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Close Association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 Haplotype and Its Apparent Influence on 7-Ethyl-10-hydroxycamptothecin (SN-38) Glucuronidation in Japanese

Yoshiro Saito, Kimie Sai, Keiko Maekawa, Nahoko Kaniwa, Kuniaki Shirao, Tetsuya Hamaguchi, Noboru Yamamoto, Hideo Kunitoh, Yuichiro Ohe, Yasuhide Yamada, Tomohide Tamura, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Yasuhiro Matsumura, Nagahiro Saijo and Jun-ichi Sawada
Drug Metabolism and Disposition February 2009, 37 (2) 272-276; DOI: https://doi.org/10.1124/dmd.108.024208

Article Information

vol. 37 no. 2 272-276
DOI 
https://doi.org/10.1124/dmd.108.024208
PubMed 
18981166
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 26, 2008
  • Accepted October 30, 2008
  • Published online January 21, 2009.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Yoshiro Saito,
  2. Kimie Sai,
  3. Keiko Maekawa,
  4. Nahoko Kaniwa,
  5. Kuniaki Shirao1,
  6. Tetsuya Hamaguchi,
  7. Noboru Yamamoto,
  8. Hideo Kunitoh,
  9. Yuichiro Ohe,
  10. Yasuhide Yamada,
  11. Tomohide Tamura,
  12. Teruhiko Yoshida,
  13. Hironobu Minami2,
  14. Atsushi Ohtsu,
  15. Yasuhiro Matsumura,
  16. Nagahiro Saijo and
  17. Jun-ichi Sawada
  1. Project Team for Pharmacogenetics (Y.S., K.Sa., K.M., N.K., J.S.), Division of Functional Biochemistry and Genomics (Y.S., K.Sa., K.M., J.S.), Division of Medicinal Safety Science (N.K.), National Institute of Health Sciences, Tokyo, Japan; Gastrointestinal Oncology Division (K.Sh., T.H., Y.Y.), Thoracic Oncology Division (N.Y., H.K., Y.O., T.T.), National Cancer Center Hospital, Genetics Division (T.Y.), National Cancer Center Research Institute, National Cancer Center, Tokyo, Japan; Division of Oncology/Hematology (H.M.), Division of Gastrointestinal Oncology/Digestive Endoscopy (A.O.), Investigative Treatment Division, Research Center for Innovative Oncology (Y.M.), Deputy Director (N.S.), National Cancer Center Hospital East, Kashiwa, Japan
  1. Address correspondence to:
    Dr. Yoshiro Saito, Division of Functional Biochemistry and Genomics, National Institute of Health Sciences, 1-18-1 Kamiyoga, Setagaya-ku, Tokyo 158-8501, Japan. E-mail: yoshiro{at}nihs.go.jp
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OtherShort Communication

Close Association of UGT1A9 IVS1+399C>T with UGT1A1*28, *6, or *60 Haplotype and Its Apparent Influence on 7-Ethyl-10-hydroxycamptothecin (SN-38) Glucuronidation in Japanese

Yoshiro Saito, Kimie Sai, Keiko Maekawa, Nahoko Kaniwa, Kuniaki Shirao, Tetsuya Hamaguchi, Noboru Yamamoto, Hideo Kunitoh, Yuichiro Ohe, Yasuhide Yamada, Tomohide Tamura, Teruhiko Yoshida, Hironobu Minami, Atsushi Ohtsu, Yasuhiro Matsumura, Nagahiro Saijo and Jun-ichi Sawada
Drug Metabolism and Disposition February 1, 2009, 37 (2) 272-276; DOI: https://doi.org/10.1124/dmd.108.024208
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