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Drug Metabolism & Disposition

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Table of Contents

January 01, 2009; Volume 37,Issue 1

Short Communications

  • You have access
    Expression and Functional Analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 Isozymes
    Wei-Yan Zhang, You-Bin Tu, Robert L. Haining and Ai-Ming Yu
    Drug Metabolism and Disposition January 2009, 37 (1) 1-4; DOI: https://doi.org/10.1124/dmd.108.023663
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    Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
    Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez and Margarita M. Marques
    Drug Metabolism and Disposition January 2009, 37 (1) 5-9; DOI: https://doi.org/10.1124/dmd.108.022715
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    Is 1-Aminobenzotriazole an Appropriate in Vitro Tool as a Nonspecific Cytochrome P450 Inactivator?
    Collette D. Linder, Nicole A. Renaud and J. Matthew Hutzler
    Drug Metabolism and Disposition January 2009, 37 (1) 10-13; DOI: https://doi.org/10.1124/dmd.108.024075
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    A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
    Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
    Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

Articles

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    Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5
    Yusuke Okada, Norie Murayama, Chihiro Yanagida, Makiko Shimizu, F. Peter Guengerich and Hiroshi Yamazaki
    Drug Metabolism and Disposition January 2009, 37 (1) 18-23; DOI: https://doi.org/10.1124/dmd.108.024679
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    Cytoskeleton Interruption in Human Hepatoma HepG2 Cells Induced by Ketamine Occurs Possibly through Suppression of Calcium Mobilization and Mitochondrial Function
    Huai-Chia Chang, Ta-Liang Chen and Ruei-Ming Chen
    Drug Metabolism and Disposition January 2009, 37 (1) 24-31; DOI: https://doi.org/10.1124/dmd.108.023325
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    Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction
    Shuji Ohno and Shizuo Nakajin
    Drug Metabolism and Disposition January 2009, 37 (1) 32-40; DOI: https://doi.org/10.1124/dmd.108.023598
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    Key Amino Acid Residues Responsible for the Differences in Substrate Specificity of Human UDP-Glucuronosyltransferase (UGT)1A9 and UGT1A8
    Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka and Tsuyoshi Yokoi
    Drug Metabolism and Disposition January 2009, 37 (1) 41-46; DOI: https://doi.org/10.1124/dmd.108.022913
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    The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations
    Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö and Ulf Bredberg
    Drug Metabolism and Disposition January 2009, 37 (1) 47-58; DOI: https://doi.org/10.1124/dmd.108.021477
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    Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection
    J. Matthew Hutzler, Larissa M. Balogh, Michael Zientek, Vikas Kumar and Timothy S. Tracy
    Drug Metabolism and Disposition January 2009, 37 (1) 59-65; DOI: https://doi.org/10.1124/dmd.108.023358
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    Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human
    Na Li, Yiqun Zhang, Fengmei Hua and Yurong Lai
    Drug Metabolism and Disposition January 2009, 37 (1) 66-73; DOI: https://doi.org/10.1124/dmd.108.023234
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    Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
    Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
    Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143
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    Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes
    Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
    Drug Metabolism and Disposition January 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853
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    Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5 Reductase in Variability of CYP3A Activity in Human Liver Microsomes
    Lu Gan, Lisa L. von Moltke, Lauren A. Trepanier, Jerold S. Harmatz, David J. Greenblatt and Michael H. Court
    Drug Metabolism and Disposition January 2009, 37 (1) 90-96; DOI: https://doi.org/10.1124/dmd.108.023424
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    Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity
    Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari and Yasushi Yamazoe
    Drug Metabolism and Disposition January 2009, 37 (1) 97-105; DOI: https://doi.org/10.1124/dmd.108.021964
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    Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver
    Yu-Kun Jennifer Zhang, Ronnie L. Yeager and Curtis D. Klaassen
    Drug Metabolism and Disposition January 2009, 37 (1) 106-115; DOI: https://doi.org/10.1124/dmd.108.024174
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    Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice
    Steven N. Hart, Yue Cui, Curtis D. Klaassen and Xiao-bo Zhong
    Drug Metabolism and Disposition January 2009, 37 (1) 116-121; DOI: https://doi.org/10.1124/dmd.108.023812
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    Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
    Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume and Koichiro Fukuzaki
    Drug Metabolism and Disposition January 2009, 37 (1) 122-128; DOI: https://doi.org/10.1124/dmd.108.022574
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    Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone
    Jurjen S. Lagas, Cornelia M. M. van der Kruijssen, Koen van de Wetering, Jos H. Beijnen and Alfred H. Schinkel
    Drug Metabolism and Disposition January 2009, 37 (1) 129-136; DOI: https://doi.org/10.1124/dmd.108.023200
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    Microdialysis Evaluation of Atomoxetine Brain Penetration and Central Nervous System Pharmacokinetics in Rats
    William Kielbasa, J. Cory Kalvass and Robert Stratford
    Drug Metabolism and Disposition January 2009, 37 (1) 137-142; DOI: https://doi.org/10.1124/dmd.108.023119
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    High-Affinity Interaction of Sartans with H+/Peptide Transporters
    Ilka Knütter, Gabor Kottra, Wiebke Fischer, Hannelore Daniel and Matthias Brandsch
    Drug Metabolism and Disposition January 2009, 37 (1) 143-149; DOI: https://doi.org/10.1124/dmd.108.022418
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    Prediction of the Effect of Erythromycin, Diltiazem, and Their Metabolites, Alone and in Combination, on CYP3A4 Inhibition
    Xin Zhang, David R. Jones and Stephen D. Hall
    Drug Metabolism and Disposition January 2009, 37 (1) 150-160; DOI: https://doi.org/10.1124/dmd.108.022178
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    Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
    Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
    Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408
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    Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis
    Ai-Ming Yu, Jun Qu, Melanie A. Felmlee, Jin Cao and Xi-Ling Jiang
    Drug Metabolism and Disposition January 2009, 37 (1) 170-177; DOI: https://doi.org/10.1124/dmd.108.024166
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    Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide
    Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips and Elizabeth A. Shephard
    Drug Metabolism and Disposition January 2009, 37 (1) 178-186; DOI: https://doi.org/10.1124/dmd.108.024158
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    Disparity in Intestine Disposition between Formed and Preformed Metabolites and Implications: A Theoretical Study
    Huadong Sun and K. Sandy Pang
    Drug Metabolism and Disposition January 2009, 37 (1) 187-202; DOI: https://doi.org/10.1124/dmd.108.022483
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    Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice
    Yue Julia Cui, Xingguo Cheng, Yi Miao Weaver and Curtis D. Klaassen
    Drug Metabolism and Disposition January 2009, 37 (1) 203-210; DOI: https://doi.org/10.1124/dmd.108.023721
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    Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2′-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)
    Manthena V. S. Varma, André H. Eriksson, Geri Sawada, Youngeen A. Pak, Everett J. Perkins and Cheryl L. Zimmerman
    Drug Metabolism and Disposition January 2009, 37 (1) 211-220; DOI: https://doi.org/10.1124/dmd.108.022012
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    In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms
    Edward J. Scollon, James M. Starr, Stephen J. Godin, Michael J. DeVito and Michael F. Hughes
    Drug Metabolism and Disposition January 2009, 37 (1) 221-228; DOI: https://doi.org/10.1124/dmd.108.022343
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    Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10
    Upendra A. Argikar and Rory P. Remmel
    Drug Metabolism and Disposition January 2009, 37 (1) 229-236; DOI: https://doi.org/10.1124/dmd.108.022426
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    Discovering Plausible Mechanistic Details of Hepatic Drug Interactions
    Tai Ning Lam and C. Anthony Hunt
    Drug Metabolism and Disposition January 2009, 37 (1) 237-246; DOI: https://doi.org/10.1124/dmd.108.023820
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Drug Metabolism and Disposition: 37 (1)
Drug Metabolism and Disposition
Vol. 37, Issue 1
1 Jan 2009
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