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Research ArticleArticle

Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption

Masaaki Miyata, Yoshiki Matsuda, Masahiro Nomoto, Yuki Takamatsu, Nozomi Sato, Mayumi Hamatsu, Paul A. Dawson, Frank J. Gonzalez and Yasushi Yamazoe
Drug Metabolism and Disposition February 2009, 37 (2) 338-344; DOI: https://doi.org/10.1124/dmd.108.022590
Masaaki Miyata
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Yoshiki Matsuda
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Masahiro Nomoto
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Yuki Takamatsu
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Nozomi Sato
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Mayumi Hamatsu
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Paul A. Dawson
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Frank J. Gonzalez
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Yasushi Yamazoe
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Article Information

vol. 37 no. 2 338-344
DOI 
https://doi.org/10.1124/dmd.108.022590
PubMed 
18988759

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received May 29, 2008
  • Accepted November 3, 2008
  • Published online January 21, 2009.

Article Versions

  • Earlier version (November 6, 2008 - 10:36).
  • You are viewing the most recent version of this article.
Copyright & Usage 
U.S. Government work not protected by U.S. copyright.

Author Information

  1. Masaaki Miyata,
  2. Yoshiki Matsuda,
  3. Masahiro Nomoto,
  4. Yuki Takamatsu,
  5. Nozomi Sato,
  6. Mayumi Hamatsu,
  7. Paul A. Dawson,
  8. Frank J. Gonzalez and
  9. Yasushi Yamazoe
  1. Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, Sendai, Japan (M.M., Y.M., M.N., Y.T., N.S., M.H., Y.Y.); Department of Internal Medicine, Wake Forest University School of Medicine, Winston-Salem, North Carolina (P.A.D.); Laboratory of Metabolism, National Cancer Institute, National Institutes of Health, Bethesda, Maryland (F.J.G.); and CRESCENDO, the Tohoku University 21st Century “Center of Excellence” Program, Sendai, Japan (Y.Y.)
  1. Address correspondence to:
    Masaaki Miyata, Division of Drug Metabolism and Molecular Toxicology, Graduate School of Pharmaceutical Sciences, Tohoku University, 6-3, Aoba, Aramaki, Aoba-ku, Sendai, 980-8578, Japan. E-mail: miyata{at}mail.pharm.tohoku.ac.jp
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Drug Metabolism and Disposition: 37 (2)
Drug Metabolism and Disposition
Vol. 37, Issue 2
1 Feb 2009
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Research ArticleArticle

Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption

Masaaki Miyata, Yoshiki Matsuda, Masahiro Nomoto, Yuki Takamatsu, Nozomi Sato, Mayumi Hamatsu, Paul A. Dawson, Frank J. Gonzalez and Yasushi Yamazoe
Drug Metabolism and Disposition February 1, 2009, 37 (2) 338-344; DOI: https://doi.org/10.1124/dmd.108.022590

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Research ArticleArticle

Cholesterol Feeding Prevents Hepatic Accumulation of Bile Acids in Cholic Acid-Fed Farnesoid X Receptor (FXR)-Null Mice: FXR-Independent Suppression of Intestinal Bile Acid Absorption

Masaaki Miyata, Yoshiki Matsuda, Masahiro Nomoto, Yuki Takamatsu, Nozomi Sato, Mayumi Hamatsu, Paul A. Dawson, Frank J. Gonzalez and Yasushi Yamazoe
Drug Metabolism and Disposition February 1, 2009, 37 (2) 338-344; DOI: https://doi.org/10.1124/dmd.108.022590
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