124/dmd.107.018234
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  Metabolism and Disposition of Dasatinib after Oral Administration to Humans

  Lisa J. Christopher, Donghui Cui, Chiyuan Wu, Roger Luo, James A. Manning, Samuel J. Bonacorsi, Michael Lago, Alban Allentoff, Francis Y. F. Lee, Betty McCann, Susan Galbraith, Donald P. Reitberg, Kan He, Anthony Barros, Anne Blackwood-Chirchir, W. Griffith Humphreys and Ramaswamy A. Iyer

  Drug Metabolism and Disposition July 2008, 36 (7) 1357-1364; DOI: https://doi.org/10.1124/dmd.107.018267
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  Prediction of the Pharmacokinetics of Atorvastatin, Cerivastatin, and Indomethacin Using Kinetic Models Applied to Isolated Rat Hepatocytes

  Stuart W. Paine, Alison J. Parker, Philip Gardiner, Peter J. H. Webborn and Robert J. Riley

  Drug Metabolism and Disposition July 2008, 36 (7) 1365-1374; DOI: https://doi.org/10.1124/dmd.107.019455
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  Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir

  Alison J. Parker and J. Brian Houston

  Drug Metabolism and Disposition July 2008, 36 (7) 1375-1384; DOI: https://doi.org/10.1124/dmd.108.020917
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  Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 670 Drug Compounds

  R. Scott Obach, Franco Lombardo and Nigel J. Waters

  Drug Metabolism and Disposition July 2008, 36 (7) 1385-1405; DOI: https://doi.org/10.1124/dmd.108.020479
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  Use of Online Microdialysis Sampling to Determine the in Vivo Rate of Phenol Glucuronidation in Rainbow Trout

  John W. Nichols, Alex D. Hoffman, Patrick N. Fitzsimmons, Gregory J. Lien and Correne T. Jenson

  Drug Metabolism and Disposition July 2008, 36 (7) 1406-1413; DOI: https://doi.org/10.1124/dmd.107.020123
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  In Silico Methods for Unraveling the Mechanistic Complexities of Intestinal Absorption: Metabolism-Efflux Transport Interactions

  Lana X. Garmire and C. Anthony Hunt

  Drug Metabolism and Disposition July 2008, 36 (7) 1414-1424; DOI: https://doi.org/10.1124/dmd.107.020164
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  Bioactivation of Flutamide Metabolites by Human Liver Microsomes

  Ping Kang, Deepak Dalvie, Evan Smith, Sue Zhou, Alan Deese and James A. Nieman

  Drug Metabolism and Disposition July 2008, 36 (7) 1425-1437; DOI: https://doi.org/10.1124/dmd.108.020370
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  Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

  Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami

  Drug Metabolism and Disposition July 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089
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  Evaluation of HepaRG Cells as an in Vitro Model for Human Drug Metabolism Studies

  Kajsa P. Kanebratt and Tommy B. Andersson

  Drug Metabolism and Disposition July 2008, 36 (7) 1444-1452; DOI: https://doi.org/10.1124/dmd.107.020016