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Drug Metabolism & Disposition

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Table of Contents

October 2009; Volume 37,Issue 10

Short Communications

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    Expression and Characterization of Functional Dog Flavin-Containing Monooxygenase 3
    Andrew J. Lickteig, Rochelle Riley, Roger J. Melton, Beverly A. Reitz, H. David Fischer and Jeffrey C. Stevens
    Drug Metabolism and Disposition October 2009, 37 (10) 1987-1990; DOI: https://doi.org/10.1124/dmd.109.027714
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    Allele and Genotype Frequencies of Cytochrome P450 2B6 Gene in a Mongolian Population
    Jagdagsuren Davaalkham, Tsunefusa Hayashida, Kiyoto Tsuchiya, Hiroyuki Gatanaga, Dulmaa Nyamkhuu and Shinichi Oka
    Drug Metabolism and Disposition October 2009, 37 (10) 1991-1993; DOI: https://doi.org/10.1124/dmd.109.027755
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    Presystemic Elimination of Trichloroethylene in Rats Following Environmentally Relevant Oral Exposures
    Y. Liu, M. G. Bartlett, C. A. White, S. Muralidhara and J. V. Bruckner
    Drug Metabolism and Disposition October 2009, 37 (10) 1994-1998; DOI: https://doi.org/10.1124/dmd.109.028100

Articles

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    Functional Characterization of Low-Prevalence Missense Polymorphisms in the UDP-Glucuronosyltransferase 1A9 Gene
    Kristine C. Olson, Ryan W. Dellinger, Qing Zhong, Dongxiao Sun, Shantu Amin, Thomas E. Spratt and Philip Lazarus
    Drug Metabolism and Disposition October 2009, 37 (10) 1999-2007; DOI: https://doi.org/10.1124/dmd.108.024596
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    Identification of Finasteride Metabolites in Human Bile and Urine by High-Performance Liquid Chromatography/Tandem Mass Spectrometry
    Anna Lundahl, Hans Lennernäs, Lars Knutson, Ulf Bondesson and Mikael Hedeland
    Drug Metabolism and Disposition October 2009, 37 (10) 2008-2017; DOI: https://doi.org/10.1124/dmd.109.027870
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    The Pneumotoxin 3-Methylindole Is a Substrate and a Mechanism-Based Inactivator of CYP2A13, a Human Cytochrome P450 Enzyme Preferentially Expressed in the Respiratory Tract
    Jaime D'Agostino, Xiaoliang Zhuo, Mohammad Shadid, Daniel G. Morgan, Xiuling Zhang, W. Griffith Humphreys, Yue-Zhong Shu, Garold S. Yost and Xinxin Ding
    Drug Metabolism and Disposition October 2009, 37 (10) 2018-2027; DOI: https://doi.org/10.1124/dmd.109.027300
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    Multiple Efflux Pumps Are Involved in the Transepithelial Transport of Colchicine: Combined Effect of P-Glycoprotein and Multidrug Resistance-Associated Protein 2 Leads to Decreased Intestinal Absorption Throughout the Entire Small Intestine
    Arik Dahan, Hairat Sabit and Gordon L. Amidon
    Drug Metabolism and Disposition October 2009, 37 (10) 2028-2036; DOI: https://doi.org/10.1124/dmd.109.028282
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    Modulation of Bile Acid Metabolism by 1α-Hydroxyvitamin D3 Administration in Mice
    Shigeru Nishida, Jun Ozeki and Makoto Makishima
    Drug Metabolism and Disposition October 2009, 37 (10) 2037-2044; DOI: https://doi.org/10.1124/dmd.109.027334
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    In Vitro Inhibition and Induction of Human Liver Cytochrome P450 Enzymes by Milnacipran
    Brandy L. Paris, Brian W. Ogilvie, Julie A. Scheinkoenig, Florence Ndikum-Moffor, Remi Gibson and Andrew Parkinson
    Drug Metabolism and Disposition October 2009, 37 (10) 2045-2054; DOI: https://doi.org/10.1124/dmd.109.028274
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    Absorption, Disposition, Metabolic Fate, and Elimination of the Dopamine Agonist Rotigotine in Man: Administration by Intravenous Infusion or Transdermal Delivery
    Willi Cawello, Marina Braun and Hilmar Boekens
    Drug Metabolism and Disposition October 2009, 37 (10) 2055-2060; DOI: https://doi.org/10.1124/dmd.109.027383
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    Investigation of the Influence of CYP1A2 and CYP2C19 Genetic Polymorphism on 2-Cyano-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-butenamide (A77 1726) Pharmacokinetics in Leflunomide-Treated Patients with Rheumatoid Arthritis
    Petra Bohanec Grabar, Iztok Grabnar, Blaž Rozman, Dušan Logar, Matija Tomšič, Daša Šuput, Tina Trdan, Lucija Peterlin Mašič, Aleš Mrhar and Vita Dolžan
    Drug Metabolism and Disposition October 2009, 37 (10) 2061-2068; DOI: https://doi.org/10.1124/dmd.109.027482
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    24-Hydroxycholesterol Sulfation by Human Cytosolic Sulfotransferases: Formation of Monosulfates and Disulfates, Molecular Modeling, Sulfatase Sensitivity, and Inhibition of Liver X Receptor Activation
    Ian T. Cook, Zofia Duniec-Dmuchowski, Thomas A. Kocarek, Melissa Runge-Morris and Charles N. Falany
    Drug Metabolism and Disposition October 2009, 37 (10) 2069-2078; DOI: https://doi.org/10.1124/dmd.108.025759
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    Further Studies on the Role of Metabolites in (±)-3,4-Methylenedioxymethamphetamine-Induced Serotonergic Neurotoxicity
    Melanie Mueller, Jie Yuan, Anne Felim, Anne Neudörffer, Frank T. Peters, Hans H. Maurer, Una D. McCann, Martine Largeron and George A. Ricaurte
    Drug Metabolism and Disposition October 2009, 37 (10) 2079-2086; DOI: https://doi.org/10.1124/dmd.109.028340
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    Hepatic Cytochrome P450 Enzyme Alterations in Humans with Progressive Stages of Nonalcoholic Fatty Liver Disease
    Craig D. Fisher, Andrew J. Lickteig, Lisa M. Augustine, James Ranger-Moore, Jonathan P. Jackson, Stephen S. Ferguson and Nathan J. Cherrington
    Drug Metabolism and Disposition October 2009, 37 (10) 2087-2094; DOI: https://doi.org/10.1124/dmd.109.027466
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    4-Hydroxy-2,2′,3,4′,5,5′,6-heptachlorobiphenyl-Mediated Decrease in Serum Thyroxine Level in Mice Occurs through Increase in Accumulation of Thyroxine in the Liver
    Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Yoshiki Seto, Shin-ichi Ikushiro, Toshiyuki Sakaki, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa
    Drug Metabolism and Disposition October 2009, 37 (10) 2095-2102; DOI: https://doi.org/10.1124/dmd.109.028621
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    Construction of Triple-Transfected Cells [Organic Anion-Transporting Polypeptide (OATP) 1B1/Multidrug Resistance-Associated Protein (MRP) 2/MRP3 and OATP1B1/MRP2/MRP4] for Analysis of the Sinusoidal Function of MRP3 and MRP4
    Masakazu Hirouchi, Hiroyuki Kusuhara, Reiko Onuki, Brian W. Ogilvie, Andrew Parkinson and Yuichi Sugiyama
    Drug Metabolism and Disposition October 2009, 37 (10) 2103-2111; DOI: https://doi.org/10.1124/dmd.109.027193

Accelerated Communication

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    MicroRNAs Regulate CYP3A4 Expression via Direct and Indirect Targeting
    Yu-Zhuo Pan, Wenqing Gao and Ai-Ming Yu
    Drug Metabolism and Disposition October 2009, 37 (10) 2112-2117; DOI: https://doi.org/10.1124/dmd.109.027680

Erratum

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    CORRECTION TO “CHARACTERIZATION OF DASATINIB AND ITS STRUCTURAL ANALOGS AS CYP3A4 MECHANISM-BASED INACTIVATORS AND THE PROPOSED BIOACTIVATION PATHWAYS”
    Drug Metabolism and Disposition October 2009, 37 (10) 2118; DOI: https://doi.org/10.1124/dmd.37.10.2118
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In this issue

Drug Metabolism and Disposition: 37 (10)
Drug Metabolism and Disposition
Vol. 37, Issue 10
October 2009
  • Table of Contents
  • Table of Contents (PDF)
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  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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