Drug Metabolism and Disposition: 37 (10)

October 2009; Volume 37,Issue 10

Short Communications

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Expression and Characterization of Functional Dog Flavin-Containing Monooxygenase 3
Andrew J. Lickteig, Rochelle Riley, Roger J. Melton, Beverly A. Reitz, H. David Fischer and Jeffrey C. Stevens

Drug Metabolism and Disposition October 2009, 37 (10) 1987-1990; DOI: https://doi.org/10.1124/dmd.109.027714
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Allele and Genotype Frequencies of Cytochrome P450 2B6 Gene in a Mongolian Population
Jagdagsuren Davaalkham, Tsunefusa Hayashida, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Dulmaa Nyamkhuu and Shinichi Oka

Drug Metabolism and Disposition October 2009, 37 (10) 1991-1993; DOI: https://doi.org/10.1124/dmd.109.027755
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Presystemic Elimination of Trichloroethylene in Rats Following Environmentally Relevant Oral Exposures
Y. Liu, M. G. Bartlett, C. A. White, S. Muralidhara and J. V. Bruckner

Drug Metabolism and Disposition October 2009, 37 (10) 1994-1998; DOI: https://doi.org/10.1124/dmd.109.028100

Articles

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Functional Characterization of Low-Prevalence Missense Polymorphisms in the UDP-Glucuronosyltransferase 1A9 Gene
Kristine C. Olson, Ryan W. Dellinger, Qing Zhong, Dongxiao Sun, Shantu Amin, Thomas E. Spratt and Philip Lazarus

Drug Metabolism and Disposition October 2009, 37 (10) 1999-2007; DOI: https://doi.org/10.1124/dmd.108.024596
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Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry
Anna Lundahl, Hans Lennernäs, Lars Knutson, Ulf Bondesson and Mikael Hedeland

Drug Metabolism and Disposition October 2009, 37 (10) 2008-2017; DOI: https://doi.org/10.1124/dmd.109.027870
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The Pneumotoxin 3-Methylindole Is a Substrate and a Mechanism-Based Inactivator of CYP2A13, a Human Cytochrome P450 Enzyme Preferentially Expressed in the Respiratory Tract
Jaime D'Agostino, Xiaoliang Zhuo, Mohammad Shadid, Daniel G. Morgan, Xiuling Zhang, W. Griffith Humphreys, Yue-Zhong Shu, Garold S. Yost and Xinxin Ding

Drug Metabolism and Disposition October 2009, 37 (10) 2018-2027; DOI: https://doi.org/10.1124/dmd.109.027300
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Multiple Efflux Pumps Are Involved in the Transepithelial Transport of Colchicine: Combined Effect of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Leads to Decreased Intestinal Absorption Throughout the Entire Small Intestine
Arik Dahan, Hairat Sabit and Gordon L. Amidon

Drug Metabolism and Disposition October 2009, 37 (10) 2028-2036; DOI: https://doi.org/10.1124/dmd.109.028282
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Modulation of Bile Acid Metabolism by 1α-Hydroxyvitamin D₃ Administration in Mice
Shigeru Nishida, Jun Ozeki and Makoto Makishima

Drug Metabolism and Disposition October 2009, 37 (10) 2037-2044; DOI: https://doi.org/10.1124/dmd.109.027334
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In Vitro Inhibition and Induction of Human Liver Cytochrome P450 Enzymes by Milnacipran
Brandy L. Paris, Brian W. Ogilvie, Julie A. Scheinkoenig, Florence Ndikum-Moffor, Remi Gibson and Andrew Parkinson

Drug Metabolism and Disposition October 2009, 37 (10) 2045-2054; DOI: https://doi.org/10.1124/dmd.109.028274
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Absorption, Disposition, Metabolic Fate, and Elimination of the Dopamine Agonist Rotigotine in Man: Administration by Intravenous Infusion or Transdermal Delivery
Willi Cawello, Marina Braun and Hilmar Boekens

Drug Metabolism and Disposition October 2009, 37 (10) 2055-2060; DOI: https://doi.org/10.1124/dmd.109.027383
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Investigation of the Influence of CYP1A2 and CYP2C19 Genetic Polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) Pharmacokinetics in Leflunomide-Treated Patients with Rheumatoid Arthritis
Petra Bohanec Grabar, Iztok Grabnar, Blaž Rozman, Dušan Logar, Matija Tomšič, Daša Šuput, Tina Trdan, Lucija Peterlin Mašič, Aleš Mrhar and Vita Dolžan

Drug Metabolism and Disposition October 2009, 37 (10) 2061-2068; DOI: https://doi.org/10.1124/dmd.109.027482
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24-Hydroxycholesterol Sulfation by Human Cytosolic Sulfotransferases: Formation of Monosulfates and Disulfates, Molecular Modeling, Sulfatase Sensitivity, and Inhibition of Liver X Receptor Activation
Ian T. Cook, Zofia Duniec-Dmuchowski, Thomas A. Kocarek, Melissa Runge-Morris and Charles N. Falany

Drug Metabolism and Disposition October 2009, 37 (10) 2069-2078; DOI: https://doi.org/10.1124/dmd.108.025759
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Further Studies on the Role of Metabolites in (±)-3,4-Methylenedioxymethamphetamine-Induced Serotonergic Neurotoxicity
Melanie Mueller, Jie Yuan, Anne Felim, Anne Neudörffer, Frank T. Peters, Hans H. Maurer, Una D. McCann, Martine Largeron and George A. Ricaurte

Drug Metabolism and Disposition October 2009, 37 (10) 2079-2086; DOI: https://doi.org/10.1124/dmd.109.028340
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Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease
Craig D. Fisher, Andrew J. Lickteig, Lisa M. Augustine, James Ranger-Moore, Jonathan P. Jackson, Stephen S. Ferguson and Nathan J. Cherrington

Drug Metabolism and Disposition October 2009, 37 (10) 2087-2094; DOI: https://doi.org/10.1124/dmd.109.027466
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4-Hydroxy-2,2′,3,4′,5,5′,6-heptachlorobiphenyl-Mediated Decrease in Serum Thyroxine Level in Mice Occurs through Increase in Accumulation of Thyroxine in the Liver
Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Yoshiki Seto, Shin-ichi Ikushiro, Toshiyuki Sakaki, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa

Drug Metabolism and Disposition October 2009, 37 (10) 2095-2102; DOI: https://doi.org/10.1124/dmd.109.028621
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Construction of Triple-Transfected Cells [Organic Anion-Transporting Polypeptide (OATP) 1B1/Multidrug Resistance-Associated Protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for Analysis of the Sinusoidal Function of MRP3 and MRP4
Masakazu Hirouchi, Hiroyuki Kusuhara, Reiko Onuki, Brian W. Ogilvie, Andrew Parkinson and Yuichi Sugiyama

Drug Metabolism and Disposition October 2009, 37 (10) 2103-2111; DOI: https://doi.org/10.1124/dmd.109.027193

Accelerated Communication

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MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targeting
Yu-Zhuo Pan, Wenqing Gao and Ai-Ming Yu

Drug Metabolism and Disposition October 2009, 37 (10) 2112-2117; DOI: https://doi.org/10.1124/dmd.109.027680

Erratum

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CORRECTION TO “CHARACTERIZATION OF DASATINIB AND ITS STRUCTURAL ANALOGS AS CYP3A4 MECHANISM-BASED INACTIVATORS AND THE PROPOSED BIOACTIVATION PATHWAYS”
Drug Metabolism and Disposition October 2009, 37 (10) 2118; DOI: https://doi.org/10.1124/dmd.37.10.2118

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