Table of Contents

Articles

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  Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models

  Jun Zhang, Madhusudana R. Chaluvadi, Rob Reddy, Meike S. Motika, Terrilyn A. Richardson, John R. Cashman and Edward T. Morgan

  Drug Metabolism and Disposition March 2009, 37 (3) 462-468; DOI: https://doi.org/10.1124/dmd.108.025338
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  Mechanism of Vitamin D Receptor Inhibition of Cholesterol 7α-Hydroxylase Gene Transcription in Human Hepatocytes

  Shuxin Han and John Y. L. Chiang

  Drug Metabolism and Disposition March 2009, 37 (3) 469-478; DOI: https://doi.org/10.1124/dmd.108.025155
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  Investigation of the in Vitro Metabolism of the Analgesic Flupirtine

  Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski

  Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364
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  5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters

  Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova

  Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269
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  An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing

  George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong

  Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931
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  Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans

  Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine

  Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968
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  Developmental Expression and Endocrine Regulation of CYP1B1 in Rat Testis

  Grace S. Leung, Masahiko Kawai, Jenny K. Tai, Jie Chen, Stelvio M. Bandiera and Thomas K. H. Chang

  Drug Metabolism and Disposition March 2009, 37 (3) 523-528; DOI: https://doi.org/10.1124/dmd.108.025635
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  Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration

  Rong Zhao, J. Cory Kalvass, Souzan B. Yanni, Arlene S. Bridges and Gary M. Pollack

  Drug Metabolism and Disposition March 2009, 37 (3) 529-535; DOI: https://doi.org/10.1124/dmd.107.019893
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  Absorption, Metabolism, and Excretion of [¹⁴C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans

  Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard

  Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010
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  Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs

  Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard

  Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002
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  The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine

  Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama

  Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911
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  Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design

  Nagdeep Giri, Sagar Agarwal, Naveed Shaik, Guoyu Pan, Ying Chen and William F. Elmquist

  Drug Metabolism and Disposition March 2009, 37 (3) 560-570; DOI: https://doi.org/10.1124/dmd.108.022046
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  Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry, and NMR

  Tove Johansson, Ulrik Jurva, Gunnar Grönberg, Lars Weidolf and Collen Masimirembwa

  Drug Metabolism and Disposition March 2009, 37 (3) 571-579; DOI: https://doi.org/10.1124/dmd.108.025171
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  Dexamethasone Induction of Murine CYP2B Genes Requires the Glucocorticoid Receptor

  Étienne Audet-Walsh and Alan Anderson

  Drug Metabolism and Disposition March 2009, 37 (3) 580-588; DOI: https://doi.org/10.1124/dmd.108.022772
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  Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel

  Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda

  Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988
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  Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent

  Marc J. Evanchik, Darin Allen, Josh C. Yoburn, Jeffrey A. Silverman and Ute Hoch

  Drug Metabolism and Disposition March 2009, 37 (3) 594-601; DOI: https://doi.org/10.1124/dmd.108.023432
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  Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice

  Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji

  Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689
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  SIMDOT-AbMe: Microphysiologically Based Simulation Tool for Quantitative Prediction of Systemic and Local Bioavailability of Targeted Oral Delivery Formulations

  Nahor Haddish-Berhane, Ashkan Farhadi, Chell Nyquist, Kamyar Haghighi and Ali Keshavarzian

  Drug Metabolism and Disposition March 2009, 37 (3) 608-618; DOI: https://doi.org/10.1124/dmd.108.021949
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  Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells

  Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui and Hidetaka Kamimura

  Drug Metabolism and Disposition March 2009, 37 (3) 619-628; DOI: https://doi.org/10.1124/dmd.108.025254
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  Mechanism of CYP2C9 Inhibition by Flavones and Flavonols

  Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett

  Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416
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  Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

  Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes

  Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745
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  Decreased Susceptibility of the Cytochrome P450 2B6 Variant K262R to Inhibition by Several Clinically Important Drugs

  Jyothi C. Talakad, Santosh Kumar and James R. Halpert

  Drug Metabolism and Disposition March 2009, 37 (3) 644-650; DOI: https://doi.org/10.1124/dmd.108.023655
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  An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine

  Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding

  Drug Metabolism and Disposition March 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429
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  Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques

  Poongavanam Vasanthanathan, Olivier Taboureau, Chris Oostenbrink, Nico P. E. Vermeulen, Lars Olsen and Flemming Steen Jørgensen

  Drug Metabolism and Disposition March 2009, 37 (3) 658-664; DOI: https://doi.org/10.1124/dmd.108.023507
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  Effect of CYP2A13 Active Site Mutation N297A on Metabolism of Coumarin and Tobacco-Specific Nitrosamines

  Kari E. Schlicht, Jeannette Zinggeler Berg and Sharon E. Murphy

  Drug Metabolism and Disposition March 2009, 37 (3) 665-671; DOI: https://doi.org/10.1124/dmd.108.025072
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  Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions

  Hao Sun, Chad Moore, Patrick M. Dansette, Santosh Kumar, James R. Halpert and Garold S. Yost

  Drug Metabolism and Disposition March 2009, 37 (3) 672-684; DOI: https://doi.org/10.1124/dmd.108.022707
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  Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-α or Interleukin-6

  Marc Le Vee, Valérie Lecureur, Bruno Stieger and Olivier Fardel

  Drug Metabolism and Disposition March 2009, 37 (3) 685-693; DOI: https://doi.org/10.1124/dmd.108.023630