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Index by author

January 01, 2009; Volume 37,Issue 1

A

  1. Alvarez, Ana I.

    1. Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
      Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez and Margarita M. Marques
      Drug Metabolism and Disposition January 2009, 37 (1) 5-9; DOI: https://doi.org/10.1124/dmd.108.022715

  2. Andersson, Tommy B.

    1. The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations
      Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö and Ulf Bredberg
      Drug Metabolism and Disposition January 2009, 37 (1) 47-58; DOI: https://doi.org/10.1124/dmd.108.021477

  3. Argikar, Upendra A.

    1. Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10
      Upendra A. Argikar and Rory P. Remmel
      Drug Metabolism and Disposition January 2009, 37 (1) 229-236; DOI: https://doi.org/10.1124/dmd.108.022426

  4. Ashgodom, Rezene T.

    1. Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
      Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
      Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408

B

  1. Balogh, Larissa M.

    1. Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection
      J. Matthew Hutzler, Larissa M. Balogh, Michael Zientek, Vikas Kumar and Timothy S. Tracy
      Drug Metabolism and Disposition January 2009, 37 (1) 59-65; DOI: https://doi.org/10.1124/dmd.108.023358

  2. Baro, Marta F.

    1. Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
      Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez and Margarita M. Marques
      Drug Metabolism and Disposition January 2009, 37 (1) 5-9; DOI: https://doi.org/10.1124/dmd.108.022715

  3. Beijnen, Jos H.

    1. Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone
      Jurjen S. Lagas, Cornelia M. M. van der Kruijssen, Koen van de Wetering, Jos H. Beijnen and Alfred H. Schinkel
      Drug Metabolism and Disposition January 2009, 37 (1) 129-136; DOI: https://doi.org/10.1124/dmd.108.023200

  4. Bolton, Judy L.

    1. Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
      Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
      Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408

  5. Bonacorsi, Samuel

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

  6. Brandsch, Matthias

    1. High-Affinity Interaction of Sartans with H+/Peptide Transporters
      Ilka Knütter, Gabor Kottra, Wiebke Fischer, Hannelore Daniel and Matthias Brandsch
      Drug Metabolism and Disposition January 2009, 37 (1) 143-149; DOI: https://doi.org/10.1124/dmd.108.022418

  7. Bredberg, Ulf

    1. The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations
      Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö and Ulf Bredberg
      Drug Metabolism and Disposition January 2009, 37 (1) 47-58; DOI: https://doi.org/10.1124/dmd.108.021477

C

  1. Cao, Jin

    1. Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis
      Ai-Ming Yu, Jun Qu, Melanie A. Felmlee, Jin Cao and Xi-Ling Jiang
      Drug Metabolism and Disposition January 2009, 37 (1) 170-177; DOI: https://doi.org/10.1124/dmd.108.024166

  2. Chang, Huai-Chia

    1. Cytoskeleton Interruption in Human Hepatoma HepG2 Cells Induced by Ketamine Occurs Possibly through Suppression of Calcium Mobilization and Mitochondrial Function
      Huai-Chia Chang, Ta-Liang Chen and Ruei-Ming Chen
      Drug Metabolism and Disposition January 2009, 37 (1) 24-31; DOI: https://doi.org/10.1124/dmd.108.023325

  3. Chen, Ruei-Ming

    1. Cytoskeleton Interruption in Human Hepatoma HepG2 Cells Induced by Ketamine Occurs Possibly through Suppression of Calcium Mobilization and Mitochondrial Function
      Huai-Chia Chang, Ta-Liang Chen and Ruei-Ming Chen
      Drug Metabolism and Disposition January 2009, 37 (1) 24-31; DOI: https://doi.org/10.1124/dmd.108.023325

  4. Chen, Shiangyuan

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

  5. Chen, Ta-Liang

    1. Cytoskeleton Interruption in Human Hepatoma HepG2 Cells Induced by Ketamine Occurs Possibly through Suppression of Calcium Mobilization and Mitochondrial Function
      Huai-Chia Chang, Ta-Liang Chen and Ruei-Ming Chen
      Drug Metabolism and Disposition January 2009, 37 (1) 24-31; DOI: https://doi.org/10.1124/dmd.108.023325

  6. Cheng, Xingguo

    1. Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice
      Yue Julia Cui, Xingguo Cheng, Yi Miao Weaver and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2009, 37 (1) 203-210; DOI: https://doi.org/10.1124/dmd.108.023721

  7. Choi, Yongsoo

    1. Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
      Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
      Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408

  8. Court, Michael H.

    1. Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5 Reductase in Variability of CYP3A Activity in Human Liver Microsomes
      Lu Gan, Lisa L. von Moltke, Lauren A. Trepanier, Jerold S. Harmatz, David J. Greenblatt and Michael H. Court
      Drug Metabolism and Disposition January 2009, 37 (1) 90-96; DOI: https://doi.org/10.1124/dmd.108.023424

  9. Cui, Yue

    1. Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice
      Steven N. Hart, Yue Cui, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition January 2009, 37 (1) 116-121; DOI: https://doi.org/10.1124/dmd.108.023812

  10. Cui, Yue Julia

    1. Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice
      Yue Julia Cui, Xingguo Cheng, Yi Miao Weaver and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2009, 37 (1) 203-210; DOI: https://doi.org/10.1124/dmd.108.023721

D

  1. Daniel, Hannelore

    1. High-Affinity Interaction of Sartans with H+/Peptide Transporters
      Ilka Knütter, Gabor Kottra, Wiebke Fischer, Hannelore Daniel and Matthias Brandsch
      Drug Metabolism and Disposition January 2009, 37 (1) 143-149; DOI: https://doi.org/10.1124/dmd.108.022418

  2. de Montellano, Paul R. Ortiz

    1. Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide
      Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips and Elizabeth A. Shephard
      Drug Metabolism and Disposition January 2009, 37 (1) 178-186; DOI: https://doi.org/10.1124/dmd.108.024158

  3. DeVito, Michael J.

    1. In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms
      Edward J. Scollon, James M. Starr, Stephen J. Godin, Michael J. DeVito and Michael F. Hughes
      Drug Metabolism and Disposition January 2009, 37 (1) 221-228; DOI: https://doi.org/10.1124/dmd.108.022343

E

  1. Eriksson, André H.

    1. Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2′-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)
      Manthena V. S. Varma, André H. Eriksson, Geri Sawada, Youngeen A. Pak, Everett J. Perkins and Cheryl L. Zimmerman
      Drug Metabolism and Disposition January 2009, 37 (1) 211-220; DOI: https://doi.org/10.1124/dmd.108.022012

F

  1. Felmlee, Melanie A.

    1. Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis
      Ai-Ming Yu, Jun Qu, Melanie A. Felmlee, Jin Cao and Xi-Ling Jiang
      Drug Metabolism and Disposition January 2009, 37 (1) 170-177; DOI: https://doi.org/10.1124/dmd.108.024166

  2. Fischer, Wiebke

    1. High-Affinity Interaction of Sartans with H+/Peptide Transporters
      Ilka Knütter, Gabor Kottra, Wiebke Fischer, Hannelore Daniel and Matthias Brandsch
      Drug Metabolism and Disposition January 2009, 37 (1) 143-149; DOI: https://doi.org/10.1124/dmd.108.022418

  3. Francois, Asvi A.

    1. Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide
      Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips and Elizabeth A. Shephard
      Drug Metabolism and Disposition January 2009, 37 (1) 178-186; DOI: https://doi.org/10.1124/dmd.108.024158

  4. Frost, Charles E.

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

  5. Fujiwara, Ryoichi

    1. Key Amino Acid Residues Responsible for the Differences in Substrate Specificity of Human UDP-Glucuronosyltransferase (UGT)1A9 and UGT1A8
      Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka and Tsuyoshi Yokoi
      Drug Metabolism and Disposition January 2009, 37 (1) 41-46; DOI: https://doi.org/10.1124/dmd.108.022913

  6. Fukuzaki, Koichiro

    1. Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
      Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume and Koichiro Fukuzaki
      Drug Metabolism and Disposition January 2009, 37 (1) 122-128; DOI: https://doi.org/10.1124/dmd.108.022574

G

  1. Galetin, Aleksandra

    1. Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes
      Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition January 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853

  2. Gan, Lu

    1. Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5 Reductase in Variability of CYP3A Activity in Human Liver Microsomes
      Lu Gan, Lisa L. von Moltke, Lauren A. Trepanier, Jerold S. Harmatz, David J. Greenblatt and Michael H. Court
      Drug Metabolism and Disposition January 2009, 37 (1) 90-96; DOI: https://doi.org/10.1124/dmd.108.023424

  3. Godin, Stephen J.

    1. In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms
      Edward J. Scollon, James M. Starr, Stephen J. Godin, Michael J. DeVito and Michael F. Hughes
      Drug Metabolism and Disposition January 2009, 37 (1) 221-228; DOI: https://doi.org/10.1124/dmd.108.022343

  4. Gonzalez-Lobato, Lucia

    1. Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
      Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez and Margarita M. Marques
      Drug Metabolism and Disposition January 2009, 37 (1) 5-9; DOI: https://doi.org/10.1124/dmd.108.022715

  5. Gråsjö, Johan

    1. The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations
      Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö and Ulf Bredberg
      Drug Metabolism and Disposition January 2009, 37 (1) 47-58; DOI: https://doi.org/10.1124/dmd.108.021477

  6. Greenblatt, David J.

    1. Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5 Reductase in Variability of CYP3A Activity in Human Liver Microsomes
      Lu Gan, Lisa L. von Moltke, Lauren A. Trepanier, Jerold S. Harmatz, David J. Greenblatt and Michael H. Court
      Drug Metabolism and Disposition January 2009, 37 (1) 90-96; DOI: https://doi.org/10.1124/dmd.108.023424

  7. Guengerich, F. Peter

    1. Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5
      Yusuke Okada, Norie Murayama, Chihiro Yanagida, Makiko Shimizu, F. Peter Guengerich and Hiroshi Yamazaki
      Drug Metabolism and Disposition January 2009, 37 (1) 18-23; DOI: https://doi.org/10.1124/dmd.108.024679

H

  1. Haining, Robert L.

    1. Expression and Functional Analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 Isozymes
      Wei-Yan Zhang, You-Bin Tu, Robert L. Haining and Ai-Ming Yu
      Drug Metabolism and Disposition January 2009, 37 (1) 1-4; DOI: https://doi.org/10.1124/dmd.108.023663

  2. Hall, Stephen D.

    1. Prediction of the Effect of Erythromycin, Diltiazem, and Their Metabolites, Alone and in Combination, on CYP3A4 Inhibition
      Xin Zhang, David R. Jones and Stephen D. Hall
      Drug Metabolism and Disposition January 2009, 37 (1) 150-160; DOI: https://doi.org/10.1124/dmd.108.022178

  3. Harmatz, Jerold S.

    1. Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5 Reductase in Variability of CYP3A Activity in Human Liver Microsomes
      Lu Gan, Lisa L. von Moltke, Lauren A. Trepanier, Jerold S. Harmatz, David J. Greenblatt and Michael H. Court
      Drug Metabolism and Disposition January 2009, 37 (1) 90-96; DOI: https://doi.org/10.1124/dmd.108.023424

  4. Hart, Steven N.

    1. Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice
      Steven N. Hart, Yue Cui, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition January 2009, 37 (1) 116-121; DOI: https://doi.org/10.1124/dmd.108.023812

  5. He, Kan

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

  6. Houston, J. Brian

    1. Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes
      Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition January 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853

  7. Hua, Fengmei

    1. Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human
      Na Li, Yiqun Zhang, Fengmei Hua and Yurong Lai
      Drug Metabolism and Disposition January 2009, 37 (1) 66-73; DOI: https://doi.org/10.1124/dmd.108.023234

  8. Hughes, Michael F.

    1. In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms
      Edward J. Scollon, James M. Starr, Stephen J. Godin, Michael J. DeVito and Michael F. Hughes
      Drug Metabolism and Disposition January 2009, 37 (1) 221-228; DOI: https://doi.org/10.1124/dmd.108.022343

  9. Humphreys, W. Griffith

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

  10. Hunt, C. Anthony

    1. Discovering Plausible Mechanistic Details of Hepatic Drug Interactions
      Tai Ning Lam and C. Anthony Hunt
      Drug Metabolism and Disposition January 2009, 37 (1) 237-246; DOI: https://doi.org/10.1124/dmd.108.023820

  11. Hutzler, J. Matthew

    1. Is 1-Aminobenzotriazole an Appropriate in Vitro Tool as a Nonspecific Cytochrome P450 Inactivator?
      Collette D. Linder, Nicole A. Renaud and J. Matthew Hutzler
      Drug Metabolism and Disposition January 2009, 37 (1) 10-13; DOI: https://doi.org/10.1124/dmd.108.024075
    2. Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection
      J. Matthew Hutzler, Larissa M. Balogh, Michael Zientek, Vikas Kumar and Timothy S. Tracy
      Drug Metabolism and Disposition January 2009, 37 (1) 59-65; DOI: https://doi.org/10.1124/dmd.108.023358

J

  1. Jiang, Xi-Ling

    1. Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis
      Ai-Ming Yu, Jun Qu, Melanie A. Felmlee, Jin Cao and Xi-Ling Jiang
      Drug Metabolism and Disposition January 2009, 37 (1) 170-177; DOI: https://doi.org/10.1124/dmd.108.024166

  2. Jones, David R.

    1. Prediction of the Effect of Erythromycin, Diltiazem, and Their Metabolites, Alone and in Combination, on CYP3A4 Inhibition
      Xin Zhang, David R. Jones and Stephen D. Hall
      Drug Metabolism and Disposition January 2009, 37 (1) 150-160; DOI: https://doi.org/10.1124/dmd.108.022178

K

  1. Kalvass, J. Cory

    1. Microdialysis Evaluation of Atomoxetine Brain Penetration and Central Nervous System Pharmacokinetics in Rats
      William Kielbasa, J. Cory Kalvass and Robert Stratford
      Drug Metabolism and Disposition January 2009, 37 (1) 137-142; DOI: https://doi.org/10.1124/dmd.108.023119

  2. Kamataki, Tetsuya

    1. A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
      Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

  3. Kastrati, Irida

    1. Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
      Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
      Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408

  4. Kielbasa, William

    1. Microdialysis Evaluation of Atomoxetine Brain Penetration and Central Nervous System Pharmacokinetics in Rats
      William Kielbasa, J. Cory Kalvass and Robert Stratford
      Drug Metabolism and Disposition January 2009, 37 (1) 137-142; DOI: https://doi.org/10.1124/dmd.108.023119

  5. Kilford, Peter J.

    1. Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes
      Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition January 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853

  6. Kito, Go

    1. A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
      Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

  7. Klaassen, Curtis D.

    1. Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver
      Yu-Kun Jennifer Zhang, Ronnie L. Yeager and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2009, 37 (1) 106-115; DOI: https://doi.org/10.1124/dmd.108.024174
    2. Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice
      Steven N. Hart, Yue Cui, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition January 2009, 37 (1) 116-121; DOI: https://doi.org/10.1124/dmd.108.023812
    3. Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice
      Yue Julia Cui, Xingguo Cheng, Yi Miao Weaver and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2009, 37 (1) 203-210; DOI: https://doi.org/10.1124/dmd.108.023721

  8. Knütter, Ilka

    1. High-Affinity Interaction of Sartans with H+/Peptide Transporters
      Ilka Knütter, Gabor Kottra, Wiebke Fischer, Hannelore Daniel and Matthias Brandsch
      Drug Metabolism and Disposition January 2009, 37 (1) 143-149; DOI: https://doi.org/10.1124/dmd.108.022418

  9. Kottra, Gabor

    1. High-Affinity Interaction of Sartans with H+/Peptide Transporters
      Ilka Knütter, Gabor Kottra, Wiebke Fischer, Hannelore Daniel and Matthias Brandsch
      Drug Metabolism and Disposition January 2009, 37 (1) 143-149; DOI: https://doi.org/10.1124/dmd.108.022418

  10. Kumano, Takayuki

    1. A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
      Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

  11. Kumar, Vikas

    1. Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection
      J. Matthew Hutzler, Larissa M. Balogh, Michael Zientek, Vikas Kumar and Timothy S. Tracy
      Drug Metabolism and Disposition January 2009, 37 (1) 59-65; DOI: https://doi.org/10.1124/dmd.108.023358

  12. Kume, Toshiyuki

    1. Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
      Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume and Koichiro Fukuzaki
      Drug Metabolism and Disposition January 2009, 37 (1) 122-128; DOI: https://doi.org/10.1124/dmd.108.022574

L

  1. Lagas, Jurjen S.

    1. Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone
      Jurjen S. Lagas, Cornelia M. M. van der Kruijssen, Koen van de Wetering, Jos H. Beijnen and Alfred H. Schinkel
      Drug Metabolism and Disposition January 2009, 37 (1) 129-136; DOI: https://doi.org/10.1124/dmd.108.023200

  2. Lai, Yurong

    1. Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human
      Na Li, Yiqun Zhang, Fengmei Hua and Yurong Lai
      Drug Metabolism and Disposition January 2009, 37 (1) 66-73; DOI: https://doi.org/10.1124/dmd.108.023234

  3. Lam, Tai Ning

    1. Discovering Plausible Mechanistic Details of Hepatic Drug Interactions
      Tai Ning Lam and C. Anthony Hunt
      Drug Metabolism and Disposition January 2009, 37 (1) 237-246; DOI: https://doi.org/10.1124/dmd.108.023820

  4. Lantvit, Daniel D.

    1. Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
      Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
      Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408

  5. Lennernäs, Hans

    1. The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations
      Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö and Ulf Bredberg
      Drug Metabolism and Disposition January 2009, 37 (1) 47-58; DOI: https://doi.org/10.1124/dmd.108.021477

  6. Li, Na

    1. Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human
      Na Li, Yiqun Zhang, Fengmei Hua and Yurong Lai
      Drug Metabolism and Disposition January 2009, 37 (1) 66-73; DOI: https://doi.org/10.1124/dmd.108.023234

  7. Linder, Collette D.

    1. Is 1-Aminobenzotriazole an Appropriate in Vitro Tool as a Nonspecific Cytochrome P450 Inactivator?
      Collette D. Linder, Nicole A. Renaud and J. Matthew Hutzler
      Drug Metabolism and Disposition January 2009, 37 (1) 10-13; DOI: https://doi.org/10.1124/dmd.108.024075

M

  1. Marques, Margarita M.

    1. Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
      Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez and Margarita M. Marques
      Drug Metabolism and Disposition January 2009, 37 (1) 5-9; DOI: https://doi.org/10.1124/dmd.108.022715

  2. Matsuno, Kiyomi

    1. A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
      Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

  3. Merino, Gracia

    1. Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
      Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez and Margarita M. Marques
      Drug Metabolism and Disposition January 2009, 37 (1) 5-9; DOI: https://doi.org/10.1124/dmd.108.022715

  4. Miyata, Masaaki

    1. Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity
      Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari and Yasushi Yamazoe
      Drug Metabolism and Disposition January 2009, 37 (1) 97-105; DOI: https://doi.org/10.1124/dmd.108.021964

  5. Murayama, Norie

    1. Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5
      Yusuke Okada, Norie Murayama, Chihiro Yanagida, Makiko Shimizu, F. Peter Guengerich and Hiroshi Yamazaki
      Drug Metabolism and Disposition January 2009, 37 (1) 18-23; DOI: https://doi.org/10.1124/dmd.108.024679

N

  1. Nagai, Daichi

    1. Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity
      Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari and Yasushi Yamazoe
      Drug Metabolism and Disposition January 2009, 37 (1) 97-105; DOI: https://doi.org/10.1124/dmd.108.021964

  2. Nagata, Ryoichi

    1. A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
      Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

  3. Nakajima, Miki

    1. Key Amino Acid Residues Responsible for the Differences in Substrate Specificity of Human UDP-Glucuronosyltransferase (UGT)1A9 and UGT1A8
      Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka and Tsuyoshi Yokoi
      Drug Metabolism and Disposition January 2009, 37 (1) 41-46; DOI: https://doi.org/10.1124/dmd.108.022913

  4. Nakajin, Shizuo

    1. Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction
      Shuji Ohno and Shizuo Nakajin
      Drug Metabolism and Disposition January 2009, 37 (1) 32-40; DOI: https://doi.org/10.1124/dmd.108.023598

  5. Nakamura, Chika

    1. A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
      Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

  6. Nii, Kazuo

    1. Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
      Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume and Koichiro Fukuzaki
      Drug Metabolism and Disposition January 2009, 37 (1) 122-128; DOI: https://doi.org/10.1124/dmd.108.022574

  7. Nishida, Clinton R.

    1. Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide
      Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips and Elizabeth A. Shephard
      Drug Metabolism and Disposition January 2009, 37 (1) 178-186; DOI: https://doi.org/10.1124/dmd.108.024158

O

  1. Ogasawara, Akihito

    1. Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
      Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume and Koichiro Fukuzaki
      Drug Metabolism and Disposition January 2009, 37 (1) 122-128; DOI: https://doi.org/10.1124/dmd.108.022574

  2. Ohbuchi, Masato

    1. Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity
      Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari and Yasushi Yamazoe
      Drug Metabolism and Disposition January 2009, 37 (1) 97-105; DOI: https://doi.org/10.1124/dmd.108.021964

  3. Ohno, Shuji

    1. Determination of mRNA Expression of Human UDP-Glucuronosyltransferases and Application for Localization in Various Human Tissues by Real-Time Reverse Transcriptase-Polymerase Chain Reaction
      Shuji Ohno and Shizuo Nakajin
      Drug Metabolism and Disposition January 2009, 37 (1) 32-40; DOI: https://doi.org/10.1124/dmd.108.023598

  4. Okada, Yusuke

    1. Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5
      Yusuke Okada, Norie Murayama, Chihiro Yanagida, Makiko Shimizu, F. Peter Guengerich and Hiroshi Yamazaki
      Drug Metabolism and Disposition January 2009, 37 (1) 18-23; DOI: https://doi.org/10.1124/dmd.108.024679

  5. Overk, Cassia R.

    1. Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
      Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
      Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408

P

  1. Pak, Youngeen A.

    1. Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2′-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)
      Manthena V. S. Varma, André H. Eriksson, Geri Sawada, Youngeen A. Pak, Everett J. Perkins and Cheryl L. Zimmerman
      Drug Metabolism and Disposition January 2009, 37 (1) 211-220; DOI: https://doi.org/10.1124/dmd.108.022012

  2. Pang, K. Sandy

    1. Disparity in Intestine Disposition between Formed and Preformed Metabolites and Implications: A Theoretical Study
      Huadong Sun and K. Sandy Pang
      Drug Metabolism and Disposition January 2009, 37 (1) 187-202; DOI: https://doi.org/10.1124/dmd.108.022483

  3. Perkins, Everett J.

    1. Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2′-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)
      Manthena V. S. Varma, André H. Eriksson, Geri Sawada, Youngeen A. Pak, Everett J. Perkins and Cheryl L. Zimmerman
      Drug Metabolism and Disposition January 2009, 37 (1) 211-220; DOI: https://doi.org/10.1124/dmd.108.022012

  4. Phillips, Ian R.

    1. Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide
      Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips and Elizabeth A. Shephard
      Drug Metabolism and Disposition January 2009, 37 (1) 178-186; DOI: https://doi.org/10.1124/dmd.108.024158

  5. Pinto, Donald

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

  6. Prieto, Julio G.

    1. Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
      Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez and Margarita M. Marques
      Drug Metabolism and Disposition January 2009, 37 (1) 5-9; DOI: https://doi.org/10.1124/dmd.108.022715

Q

  1. Qin, Zhihui

    1. Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
      Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
      Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408

  2. Qu, Jun

    1. Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis
      Ai-Ming Yu, Jun Qu, Melanie A. Felmlee, Jin Cao and Xi-Ling Jiang
      Drug Metabolism and Disposition January 2009, 37 (1) 170-177; DOI: https://doi.org/10.1124/dmd.108.024166

R

  1. Raghavan, Nirmala

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

  2. Real, Rebeca

    1. Natural Allelic Variants of Bovine ATP-Binding Cassette Transporter ABCG2: Increased Activity of the Ser581 Variant and Development of Tools for the Discovery of New ABCG2 Inhibitors
      Gracia Merino, Rebeca Real, Marta F. Baro, Lucia Gonzalez-Lobato, Julio G. Prieto, Ana I. Alvarez and Margarita M. Marques
      Drug Metabolism and Disposition January 2009, 37 (1) 5-9; DOI: https://doi.org/10.1124/dmd.108.022715

  3. Remmel, Rory P.

    1. Effect of Aging on Glucuronidation of Valproic Acid in Human Liver Microsomes and the Role of UDP-Glucuronosyltransferase UGT1A4, UGT1A8, and UGT1A10
      Upendra A. Argikar and Rory P. Remmel
      Drug Metabolism and Disposition January 2009, 37 (1) 229-236; DOI: https://doi.org/10.1124/dmd.108.022426

  4. Renaud, Nicole A.

    1. Is 1-Aminobenzotriazole an Appropriate in Vitro Tool as a Nonspecific Cytochrome P450 Inactivator?
      Collette D. Linder, Nicole A. Renaud and J. Matthew Hutzler
      Drug Metabolism and Disposition January 2009, 37 (1) 10-13; DOI: https://doi.org/10.1124/dmd.108.024075

S

  1. Sakuraba, Hiroko

    1. A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
      Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

  2. Sawada, Geri

    1. Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2′-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)
      Manthena V. S. Varma, André H. Eriksson, Geri Sawada, Youngeen A. Pak, Everett J. Perkins and Cheryl L. Zimmerman
      Drug Metabolism and Disposition January 2009, 37 (1) 211-220; DOI: https://doi.org/10.1124/dmd.108.022012

  3. Schinkel, Alfred H.

    1. Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone
      Jurjen S. Lagas, Cornelia M. M. van der Kruijssen, Koen van de Wetering, Jos H. Beijnen and Alfred H. Schinkel
      Drug Metabolism and Disposition January 2009, 37 (1) 129-136; DOI: https://doi.org/10.1124/dmd.108.023200

  4. Scollon, Edward J.

    1. In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms
      Edward J. Scollon, James M. Starr, Stephen J. Godin, Michael J. DeVito and Michael F. Hughes
      Drug Metabolism and Disposition January 2009, 37 (1) 221-228; DOI: https://doi.org/10.1124/dmd.108.022343

  5. Shephard, Elizabeth A.

    1. Human Flavin-Containing Monooxygenase 2.1 Catalyzes Oxygenation of the Antitubercular Drugs Thiacetazone and Ethionamide
      Asvi A. Francois, Clinton R. Nishida, Paul R. Ortiz de Montellano, Ian R. Phillips and Elizabeth A. Shephard
      Drug Metabolism and Disposition January 2009, 37 (1) 178-186; DOI: https://doi.org/10.1124/dmd.108.024158

  6. Shimada, Miki

    1. Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity
      Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari and Yasushi Yamazoe
      Drug Metabolism and Disposition January 2009, 37 (1) 97-105; DOI: https://doi.org/10.1124/dmd.108.021964

  7. Shimizu, Makiko

    1. Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5
      Yusuke Okada, Norie Murayama, Chihiro Yanagida, Makiko Shimizu, F. Peter Guengerich and Hiroshi Yamazaki
      Drug Metabolism and Disposition January 2009, 37 (1) 18-23; DOI: https://doi.org/10.1124/dmd.108.024679

  8. Sjögren, Erik

    1. The Multiple Depletion Curves Method Provides Accurate Estimates of Intrinsic Clearance (CLint), Maximum Velocity of the Metabolic Reaction (Vmax), and Michaelis Constant (Km): Accuracy and Robustness Evaluated through Experimental Data and Monte Carlo Simulations
      Erik Sjögren, Hans Lennernäs, Tommy B. Andersson, Johan Gråsjö and Ulf Bredberg
      Drug Metabolism and Disposition January 2009, 37 (1) 47-58; DOI: https://doi.org/10.1124/dmd.108.021477

  9. Sohal, Bindi

    1. Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes
      Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition January 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853

  10. Starr, James M.

    1. In Vitro Metabolism of Pyrethroid Pesticides by Rat and Human Hepatic Microsomes and Cytochrome P450 Isoforms
      Edward J. Scollon, James M. Starr, Stephen J. Godin, Michael J. DeVito and Michael F. Hughes
      Drug Metabolism and Disposition January 2009, 37 (1) 221-228; DOI: https://doi.org/10.1124/dmd.108.022343

  11. Stratford, Robert

    1. Microdialysis Evaluation of Atomoxetine Brain Penetration and Central Nervous System Pharmacokinetics in Rats
      William Kielbasa, J. Cory Kalvass and Robert Stratford
      Drug Metabolism and Disposition January 2009, 37 (1) 137-142; DOI: https://doi.org/10.1124/dmd.108.023119

  12. Stringer, Rowan

    1. Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes
      Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
      Drug Metabolism and Disposition January 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853

  13. Sun, Huadong

    1. Disparity in Intestine Disposition between Formed and Preformed Metabolites and Implications: A Theoretical Study
      Huadong Sun and K. Sandy Pang
      Drug Metabolism and Disposition January 2009, 37 (1) 187-202; DOI: https://doi.org/10.1124/dmd.108.022483

T

  1. Thatcher, Gregory R. J.

    1. Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
      Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
      Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408

  2. Tracy, Timothy S.

    1. Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection
      J. Matthew Hutzler, Larissa M. Balogh, Michael Zientek, Vikas Kumar and Timothy S. Tracy
      Drug Metabolism and Disposition January 2009, 37 (1) 59-65; DOI: https://doi.org/10.1124/dmd.108.023358

  3. Trepanier, Lauren A.

    1. Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5 Reductase in Variability of CYP3A Activity in Human Liver Microsomes
      Lu Gan, Lisa L. von Moltke, Lauren A. Trepanier, Jerold S. Harmatz, David J. Greenblatt and Michael H. Court
      Drug Metabolism and Disposition January 2009, 37 (1) 90-96; DOI: https://doi.org/10.1124/dmd.108.023424

  4. Tu, You-Bin

    1. Expression and Functional Analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 Isozymes
      Wei-Yan Zhang, You-Bin Tu, Robert L. Haining and Ai-Ming Yu
      Drug Metabolism and Disposition January 2009, 37 (1) 1-4; DOI: https://doi.org/10.1124/dmd.108.023663

U

  1. Ueda, Ayumi

    1. Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
      Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume and Koichiro Fukuzaki
      Drug Metabolism and Disposition January 2009, 37 (1) 122-128; DOI: https://doi.org/10.1124/dmd.108.022574

  2. Uehara, Shotaro

    1. A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
      Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

  3. Uno, Yasuhiro

    1. A Null Allele Impairs Function of CYP2C76 Gene in Cynomolgus Monkeys: A Possible Genetic Tool for Generation of a Better Animal Model in Drug Metabolism
      Yasuhiro Uno, Hiroko Sakuraba, Shotaro Uehara, Takayuki Kumano, Kiyomi Matsuno, Chika Nakamura, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition January 2009, 37 (1) 14-17; DOI: https://doi.org/10.1124/dmd.108.023622

  4. Utoh, Masahiro

    1. Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
      Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume and Koichiro Fukuzaki
      Drug Metabolism and Disposition January 2009, 37 (1) 122-128; DOI: https://doi.org/10.1124/dmd.108.022574

V

  1. van Breemen, Richard B.

    1. Structural Modulation of Oxidative Metabolism in Design of Improved Benzothiophene Selective Estrogen Receptor Modulators
      Zhihui Qin, Irida Kastrati, Rezene T. Ashgodom, Daniel D. Lantvit, Cassia R. Overk, Yongsoo Choi, Richard B. van Breemen, Judy L. Bolton and Gregory R. J. Thatcher
      Drug Metabolism and Disposition January 2009, 37 (1) 161-169; DOI: https://doi.org/10.1124/dmd.108.023408

  2. van der Kruijssen, Cornelia M. M.

    1. Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone
      Jurjen S. Lagas, Cornelia M. M. van der Kruijssen, Koen van de Wetering, Jos H. Beijnen and Alfred H. Schinkel
      Drug Metabolism and Disposition January 2009, 37 (1) 129-136; DOI: https://doi.org/10.1124/dmd.108.023200

  3. van de Wetering, Koen

    1. Transport of Diclofenac by Breast Cancer Resistance Protein (ABCG2) and Stimulation of Multidrug Resistance Protein 2 (ABCC2)-Mediated Drug Transport by Diclofenac and Benzbromarone
      Jurjen S. Lagas, Cornelia M. M. van der Kruijssen, Koen van de Wetering, Jos H. Beijnen and Alfred H. Schinkel
      Drug Metabolism and Disposition January 2009, 37 (1) 129-136; DOI: https://doi.org/10.1124/dmd.108.023200

  4. Varma, Manthena V. S.

    1. Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2′-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)
      Manthena V. S. Varma, André H. Eriksson, Geri Sawada, Youngeen A. Pak, Everett J. Perkins and Cheryl L. Zimmerman
      Drug Metabolism and Disposition January 2009, 37 (1) 211-220; DOI: https://doi.org/10.1124/dmd.108.022012

  5. von Moltke, Lisa L.

    1. Role of NADPH-Cytochrome P450 Reductase and Cytochrome-b5/NADH-b5 Reductase in Variability of CYP3A Activity in Human Liver Microsomes
      Lu Gan, Lisa L. von Moltke, Lauren A. Trepanier, Jerold S. Harmatz, David J. Greenblatt and Michael H. Court
      Drug Metabolism and Disposition January 2009, 37 (1) 90-96; DOI: https://doi.org/10.1124/dmd.108.023424

W

  1. Weaver, Yi Miao

    1. Tissue Distribution, Gender-Divergent Expression, Ontogeny, and Chemical Induction of Multidrug Resistance Transporter Genes (Mdr1a, Mdr1b, Mdr2) in Mice
      Yue Julia Cui, Xingguo Cheng, Yi Miao Weaver and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2009, 37 (1) 203-210; DOI: https://doi.org/10.1124/dmd.108.023721

  2. Wong, Pancras C.

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

Y

  1. Yamanaka, Hiroyuki

    1. Key Amino Acid Residues Responsible for the Differences in Substrate Specificity of Human UDP-Glucuronosyltransferase (UGT)1A9 and UGT1A8
      Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka and Tsuyoshi Yokoi
      Drug Metabolism and Disposition January 2009, 37 (1) 41-46; DOI: https://doi.org/10.1124/dmd.108.022913

  2. Yamazaki, Hiroshi

    1. Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5
      Yusuke Okada, Norie Murayama, Chihiro Yanagida, Makiko Shimizu, F. Peter Guengerich and Hiroshi Yamazaki
      Drug Metabolism and Disposition January 2009, 37 (1) 18-23; DOI: https://doi.org/10.1124/dmd.108.024679

  3. Yamazoe, Yasushi

    1. Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity
      Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari and Yasushi Yamazoe
      Drug Metabolism and Disposition January 2009, 37 (1) 97-105; DOI: https://doi.org/10.1124/dmd.108.021964

  4. Yanagida, Chihiro

    1. Drug Interactions of Thalidomide with Midazolam and Cyclosporine A: Heterotropic Cooperativity of Human Cytochrome P450 3A5
      Yusuke Okada, Norie Murayama, Chihiro Yanagida, Makiko Shimizu, F. Peter Guengerich and Hiroshi Yamazaki
      Drug Metabolism and Disposition January 2009, 37 (1) 18-23; DOI: https://doi.org/10.1124/dmd.108.024679

  5. Yeager, Ronnie L.

    1. Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver
      Yu-Kun Jennifer Zhang, Ronnie L. Yeager and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2009, 37 (1) 106-115; DOI: https://doi.org/10.1124/dmd.108.024174

  6. Yokoi, Tsuyoshi

    1. Key Amino Acid Residues Responsible for the Differences in Substrate Specificity of Human UDP-Glucuronosyltransferase (UGT)1A9 and UGT1A8
      Ryoichi Fujiwara, Miki Nakajima, Hiroyuki Yamanaka and Tsuyoshi Yokoi
      Drug Metabolism and Disposition January 2009, 37 (1) 41-46; DOI: https://doi.org/10.1124/dmd.108.022913

  7. Yoshikawa, Takahiro

    1. Effect of Oral Ketoconazole on Oral and Intravenous Pharmacokinetics of Simvastatin and Its Acid in Cynomolgus Monkeys
      Akihito Ogasawara, Masahiro Utoh, Kazuo Nii, Ayumi Ueda, Takahiro Yoshikawa, Toshiyuki Kume and Koichiro Fukuzaki
      Drug Metabolism and Disposition January 2009, 37 (1) 122-128; DOI: https://doi.org/10.1124/dmd.108.022574

  8. Yoshinari, Kouichi

    1. Role of Enzymatic N-Hydroxylation and Reduction in Flutamide Metabolite-Induced Liver Toxicity
      Masato Ohbuchi, Masaaki Miyata, Daichi Nagai, Miki Shimada, Kouichi Yoshinari and Yasushi Yamazoe
      Drug Metabolism and Disposition January 2009, 37 (1) 97-105; DOI: https://doi.org/10.1124/dmd.108.021964

  9. Yu, Ai-Ming

    1. Quantitation of Human Cytochrome P450 2D6 Protein with Immunoblot and Mass Spectrometry Analysis
      Ai-Ming Yu, Jun Qu, Melanie A. Felmlee, Jin Cao and Xi-Ling Jiang
      Drug Metabolism and Disposition January 2009, 37 (1) 170-177; DOI: https://doi.org/10.1124/dmd.108.024166
    2. Expression and Functional Analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 Isozymes
      Wei-Yan Zhang, You-Bin Tu, Robert L. Haining and Ai-Ming Yu
      Drug Metabolism and Disposition January 2009, 37 (1) 1-4; DOI: https://doi.org/10.1124/dmd.108.023663

  10. Yu, Zhigang

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

Z

  1. Zhang, Donglu

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

  2. Zhang, Haiying

    1. Apixaban Metabolism and Pharmacokinetics after Oral Administration to Humans
      Nirmala Raghavan, Charles E. Frost, Zhigang Yu, Kan He, Haiying Zhang, W. Griffith Humphreys, Donald Pinto, Shiangyuan Chen, Samuel Bonacorsi, Pancras C. Wong and Donglu Zhang
      Drug Metabolism and Disposition January 2009, 37 (1) 74-81; DOI: https://doi.org/10.1124/dmd.108.023143

  3. Zhang, Wei-Yan

    1. Expression and Functional Analysis of CYP2D6.24, CYP2D6.26, CYP2D6.27, and CYP2D7 Isozymes
      Wei-Yan Zhang, You-Bin Tu, Robert L. Haining and Ai-Ming Yu
      Drug Metabolism and Disposition January 2009, 37 (1) 1-4; DOI: https://doi.org/10.1124/dmd.108.023663

  4. Zhang, Xin

    1. Prediction of the Effect of Erythromycin, Diltiazem, and Their Metabolites, Alone and in Combination, on CYP3A4 Inhibition
      Xin Zhang, David R. Jones and Stephen D. Hall
      Drug Metabolism and Disposition January 2009, 37 (1) 150-160; DOI: https://doi.org/10.1124/dmd.108.022178

  5. Zhang, Yiqun

    1. Absolute Difference of Hepatobiliary Transporter Multidrug Resistance-Associated Protein (MRP2/Mrp2) in Liver Tissues and Isolated Hepatocytes from Rat, Dog, Monkey, and Human
      Na Li, Yiqun Zhang, Fengmei Hua and Yurong Lai
      Drug Metabolism and Disposition January 2009, 37 (1) 66-73; DOI: https://doi.org/10.1124/dmd.108.023234

  6. Zhang, Yu-Kun Jennifer

    1. Circadian Expression Profiles of Drug-Processing Genes and Transcription Factors in Mouse Liver
      Yu-Kun Jennifer Zhang, Ronnie L. Yeager and Curtis D. Klaassen
      Drug Metabolism and Disposition January 2009, 37 (1) 106-115; DOI: https://doi.org/10.1124/dmd.108.024174

  7. Zhong, Xiao-bo

    1. Three Patterns of Cytochrome P450 Gene Expression during Liver Maturation in Mice
      Steven N. Hart, Yue Cui, Curtis D. Klaassen and Xiao-bo Zhong
      Drug Metabolism and Disposition January 2009, 37 (1) 116-121; DOI: https://doi.org/10.1124/dmd.108.023812

  8. Zientek, Michael

    1. Mechanism-Based Inactivation of Cytochrome P450 2C9 by Tienilic Acid and (±)-Suprofen: A Comparison of Kinetics and Probe Substrate Selection
      J. Matthew Hutzler, Larissa M. Balogh, Michael Zientek, Vikas Kumar and Timothy S. Tracy
      Drug Metabolism and Disposition January 2009, 37 (1) 59-65; DOI: https://doi.org/10.1124/dmd.108.023358

  9. Zimmerman, Cheryl L.

    1. Transepithelial Transport of the Group II Metabotropic Glutamate 2/3 Receptor Agonist (1S,2S,5R,6S)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY354740) and Its Prodrug (1S,2S,5R,6S)-2-[(2′S)-(2′-Amino)propionyl]aminobicyclo[3.1.0]hexane-2,6-dicarboxylate (LY544344)
      Manthena V. S. Varma, André H. Eriksson, Geri Sawada, Youngeen A. Pak, Everett J. Perkins and Cheryl L. Zimmerman
      Drug Metabolism and Disposition January 2009, 37 (1) 211-220; DOI: https://doi.org/10.1124/dmd.108.022012
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