A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research & Development, Groton, Connecticut (O.A.F., T.S.M., M.K., S.B.); Novartis Institutes for BioMedical Research, Cambridge, Massachusetts (D.N.); and University of Connecticut, Storrs, Connecticut (E.C.)

Address correspondence to:
Dr. Odette Fahmi, Department of Pharmacokinetics, Dynamics, and Metabolism, Mail Stop MS-8118W-128, Pfizer Global Research & Development, Eastern Point Rd., Groton, CT 06340. E-mail: odette.a.fahmi{at}pfizer.com

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