Table of Contents

Articles

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  Species Differences in UDP-Glucuronosyltransferase Activities in Mice and Rats

  Hirotada Shiratani, Miki Katoh, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition September 2008, 36 (9) 1745-1752; DOI: https://doi.org/10.1124/dmd.108.021469
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  Metabolism, Distribution, and Excretion of a Next Generation Selective Estrogen Receptor Modulator, Lasofoxifene, in Rats and Monkeys

  Chandra Prakash, Kim A. Johnson, Clinton M. Schroeder and Michael J. Potchoiba

  Drug Metabolism and Disposition September 2008, 36 (9) 1753-1769; DOI: https://doi.org/10.1124/dmd.108.021808
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  Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity

  Hideo Takakusa, Hiroshi Masumoto, Hideo Yukinaga, Chie Makino, Shintaro Nakayama, Osamu Okazaki and Kenichi Sudo

  Drug Metabolism and Disposition September 2008, 36 (9) 1770-1779; DOI: https://doi.org/10.1124/dmd.108.021725
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  The Dihydroorotase Inhibitor 5-Aminoorotic Acid Inhibits the Metabolism in the Rat of the Cardioprotective Drug Dexrazoxane and Its One-Ring Open Metabolites

  Patricia E. Schroeder, Daywin Patel and Brian B. Hasinoff

  Drug Metabolism and Disposition September 2008, 36 (9) 1780-1785; DOI: https://doi.org/10.1124/dmd.108.021626
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  Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na⁺-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

  Kenya Nakai, Hiromasa Tanaka, Kazuhiko Hanada, Hiroyasu Ogata, Fumitaka Suzuki, Hiromitsu Kumada, Atsuko Miyajima, Seiichi Ishida, Momoko Sunouchi, Wataru Habano, Yuichiro Kamikawa, Keiichi Kubota, Junji Kita, Shogo Ozawa and Yasuo Ohno

  Drug Metabolism and Disposition September 2008, 36 (9) 1786-1793; DOI: https://doi.org/10.1124/dmd.107.020073
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  Metabolism and Transport of the Citrus Flavonoid Hesperetin in Caco-2 Cell Monolayers

  Walter Brand, Petronella A. I. van der Wel, Maarit J. Rein, Denis Barron, Gary Williamson, Peter J. van Bladeren and Ivonne M. C. M. Rietjens

  Drug Metabolism and Disposition September 2008, 36 (9) 1794-1802; DOI: https://doi.org/10.1124/dmd.107.019943
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  Cytochrome P450 2C11 5′-Flanking Region and Promoter Mediate in Vivo Suppression by 3-Methylcholanthrene

  Rana M. Sawaya and David S. Riddick

  Drug Metabolism and Disposition September 2008, 36 (9) 1803-1811; DOI: https://doi.org/10.1124/dmd.108.020966
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  Binding of Pimecrolimus and Tacrolimus to Skin and Plasma Proteins: Implications for Systemic Exposure after Topical Application

  H. Markus Weiss, Marcel Fresneau, Thomas Moenius, Anton Stuetz and Andreas Billich

  Drug Metabolism and Disposition September 2008, 36 (9) 1812-1818; DOI: https://doi.org/10.1124/dmd.108.021915
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  Down-Regulation of the Carcinogen-Metabolizing Enzyme Cytochrome P450 1a1 by Vanadium

  Anwar Anwar-Mohamed and Ayman O. S. El-Kadi

  Drug Metabolism and Disposition September 2008, 36 (9) 1819-1827; DOI: https://doi.org/10.1124/dmd.108.021154
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  Identification of the Human Enzymes Involved in the Oxidative Metabolism of Dasatinib: An Effective Approach for Determining Metabolite Formation Kinetics

  Lifei Wang, Lisa J. Christopher, Donghui Cui, Wenying Li, Ramaswamy Iyer, W. Griffith Humphreys and Donglu Zhang

  Drug Metabolism and Disposition September 2008, 36 (9) 1828-1839; DOI: https://doi.org/10.1124/dmd.107.020255
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  Utility of a Novel Oatp1b2 Knockout Mouse Model for Evaluating the Role of Oatp1b2 in the Hepatic Uptake of Model Compounds

  Cuiping Chen, Jeffery L. Stock, Xingrong Liu, Jilin Shi, Jeffrey W. Van Deusen, Debra A. DiMattia, Robert G. Dullea and Sonia M. de Morais

  Drug Metabolism and Disposition September 2008, 36 (9) 1840-1845; DOI: https://doi.org/10.1124/dmd.108.020594
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  Pharmacokinetics and Brain Penetration of Casopitant, a Potent and Selective Neurokinin-1 Receptor Antagonist, in the Ferret

  Elisabeth Minthorn, Thomas Mencken, Andrew G. King, Art Shu, David Rominger, Richard R. Gontarek, Chao Han, Ramesh Bambal and Charles B. Davis

  Drug Metabolism and Disposition September 2008, 36 (9) 1846-1852; DOI: https://doi.org/10.1124/dmd.108.021758
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  Biodistribution of Radiolabeled Ethanol in Rodents

  Andrew N. Gifford, Mel Pilar Espaillat and S. John Gatley

  Drug Metabolism and Disposition September 2008, 36 (9) 1853-1858; DOI: https://doi.org/10.1124/dmd.107.020271
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  Placental Transfer and Fetal Elimination of Morphine-3-β-glucuronide in the Pregnant Baboon

  Marianne Garland, Kirsten M. Abildskov, Tung-wah Kiu, Salha S. Daniel, Piper Weldy and Raymond I. Stark

  Drug Metabolism and Disposition September 2008, 36 (9) 1859-1868; DOI: https://doi.org/10.1124/dmd.108.021352
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  Metabolism Distribution and Excretion of a Matrix Metalloproteinase-13 Inhibitor, 4-[4-(4-Fluorophenoxy)-benzenesulfonylamino]tetrahydropyran-4-carboxylic Acid Hydroxyamide (CP-544439), in Rats and Dogs: Assessment of the Metabolic Profile of CP-544439 in Plasma and Urine of Humans

  Deepak Dalvie, Theresa Cosker, Tracey Boyden, Sue Zhou, Clinton Schroeder and Michael J. Potchoiba

  Drug Metabolism and Disposition September 2008, 36 (9) 1869-1883; DOI: https://doi.org/10.1124/dmd.108.022566
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  Inherent Sexually Dimorphic Expression of Hepatic CYP2C12 Correlated with Repressed Activation of Growth Hormone-Regulated Signal Transduction in Male Rats

  Chellappagounder Thangavel and Bernard H. Shapiro

  Drug Metabolism and Disposition September 2008, 36 (9) 1884-1895; DOI: https://doi.org/10.1124/dmd.108.021451
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  Identification of Enzymes Involved in the Metabolism of 17α-Hydroxyprogesterone Caproate: An Effective Agent for Prevention of Preterm Birth

  Shringi Sharma, Junhai Ou, Stephen Strom, Don Mattison, Steve Caritis and Raman Venkataramanan

  Drug Metabolism and Disposition September 2008, 36 (9) 1896-1902; DOI: https://doi.org/10.1124/dmd.108.021444
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  Characterization of Substrate Specificity of Dog CYP1A2 Using CYP1A2-Deficient and Wild-Type Dog Liver Microsomes

  Masashi Mise, Takanori Hashizume and Setsuko Komuro

  Drug Metabolism and Disposition September 2008, 36 (9) 1903-1908; DOI: https://doi.org/10.1124/dmd.108.022301
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  The Pharmacokinetics of Silymarin Is Altered in Patients with Hepatitis C Virus and Nonalcoholic Fatty Liver Disease and Correlates with Plasma Caspase-3/7 Activity

  Sarah J. Schrieber, Zhiming Wen, Manoli Vourvahis, Philip C. Smith, Michael W. Fried, Angela D. M. Kashuba and Roy L. Hawke

  Drug Metabolism and Disposition September 2008, 36 (9) 1909-1916; DOI: https://doi.org/10.1124/dmd.107.019604
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  Cannabidiolic Acid as a Selective Cyclooxygenase-2 Inhibitory Component in Cannabis

  Shuso Takeda, Koichiro Misawa, Ikuo Yamamoto and Kazuhito Watanabe

  Drug Metabolism and Disposition September 2008, 36 (9) 1917-1921; DOI: https://doi.org/10.1124/dmd.108.020909
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  Blood Monocyte-Derived Neohepatocytes as in Vitro Test System for Drug Metabolism

  S Ehnert, A. K. Nussler, A. Lehmann and S. Dooley

  Drug Metabolism and Disposition September 2008, 36 (9) 1922-1929; DOI: https://doi.org/10.1124/dmd.108.020453
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  mRNA Distribution and Heterologous Expression of Orphan Cytochrome P450 20A1

  Katarina Stark, Zhong-Liu Wu, Cheryl J. Bartleson and F. Peter Guengerich

  Drug Metabolism and Disposition September 2008, 36 (9) 1930-1937; DOI: https://doi.org/10.1124/dmd.108.022020
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  Novel Binding Mode of the Acidic CYP2D6 Substrates Pactimibe and Its Metabolite R-125528

  Masakatsu Kotsuma, Hiroyuki Hanzawa, Yoriko Iwata, Kenji Takahashi and Taro Tokui

  Drug Metabolism and Disposition September 2008, 36 (9) 1938-1943; DOI: https://doi.org/10.1124/dmd.108.020776
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  Effect of Endotoxin on the Expression of Placental Drug Transporters and Glyburide Disposition in Pregnant Rats

  Vanja Petrovic, Jing-Hung Wang and Micheline Piquette-Miller

  Drug Metabolism and Disposition September 2008, 36 (9) 1944-1950; DOI: https://doi.org/10.1124/dmd.107.019851
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  Gemcitabine Pharmacogenomics: Deoxycytidine Kinase and Cytidylate Kinase Gene Resequencing and Functional Genomics

  Neslihan Aygun Kocabas, Pinar Aksoy, Linda L. Pelleymounter, Irene Moon, Jeong-Seon Ryu, Judith A. Gilbert, Oreste Ezequel Salavaggione, Bruce W. Eckloff, Eric D. Wieben, Vivien Yee, Richard M. Weinshilboum and Matthew M. Ames

  Drug Metabolism and Disposition September 2008, 36 (9) 1951-1959; DOI: https://doi.org/10.1124/dmd.108.020925
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  Prominent Expression of Xenobiotic Efflux Transporters in Mouse Extraembryonic Fetal Membranes Compared with Placenta

  Lauren M. Aleksunes, Yue Cui and Curtis D. Klaassen

  Drug Metabolism and Disposition September 2008, 36 (9) 1960-1970; DOI: https://doi.org/10.1124/dmd.108.021337