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Research ArticleArticle

Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4)

Atsushi Ose, Mototsugu Ito, Hiroyuki Kusuhara, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Masakiyo Hosokawa, John D. Schuetz and Yuichi Sugiyama
Drug Metabolism and Disposition February 2009, 37 (2) 315-321; DOI: https://doi.org/10.1124/dmd.108.024018
Atsushi Ose
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Mototsugu Ito
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Hiroyuki Kusuhara
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Kenzo Yamatsugu
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Motomu Kanai
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Masakatsu Shibasaki
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Masakiyo Hosokawa
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John D. Schuetz
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Yuichi Sugiyama
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Article Information

vol. 37 no. 2 315-321
DOI 
https://doi.org/10.1124/dmd.108.024018
PubMed 
19029202

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received August 18, 2008
  • Accepted November 20, 2008
  • Published online January 21, 2009.

Article Versions

  • Earlier version (November 24, 2008 - 06:51).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Atsushi Ose,
  2. Mototsugu Ito,
  3. Hiroyuki Kusuhara,
  4. Kenzo Yamatsugu,
  5. Motomu Kanai,
  6. Masakatsu Shibasaki,
  7. Masakiyo Hosokawa,
  8. John D. Schuetz and
  9. Yuichi Sugiyama
  1. Graduate School of Pharmaceutical Sciences, the University of Tokyo, Bunkyo-ku, Tokyo, Japan (A.O., M.I., H.K., K.Y., M.K., M.S., Y.S.); Chiba Institute of Science, Choshi-city, Chiba, Japan (M.H.); and Department of Pharmaceutical Sciences, St. Jude Children's Research Hospital, Memphis, Tennessee (J.D.S.)
  1. Address correspondence to:
    Dr. Yuichi Sugiyama, Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp
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Drug Metabolism and Disposition: 37 (2)
Drug Metabolism and Disposition
Vol. 37, Issue 2
1 Feb 2009
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Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion …
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Research ArticleArticle

Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4)

Atsushi Ose, Mototsugu Ito, Hiroyuki Kusuhara, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Masakiyo Hosokawa, John D. Schuetz and Yuichi Sugiyama
Drug Metabolism and Disposition February 1, 2009, 37 (2) 315-321; DOI: https://doi.org/10.1124/dmd.108.024018

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Research ArticleArticle

Limited Brain Distribution of [3R,4R,5S]-4-Acetamido-5-amino-3-(1-ethylpropoxy)-1-cyclohexene-1-carboxylate Phosphate (Ro 64-0802), a Pharmacologically Active Form of Oseltamivir, by Active Efflux across the Blood-Brain Barrier Mediated by Organic Anion Transporter 3 (Oat3/Slc22a8) and Multidrug Resistance-Associated Protein 4 (Mrp4/Abcc4)

Atsushi Ose, Mototsugu Ito, Hiroyuki Kusuhara, Kenzo Yamatsugu, Motomu Kanai, Masakatsu Shibasaki, Masakiyo Hosokawa, John D. Schuetz and Yuichi Sugiyama
Drug Metabolism and Disposition February 1, 2009, 37 (2) 315-321; DOI: https://doi.org/10.1124/dmd.108.024018
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