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Research ArticleArticle

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

Kenya Nakai, Hiromasa Tanaka, Kazuhiko Hanada, Hiroyasu Ogata, Fumitaka Suzuki, Hiromitsu Kumada, Atsuko Miyajima, Seiichi Ishida, Momoko Sunouchi, Wataru Habano, Yuichiro Kamikawa, Keiichi Kubota, Junji Kita, Shogo Ozawa and Yasuo Ohno
Drug Metabolism and Disposition September 2008, 36 (9) 1786-1793; DOI: https://doi.org/10.1124/dmd.107.020073
Kenya Nakai
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Hiromasa Tanaka
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Kazuhiko Hanada
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Hiroyasu Ogata
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Fumitaka Suzuki
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Hiromitsu Kumada
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Atsuko Miyajima
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Seiichi Ishida
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Momoko Sunouchi
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Wataru Habano
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Yuichiro Kamikawa
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Keiichi Kubota
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Junji Kita
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Shogo Ozawa
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Article Information

vol. 36 no. 9 1786-1793
DOI 
https://doi.org/10.1124/dmd.107.020073
PubMed 
18515332

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received December 18, 2007
  • Accepted May 29, 2008
  • Published online August 20, 2008.

Article Versions

  • Earlier version (May 30, 2008 - 06:04).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Kenya Nakai,
  2. Hiromasa Tanaka,
  3. Kazuhiko Hanada,
  4. Hiroyasu Ogata,
  5. Fumitaka Suzuki,
  6. Hiromitsu Kumada,
  7. Atsuko Miyajima,
  8. Seiichi Ishida,
  9. Momoko Sunouchi,
  10. Wataru Habano,
  11. Yuichiro Kamikawa,
  12. Keiichi Kubota,
  13. Junji Kita,
  14. Shogo Ozawa and
  15. Yasuo Ohno
  1. Division of Pharmacology (K.N., H.T., A.M., S.I., M.S., S.O.) and Deputy Director General (Y.O.), National Institute of Health Sciences, Kamiyoga, Setagaya-ku, Tokyo, Japan; Department of Biopharmaceutics, Meiji Pharmaceutical University, Noshio, Kiyose, Tokyo, Japan (K.N., H.T., K.H., H.O.); Department of Hepatology, Toranomon Hospital, Toranomon, Minato-ku, Tokyo, Japan (F.S., H.K.); Department of Pharmacodynamics and Molecular Genetics, Faculty of Pharmaceutical Sciences, Iwate Medical University, Nishitokuta, Yahabacho, Shiwa-gun, Iwate, Japan (W.H., S.O.); Department of Pharmacology and Surgery Division (Y.K.) and Second Department of Surgery (K.K., J.K.), Dokkyo Medical University School of Medicine, Mibu, Tochigi, Japan
  1. Address correspondence to:
    Shogo Ozawa, Faculty of Pharmaceutical Sciences, Iwate Medical University, 2-1-1, Nishitokuta, Yahaba-cho, Shiwa-gun, Iwate 028-3694, Japan. E-mail: sozawa{at}iwate-med.ac.jp
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Drug Metabolism and Disposition: 36 (9)
Drug Metabolism and Disposition
Vol. 36, Issue 9
1 Sep 2008
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Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chro…
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Research ArticleArticle

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

Kenya Nakai, Hiromasa Tanaka, Kazuhiko Hanada, Hiroyasu Ogata, Fumitaka Suzuki, Hiromitsu Kumada, Atsuko Miyajima, Seiichi Ishida, Momoko Sunouchi, Wataru Habano, Yuichiro Kamikawa, Keiichi Kubota, Junji Kita, Shogo Ozawa and Yasuo Ohno
Drug Metabolism and Disposition September 1, 2008, 36 (9) 1786-1793; DOI: https://doi.org/10.1124/dmd.107.020073

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Research ArticleArticle

Decreased Expression of Cytochromes P450 1A2, 2E1, and 3A4 and Drug Transporters Na+-Taurocholate-Cotransporting Polypeptide, Organic Cation Transporter 1, and Organic Anion-Transporting Peptide-C Correlates with the Progression of Liver Fibrosis in Chronic Hepatitis C Patients

Kenya Nakai, Hiromasa Tanaka, Kazuhiko Hanada, Hiroyasu Ogata, Fumitaka Suzuki, Hiromitsu Kumada, Atsuko Miyajima, Seiichi Ishida, Momoko Sunouchi, Wataru Habano, Yuichiro Kamikawa, Keiichi Kubota, Junji Kita, Shogo Ozawa and Yasuo Ohno
Drug Metabolism and Disposition September 1, 2008, 36 (9) 1786-1793; DOI: https://doi.org/10.1124/dmd.107.020073
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