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Research ArticleArticle

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition January 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853
Peter J. Kilford
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Rowan Stringer
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Bindi Sohal
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J. Brian Houston
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Aleksandra Galetin
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Article Information

vol. 37 no. 1 82-89
DOI 
https://doi.org/10.1124/dmd.108.023853
PubMed 
18832476

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 12, 2008
  • Accepted October 1, 2008
  • Published online December 23, 2008.

Article Versions

  • Earlier version (October 2, 2008 - 08:38).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Peter J. Kilford,
  2. Rowan Stringer,
  3. Bindi Sohal,
  4. J. Brian Houston and
  5. Aleksandra Galetin
  1. School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Manchester, United Kingdom (P.J.K., J.B.H., A.G.); and Novartis Horsham Research Centre, Horsham, West Sussex, United Kingdom (R.S., B.S.)
  1. Address correspondence to:
    Dr. A. Galetin, School of Pharmacy and Pharmaceutical Sciences, University of Manchester, Stopford Building, Oxford Road, Manchester, M13 9PT, UK. E-mail: aleksandra.galetin{at}manchester.ac.uk
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Drug Metabolism and Disposition: 37 (1)
Drug Metabolism and Disposition
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1 Jan 2009
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Research ArticleArticle

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition January 1, 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853

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Research ArticleArticle

Prediction of Drug Clearance by Glucuronidation from in Vitro Data: Use of Combined Cytochrome P450 and UDP-Glucuronosyltransferase Cofactors in Alamethicin-Activated Human Liver Microsomes

Peter J. Kilford, Rowan Stringer, Bindi Sohal, J. Brian Houston and Aleksandra Galetin
Drug Metabolism and Disposition January 1, 2009, 37 (1) 82-89; DOI: https://doi.org/10.1124/dmd.108.023853
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