Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino; Nobuhiro Ohtake; Akito Watanabe; Naoko Tsuchiya; Sachiko Imamura; Seiichi Iizuka; Makoto Inoue; Hajime Mizukami

doi:10.1124/dmd.108.021089

Research ArticleArticle

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami

Drug Metabolism and Disposition July 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089

Toshiaki Makino

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Nobuhiro Ohtake

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Akito Watanabe

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Naoko Tsuchiya

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Sachiko Imamura

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Seiichi Iizuka

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Makoto Inoue

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Hajime Mizukami

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Drug Metabolism and Disposition

Vol. 36, Issue 7

1 Jul 2008

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Research ArticleArticle

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami

Drug Metabolism and Disposition July 1, 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089

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Research ArticleArticle

Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

Toshiaki Makino, Nobuhiro Ohtake, Akito Watanabe, Naoko Tsuchiya, Sachiko Imamura, Seiichi Iizuka, Makoto Inoue and Hajime Mizukami

Drug Metabolism and Disposition July 1, 2008, 36 (7) 1438-1443; DOI: https://doi.org/10.1124/dmd.108.021089

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Down-Regulation of a Hepatic Transporter Multidrug Resistance-Associated Protein 2 Is Involved in Alteration of Pharmacokinetics of Glycyrrhizin and Its Metabolites in a Rat Model of Chronic Liver Injury

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