Skip to main content
Advertisement

Main menu

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET

User menu

  • My alerts
  • Log in
  • My Cart

Search

  • Advanced search
Drug Metabolism & Disposition
  • Other Publications
    • Drug Metabolism and Disposition
    • Journal of Pharmacology and Experimental Therapeutics
    • Molecular Pharmacology
    • Pharmacological Reviews
    • Pharmacology Research & Perspectives
    • ASPET
  • My alerts
  • Log in
  • My Cart
Drug Metabolism & Disposition

Advanced Search

  • Home
  • Articles
    • Current Issue
    • Fast Forward
    • Latest Articles
    • Special Sections
    • Archive
  • Information
    • Instructions to Authors
    • Submit a Manuscript
    • FAQs
    • For Subscribers
    • Terms & Conditions of Use
    • Permissions
  • Editorial Board
  • Alerts
    • Alerts
    • RSS Feeds
  • Virtual Issues
  • Feedback
  • Submit
  • Visit dmd on Facebook
  • Follow dmd on Twitter
  • Follow ASPET on LinkedIn

Table of Contents

August 01, 2008; Volume 36,Issue 8

Short Communications

  • You have access
    Hepatic Nuclear Factor 1α Inhibitor Ursodeoxycholic Acid Influences Pharmacokinetics of the Organic Anion Transporting Polypeptide 1B1 Substrate Rosuvastatin and Bilirubin
    Yi-Jing He, Wei Zhang, Jiang-Hua Tu, Julia Kirchheiner, Yao Chen, Dong Guo, Qing Li, Zhong-Yu Li, Hao Chen, Dong-Li Hu, Dan Wang and Hong-Hao Zhou
    Drug Metabolism and Disposition August 2008, 36 (8) 1453-1456; DOI: https://doi.org/10.1124/dmd.108.020503
  • You have access
    The Macrolide Everolimus Forms an Unusual Metabolite in Animals and Humans: Identification of a Phosphocholine Ester
    Markus Zollinger, Claudia Sayer, Robert Dannecker, Walter Schuler and Richard Sedrani
    Drug Metabolism and Disposition August 2008, 36 (8) 1457-1460; DOI: https://doi.org/10.1124/dmd.108.020651
  • You have access
    Expression of UGT1A and UGT2B mRNA in Human Normal Tissues and Various Cell Lines
    Akiko Nakamura, Miki Nakajima, Hiroyuki Yamanaka, Ryoichi Fujiwara and Tsuyoshi Yokoi
    Drug Metabolism and Disposition August 2008, 36 (8) 1461-1464; DOI: https://doi.org/10.1124/dmd.108.021428
  • You have access
    The Influence of CYP3A5 Genotype on Dexamethasone Induction of CYP3A Activity in African Americans
    Patrick J. Roberts, Kristan D. Rollins, Angela D. M. Kashuba, Mary F. Paine, Andrew C. Nelsen, Eric E. Williams, Cassandra Moran, Jatinder K. Lamba, Erin G. Schuetz and Roy L. Hawke
    Drug Metabolism and Disposition August 2008, 36 (8) 1465-1469; DOI: https://doi.org/10.1124/dmd.107.020065

Articles

  • You have access
    Assessment of the Medicines Lidocaine, Prilocaine, and Their Metabolites, 2,6-Dimethylaniline and 2-Methylaniline, for DNA Adduct Formation in Rat Tissues
    Jian-Dong Duan, Alan M. Jeffrey and Gary M. Williams
    Drug Metabolism and Disposition August 2008, 36 (8) 1470-1475; DOI: https://doi.org/10.1124/dmd.107.019950
  • You have access
    Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse
    Nagdeep Giri, Naveed Shaik, Guoyu Pan, Tetsuya Terasaki, Chisato Mukai, Shinji Kitagaki, Naoki Miyakoshi and William F. Elmquist
    Drug Metabolism and Disposition August 2008, 36 (8) 1476-1484; DOI: https://doi.org/10.1124/dmd.108.020974
  • You have access
    Plasma Profiling of Intact Isoflavone Metabolites by High-Performance Liquid Chromatography and Mass Spectrometric Identification of Flavone Glycosides Daidzin and Genistin in Human Plasma after Administration of Kinako
    Kaori Hosoda, Takashi Furuta, Akitomo Yokokawa, Kenichiro Ogura, Akira Hiratsuka and Kazuo Ishii
    Drug Metabolism and Disposition August 2008, 36 (8) 1485-1495; DOI: https://doi.org/10.1124/dmd.108.021006
  • You have access
    Role of Organic Anion Transporters in the Pharmacokinetics of Zonampanel, an α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonist, in Rats
    Tsuyoshi Minematsu, Tadashi Hashimoto, Toshiko Aoki, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition August 2008, 36 (8) 1496-1504; DOI: https://doi.org/10.1124/dmd.107.019828
  • You have access
    Effects of Ketoconazole and Quinidine on Pharmacokinetics of Pactimibe and Its Plasma Metabolite, R-125528, in Humans
    Masakatsu Kotsuma, Taro Tokui, Stefan Freudenthaler and Kenji Nishimura
    Drug Metabolism and Disposition August 2008, 36 (8) 1505-1511; DOI: https://doi.org/10.1124/dmd.108.021394
  • You have access
    In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition
    Divesh Aidasani, Matthew J. Zaya, Phyllis B. Malpas and Charles W. Locuson
    Drug Metabolism and Disposition August 2008, 36 (8) 1512-1518; DOI: https://doi.org/10.1124/dmd.108.021196
  • You have access
    Intestinal and Hepatobiliary Transport of Ximelagatran and Its Metabolites in Pigs
    Elin Sjödin, Holger Fritsch, Ulf G. Eriksson, Ulrika Logren, Anders Nordgren, Patrik Forsell, Lars Knutson and Hans Lennernäs
    Drug Metabolism and Disposition August 2008, 36 (8) 1519-1528; DOI: https://doi.org/10.1124/dmd.108.020412
  • You have access
    Regio- and Stereospecific N-Glucuronidation of Medetomidine: The Differences between UDP Glucuronosyltransferase (UGT) 1A4 and UGT2B10 Account for the Complex Kinetics of Human Liver Microsomes
    Sanna Kaivosaari, Päivi Toivonen, Olli Aitio, Julius Sipilä, Mikko Koskinen, Jarmo S. Salonen and Moshe Finel
    Drug Metabolism and Disposition August 2008, 36 (8) 1529-1537; DOI: https://doi.org/10.1124/dmd.108.021709
  • You have access
    The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes
    Kristin Lichti-Kaiser and Jeff L. Staudinger
    Drug Metabolism and Disposition August 2008, 36 (8) 1538-1545; DOI: https://doi.org/10.1124/dmd.108.021774
  • You have access
    Metabolism of the Cysteine S-Conjugate of Busulfan Involves a β-Lyase Reaction
    Arthur J. L. Cooper, Islam R. Younis, Zoya V. Niatsetskaya, Boris F. Krasnikov, John T. Pinto, William P. Petros and Patrick S. Callery
    Drug Metabolism and Disposition August 2008, 36 (8) 1546-1552; DOI: https://doi.org/10.1124/dmd.108.020768
  • You have access
    Identification of the Transporters Involved in the Hepatobiliary Transport and Intestinal Efflux of Methyl 1-(3,4-Dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) Glucuronide, a Pharmacologically Active Metabolite of S-8921
    Shingo Sakamoto, Hiroyuki Kusuhara, Kazutoshi Horie, Kohji Takahashi, Takahiko Baba, Jun Ishizaki and Yuichi Sugiyama
    Drug Metabolism and Disposition August 2008, 36 (8) 1553-1561; DOI: https://doi.org/10.1124/dmd.108.020511
  • You have access
    UDP-Glucuronosyltransferase 1A6 Is the Major Isozyme Responsible for Protocatechuic Aldehyde Glucuronidation in Human Liver Microsomes
    Hui-Xin Liu, Yong Liu, Jiang-Wei Zhang, Wei Li, Hong-Tao Liu and Ling Yang
    Drug Metabolism and Disposition August 2008, 36 (8) 1562-1569; DOI: https://doi.org/10.1124/dmd.108.020560
  • You have access
    Squalenoylation Favorably Modifies the in Vivo Pharmacokinetics and Biodistribution of Gemcitabine in Mice
    L. Harivardhan Reddy, Hania Khoury, Angelo Paci, Alain Deroussent, Humberto Ferreira, Catherine Dubernet, Xavier Declèves, Madeleine Besnard, Helène Chacun, Sinda Lepêtre-Mouelhi, Didier Desmaële, Bernard Rousseau, Christelle Laugier, Jean-Christophe Cintrat, Gilles Vassal and Patrick Couvreur
    Drug Metabolism and Disposition August 2008, 36 (8) 1570-1577; DOI: https://doi.org/10.1124/dmd.108.020735
  • You have access
    Plasma and Urinary Tanshinol from Salvia miltiorrhiza (Danshen) Can Be Used as Pharmacokinetic Markers for Cardiotonic Pills, a Cardiovascular Herbal Medicine
    Tong Lu, Junling Yang, Xiumei Gao, Ping Chen, Feifei Du, Yan Sun, Fengqing Wang, Fang Xu, Hongcai Shang, Yuhong Huang, Yi Wang, Renzhong Wan, Changxiao Liu, Boli Zhang and Chuan Li
    Drug Metabolism and Disposition August 2008, 36 (8) 1578-1586; DOI: https://doi.org/10.1124/dmd.108.021592
  • You have access
    Developmental Changes in Human Liver CYP2D6 Expression
    Jeffrey C. Stevens, Sandra A. Marsh, Matthew J. Zaya, Karen J. Regina, Karthika Divakaran, Min Le and Ronald N. Hines
    Drug Metabolism and Disposition August 2008, 36 (8) 1587-1593; DOI: https://doi.org/10.1124/dmd.108.021873
  • You have access
    Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor
    Laurie P. Volak, Senait Ghirmai, John R. Cashman and Michael H. Court
    Drug Metabolism and Disposition August 2008, 36 (8) 1594-1605; DOI: https://doi.org/10.1124/dmd.108.020552
  • You have access
    Extensive Metabolism and Hepatic Accumulation of Gemcitabine After Multiple Oral and Intravenous Administration in Mice
    Stephan A. Veltkamp, Dick Pluim, Olaf van Tellingen, Jos H. Beijnen and Jan H. M. Schellens
    Drug Metabolism and Disposition August 2008, 36 (8) 1606-1615; DOI: https://doi.org/10.1124/dmd.108.021048
  • You have access
    Relevance of the Organic Cation Transporters 1 and 2 for Antiretroviral Drug Therapy in Human Immunodeficiency Virus Infection
    Norma Jung, Clara Lehmann, Andrea Rubbert, Meike Knispel, Pia Hartmann, Jan van Lunzen, Hans-Juergen Stellbrink, Gerd Faetkenheuer and Dirk Taubert
    Drug Metabolism and Disposition August 2008, 36 (8) 1616-1623; DOI: https://doi.org/10.1124/dmd.108.020826
  • You have access
    Peroxidase-Mediated Bioactivation of Hydroxylated Metabolites of Carbamazepine and Phenytoin
    Wei Lu and Jack P. Uetrecht
    Drug Metabolism and Disposition August 2008, 36 (8) 1624-1636; DOI: https://doi.org/10.1124/dmd.107.019554
  • You have access
    Pathways of Carbamazepine Bioactivation in Vitro. III. The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine
    Robin E. Pearce, Wei Lu, YongQiang Wang, Jack P. Uetrecht, Maria Almira Correia and J. Steven Leeder
    Drug Metabolism and Disposition August 2008, 36 (8) 1637-1649; DOI: https://doi.org/10.1124/dmd.107.019562
  • You have access
    Mechanisms Underlying Saturable Intestinal Absorption of Metformin
    William R. Proctor, David L. Bourdet and Dhiren R. Thakker
    Drug Metabolism and Disposition August 2008, 36 (8) 1650-1658; DOI: https://doi.org/10.1124/dmd.107.020180
  • You have access
    Comparative Disposition and Metabolism of Paraherquamide in Sheep, Gerbils, and Dogs
    Herve A. Aloysius, Maria V. Silva Elipe, Byron H. Arison, Terry D. Faidley, Bruce F. Michael, Timothy A. Blizzard, Donald R. Thompson, Wesley L. Shoop and Richard A. Tschirret-Guth
    Drug Metabolism and Disposition August 2008, 36 (8) 1659-1669; DOI: https://doi.org/10.1124/dmd.107.019430
  • You have access
    Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes
    Ken Grime, Peter J. H. Webborn and Robert J. Riley
    Drug Metabolism and Disposition August 2008, 36 (8) 1670-1678; DOI: https://doi.org/10.1124/dmd.108.021055
  • You have access
    Cytochrome P450 2B6 Catalyzes the Formation of Pharmacologically Active Sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) Metabolites in Human Liver Microsomes
    Soo Kyung Bae, Shan Cao, Kyung-Ah Seo, Hyunmi Kim, Min-Jung Kim, Ji-Hong Shon, Kwang-Hyeon Liu, Hong-Hao Zhou and Jae-Gook Shin
    Drug Metabolism and Disposition August 2008, 36 (8) 1679-1688; DOI: https://doi.org/10.1124/dmd.108.020727
  • You have access
    A Comprehensive in Vitro and in Silico Analysis of Antibiotics That Activate Pregnane X Receptor and Induce CYP3A4 in Liver and Intestine
    Kazuto Yasuda, Aarati Ranade, Raman Venkataramanan, Stephen Strom, Jonathan Chupka, Sean Ekins, Erin Schuetz and Kenneth Bachmann
    Drug Metabolism and Disposition August 2008, 36 (8) 1689-1697; DOI: https://doi.org/10.1124/dmd.108.020701
  • You have access
    A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro
    Odette A. Fahmi, Tristan S. Maurer, Mary Kish, Edwin Cardenas, Sherri Boldt and David Nettleton
    Drug Metabolism and Disposition August 2008, 36 (8) 1698-1708; DOI: https://doi.org/10.1124/dmd.107.018663
  • You have access
    Rapid Distribution of Liposomal Short-Chain Ceramide in Vitro and in Vivo
    Banu S. Zolnik, Stephan T. Stern, James M. Kaiser, Yasser Heakal, Jeffrey D. Clogston, Mark Kester and Scott E. McNeil
    Drug Metabolism and Disposition August 2008, 36 (8) 1709-1715; DOI: https://doi.org/10.1124/dmd.107.019679
  • You have access
    The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor
    Matthew D. Merrell, Jonathan P. Jackson, Lisa M. Augustine, Craig D. Fisher, Angela L. Slitt, Jonathan M. Maher, Wendong Huang, David D. Moore, Youcai Zhang, Curtis D. Klaassen and Nathan J. Cherrington
    Drug Metabolism and Disposition August 2008, 36 (8) 1716-1721; DOI: https://doi.org/10.1124/dmd.108.020867
  • You have access
    Deletion of the NADPH-Cytochrome P450 Reductase Gene in Cardiomyocytes Does Not Protect Mice against Doxorubicin-Mediated Acute Cardiac Toxicity
    Cheng Fang, Jun Gu, Fang Xie, Melissa Behr, Weizhu Yang, E. Dale Abel and Xinxin Ding
    Drug Metabolism and Disposition August 2008, 36 (8) 1722-1728; DOI: https://doi.org/10.1124/dmd.108.021881
  • You have access
    Effect of Interleukin-2 Pretreatment on Paclitaxel Absorption and Tissue Disposition after Oral and Intravenous Administration in Mice
    Benoît Hosten, Chadi Abbara, Benoît Petit, Angélique Dauvin, Fanchon Bourasset, Robert Farinotti, Patrick Gonin and Laurence Bonhomme-Faivre
    Drug Metabolism and Disposition August 2008, 36 (8) 1729-1735; DOI: https://doi.org/10.1124/dmd.107.019091

Erratum

  • You have access
    CORRECTION TO “IDENTIFICATION AND CHARACTERIZATION OF POTENT CYP2B6 INHIBITORS IN WOOHWANGCHEONGSIMWON SUSPENSION, AN HERBAL PREPARATION USED IN THE TREATMENT AND PREVENTION OF APOPLEXY IN KOREA AND CHINA”
    Drug Metabolism and Disposition August 2008, 36 (8) 1736; DOI: https://doi.org/10.1124/dmd.36.8.1736
Back to top
PreviousNext

In this issue

Drug Metabolism and Disposition: 36 (8)
Drug Metabolism and Disposition
Vol. 36, Issue 8
1 Aug 2008
  • Table of Contents
  • Table of Contents (PDF)
  • About the Cover
  • Index by author
  • Back Matter (PDF)
  • Editorial Board (PDF)
  • Front Matter (PDF)
Sign up for alerts

Jump to

  • Short Communications
  • Articles
  • Erratum
  • Most Cited
  • Most Read
Loading
  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
More...
Advertisement
  • Home
  • Alerts
Facebook   Twitter   LinkedIn   RSS

Navigate

  • Current Issue
  • Fast Forward by date
  • Fast Forward by section
  • Latest Articles
  • Archive
  • Search for Articles
  • Feedback
  • ASPET

More Information

  • About DMD
  • Editorial Board
  • Instructions to Authors
  • Submit a Manuscript
  • Customized Alerts
  • RSS Feeds
  • Subscriptions
  • Permissions
  • Terms & Conditions of Use

ASPET's Other Journals

  • Journal of Pharmacology and Experimental Therapeutics
  • Molecular Pharmacology
  • Pharmacological Reviews
  • Pharmacology Research & Perspectives
ISSN 1521-009X (Online)

Copyright © 2023 by the American Society for Pharmacology and Experimental Therapeutics