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Research ArticleArticle

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition January 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853

Article Information

vol. 37 no. 1 82-89
DOI 
https://doi.org/10.1124/dmd.108.023853
PubMed 
18832476
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 12, 2008
  • Accepted October 1, 2008
  • Published online December 23, 2008.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Peter J. Kilford,
  2. Rowan Stringer,
  3. Bindi Sohal,
  4. J. Brian Houston and
  5. Aleksandra Galetin
  1. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (P.J.K., J.B.H., A.G.); and Novartis Horsham Research Centre, Horsham, West Sussex, United Kingdom (R.S., B.S.)
  1. Address correspondence to:
    Dr. A. Galetin, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK. E-mail: aleksandra.galetin{at}manchester.ac.uk
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Research ArticleArticle

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition January 1, 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853
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