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Research ArticleArticle

CYP2C8 Activity Recovers within 96 Hours after Gemfibrozil Dosing: Estimation of CYP2C8 Half-Life Using Repaglinide as an in Vivo Probe

Janne T. Backman, Johanna Honkalammi, Mikko Neuvonen, Kaisa J. Kurkinen, Aleksi Tornio, Mikko Niemi and Pertti J. Neuvonen
Drug Metabolism and Disposition December 2009, 37 (12) 2359-2366; DOI: https://doi.org/10.1124/dmd.109.029728
Janne T. Backman
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Johanna Honkalammi
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Mikko Neuvonen
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Kaisa J. Kurkinen
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Aleksi Tornio
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Mikko Niemi
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Pertti J. Neuvonen
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Article Information

vol. 37 no. 12 2359-2366
DOI 
https://doi.org/10.1124/dmd.109.029728
PubMed 
19773535

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received July 30, 2009
  • Accepted September 21, 2009
  • Published online November 19, 2009.

Article Versions

  • Earlier version (September 22, 2009 - 11:39).
  • You are viewing the most recent version of this article.
Copyright & Usage 
Copyright © 2009 by The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Janne T. Backman,
  2. Johanna Honkalammi,
  3. Mikko Neuvonen,
  4. Kaisa J. Kurkinen,
  5. Aleksi Tornio,
  6. Mikko Niemi and
  7. Pertti J. Neuvonen
  1. Department of Clinical Pharmacology, University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland
  1. Address correspondence to:
    Dr. Janne T. Backman,
    P.O. Box 705, Helsinki, FI-00029 HUS, Finland.
    E-mail: janne.backman{at}helsinki.fi
  1. Parts of this work were previously presented at the following meeting: Backman JT, Honkalammi J, Niemi M, Tornio A, and Neuvonen PJ (2009) Recovery of CYP2C8 activity after gemfibrozil administration: estimation of CYP2C8 half-life using repaglinide as an in vivo probe. 11th European Regional ISSX Meeting; 2009 May 17–19; Lisbon, Portugal. International Society for the Study of Xenobiotics, Washington, DC.

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Drug Metabolism and Disposition: 37 (12)
Drug Metabolism and Disposition
Vol. 37, Issue 12
1 Dec 2009
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Research ArticleArticle

CYP2C8 Activity Recovers within 96 Hours after Gemfibrozil Dosing: Estimation of CYP2C8 Half-Life Using Repaglinide as an in Vivo Probe

Janne T. Backman, Johanna Honkalammi, Mikko Neuvonen, Kaisa J. Kurkinen, Aleksi Tornio, Mikko Niemi and Pertti J. Neuvonen
Drug Metabolism and Disposition December 1, 2009, 37 (12) 2359-2366; DOI: https://doi.org/10.1124/dmd.109.029728

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Research ArticleArticle

CYP2C8 Activity Recovers within 96 Hours after Gemfibrozil Dosing: Estimation of CYP2C8 Half-Life Using Repaglinide as an in Vivo Probe

Janne T. Backman, Johanna Honkalammi, Mikko Neuvonen, Kaisa J. Kurkinen, Aleksi Tornio, Mikko Niemi and Pertti J. Neuvonen
Drug Metabolism and Disposition December 1, 2009, 37 (12) 2359-2366; DOI: https://doi.org/10.1124/dmd.109.029728
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