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Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

Peter J. Kilford, Michael Gertz, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition July 2008, 36 (7) 1194-1197; DOI: https://doi.org/10.1124/dmd.108.020834

Article Information

vol. 36 no. 7 1194-1197
DOI 
https://doi.org/10.1124/dmd.108.020834
PubMed 
18411401
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 8, 2008
  • Accepted April 9, 2008
  • Published online June 19, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Peter J. Kilford,
  2. Michael Gertz,
  3. J. Brian Houston and
  4. Aleksandra Galetin
  1. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom
  1. Address correspondence to:
    Dr. A. Galetin, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK. E-mail: aleksandra.galetin{at}manchester.ac.uk
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OtherShort Communication

Hepatocellular Binding of Drugs: Correction for Unbound Fraction in Hepatocyte Incubations Using Microsomal Binding or Drug Lipophilicity Data

Peter J. Kilford, Michael Gertz, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition July 1, 2008, 36 (7) 1194-1197; DOI: https://doi.org/10.1124/dmd.108.020834
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