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Research ArticleArticle

A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

Odette A. Fahmi, Tristan S. Maurer, Mary Kish, Edwin Cardenas, Sherri Boldt and David Nettleton
Drug Metabolism and Disposition August 2008, 36 (8) 1698-1708; DOI: https://doi.org/10.1124/dmd.107.018663
Odette A. Fahmi
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Tristan S. Maurer
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Mary Kish
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Edwin Cardenas
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Sherri Boldt
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David Nettleton
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Article Information

vol. 36 no. 8 1698-1708
DOI 
https://doi.org/10.1124/dmd.107.018663
PubMed 
18490437

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 30, 2007
  • Accepted May 16, 2008
  • Published online July 21, 2008.

Article Versions

  • Earlier version (May 19, 2008 - 08:25).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Odette A. Fahmi,
  2. Tristan S. Maurer,
  3. Mary Kish,
  4. Edwin Cardenas,
  5. Sherri Boldt and
  6. David Nettleton
  1. Department of Pharmacokinetics, Dynamics, and Metabolism, Pfizer Global Research & Development, Groton, Connecticut (O.A.F., T.S.M., M.K., S.B.); Novartis Institutes for BioMedical Research, Cambridge, Massachusetts (D.N.); and University of Connecticut, Storrs, Connecticut (E.C.)
  1. Address correspondence to:
    Dr. Odette Fahmi, Department of Pharmacokinetics, Dynamics, and Metabolism, Mail Stop MS-8118W-128, Pfizer Global Research & Development, Eastern Point Rd., Groton, CT 06340. E-mail: odette.a.fahmi{at}pfizer.com
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Drug Metabolism and Disposition: 36 (8)
Drug Metabolism and Disposition
Vol. 36, Issue 8
1 Aug 2008
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Research ArticleArticle

A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

Odette A. Fahmi, Tristan S. Maurer, Mary Kish, Edwin Cardenas, Sherri Boldt and David Nettleton
Drug Metabolism and Disposition August 1, 2008, 36 (8) 1698-1708; DOI: https://doi.org/10.1124/dmd.107.018663

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Research ArticleArticle

A Combined Model for Predicting CYP3A4 Clinical Net Drug-Drug Interaction Based on CYP3A4 Inhibition, Inactivation, and Induction Determined in Vitro

Odette A. Fahmi, Tristan S. Maurer, Mary Kish, Edwin Cardenas, Sherri Boldt and David Nettleton
Drug Metabolism and Disposition August 1, 2008, 36 (8) 1698-1708; DOI: https://doi.org/10.1124/dmd.107.018663
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