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Research ArticleArticle

Prediction of Human Drug-Drug Interactions from Time-Dependent Inactivation of CYP3A4 in Primary Hepatocytes Using a Population-Based Simulator

Lilly Xu, Yuping Chen, Yvonne Pan, Gary L. Skiles and Magang Shou
Drug Metabolism and Disposition December 2009, 37 (12) 2330-2339; DOI: https://doi.org/10.1124/dmd.108.025494

Article Information

vol. 37 no. 12 2330-2339
DOI 
https://doi.org/10.1124/dmd.108.025494
PubMed 
19773538
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 3, 2008
  • Accepted September 16, 2009
  • Published online November 19, 2009.

Article Versions

Copyright & Usage 
Copyright © 2009 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lilly Xu,
  2. Yuping Chen,
  3. Yvonne Pan,
  4. Gary L. Skiles and
  5. Magang Shou
  1. Department of Pharmacokinetics and Drug Metabolism, Amgen Inc., Thousand Oaks, California
  1. Address correspondence to:
    Dr. Magang Shou,
    Department of Pharmacokinetics and Drug Metabolism, 30E-2-B, Amgen, One Amgen Center Drive, Thousand Oaks, CA 91320-1799.
    E-mail: mshou{at}amgen.com
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Research ArticleArticle

Prediction of Human Drug-Drug Interactions from Time-Dependent Inactivation of CYP3A4 in Primary Hepatocytes Using a Population-Based Simulator

Lilly Xu, Yuping Chen, Yvonne Pan, Gary L. Skiles and Magang Shou
Drug Metabolism and Disposition December 1, 2009, 37 (12) 2330-2339; DOI: https://doi.org/10.1124/dmd.108.025494
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