Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn
Research ArticleArticle

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami
Drug Metabolism and Disposition July 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089
Toshiaki Makino
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Nobuhiro Ohtake
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Akito Watanabe
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Naoko Tsuchiya
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Sachiko Imamura
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Seiichi Iizuka
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Makoto Inoue
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
Hajime Mizukami
  • Find this author on Google Scholar
  • Find this author on PubMed
  • Search for this author on this site
  • Article
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF
Loading

Article Information

vol. 36 no. 7 1438-1443
DOI 
https://doi.org/10.1124/dmd.108.021089
PubMed 
18362159

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received February 15, 2008
  • Accepted March 21, 2008
  • Published online June 19, 2008.

Article Versions

  • Earlier version (March 24, 2008 - 09:11).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Toshiaki Makino,
  2. Nobuhiro Ohtake,
  3. Akito Watanabe,
  4. Naoko Tsuchiya,
  5. Sachiko Imamura,
  6. Seiichi Iizuka,
  7. Makoto Inoue and
  8. Hajime Mizukami
  1. Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Nagoya City University, Nagoya, Japan (T.M., A.W., H.M.); Tsumura Research Laboratories, Tsumura Co. Ltd., Ami-machi, Ibaraki, Japan (N.O., N.T., S.Im., S.Ii.); and Laboratory of Medicinal Resources, School of Pharmacy, Aichi Gakuin University, Nagoya, Japan (M.I.)
  1. Address correspondence to:
    Dr. Toshiaki Makino, Department of Pharmacognosy, Graduate School of Pharmaceutical Science, Nagoya City University, 3-1 Mizuho-ku, Nagoya 467-8603, Japan. E-mail: makino{at}phar.nagoya-cu.ac.jp
View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2017 to January 2023

AbstractFullPdf
Aug 201702317
Sep 201735322
Oct 20171406
Nov 20172377
Dec 201733014
Jan 20181288
Feb 20183625
Mar 20183317
Apr 201822310
May 201813610
Jun 201822313
Jul 20181114
Aug 201802310
Sep 20180148
Oct 20181178
Nov 201802011
Dec 201819108
Jan 20191103
Feb 2019719
Mar 20191536
Apr 20192509
May 20191615
Jun 2019306
Jul 20192015
Aug 201928110
Oct 20192302
Nov 20192420
Dec 20192902
Jan 20204146
Feb 20202914
Mar 20201422
May 20201031
Jun 2020811
Jul 20201110
Aug 20203303
Sep 20201520
Oct 2020935
Nov 20201803
Dec 20201612
Jan 20211887
Feb 20211342
Mar 20212522
Apr 20211110
May 20212421
Jun 20211021
Jul 20211838
Aug 20211430
Sep 2021821
Oct 20211110
Nov 20212824
Dec 20211944
Jan 20223444
Feb 20222610
Mar 20222412
Apr 20221362
May 20222133
Jun 20223523
Jul 202217213
Aug 20221421
Sep 20222722
Oct 20221533
Nov 20222534
Dec 2022836
Jan 20232621

PreviousNext
Back to top

In this issue

Drug Metabolism and Disposition: 36 (7)
Drug Metabolism and Disposition
Vol. 36, Issue 7
1 Jul 2008
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Download PDF
Article Alerts
Sign In to Email Alerts with your Email Address
Email Article

Thank you for sharing this Drug Metabolism & Disposition article.

NOTE: We request your email address only to inform the recipient that it was you who recommended this article, and that it is not junk mail. We do not retain these email addresses.

Enter multiple addresses on separate lines or separate them with commas.
Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury
(Your Name) has forwarded a page to you from Drug Metabolism & Disposition
(Your Name) thought you would be interested in this article in Drug Metabolism & Disposition.
CAPTCHA
This question is for testing whether or not you are a human visitor and to prevent automated spam submissions.
Citation Tools
Research ArticleArticle

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami
Drug Metabolism and Disposition July 1, 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089

Citation Manager Formats

  • BibTeX
  • Bookends
  • EasyBib
  • EndNote (tagged)
  • EndNote 8 (xml)
  • Medlars
  • Mendeley
  • Papers
  • RefWorks Tagged
  • Ref Manager
  • RIS
  • Zotero

Share
Research ArticleArticle

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami
Drug Metabolism and Disposition July 1, 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089
del.icio.us logo Digg logo Reddit logo Twitter logo Facebook logo Google logo Mendeley logo
  • Tweet Widget
  • Facebook Like
  • Google Plus One

Jump to section

  • Article
    • Abstract
    • Materials and Methods
    • Results
    • Discussion
    • Footnotes
    • References
  • Figures & Data
  • Info & Metrics
  • eLetters
  • PDF

Related Articles

Cited By...

More in this TOC Section

  • Identification of payload-containing catabolites of ADCs
  • PK Interactions of Licorice with Cytochrome P450s
  • Biotransformation of Trastuzumab and Pertuzumab
Show more Articles

Similar Articles

Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics