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Research ArticleArticle

A Comprehensive in Vitro and in Silico Analysis of Antibiotics That Activate Pregnane X Receptor and Induce CYP3A4 in Liver and Intestine

Kazuto Yasuda, Aarati Ranade, Raman Venkataramanan, Stephen Strom, Jonathan Chupka, Sean Ekins, Erin Schuetz and Kenneth Bachmann
Drug Metabolism and Disposition August 2008, 36 (8) 1689-1697; DOI: https://doi.org/10.1124/dmd.108.020701

Article Information

vol. 36 no. 8 1689-1697
DOI 
https://doi.org/10.1124/dmd.108.020701
PubMed 
18505790
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received January 31, 2008
  • Accepted May 19, 2008
  • Published online July 21, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kazuto Yasuda,
  2. Aarati Ranade,
  3. Raman Venkataramanan,
  4. Stephen Strom,
  5. Jonathan Chupka,
  6. Sean Ekins,
  7. Erin Schuetz and
  8. Kenneth Bachmann
  1. Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (K.Y., E.S.); Department of Pharmaceutical Sciences, School of Pharmacy, University of Pittsburgh, Pittsburgh, Pennsylvania (A.R., R.V., S.S.); Department of Pharmacology, University of Toledo College of Pharmacy, Toledo, Ohio (J.C., K.B.); Collaborations in Chemistry, Jenkintown, Pennsylvania (S.E.); Department of Pharmaceutical Sciences, University of Maryland, Baltimore, Maryland (S.E.); and Department of Pharmacology, Robert Wood Johnson Medical School, and University of Medicine and Dentistry of New Jersey, Piscataway, New Jersey (S.E.)
  1. Address correspondence to:
    Dr. Kenneth Bachmann, Department of Pharmacology, The University of Toledo College of Pharmacy, 2801 W. Bancroft St., Toledo, OH 43606. E-mail: kbachma{at}utnet.utoledo.edu
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Research ArticleArticle

A Comprehensive in Vitro and in Silico Analysis of Antibiotics That Activate Pregnane X Receptor and Induce CYP3A4 in Liver and Intestine

Kazuto Yasuda, Aarati Ranade, Raman Venkataramanan, Stephen Strom, Jonathan Chupka, Sean Ekins, Erin Schuetz and Kenneth Bachmann
Drug Metabolism and Disposition August 1, 2008, 36 (8) 1689-1697; DOI: https://doi.org/10.1124/dmd.108.020701
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