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Drug Metabolism & Disposition

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Table of Contents

February 01, 2009; Volume 37,Issue 2

MINIREVIEW

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    Biotransformation of Drugs in Human Skin
    Craig K. Svensson
    Drug Metabolism and Disposition February 2009, 37 (2) 247-253; DOI: https://doi.org/10.1124/dmd.108.024794

Short Communications

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    Metabolism of Quetiapine by CYP3A4 and CYP3A5 in Presence or Absence of Cytochrome B5
    Gry Vibeke Bakken, Ida Rudberg, Hege Christensen, Espen Molden, Helge Refsum and Monica Hermann
    Drug Metabolism and Disposition February 2009, 37 (2) 254-258; DOI: https://doi.org/10.1124/dmd.108.023291
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    Effect of Dose Volume on the Toxicokinetics of Acrylamide and Its Metabolites and 2-Deoxy-d-glucose
    Burhan I. Ghanayem, Re Bai and Leo T. Burka
    Drug Metabolism and Disposition February 2009, 37 (2) 259-263; DOI: https://doi.org/10.1124/dmd.108.024265
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    Activation of the Antiviral Prodrug Oseltamivir Is Impaired by Two Newly Identified Carboxylesterase 1 Variants
    Hao-Jie Zhu and John S. Markowitz
    Drug Metabolism and Disposition February 2009, 37 (2) 264-267; DOI: https://doi.org/10.1124/dmd.108.024943
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    Genetic Basis of Inter- and Intrastrain Differences in Diazepam p-Hydroxylation in Rats
    Noriaki Sakai, Konomu Saito, Kentaro Q. Sakamoto, Mayumi Ishizuka and Shoichi Fujita
    Drug Metabolism and Disposition February 2009, 37 (2) 268-271; DOI: https://doi.org/10.1124/dmd.108.024273
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    Close Association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 Haplotype and Its Apparent Influence on 7-Ethyl-10-hydroxycamptothecin (SN-38) Glucuronidation in Japanese
    Yoshiro Saito, Kimie Sai, Keiko Maekawa, Nahoko Kaniwa, Kuniaki Shirao, Tetsuya Hamaguchi, Noboru Yamamoto, Hideo Kunitoh, Yuichiro Ohe, Yasuhide Yamada, Tomohide Tamura, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Yasuhiro Matsumura, Nagahiro Saijo and Jun-ichi Sawada
    Drug Metabolism and Disposition February 2009, 37 (2) 272-276; DOI: https://doi.org/10.1124/dmd.108.024208
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    Methotrexate Pharmacokinetics in Transgenic Mice with Liver-Specific Expression of Human Organic Anion-Transporting Polypeptide 1B1 (SLCO1B1)
    Evita van de Steeg, Cornelia M.M. van der Kruijssen, Els Wagenaar, Johanna E.C. Burggraaff, Elly Mesman, Kathryn E. Kenworthy and Alfred H. Schinkel
    Drug Metabolism and Disposition February 2009, 37 (2) 277-281; DOI: https://doi.org/10.1124/dmd.108.024315

Articles

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    Induction of CYP4F3 by Benzene Metabolites in Human White Blood Cells in Vivo in Human Promyelocytic Leukemic Cell Lines and ex Vivo in Human Blood Neutrophils
    Zhiwei Zhao, Xiaoqing He, Yongyi Bi, Ying Xia, Ning Tao, Li Li and Qiang Ma
    Drug Metabolism and Disposition February 2009, 37 (2) 282-291; DOI: https://doi.org/10.1124/dmd.108.023192
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    Identification and Quantitation of the N-Acetyl-L-cysteine S-Conjugates of Bendamustine and Its Sulfoxides in Human Bile after Administration of Bendamustine Hydrochloride
    Jens Teichert, Reinhard Sohr, Lothar Hennig, Frank Baumann, Konrad Schoppmeyer, Ulrich Patzak and Rainer Preiss
    Drug Metabolism and Disposition February 2009, 37 (2) 292-301; DOI: https://doi.org/10.1124/dmd.108.022855
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    Recombinant Zebrafish γ-Glutamyl Hydrolase Exhibits Properties and Catalytic Activities Comparable with Those of Mammalian Enzyme
    Tseng-Ting Kao, Wen-Ni Chang, Hua-Lin Wu, Guey-Yueh Shi and Tzu-Fun Fu
    Drug Metabolism and Disposition February 2009, 37 (2) 302-309; DOI: https://doi.org/10.1124/dmd.108.024042
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    Pharmacodynamic Evaluation of the Cardiovascular Effects after the Coadministration of Cocaine and Ethanol
    S. Casey Laizure and Robert B. Parker
    Drug Metabolism and Disposition February 2009, 37 (2) 310-314; DOI: https://doi.org/10.1124/dmd.108.023531
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    Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4)
    Atsushi Ose, Mototsugu Ito, Hiroyuki Kusuhara, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Masakiyo Hosokawa, John D. Schuetz and Yuichi Sugiyama
    Drug Metabolism and Disposition February 2009, 37 (2) 315-321; DOI: https://doi.org/10.1124/dmd.108.024018
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    Deferiprone Glucuronidation by Human Tissues and Recombinant UDP Glucuronosyltransferase 1A6: An in Vitro Investigation of Genetic and Splice Variants
    Marie-Odile Benoit-Biancamano, John Connelly, Lyne Villeneuve, Patrick Caron and Chantal Guillemette
    Drug Metabolism and Disposition February 2009, 37 (2) 322-329; DOI: https://doi.org/10.1124/dmd.108.023101
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    The Carnitine Transporter SLC22A5 Is Not a General Drug Transporter, but It Efficiently Translocates Mildronate
    Silke Grigat, Christian Fork, Markus Bach, Stefan Golz, Andreas Geerts, Edgar Schömig and Dirk Gründemann
    Drug Metabolism and Disposition February 2009, 37 (2) 330-337; DOI: https://doi.org/10.1124/dmd.108.023929
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    Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption
    Masaaki Miyata, Yoshiki Matsuda, Masahiro Nomoto, Yuki Takamatsu, Nozomi Sato, Mayumi Hamatsu, Paul A. Dawson, Frank J. Gonzalez and Yasushi Yamazoe
    Drug Metabolism and Disposition February 2009, 37 (2) 338-344; DOI: https://doi.org/10.1124/dmd.108.022590
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    Metabolic Activation of Benzodiazepines by CYP3A4
    Katsuhiko Mizuno, Miki Katoh, Hirotoshi Okumura, Nao Nakagawa, Toru Negishi, Takanori Hashizume, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition February 2009, 37 (2) 345-351; DOI: https://doi.org/10.1124/dmd.108.024521
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    Determination of Trimethylbismuth in the Human Body after Ingestion of Colloidal Bismuth Subcitrate
    Jens Boertz, Louise Michele Hartmann, Margareta Sulkowski, Joerg Hippler, Frank Mosel, Roland Arturo Diaz-Bone, Klaus Michalke, Albert Wolfgang Rettenmeier and Alfred Vitalis Hirner
    Drug Metabolism and Disposition February 2009, 37 (2) 352-358; DOI: https://doi.org/10.1124/dmd.107.020313
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    Sunitinib (Sutent, SU11248), a Small-Molecule Receptor Tyrosine Kinase Inhibitor, Blocks Function of the ATP-Binding Cassette (ABC) Transporters P-Glycoprotein (ABCB1) and ABCG2
    Suneet Shukla, Robert W. Robey, Susan E. Bates and Suresh V. Ambudkar
    Drug Metabolism and Disposition February 2009, 37 (2) 359-365; DOI: https://doi.org/10.1124/dmd.108.024612
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    Regulation of Hepatic Cytochrome P450 Expression in Mice with Intestinal or Systemic Infections of Citrobacter rodentium
    Madhusudana R. Chaluvadi, Ryan D. Kinloch, Beatrice A. Nyagode, Terrilyn A. Richardson, Malik J. Raynor, Melanie Sherman, Leposava Antonovic, Henry W. Strobel, Dirck L. Dillehay and Edward T. Morgan
    Drug Metabolism and Disposition February 2009, 37 (2) 366-374; DOI: https://doi.org/10.1124/dmd.108.024240
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    Drug Interaction Potential of 2-((3,4-Dichlorophenethyl)(propyl)amino)-1-(pyridin-3-yl)ethanol (LK-935), the Novel Nonstatin-Type Cholesterol-Lowering Agent
    Katalin Monostory, Jean-Marc Pascussi, Pál Szabó, Manna Temesvári, Krisztina Köhalmy, Jure Acimovic, Darko Kocjan, Drago Kuzman, Britta Wilzewski, Rita Bernhardt, László Kóbori and Damjana Rozman
    Drug Metabolism and Disposition February 2009, 37 (2) 375-385; DOI: https://doi.org/10.1124/dmd.108.023887
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    Relationship between Drug/Metabolite Exposure and Impairment of Excretory Transport Function
    Maciej J. Zamek-Gliszczynski, J. Cory Kalvass, Gary M. Pollack and Kim L. R. Brouwer
    Drug Metabolism and Disposition February 2009, 37 (2) 386-390; DOI: https://doi.org/10.1124/dmd.108.023648
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    In Silico and in Vitro Modeling of Hepatocyte Drug Transport Processes: Importance of ABCC2 Expression Levels in the Disposition of Carboxydichlorofluroscein
    Katharine Howe, G. Gordon Gibson, Tanya Coleman and Nick Plant
    Drug Metabolism and Disposition February 2009, 37 (2) 391-399; DOI: https://doi.org/10.1124/dmd.108.022921
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    Pharmacogenetics of Human Carbonyl Reductase 1 (CBR1) in Livers from Black and White Donors
    Vanessa Gonzalez-Covarrubias, Jianping Zhang, James L. Kalabus, Mary V. Relling and Javier G. Blanco
    Drug Metabolism and Disposition February 2009, 37 (2) 400-407; DOI: https://doi.org/10.1124/dmd.108.024547
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    Absorption, Distribution, Metabolism, and Excretion of 2,2-Bis(bromomethyl)-1,3-propanediol in Male Fischer-344 Rats
    Simone I. Hoehle, Gabriel A. Knudsen, J. Michael Sanders and I. Glenn Sipes
    Drug Metabolism and Disposition February 2009, 37 (2) 408-416; DOI: https://doi.org/10.1124/dmd.108.023937
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    UDP-Glucuronosyltransferases (UGTs) 2B7 and UGT2B17 Display Converse Specificity in Testosterone and Epitestosterone Glucuronidation, whereas UGT2A1 Conjugates Both Androgens Similarly
    Taina Sten, Ingo Bichlmaier, Tiia Kuuranne, Antti Leinonen, Jari Yli-Kauhaluoma and Moshe Finel
    Drug Metabolism and Disposition February 2009, 37 (2) 417-423; DOI: https://doi.org/10.1124/dmd.108.024844
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    Transport of Dicationic Drugs Pentamidine and Furamidine by Human Organic Cation Transporters
    Xin Ming, Wujian Ju, Huali Wu, Richard R. Tidwell, James E. Hall and Dhiren R. Thakker
    Drug Metabolism and Disposition February 2009, 37 (2) 424-430; DOI: https://doi.org/10.1124/dmd.108.024083
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    Metabolism of Echinacoside, a Good Antioxidant, in Rats: Isolation and Identification of Its Biliary Metabolites
    Cunqin Jia, Haiming Shi, Wei Jin, Ke Zhang, Yong Jiang, Mingbo Zhao and Pengfei Tu
    Drug Metabolism and Disposition February 2009, 37 (2) 431-438; DOI: https://doi.org/10.1124/dmd.108.023697

Accelerated Communication

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    An Unexpected Synergist Role of P-Glycoprotein and Breast Cancer Resistance Protein on the Central Nervous System Penetration of the Tyrosine Kinase Inhibitor Lapatinib (N-{3-Chloro-4-[(3-fluorobenzyl)oxy]phenyl}-6-[5-({[2-(methylsulfonyl)ethyl]amino}methyl)-2-furyl]-4-quinazolinamine; GW572016)
    Joseph W. Polli, Katie L. Olson, John P. Chism, Lisa St. John-Williams, Russell L. Yeager, Sesha M. Woodard, Vicky Otto, Stephen Castellino and Victoria E. Demby
    Drug Metabolism and Disposition February 2009, 37 (2) 439-442; DOI: https://doi.org/10.1124/dmd.108.024646
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Drug Metabolism and Disposition: 37 (2)
Drug Metabolism and Disposition
Vol. 37, Issue 2
1 Feb 2009
  • Table of Contents
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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