Evaluation of the Potential for Drug-Induced Liver Injury Based on in Vitro Covalent Binding to Human Liver Proteins

Address correspondence to:
Dr. Takanori Hashizume,
Pharmacokinetics Research Laboratories, Dainippon Sumitomo Pharma Co., Ltd., 3-1-98, Kasugade-naka, Konohana-ku, Osaka, 554-0022, Japan.
E-mail: takanori-hashizume{at}ds-pharma.co.jp

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: August 2009 to May 2021

	Abstract	Full	Pdf
Aug 2009	39	0	42
Sep 2009	199	0	444
Oct 2009	60	0	132
Nov 2009	63	0	112
Dec 2009	128	4	101
Jan 2010	242	39	127
Feb 2010	185	35	53
Mar 2010	161	42	69
Apr 2010	126	36	42
May 2010	85	24	27
Jun 2010	100	36	53
Jul 2010	93	27	39
Aug 2010	90	32	31
Sep 2010	66	47	37
Oct 2010	101	36	55
Nov 2010	84	25	39
Dec 2010	69	52	63
Jan 2011	56	58	73
Feb 2011	65	66	46
Mar 2011	60	55	70
Apr 2011	84	64	82
May 2011	41	58	67
Jun 2011	60	60	72
Jul 2011	47	49	63
Aug 2011	48	54	61
Sep 2011	41	51	58
Oct 2011	56	58	78
Nov 2011	45	61	81
Dec 2011	65	39	54
Jan 2012	52	53	61
Feb 2012	53	71	83
Mar 2012	75	75	78
Apr 2012	53	72	63
May 2012	28	56	48
Jun 2012	40	68	59
Jul 2012	52	59	66
Aug 2012	47	45	72
Sep 2012	39	34	66
Oct 2012	54	50	67
Nov 2012	53	39	66
Dec 2012	51	32	45
Jan 2013	61	51	54
Feb 2013	41	45	49
Mar 2013	44	54	69
Apr 2013	53	43	56
May 2013	28	44	43
Jun 2013	30	33	21
Jul 2013	27	39	32
Aug 2013	18	38	32
Sep 2013	55	43	34
Oct 2013	38	55	40
Nov 2013	22	49	39
Dec 2013	30	40	27
Jan 2014	29	40	36
Feb 2014	24	45	58
Mar 2014	31	53	41
Apr 2014	40	57	39
May 2014	37	62	45
Jun 2014	29	29	29
Jul 2014	23	42	26
Aug 2014	20	33	13
Sep 2014	40	38	38
Oct 2014	22	27	28
Nov 2014	24	30	24
Dec 2014	33	25	19
Jan 2015	37	37	35
Feb 2015	34	36	34
Mar 2015	21	28	28
Apr 2015	29	39	33
May 2015	20	35	41
Jun 2015	25	44	43
Jul 2015	22	31	30
Aug 2015	17	32	24
Sep 2015	8	24	16
Oct 2015	17	26	18
Nov 2015	38	41	38
Dec 2015	20	21	24
Jan 2016	31	40	40
Feb 2016	13	34	27
Mar 2016	19	27	35
Apr 2016	21	34	29
May 2016	17	38	38
Jun 2016	17	45	24
Jul 2016	13	28	38
Aug 2016	17	33	33
Sep 2016	18	28	46
Oct 2016	8	124	26
Nov 2016	9	24	23
Dec 2016	3	19	17
Jan 2017	5	40	36
Feb 2017	6	56	32
Mar 2017	6	44	29
Apr 2017	4	23	30
May 2017	5	39	36
Jun 2017	6	26	14
Jul 2017	5	45	35
Aug 2017	4	46	23
Sep 2017	2	47	20
Oct 2017	12	28	16
Nov 2017	2	30	32
Dec 2017	3	32	15
Jan 2018	4	41	23
Feb 2018	3	52	22
Mar 2018	1	44	36
Apr 2018	0	50	40
May 2018	0	46	21
Jun 2018	0	39	11
Jul 2018	2	36	32
Aug 2018	0	27	23
Sep 2018	0	37	10
Oct 2018	1	30	34
Nov 2018	1	36	32
Dec 2018	34	23	17
Jan 2019	27	37	15
Feb 2019	17	8	9
Mar 2019	16	8	12
Apr 2019	29	9	22
May 2019	28	5	8
Jun 2019	29	6	15
Jul 2019	12	15	8
Aug 2019	23	3	4
Sep 2019	42	2	7
Oct 2019	36	5	9
Nov 2019	32	5	9
Dec 2019	26	6	9
Jan 2020	36	7	5
Feb 2020	57	11	18
Mar 2020	23	9	8
Apr 2020	31	6	10
May 2020	38	15	16
Jun 2020	30	2	4
Jul 2020	24	3	11
Aug 2020	17	5	13
Sep 2020	26	9	10
Oct 2020	31	2	9
Nov 2020	37	5	5
Dec 2020	33	4	5
Jan 2021	33	16	13
Feb 2021	25	13	11
Mar 2021	26	11	9
Apr 2021	31	16	11
May 2021	0	2	1