Table of Contents

Articles

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  Endogenous Gene and Protein Expression of Drug-Transporting Proteins in Cell Lines Routinely Used in Drug Discovery Programs

  Gustav Ahlin, Constanze Hilgendorf, Johan Karlsson, Cristina Al-Khalili Szigyarto, Mathias Uhlén and Per Artursson

  Drug Metabolism and Disposition December 2009, 37 (12) 2275-2283; DOI: https://doi.org/10.1124/dmd.109.028654
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  Metabolism of Pyridalyl in Rats

  Hirohisa Nagahori, Koichi Saito, Yoshitaka Tomigahara, Naohiko Isobe and Hideo Kaneko

  Drug Metabolism and Disposition December 2009, 37 (12) 2284-2289; DOI: https://doi.org/10.1124/dmd.109.028878
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  Absorption and Disposition of Ginsenosides after Oral Administration of Panax notoginseng Extract to Rats

  Houfu Liu, Junling Yang, Feifei Du, Xiumei Gao, Xutao Ma, Yuhong Huang, Fang Xu, Wei Niu, Fengqing Wang, Yu Mao, Yan Sun, Tong Lu, Changxiao Liu, Boli Zhang and Chuan Li

  Drug Metabolism and Disposition December 2009, 37 (12) 2290-2298; DOI: https://doi.org/10.1124/dmd.109.029819
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  Comparison of Blood-Brain Barrier Transport of Glial-Derived Neurotrophic Factor (GDNF) and an IgG-GDNF Fusion Protein in the Rhesus Monkey

  Ruben J. Boado and William M. Pardridge

  Drug Metabolism and Disposition December 2009, 37 (12) 2299-2304; DOI: https://doi.org/10.1124/dmd.109.028787
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  Inhibition and Stimulation of Intestinal and Hepatic CYP3A Activity: Studies in Humanized CYP3A4 Transgenic Mice Using Triazolam

  Robert A. B. van Waterschoot, Rogier W. Rooswinkel, Rolf W. Sparidans, Antonius E. van Herwaarden, Jos H. Beijnen and Alfred H. Schinkel

  Drug Metabolism and Disposition December 2009, 37 (12) 2305-2313; DOI: https://doi.org/10.1124/dmd.109.029397
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  Glucuronidation and Covalent Protein Binding of Benoxaprofen and Flunoxaprofen in Sandwich-Cultured Rat and Human Hepatocytes

  Jennifer Q. Dong and Philip C. Smith

  Drug Metabolism and Disposition December 2009, 37 (12) 2314-2322; DOI: https://doi.org/10.1124/dmd.109.028944
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  Effect of Rifampin and Nelfinavir on the Metabolism of Methadone and Buprenorphine in Primary Cultures of Human Hepatocytes

  David E. Moody, Wenfang B. Fang, Shen-Nan Lin, Denise M. Weyant, Stephen C. Strom and Curtis J. Omiecinski

  Drug Metabolism and Disposition December 2009, 37 (12) 2323-2329; DOI: https://doi.org/10.1124/dmd.109.028605
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  Prediction of Human Drug-Drug Interactions from Time-Dependent Inactivation of CYP3A4 in Primary Hepatocytes Using a Population-Based Simulator

  Lilly Xu, Yuping Chen, Yvonne Pan, Gary L. Skiles and Magang Shou

  Drug Metabolism and Disposition December 2009, 37 (12) 2330-2339; DOI: https://doi.org/10.1124/dmd.108.025494
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  Identification of a Novel CYP2C19-Mediated Metabolic Pathway of S-Citalopram in Vitro

  I. Rudberg, J. L. E. Reubsaet, M. Hermann, H. Refsum and E. Molden

  Drug Metabolism and Disposition December 2009, 37 (12) 2340-2348; DOI: https://doi.org/10.1124/dmd.109.029355
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  Enterohepatic Disposition of Rosuvastatin in Pigs and the Impact of Concomitant Dosing with Cyclosporine and Gemfibrozil

  Ebba Bergman, Anna Lundahl, Patrik Fridblom, Mikael Hedeland, Ulf Bondesson, Lars Knutson and Hans Lennernäs

  Drug Metabolism and Disposition December 2009, 37 (12) 2349-2358; DOI: https://doi.org/10.1124/dmd.109.029363
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  CYP2C8 Activity Recovers within 96 Hours after Gemfibrozil Dosing: Estimation of CYP2C8 Half-Life Using Repaglinide as an in Vivo Probe

  Janne T. Backman, Johanna Honkalammi, Mikko Neuvonen, Kaisa J. Kurkinen, Aleksi Tornio, Mikko Niemi and Pertti J. Neuvonen

  Drug Metabolism and Disposition December 2009, 37 (12) 2359-2366; DOI: https://doi.org/10.1124/dmd.109.029728
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  The uPA(+/+)-SCID Mouse with Humanized Liver as a Model for in Vivo Metabolism of 4-Androstene-3,17-dione

  Leen Lootens, Peter Van Eenoo, Philip Meuleman, Geert Leroux-Roels and Frans T. Delbeke

  Drug Metabolism and Disposition December 2009, 37 (12) 2367-2374; DOI: https://doi.org/10.1124/dmd.109.028183
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  Interaction of Macrolide Antibiotics with Intestinally Expressed Human and Rat Organic Anion-Transporting Polypeptides

  Tian Lan, Anuradha Rao, Jamie Haywood, Charles B. Davis, Chao Han, Eric Garver and Paul A. Dawson

  Drug Metabolism and Disposition December 2009, 37 (12) 2375-2382; DOI: https://doi.org/10.1124/dmd.109.028522
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  Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

  Toru Usui, Masashi Mise, Takanori Hashizume, Masashi Yabuki and Setsuko Komuro

  Drug Metabolism and Disposition December 2009, 37 (12) 2383-2392; DOI: https://doi.org/10.1124/dmd.109.028860
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  Purification and Mechanism of Human Aldehyde Oxidase Expressed in Escherichia coli

  Joshua F. Alfaro, Carolyn A. Joswig-Jones, Wenyun Ouyang, Joseph Nichols, Gregory J. Crouch and Jeffrey P. Jones

  Drug Metabolism and Disposition December 2009, 37 (12) 2393-2398; DOI: https://doi.org/10.1124/dmd.109.029520
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  Effects of Short-Term and Long-Term Pretreatment of Schisandra Lignans on Regulating Hepatic and Intestinal CYP3A in Rats

  Li Lai, Haiping Hao, Qiong Wang, Chaonao Zheng, Fang Zhou, Yitong Liu, Yuxin Wang, Guo Yu, An Kang, Ying Peng, Guangji Wang and Xijing Chen

  Drug Metabolism and Disposition December 2009, 37 (12) 2399-2407; DOI: https://doi.org/10.1124/dmd.109.027433