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Drug Metabolism & Disposition

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Table of Contents

September 01, 2008; Volume 36,Issue 9

Short Communications

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    Androgen Regulation of Renal Uridine Diphosphoglucuronosyltransferase 1A1 in Rats
    Stephan T. Stern, Melanie N. Tallman, Kristini K. Miles, Joseph K. Ritter and Philip C. Smith
    Drug Metabolism and Disposition September 2008, 36 (9) 1737-1739; DOI: https://doi.org/10.1124/dmd.108.020610
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    A Novel Bioactivation Pathway for 2-[2-(2,6-Dichlorophenyl)aminophenyl]ethanoic Acid (Diclofenac) Initiated by Cytochrome P450-Mediated Oxidative Decarboxylation
    Mark P. Grillo, Ji Ma, Yohannes Teffera and Daniel J. Waldon
    Drug Metabolism and Disposition September 2008, 36 (9) 1740-1744; DOI: https://doi.org/10.1124/dmd.108.021287

Articles

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    Species Differences in UDP-Glucuronosyltransferase Activities in Mice and Rats
    Hirotada Shiratani, Miki Katoh, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition September 2008, 36 (9) 1745-1752; DOI: https://doi.org/10.1124/dmd.108.021469
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    Metabolism, Distribution, and Excretion of a Next Generation Selective Estrogen Receptor Modulator, Lasofoxifene, in Rats and Monkeys
    Chandra Prakash, Kim A. Johnson, Clinton M. Schroeder and Michael J. Potchoiba
    Drug Metabolism and Disposition September 2008, 36 (9) 1753-1769; DOI: https://doi.org/10.1124/dmd.108.021808
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    Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity
    Hideo Takakusa, Hiroshi Masumoto, Hideo Yukinaga, Chie Makino, Shintaro Nakayama, Osamu Okazaki and Kenichi Sudo
    Drug Metabolism and Disposition September 2008, 36 (9) 1770-1779; DOI: https://doi.org/10.1124/dmd.108.021725
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    The Dihydroorotase Inhibitor 5-Aminoorotic Acid Inhibits the Metabolism in the Rat of the Cardioprotective Drug Dexrazoxane and Its One-Ring Open Metabolites
    Patricia E. Schroeder, Daywin Patel and Brian B. Hasinoff
    Drug Metabolism and Disposition September 2008, 36 (9) 1780-1785; DOI: https://doi.org/10.1124/dmd.108.021626
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    Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients
    Kenya Nakai, Hiromasa Tanaka, Kazuhiko Hanada, Hiroyasu Ogata, Fumitaka Suzuki, Hiromitsu Kumada, Atsuko Miyajima, Seiichi Ishida, Momoko Sunouchi, Wataru Habano, Yuichiro Kamikawa, Keiichi Kubota, Junji Kita, Shogo Ozawa and Yasuo Ohno
    Drug Metabolism and Disposition September 2008, 36 (9) 1786-1793; DOI: https://doi.org/10.1124/dmd.107.020073
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    Metabolism and Transport of the Citrus Flavonoid Hesperetin in Caco-2 Cell Monolayers
    Walter Brand, Petronella A. I. van der Wel, Maarit J. Rein, Denis Barron, Gary Williamson, Peter J. van Bladeren and Ivonne M. C. M. Rietjens
    Drug Metabolism and Disposition September 2008, 36 (9) 1794-1802; DOI: https://doi.org/10.1124/dmd.107.019943
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    Cytochrome P450 2C11 5′-Flanking Region and Promoter Mediate in Vivo Suppression by 3-Methylcholanthrene
    Rana M. Sawaya and David S. Riddick
    Drug Metabolism and Disposition September 2008, 36 (9) 1803-1811; DOI: https://doi.org/10.1124/dmd.108.020966
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    Binding of Pimecrolimus and Tacrolimus to Skin and Plasma Proteins: Implications for Systemic Exposure after Topical Application
    H. Markus Weiss, Marcel Fresneau, Thomas Moenius, Anton Stuetz and Andreas Billich
    Drug Metabolism and Disposition September 2008, 36 (9) 1812-1818; DOI: https://doi.org/10.1124/dmd.108.021915
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    Down-Regulation of the Carcinogen-Metabolizing Enzyme Cytochrome P450 1a1 by Vanadium
    Anwar Anwar-Mohamed and Ayman O. S. El-Kadi
    Drug Metabolism and Disposition September 2008, 36 (9) 1819-1827; DOI: https://doi.org/10.1124/dmd.108.021154
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    Identification of the Human Enzymes Involved in the Oxidative Metabolism of Dasatinib: An Effective Approach for Determining Metabolite Formation Kinetics
    Lifei Wang, Lisa J. Christopher, Donghui Cui, Wenying Li, Ramaswamy Iyer, W. Griffith Humphreys and Donglu Zhang
    Drug Metabolism and Disposition September 2008, 36 (9) 1828-1839; DOI: https://doi.org/10.1124/dmd.107.020255
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    Utility of a Novel Oatp1b2 Knockout Mouse Model for Evaluating the Role of Oatp1b2 in the Hepatic Uptake of Model Compounds
    Cuiping Chen, Jeffery L. Stock, Xingrong Liu, Jilin Shi, Jeffrey W. Van Deusen, Debra A. DiMattia, Robert G. Dullea and Sonia M. de Morais
    Drug Metabolism and Disposition September 2008, 36 (9) 1840-1845; DOI: https://doi.org/10.1124/dmd.108.020594
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    Pharmacokinetics and Brain Penetration of Casopitant, a Potent and Selective Neurokinin-1 Receptor Antagonist, in the Ferret
    Elisabeth Minthorn, Thomas Mencken, Andrew G. King, Art Shu, David Rominger, Richard R. Gontarek, Chao Han, Ramesh Bambal and Charles B. Davis
    Drug Metabolism and Disposition September 2008, 36 (9) 1846-1852; DOI: https://doi.org/10.1124/dmd.108.021758
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    Biodistribution of Radiolabeled Ethanol in Rodents
    Andrew N. Gifford, Mel Pilar Espaillat and S. John Gatley
    Drug Metabolism and Disposition September 2008, 36 (9) 1853-1858; DOI: https://doi.org/10.1124/dmd.107.020271
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    Placental Transfer and Fetal Elimination of Morphine-3-β-glucuronide in the Pregnant Baboon
    Marianne Garland, Kirsten M. Abildskov, Tung-wah Kiu, Salha S. Daniel, Piper Weldy and Raymond I. Stark
    Drug Metabolism and Disposition September 2008, 36 (9) 1859-1868; DOI: https://doi.org/10.1124/dmd.108.021352
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    Metabolism Distribution and Excretion of a Matrix Metalloproteinase-13 Inhibitor, 4-[4-(4-Fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic Acid Hydroxyamide (CP-544439), in Rats and Dogs: Assessment of the Metabolic Profile of CP-544439 in Plasma and Urine of Humans
    Deepak Dalvie, Theresa Cosker, Tracey Boyden, Sue Zhou, Clinton Schroeder and Michael J. Potchoiba
    Drug Metabolism and Disposition September 2008, 36 (9) 1869-1883; DOI: https://doi.org/10.1124/dmd.108.022566
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    Inherent Sexually Dimorphic Expression of Hepatic CYP2C12 Correlated with Repressed Activation of Growth Hormone-Regulated Signal Transduction in Male Rats
    Chellappagounder Thangavel and Bernard H. Shapiro
    Drug Metabolism and Disposition September 2008, 36 (9) 1884-1895; DOI: https://doi.org/10.1124/dmd.108.021451
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    Identification of Enzymes Involved in the Metabolism of 17α-Hydroxyprogesterone Caproate: An Effective Agent for Prevention of Preterm Birth
    Shringi Sharma, Junhai Ou, Stephen Strom, Don Mattison, Steve Caritis and Raman Venkataramanan
    Drug Metabolism and Disposition September 2008, 36 (9) 1896-1902; DOI: https://doi.org/10.1124/dmd.108.021444
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    Characterization of Substrate Specificity of Dog CYP1A2 Using CYP1A2-Deficient and Wild-Type Dog Liver Microsomes
    Masashi Mise, Takanori Hashizume and Setsuko Komuro
    Drug Metabolism and Disposition September 2008, 36 (9) 1903-1908; DOI: https://doi.org/10.1124/dmd.108.022301
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    The Pharmacokinetics of Silymarin Is Altered in Patients with Hepatitis C Virus and Nonalcoholic Fatty Liver Disease and Correlates with Plasma Caspase-3/7 Activity
    Sarah J. Schrieber, Zhiming Wen, Manoli Vourvahis, Philip C. Smith, Michael W. Fried, Angela D. M. Kashuba and Roy L. Hawke
    Drug Metabolism and Disposition September 2008, 36 (9) 1909-1916; DOI: https://doi.org/10.1124/dmd.107.019604
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    Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis
    Shuso Takeda, Koichiro Misawa, Ikuo Yamamoto and Kazuhito Watanabe
    Drug Metabolism and Disposition September 2008, 36 (9) 1917-1921; DOI: https://doi.org/10.1124/dmd.108.020909
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    Blood Monocyte-Derived Neohepatocytes as in Vitro Test System for Drug Metabolism
    S Ehnert, A. K. Nussler, A. Lehmann and S. Dooley
    Drug Metabolism and Disposition September 2008, 36 (9) 1922-1929; DOI: https://doi.org/10.1124/dmd.108.020453
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    mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1
    Katarina Stark, Zhong-Liu Wu, Cheryl J. Bartleson and F. Peter Guengerich
    Drug Metabolism and Disposition September 2008, 36 (9) 1930-1937; DOI: https://doi.org/10.1124/dmd.108.022020
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    Novel Binding Mode of the Acidic CYP2D6 Substrates Pactimibe and Its Metabolite R-125528
    Masakatsu Kotsuma, Hiroyuki Hanzawa, Yoriko Iwata, Kenji Takahashi and Taro Tokui
    Drug Metabolism and Disposition September 2008, 36 (9) 1938-1943; DOI: https://doi.org/10.1124/dmd.108.020776
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    Effect of Endotoxin on the Expression of Placental Drug Transporters and Glyburide Disposition in Pregnant Rats
    Vanja Petrovic, Jing-Hung Wang and Micheline Piquette-Miller
    Drug Metabolism and Disposition September 2008, 36 (9) 1944-1950; DOI: https://doi.org/10.1124/dmd.107.019851
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    Gemcitabine Pharmacogenomics: Deoxycytidine Kinase and Cytidylate Kinase Gene Resequencing and Functional Genomics
    Neslihan Aygun Kocabas, Pinar Aksoy, Linda L. Pelleymounter, Irene Moon, Jeong-Seon Ryu, Judith A. Gilbert, Oreste Ezequel Salavaggione, Bruce W. Eckloff, Eric D. Wieben, Vivien Yee, Richard M. Weinshilboum and Matthew M. Ames
    Drug Metabolism and Disposition September 2008, 36 (9) 1951-1959; DOI: https://doi.org/10.1124/dmd.108.020925
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    Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared with Placenta
    Lauren M. Aleksunes, Yue Cui and Curtis D. Klaassen
    Drug Metabolism and Disposition September 2008, 36 (9) 1960-1970; DOI: https://doi.org/10.1124/dmd.108.021337

Accelerated Communication

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    PREDICTION OF DRUG-DRUG INTERACTIONS FROM IN VITRO INDUCTION DATA
    Odette A. Fahmi, Sherri Boldt, Mary Kish, R. Scott Obach and Larry M. Tremaine
    Drug Metabolism and Disposition September 2008, 36 (9) 1971-1974; DOI: https://doi.org/10.1124/dmd.108.021907

Erratum

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    CORRECTION TO “A COMBINED MODEL FOR PREDICTING CYP3A4 CLINICAL NET DRUG-DRUG INTERACTION BASED ON CYP3A4 INHIBITION, INACTIVATION, AND INDUCTION DETERMINED IN VITRO”
    Drug Metabolism and Disposition September 2008, 36 (9) 1975; DOI: https://doi.org/10.1124/dmd.36.9.1975
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Drug Metabolism and Disposition: 36 (9)
Drug Metabolism and Disposition
Vol. 36, Issue 9
1 Sep 2008
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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