Abstract
Although it is the largest organ of the human body, skin is often not considered in discussions of drug metabolism. However, there is growing evidence that most common drug-metabolizing enzymes are expressed in the skin. Evidence for expression of cytochromes P450, flavin monooxygenases, glutathione-S-transferases, N-acetyltransferases, and sulfotransferases in human skin and skin cells are presented. Additional discussion is focused on the evidence of actual metabolism of drugs. Finally, the potential clinical implications of metabolism within the skin are discussed briefly.
Footnotes
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Article, publication date, and citation information can be found at http://dmd.aspetjournals.org.
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doi:10.1124/dmd.108.024794.
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ABBREVIATIONS: KCs, keratinocytes; LCs, Langerhans cells; P450, cytochrome P450; FMO, flavin monooxygenase; GST, glutathione S-transferase; SULT, sulfotransferase; NAT, N-acetyltransferase; CE, carboxylesterase.
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Craig K. Svensson received his Doctor of Pharmacy degree from the University of Maryland in 1981 and his Doctor of Philosophy from the State University of New York at Buffalo in 1984. After a postdoctoral fellowship in pharmacokinetics at the University at Buffalo, he joined the faculty of Wayne State University in Detroit, Michigan as an Assistant Professor, where he rose to the rank of Professor and Associate Chairman of the Department of Pharmaceutical Sciences. In August of 2003, Dr. Svensson became the Lyle & Sharon Bighley Professor of Pharmaceutical Sciences and Head of the Division of Pharmaceutics in the College of Pharmacy, The University of Iowa. He assumed the position of Dean of the College of Pharmacy, Nursing, and Health Sciences at Purdue University in 2006, where he is also Professor of Medicinal Chemistry and Molecular Pharmacology. Dr. Svensson's research interests have focused on the mechanism of unusual adverse drug reactions, with a particular emphasis on cutaneous drug reactions.
- Received September 23, 2008.
- Accepted November 6, 2008.
- The American Society for Pharmacology and Experimental Therapeutics
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