Table of Contents

Articles

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  Assessment of the Medicines Lidocaine, Prilocaine, and Their Metabolites, 2,6-Dimethylaniline and 2-Methylaniline, for DNA Adduct Formation in Rat Tissues

  Jian-Dong Duan, Alan M. Jeffrey and Gary M. Williams

  Drug Metabolism and Disposition August 2008, 36 (8) 1470-1475; DOI: https://doi.org/10.1124/dmd.107.019950
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  Investigation of the Role of Breast Cancer Resistance Protein (Bcrp/Abcg2) on Pharmacokinetics and Central Nervous System Penetration of Abacavir and Zidovudine in the Mouse

  Nagdeep Giri, Naveed Shaik, Guoyu Pan, Tetsuya Terasaki, Chisato Mukai, Shinji Kitagaki, Naoki Miyakoshi and William F. Elmquist

  Drug Metabolism and Disposition August 2008, 36 (8) 1476-1484; DOI: https://doi.org/10.1124/dmd.108.020974
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  Plasma Profiling of Intact Isoflavone Metabolites by High-Performance Liquid Chromatography and Mass Spectrometric Identification of Flavone Glycosides Daidzin and Genistin in Human Plasma after Administration of Kinako

  Kaori Hosoda, Takashi Furuta, Akitomo Yokokawa, Kenichiro Ogura, Akira Hiratsuka and Kazuo Ishii

  Drug Metabolism and Disposition August 2008, 36 (8) 1485-1495; DOI: https://doi.org/10.1124/dmd.108.021006
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  Role of Organic Anion Transporters in the Pharmacokinetics of Zonampanel, an α-Amino-3-hydroxy-5-methylisoxazole-4-propionate Receptor Antagonist, in Rats

  Tsuyoshi Minematsu, Tadashi Hashimoto, Toshiko Aoki, Takashi Usui and Hidetaka Kamimura

  Drug Metabolism and Disposition August 2008, 36 (8) 1496-1504; DOI: https://doi.org/10.1124/dmd.107.019828
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  Effects of Ketoconazole and Quinidine on Pharmacokinetics of Pactimibe and Its Plasma Metabolite, R-125528, in Humans

  Masakatsu Kotsuma, Taro Tokui, Stefan Freudenthaler and Kenji Nishimura

  Drug Metabolism and Disposition August 2008, 36 (8) 1505-1511; DOI: https://doi.org/10.1124/dmd.108.021394
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  In Vitro Drug-Drug Interaction Screens for Canine Veterinary Medicines: Evaluation of Cytochrome P450 Reversible Inhibition

  Divesh Aidasani, Matthew J. Zaya, Phyllis B. Malpas and Charles W. Locuson

  Drug Metabolism and Disposition August 2008, 36 (8) 1512-1518; DOI: https://doi.org/10.1124/dmd.108.021196
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  Intestinal and Hepatobiliary Transport of Ximelagatran and Its Metabolites in Pigs

  Elin Sjödin, Holger Fritsch, Ulf G. Eriksson, Ulrika Logren, Anders Nordgren, Patrik Forsell, Lars Knutson and Hans Lennernäs

  Drug Metabolism and Disposition August 2008, 36 (8) 1519-1528; DOI: https://doi.org/10.1124/dmd.108.020412
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  Regio- and Stereospecific N-Glucuronidation of Medetomidine: The Differences between UDP Glucuronosyltransferase (UGT) 1A4 and UGT2B10 Account for the Complex Kinetics of Human Liver Microsomes

  Sanna Kaivosaari, Päivi Toivonen, Olli Aitio, Julius Sipilä, Mikko Koskinen, Jarmo S. Salonen and Moshe Finel

  Drug Metabolism and Disposition August 2008, 36 (8) 1529-1537; DOI: https://doi.org/10.1124/dmd.108.021709
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  The Traditional Chinese Herbal Remedy Tian Xian Activates Pregnane X Receptor and Induces CYP3A Gene Expression in Hepatocytes

  Kristin Lichti-Kaiser and Jeff L. Staudinger

  Drug Metabolism and Disposition August 2008, 36 (8) 1538-1545; DOI: https://doi.org/10.1124/dmd.108.021774
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  Metabolism of the Cysteine S-Conjugate of Busulfan Involves a β-Lyase Reaction

  Arthur J. L. Cooper, Islam R. Younis, Zoya V. Niatsetskaya, Boris F. Krasnikov, John T. Pinto, William P. Petros and Patrick S. Callery

  Drug Metabolism and Disposition August 2008, 36 (8) 1546-1552; DOI: https://doi.org/10.1124/dmd.108.020768
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  Identification of the Transporters Involved in the Hepatobiliary Transport and Intestinal Efflux of Methyl 1-(3,4-Dimethoxyphenyl)-3-(3-ethylvaleryl)-4-hydroxy-6,7,8-trimethoxy-2-naphthoate (S-8921) Glucuronide, a Pharmacologically Active Metabolite of S-8921

  Shingo Sakamoto, Hiroyuki Kusuhara, Kazutoshi Horie, Kohji Takahashi, Takahiko Baba, Jun Ishizaki and Yuichi Sugiyama

  Drug Metabolism and Disposition August 2008, 36 (8) 1553-1561; DOI: https://doi.org/10.1124/dmd.108.020511
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  UDP-Glucuronosyltransferase 1A6 Is the Major Isozyme Responsible for Protocatechuic Aldehyde Glucuronidation in Human Liver Microsomes

  Hui-Xin Liu, Yong Liu, Jiang-Wei Zhang, Wei Li, Hong-Tao Liu and Ling Yang

  Drug Metabolism and Disposition August 2008, 36 (8) 1562-1569; DOI: https://doi.org/10.1124/dmd.108.020560
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  Squalenoylation Favorably Modifies the in Vivo Pharmacokinetics and Biodistribution of Gemcitabine in Mice

  L. Harivardhan Reddy, Hania Khoury, Angelo Paci, Alain Deroussent, Humberto Ferreira, Catherine Dubernet, Xavier Declèves, Madeleine Besnard, Helène Chacun, Sinda Lepêtre-Mouelhi, Didier Desmaële, Bernard Rousseau, Christelle Laugier, Jean-Christophe Cintrat, Gilles Vassal and Patrick Couvreur

  Drug Metabolism and Disposition August 2008, 36 (8) 1570-1577; DOI: https://doi.org/10.1124/dmd.108.020735
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  Plasma and Urinary Tanshinol from Salvia miltiorrhiza (Danshen) Can Be Used as Pharmacokinetic Markers for Cardiotonic Pills, a Cardiovascular Herbal Medicine

  Tong Lu, Junling Yang, Xiumei Gao, Ping Chen, Feifei Du, Yan Sun, Fengqing Wang, Fang Xu, Hongcai Shang, Yuhong Huang, Yi Wang, Renzhong Wan, Changxiao Liu, Boli Zhang and Chuan Li

  Drug Metabolism and Disposition August 2008, 36 (8) 1578-1586; DOI: https://doi.org/10.1124/dmd.108.021592
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  Developmental Changes in Human Liver CYP2D6 Expression

  Jeffrey C. Stevens, Sandra A. Marsh, Matthew J. Zaya, Karen J. Regina, Karthika Divakaran, Min Le and Ronald N. Hines

  Drug Metabolism and Disposition August 2008, 36 (8) 1587-1593; DOI: https://doi.org/10.1124/dmd.108.021873
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  Curcuminoids Inhibit Multiple Human Cytochromes P450, UDP-Glucuronosyltransferase, and Sulfotransferase Enzymes, whereas Piperine Is a Relatively Selective CYP3A4 Inhibitor

  Laurie P. Volak, Senait Ghirmai, John R. Cashman and Michael H. Court

  Drug Metabolism and Disposition August 2008, 36 (8) 1594-1605; DOI: https://doi.org/10.1124/dmd.108.020552
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  Extensive Metabolism and Hepatic Accumulation of Gemcitabine After Multiple Oral and Intravenous Administration in Mice

  Stephan A. Veltkamp, Dick Pluim, Olaf van Tellingen, Jos H. Beijnen and Jan H. M. Schellens

  Drug Metabolism and Disposition August 2008, 36 (8) 1606-1615; DOI: https://doi.org/10.1124/dmd.108.021048
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  Relevance of the Organic Cation Transporters 1 and 2 for Antiretroviral Drug Therapy in Human Immunodeficiency Virus Infection

  Norma Jung, Clara Lehmann, Andrea Rubbert, Meike Knispel, Pia Hartmann, Jan van Lunzen, Hans-Juergen Stellbrink, Gerd Faetkenheuer and Dirk Taubert

  Drug Metabolism and Disposition August 2008, 36 (8) 1616-1623; DOI: https://doi.org/10.1124/dmd.108.020826
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  Peroxidase-Mediated Bioactivation of Hydroxylated Metabolites of Carbamazepine and Phenytoin

  Wei Lu and Jack P. Uetrecht

  Drug Metabolism and Disposition August 2008, 36 (8) 1624-1636; DOI: https://doi.org/10.1124/dmd.107.019554
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  Pathways of Carbamazepine Bioactivation in Vitro. III. The Role of Human Cytochrome P450 Enzymes in the Formation of 2,3-Dihydroxycarbamazepine

  Robin E. Pearce, Wei Lu, YongQiang Wang, Jack P. Uetrecht, Maria Almira Correia and J. Steven Leeder

  Drug Metabolism and Disposition August 2008, 36 (8) 1637-1649; DOI: https://doi.org/10.1124/dmd.107.019562
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  Mechanisms Underlying Saturable Intestinal Absorption of Metformin

  William R. Proctor, David L. Bourdet and Dhiren R. Thakker

  Drug Metabolism and Disposition August 2008, 36 (8) 1650-1658; DOI: https://doi.org/10.1124/dmd.107.020180
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  Comparative Disposition and Metabolism of Paraherquamide in Sheep, Gerbils, and Dogs

  Herve A. Aloysius, Maria V. Silva Elipe, Byron H. Arison, Terry D. Faidley, Bruce F. Michael, Timothy A. Blizzard, Donald R. Thompson, Wesley L. Shoop and Richard A. Tschirret-Guth

  Drug Metabolism and Disposition August 2008, 36 (8) 1659-1669; DOI: https://doi.org/10.1124/dmd.107.019430
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  Functional Consequences of Active Hepatic Uptake on Cytochrome P450 Inhibition in Rat and Human Hepatocytes

  Ken Grime, Peter J. H. Webborn and Robert J. Riley

  Drug Metabolism and Disposition August 2008, 36 (8) 1670-1678; DOI: https://doi.org/10.1124/dmd.108.021055
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  Cytochrome P450 2B6 Catalyzes the Formation of Pharmacologically Active Sibutramine (N-{1-[1-(4-chlorophenyl)cyclobutyl]-3-methylbutyl}-N,N-dimethylamine) Metabolites in Human Liver Microsomes

  Soo Kyung Bae, Shan Cao, Kyung-Ah Seo, Hyunmi Kim, Min-Jung Kim, Ji-Hong Shon, Kwang-Hyeon Liu, Hong-Hao Zhou and Jae-Gook Shin

  Drug Metabolism and Disposition August 2008, 36 (8) 1679-1688; DOI: https://doi.org/10.1124/dmd.108.020727
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  A Comprehensive in Vitro and in Silico Analysis of Antibiotics That Activate Pregnane X Receptor and Induce CYP3A4 in Liver and Intestine

  Kazuto Yasuda, Aarati Ranade, Raman Venkataramanan, Stephen Strom, Jonathan Chupka, Sean Ekins, Erin Schuetz and Kenneth Bachmann

  Drug Metabolism and Disposition August 2008, 36 (8) 1689-1697; DOI: https://doi.org/10.1124/dmd.108.020701
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  A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

  Odette A. Fahmi, Tristan S. Maurer, Mary Kish, Edwin Cardenas, Sherri Boldt and David Nettleton

  Drug Metabolism and Disposition August 2008, 36 (8) 1698-1708; DOI: https://doi.org/10.1124/dmd.107.018663
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  Rapid Distribution of Liposomal Short-Chain Ceramide in Vitro and in Vivo

  Banu S. Zolnik, Stephan T. Stern, James M. Kaiser, Yasser Heakal, Jeffrey D. Clogston, Mark Kester and Scott E. McNeil

  Drug Metabolism and Disposition August 2008, 36 (8) 1709-1715; DOI: https://doi.org/10.1124/dmd.107.019679
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  The Nrf2 Activator Oltipraz Also Activates the Constitutive Androstane Receptor

  Matthew D. Merrell, Jonathan P. Jackson, Lisa M. Augustine, Craig D. Fisher, Angela L. Slitt, Jonathan M. Maher, Wendong Huang, David D. Moore, Youcai Zhang, Curtis D. Klaassen and Nathan J. Cherrington

  Drug Metabolism and Disposition August 2008, 36 (8) 1716-1721; DOI: https://doi.org/10.1124/dmd.108.020867
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  Deletion of the NADPH-Cytochrome P450 Reductase Gene in Cardiomyocytes Does Not Protect Mice against Doxorubicin-Mediated Acute Cardiac Toxicity

  Cheng Fang, Jun Gu, Fang Xie, Melissa Behr, Weizhu Yang, E. Dale Abel and Xinxin Ding

  Drug Metabolism and Disposition August 2008, 36 (8) 1722-1728; DOI: https://doi.org/10.1124/dmd.108.021881
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  Effect of Interleukin-2 Pretreatment on Paclitaxel Absorption and Tissue Disposition after Oral and Intravenous Administration in Mice

  Benoît Hosten, Chadi Abbara, Benoît Petit, Angélique Dauvin, Fanchon Bourasset, Robert Farinotti, Patrick Gonin and Laurence Bonhomme-Faivre

  Drug Metabolism and Disposition August 2008, 36 (8) 1729-1735; DOI: https://doi.org/10.1124/dmd.107.019091