Drug Metabolism and Disposition: 37 (1)

January 01, 2009; Volume 37,Issue 1

Short Communications

You have access
Expression and Functional Analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 Isozymes
Wei-Yan Zhang, You-Bin Tu, Robert L. Haining and Ai-Ming Yu

Drug Metabolism and Disposition January 2009, 37 (1) 1-4; DOI: https://doi.org/10.1124/dmd.108.023663
You have access
Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez and Margarita M. Marques

Drug Metabolism and Disposition January 2009, 37 (1) 5-9; DOI: https://doi.org/10.1124/dmd.108.022715
You have access
Is 1-Aminobenzotriazole an Appropriate in Vitro Tool as a Nonspecific Cytochrome P450 Inactivator?
Collette D. Linder, Nicole A. Renaud and J. Matthew Hutzler

Drug Metabolism and Disposition January 2009, 37 (1) 10-13; DOI: https://doi.org/10.1124/dmd.108.024075
You have access
A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata

Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

Articles

You have access
Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5
Yusuke Okada, Norie Murayama, Chihiro Yanagida, Makiko Shimizu, F. Peter Guengerich and Hiroshi Yamazaki

Drug Metabolism and Disposition January 2009, 37 (1) 18-23; DOI: https://doi.org/10.1124/dmd.108.024679
You have access
Cytoskeleton Interruption in Human Hepatoma HepG2 Cells Induced by Ketamine Occurs Possibly through Suppression of Calcium Mobilization and Mitochondrial Function
Huai-Chia Chang, Ta-Liang Chen and Ruei-Ming Chen

Drug Metabolism and Disposition January 2009, 37 (1) 24-31; DOI: https://doi.org/10.1124/dmd.108.023325
You have access
Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction
Shuji Ohno and Shizuo Nakajin

Drug Metabolism and Disposition January 2009, 37 (1) 32-40; DOI: https://doi.org/10.1124/dmd.108.023598
You have access
Key Amino Acid Residues Responsible for the Differences in Substrate Specificity of Human UDP-Glucuronosyltransferase (UGT)1A9 and UGT1A8
Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka and Tsuyoshi Yokoi

Drug Metabolism and Disposition January 2009, 37 (1) 41-46; DOI: https://doi.org/10.1124/dmd.108.022913
You have access
The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CL_int), Maximum Velocity of the Metabolic Reaction (V_max), and Michaelis Constant (K_m): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations
Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö and Ulf Bredberg

Drug Metabolism and Disposition January 2009, 37 (1) 47-58; DOI: https://doi.org/10.1124/dmd.108.021477
You have access
Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection
J. Matthew Hutzler, Larissa M. Balogh, Michael Zientek, Vikas Kumar and Timothy S. Tracy

Drug Metabolism and Disposition January 2009, 37 (1) 59-65; DOI: https://doi.org/10.1124/dmd.108.023358
You have access
Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human
Na Li, Yiqun Zhang, Fengmei Hua and Yurong Lai

Drug Metabolism and Disposition January 2009, 37 (1) 66-73; DOI: https://doi.org/10.1124/dmd.108.023234
You have access
Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang

Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143
You have access
Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes
Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin

Drug Metabolism and Disposition January 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853
You have access
Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b₅/NADH-b₅ Reductase in Variability of CYP3A Activity in Human Liver Microsomes
Lu Gan, Lisa L. von Moltke, Lauren A. Trepanier, Jerold S. Harmatz, David J. Greenblatt and Michael H. Court

Drug Metabolism and Disposition January 2009, 37 (1) 90-96; DOI: https://doi.org/10.1124/dmd.108.023424
You have access
Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity
Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari and Yasushi Yamazoe

Drug Metabolism and Disposition January 2009, 37 (1) 97-105; DOI: https://doi.org/10.1124/dmd.108.021964
You have access
Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver
Yu-Kun Jennifer Zhang, Ronnie L. Yeager and Curtis D. Klaassen

Drug Metabolism and Disposition January 2009, 37 (1) 106-115; DOI: https://doi.org/10.1124/dmd.108.024174
You have access
Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice
Steven N. Hart, Yue Cui, Curtis D. Klaassen and Xiao-bo Zhong

Drug Metabolism and Disposition January 2009, 37 (1) 116-121; DOI: https://doi.org/10.1124/dmd.108.023812
You have access
Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume and Koichiro Fukuzaki

Drug Metabolism and Disposition January 2009, 37 (1) 122-128; DOI: https://doi.org/10.1124/dmd.108.022574
You have access
Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone
Jurjen S. Lagas, Cornelia M. M. van der Kruijssen, Koen van de Wetering, Jos H. Beijnen and Alfred H. Schinkel

Drug Metabolism and Disposition January 2009, 37 (1) 129-136; DOI: https://doi.org/10.1124/dmd.108.023200
You have access
Microdialysis Evaluation of Atomoxetine Brain Penetration and Central Nervous System Pharmacokinetics in Rats
William Kielbasa, J. Cory Kalvass and Robert Stratford

Drug Metabolism and Disposition January 2009, 37 (1) 137-142; DOI: https://doi.org/10.1124/dmd.108.023119
You have access
High-Affinity Interaction of Sartans with H⁺/Peptide Transporters
Ilka Knütter, Gabor Kottra, Wiebke Fischer, Hannelore Daniel and Matthias Brandsch

Drug Metabolism and Disposition January 2009, 37 (1) 143-149; DOI: https://doi.org/10.1124/dmd.108.022418
You have access
Prediction of the Effect of Erythromycin, Diltiazem, and Their Metabolites, Alone and in Combination, on CYP3A4 Inhibition
Xin Zhang, David R. Jones and Stephen D. Hall

Drug Metabolism and Disposition January 2009, 37 (1) 150-160; DOI: https://doi.org/10.1124/dmd.108.022178
You have access
Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher

Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408
You have access
Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis
Ai-Ming Yu, Jun Qu, Melanie A. Felmlee, Jin Cao and Xi-Ling Jiang

Drug Metabolism and Disposition January 2009, 37 (1) 170-177; DOI: https://doi.org/10.1124/dmd.108.024166
You have access
Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide
Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips and Elizabeth A. Shephard

Drug Metabolism and Disposition January 2009, 37 (1) 178-186; DOI: https://doi.org/10.1124/dmd.108.024158
You have access
Disparity in Intestine Disposition between Formed and Preformed Metabolites and Implications: A Theoretical Study
Huadong Sun and K. Sandy Pang

Drug Metabolism and Disposition January 2009, 37 (1) 187-202; DOI: https://doi.org/10.1124/dmd.108.022483
You have access
Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice
Yue Julia Cui, Xingguo Cheng, Yi Miao Weaver and Curtis D. Klaassen

Drug Metabolism and Disposition January 2009, 37 (1) 203-210; DOI: https://doi.org/10.1124/dmd.108.023721
You have access
Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2′-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)
Manthena V. S. Varma, André H. Eriksson, Geri Sawada, Youngeen A. Pak, Everett J. Perkins and Cheryl L. Zimmerman

Drug Metabolism and Disposition January 2009, 37 (1) 211-220; DOI: https://doi.org/10.1124/dmd.108.022012
You have access
In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms
Edward J. Scollon, James M. Starr, Stephen J. Godin, Michael J. DeVito and Michael F. Hughes

Drug Metabolism and Disposition January 2009, 37 (1) 221-228; DOI: https://doi.org/10.1124/dmd.108.022343
You have access
Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10
Upendra A. Argikar and Rory P. Remmel

Drug Metabolism and Disposition January 2009, 37 (1) 229-236; DOI: https://doi.org/10.1124/dmd.108.022426
You have access
Discovering Plausible Mechanistic Details of Hepatic Drug Interactions
Tai Ning Lam and C. Anthony Hunt

Drug Metabolism and Disposition January 2009, 37 (1) 237-246; DOI: https://doi.org/10.1124/dmd.108.023820

Main menu

User menu

Search

Table of Contents

Short Communications

Articles

In this issue

Jump to

Navigate

More Information

ASPET's Other Journals