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Research ArticleArticle

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami
Drug Metabolism and Disposition July 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089
Toshiaki Makino
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Nobuhiro Ohtake
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Akito Watanabe
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Naoko Tsuchiya
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Sachiko Imamura
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Seiichi Iizuka
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Makoto Inoue
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Hajime Mizukami
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Article Information

vol. 36 no. 7 1438-1443
DOI 
https://doi.org/10.1124/dmd.108.021089
PubMed 
18362159

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 15, 2008
  • Accepted March 21, 2008
  • Published online June 19, 2008.

Article Versions

  • Earlier version (March 24, 2008 - 09:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Toshiaki Makino,
  2. Nobuhiro Ohtake,
  3. Akito Watanabe,
  4. Naoko Tsuchiya,
  5. Sachiko Imamura,
  6. Seiichi Iizuka,
  7. Makoto Inoue and
  8. Hajime Mizukami
  1. Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Nagoya City University, Nagoya, Japan (T.M., A.W., H.M.); Tsumura Research Laboratories, Tsumura Co. Ltd., Ami-machi, Ibaraki, Japan (N.O., N.T., S.Im., S.Ii.); and Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan (M.I.)
  1. Address correspondence to:
    Dr. Toshiaki Makino, Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Nagoya City University, 3-1 Mizuho-ku, Nagoya 467-8603, Japan. E-mail: makino{at}phar.nagoya-cu.ac.jp
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Drug Metabolism and Disposition: 36 (7)
Drug Metabolism and Disposition
Vol. 36, Issue 7
1 Jul 2008
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Research ArticleArticle

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami
Drug Metabolism and Disposition July 1, 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089

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Research ArticleArticle

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami
Drug Metabolism and Disposition July 1, 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089
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