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Research ArticleArticle

Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity

Hideo Takakusa, Hiroshi Masumoto, Hideo Yukinaga, Chie Makino, Shintaro Nakayama, Osamu Okazaki and Kenichi Sudo
Drug Metabolism and Disposition September 2008, 36 (9) 1770-1779; DOI: https://doi.org/10.1124/dmd.108.021725

Article Information

vol. 36 no. 9 1770-1779
DOI 
https://doi.org/10.1124/dmd.108.021725
PubMed 
18508880
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received April 1, 2008
  • Accepted May 27, 2008
  • Published online August 20, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Hideo Takakusa,
  2. Hiroshi Masumoto,
  3. Hideo Yukinaga,
  4. Chie Makino,
  5. Shintaro Nakayama,
  6. Osamu Okazaki and
  7. Kenichi Sudo
  1. Drug Metabolism and Pharmacokinetics Research Laboratories, Research and Development Division, Daiichi Sankyo Co., Ltd., Hiromachi, Shinagawa-ku, Tokyo, Japan
  1. Address correspondence to:
    Dr. Hideo Takakusa, Drug Metabolism and Pharmacokinetics Research Laboratories, R&D Division, Shinagawa R&D Center, Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo 140-8710, Japan. E-mail: takakusa.hideo.yb{at}daiichisankyo.co.jp
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Research ArticleArticle

Covalent Binding and Tissue Distribution/Retention Assessment of Drugs Associated with Idiosyncratic Drug Toxicity

Hideo Takakusa, Hiroshi Masumoto, Hideo Yukinaga, Chie Makino, Shintaro Nakayama, Osamu Okazaki and Kenichi Sudo
Drug Metabolism and Disposition September 1, 2008, 36 (9) 1770-1779; DOI: https://doi.org/10.1124/dmd.108.021725
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