Drug Metabolism and Disposition: 37 (11)

November 2009; Volume 37,Issue 11

Short Communications

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Expression and Characterization of CYP4V2 as a Fatty Acid ω-Hydroxylase
Mariko Nakano, Edward J. Kelly and Allan E. Rettie

Drug Metabolism and Disposition November 2009, 37 (11) 2119-2122; DOI: https://doi.org/10.1124/dmd.109.028530
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Effect of N-Acetyltransferase 2 Polymorphism on Tumor Target Tissue DNA Adduct Levels in Rapid and Slow Acetylator Congenic Rats Administered 2-Amino-1-methyl-6-phenylimidazo[4,5-b]pyridine or 2-Amino-3,8-dimethylimidazo-[4,5-f]quinoxaline
Kristin J. Metry, Jason R. Neale, Jean Bendaly, Ned B. Smith, William M. Pierce and David W. Hein

Drug Metabolism and Disposition November 2009, 37 (11) 2123-2126; DOI: https://doi.org/10.1124/dmd.109.029512

Articles

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In Vivo Evaluation of Drug-Drug Interaction via Mechanism-Based Inhibition by Macrolide Antibiotics in Cynomolgus Monkeys
Akihito Ogasawara, Isao Negishi, Kazumasa Kozakai and Toshiyuki Kume

Drug Metabolism and Disposition November 2009, 37 (11) 2127-2136; DOI: https://doi.org/10.1124/dmd.109.028969
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Investigation of Long-Term Retention of Unchanged (−)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide, A Novel “Funny” If Current Channel Inhibitor, and Its Metabolites in the Eyeball and Thoracic Aorta of Rats
Ken-ichi Umehara, Naoyuki Nakada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura

Drug Metabolism and Disposition November 2009, 37 (11) 2137-2144; DOI: https://doi.org/10.1124/dmd.109.027813
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A Possible Mechanism for the Differences in Efficiency and Variability of Active Metabolite Formation from Thienopyridine Antiplatelet Agents, Prasugrel and Clopidogrel
Katsunobu Hagihara, Miho Kazui, Atsushi Kurihara, Michiharu Yoshiike, Kokichi Honda, Osamu Okazaki, Nagy A. Farid and Toshihiko Ikeda

Drug Metabolism and Disposition November 2009, 37 (11) 2145-2152; DOI: https://doi.org/10.1124/dmd.109.028498
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Detection and Characterization of a New Metabolite of 17α-Methyltestosterone
Óscar J. Pozo, Peter Van Eenoo, Koen Deventer, Leen Lootens, Wim Van Thuyne, Maria K. Parr, Wilhelm Schänzer, Juan V. Sancho, Felix Hernández, Philip Meuleman, Geert Leroux-Roels and Frans T. Delbeke

Drug Metabolism and Disposition November 2009, 37 (11) 2153-2162; DOI: https://doi.org/10.1124/dmd.109.028373
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Effects of Dose and Route of Administration on Pharmacokinetics of (±)-3,4-Methylenedioxymethamphetamine in the Rat
Michael H. Baumann, Dorota Zolkowska, Insook Kim, Karl B. Scheidweiler, Richard B. Rothman and Marilyn A. Huestis

Drug Metabolism and Disposition November 2009, 37 (11) 2163-2170; DOI: https://doi.org/10.1124/dmd.109.028506
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Effects of Dose and Route on the Disposition and Kinetics of 1-Butyl-1-methylpyrrolidinium Chloride in Male F-344 Rats
G. A. Knudsen, Y. Cheng, R. K. Kuester, M. J. Hooth and I. G. Sipes

Drug Metabolism and Disposition November 2009, 37 (11) 2171-2177; DOI: https://doi.org/10.1124/dmd.109.029082
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Tissue Distribution, Ontogeny, and Hormonal Regulation of Xenobiotic Transporters in Mouse Kidneys
Xingguo Cheng and Curtis D. Klaassen

Drug Metabolism and Disposition November 2009, 37 (11) 2178-2185; DOI: https://doi.org/10.1124/dmd.109.027177
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Different Effects of Ketoconazole on the Stereoselective First-Pass Metabolism of R/S-Verapamil in the Intestine and the Liver: Important for the Mechanistic Understanding of First-Pass Drug-Drug Interactions
Helena Anna Thörn, Mikael Hedeland, Ulf Bondesson, Lars Knutson, Mohammed Yasin, Paul Dickinson and Hans Lennernäs

Drug Metabolism and Disposition November 2009, 37 (11) 2186-2196; DOI: https://doi.org/10.1124/dmd.109.028027
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Hemoglobin Vesicles, Polyethylene Glycol (PEG)ylated Liposomes Developed as a Red Blood Cell Substitute, Do Not Induce the Accelerated Blood Clearance Phenomenon in Mice
Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Hiroshi Watanabe, Daisuke Kadowaki, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toru Maruyama and Masaki Otagiri

Drug Metabolism and Disposition November 2009, 37 (11) 2197-2203; DOI: https://doi.org/10.1124/dmd.109.028852
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Molecular Properties and CYP2D6 Substrates: Central Nervous System Therapeutics Case Study and Pattern Analysis of a Substrate Database
Laura K. Chico, Heather A. Behanna, Wenhui Hu, Guifa Zhong, Saktimayee Mitra Roy and D. Martin Watterson

Drug Metabolism and Disposition November 2009, 37 (11) 2204-2211; DOI: https://doi.org/10.1124/dmd.109.028134
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The Role of Human UDP-Glucuronyltransferases on the Formation of the Methylenedioxymethamphetamine (Ecstasy) Phase II Metabolites R- and S-3-Methoxymethamphetamine 4-O-Glucuronides
Andrea E. Schwaninger, Markus R. Meyer, Josef Zapp and Hans H. Maurer

Drug Metabolism and Disposition November 2009, 37 (11) 2212-2220; DOI: https://doi.org/10.1124/dmd.109.029215
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UDP-Glucuronosyltransferases in Conjugation of 5α- and 5β-Androstane Steroids
Taina Sten, Mika Kurkela, Tiia Kuuranne, Antti Leinonen and Moshe Finel

Drug Metabolism and Disposition November 2009, 37 (11) 2221-2227; DOI: https://doi.org/10.1124/dmd.109.029231
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Differential Regulation of Drug Transporter Expression by Hepatocyte Growth Factor in Primary Human Hepatocytes
Marc Le Vee, Valérie Lecureur, Amélie Moreau, Bruno Stieger and Olivier Fardel

Drug Metabolism and Disposition November 2009, 37 (11) 2228-2235; DOI: https://doi.org/10.1124/dmd.109.028035
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In Vitro Glucuronidation of Fenofibric Acid by Human UDP-Glucuronosyltransferases and Liver Microsomes
Jelena Tojcic, Marie-Odile Benoit-Biancamano, Michael H. Court, Robert J. Straka, Patrick Caron and Chantal Guillemette

Drug Metabolism and Disposition November 2009, 37 (11) 2236-2243; DOI: https://doi.org/10.1124/dmd.109.029058
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Inoculation of Human Tumor Cells Alters the Basal Expression but Not the Inducibility of Cytochrome P450 Enzymes in Tumor-Bearing Mouse Liver
Michiko Sugawara, Kiyoshi Okamoto, Tadashi Kadowaki, Kazutomi Kusano, Akiyoshi Fukamizu and Tsutomu Yoshimura

Drug Metabolism and Disposition November 2009, 37 (11) 2244-2254; DOI: https://doi.org/10.1124/dmd.109.028571
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Quantitative Evaluation of the Expression and Activity of Five Major Sulfotransferases (SULTs) in Human Tissues: The SULT “Pie”
Zoe Riches, Emma L. Stanley, Jackie C. Bloomer and Michael W. H. Coughtrie

Drug Metabolism and Disposition November 2009, 37 (11) 2255-2261; DOI: https://doi.org/10.1124/dmd.109.028399
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Identification of New CYP2C19 Variants Exhibiting Decreased Enzyme Activity in the Metabolism of S-Mephenytoin and Omeprazole
Su-Jun Lee, Woo-Young Kim, Hyunmi Kim, Ji-Hong Shon, Sang Seop Lee and Jae-Gook Shin

Drug Metabolism and Disposition November 2009, 37 (11) 2262-2269; DOI: https://doi.org/10.1124/dmd.109.028175

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