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Drug Metabolism & Disposition

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Table of Contents

March 01, 2009; Volume 37,Issue 3

Short Communications

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    Pinoline May be Used as a Probe for CYP2D6 Activity
    Xi-Ling Jiang, Hong-Wu Shen and Ai-Ming Yu
    Drug Metabolism and Disposition March 2009, 37 (3) 443-446; DOI: https://doi.org/10.1124/dmd.108.025056
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    Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors
    Koji Abe, Arlene S. Bridges and Kim L. R. Brouwer
    Drug Metabolism and Disposition March 2009, 37 (3) 447-452; DOI: https://doi.org/10.1124/dmd.108.023465
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    Sex-Related Differences in the Expression of mfGSTA2, a Novel GST Identified in Cynomolgus Monkey (Macaca fascicularis)
    Yasuhiro Uno, Tsukasa Ohuchi, Shotaro Uehara, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
    Drug Metabolism and Disposition March 2009, 37 (3) 453-456; DOI: https://doi.org/10.1124/dmd.108.023747
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    Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase
    Charles W. Locuson, Brian T. Ethell, Michael Voice, David Lee and Kenneth L. Feenstra
    Drug Metabolism and Disposition March 2009, 37 (3) 457-461; DOI: https://doi.org/10.1124/dmd.108.025312

Articles

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    Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models
    Jun Zhang, Madhusudana R. Chaluvadi, Rob Reddy, Meike S. Motika, Terrilyn A. Richardson, John R. Cashman and Edward T. Morgan
    Drug Metabolism and Disposition March 2009, 37 (3) 462-468; DOI: https://doi.org/10.1124/dmd.108.025338
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    Mechanism of Vitamin D Receptor Inhibition of Cholesterol 7α-Hydroxylase Gene Transcription in Human Hepatocytes
    Shuxin Han and John Y. L. Chiang
    Drug Metabolism and Disposition March 2009, 37 (3) 469-478; DOI: https://doi.org/10.1124/dmd.108.025155
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    Investigation of the in Vitro Metabolism of the Analgesic Flupirtine
    Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski
    Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364
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    5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
    Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
    Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269
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    An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
    George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
    Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931
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    Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans
    Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine
    Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968
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    Developmental Expression and Endocrine Regulation of CYP1B1 in Rat Testis
    Grace S. Leung, Masahiko Kawai, Jenny K. Tai, Jie Chen, Stelvio M. Bandiera and Thomas K. H. Chang
    Drug Metabolism and Disposition March 2009, 37 (3) 523-528; DOI: https://doi.org/10.1124/dmd.108.025635
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    Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration
    Rong Zhao, J. Cory Kalvass, Souzan B. Yanni, Arlene S. Bridges and Gary M. Pollack
    Drug Metabolism and Disposition March 2009, 37 (3) 529-535; DOI: https://doi.org/10.1124/dmd.107.019893
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    Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
    Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
    Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010
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    Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
    Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
    Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002
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    The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
    Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
    Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911
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    Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design
    Nagdeep Giri, Sagar Agarwal, Naveed Shaik, Guoyu Pan, Ying Chen and William F. Elmquist
    Drug Metabolism and Disposition March 2009, 37 (3) 560-570; DOI: https://doi.org/10.1124/dmd.108.022046
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    Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry, and NMR
    Tove Johansson, Ulrik Jurva, Gunnar Grönberg, Lars Weidolf and Collen Masimirembwa
    Drug Metabolism and Disposition March 2009, 37 (3) 571-579; DOI: https://doi.org/10.1124/dmd.108.025171
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    Dexamethasone Induction of Murine CYP2B Genes Requires the Glucocorticoid Receptor
    Étienne Audet-Walsh and Alan Anderson
    Drug Metabolism and Disposition March 2009, 37 (3) 580-588; DOI: https://doi.org/10.1124/dmd.108.022772
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    Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
    Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda
    Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988
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    Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent
    Marc J. Evanchik, Darin Allen, Josh C. Yoburn, Jeffrey A. Silverman and Ute Hoch
    Drug Metabolism and Disposition March 2009, 37 (3) 594-601; DOI: https://doi.org/10.1124/dmd.108.023432
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    Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice
    Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji
    Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689
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    SIMDOT-AbMe: Microphysiologically Based Simulation Tool for Quantitative Prediction of Systemic and Local Bioavailability of Targeted Oral Delivery Formulations
    Nahor Haddish-Berhane, Ashkan Farhadi, Chell Nyquist, Kamyar Haghighi and Ali Keshavarzian
    Drug Metabolism and Disposition March 2009, 37 (3) 608-618; DOI: https://doi.org/10.1124/dmd.108.021949
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    Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells
    Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition March 2009, 37 (3) 619-628; DOI: https://doi.org/10.1124/dmd.108.025254
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    Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
    Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett
    Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416
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    Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
    Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
    Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745
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    Decreased Susceptibility of the Cytochrome P450 2B6 Variant K262R to Inhibition by Several Clinically Important Drugs
    Jyothi C. Talakad, Santosh Kumar and James R. Halpert
    Drug Metabolism and Disposition March 2009, 37 (3) 644-650; DOI: https://doi.org/10.1124/dmd.108.023655
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    An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine
    Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding
    Drug Metabolism and Disposition March 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429
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    Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques
    Poongavanam Vasanthanathan, Olivier Taboureau, Chris Oostenbrink, Nico P. E. Vermeulen, Lars Olsen and Flemming Steen Jørgensen
    Drug Metabolism and Disposition March 2009, 37 (3) 658-664; DOI: https://doi.org/10.1124/dmd.108.023507
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    Effect of CYP2A13 Active Site Mutation N297A on Metabolism of Coumarin and Tobacco-Specific Nitrosamines
    Kari E. Schlicht, Jeannette Zinggeler Berg and Sharon E. Murphy
    Drug Metabolism and Disposition March 2009, 37 (3) 665-671; DOI: https://doi.org/10.1124/dmd.108.025072
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    Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions
    Hao Sun, Chad Moore, Patrick M. Dansette, Santosh Kumar, James R. Halpert and Garold S. Yost
    Drug Metabolism and Disposition March 2009, 37 (3) 672-684; DOI: https://doi.org/10.1124/dmd.108.022707
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    Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-α or Interleukin-6
    Marc Le Vee, Valérie Lecureur, Bruno Stieger and Olivier Fardel
    Drug Metabolism and Disposition March 2009, 37 (3) 685-693; DOI: https://doi.org/10.1124/dmd.108.023630
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Drug Metabolism and Disposition: 37 (3)
Drug Metabolism and Disposition
Vol. 37, Issue 3
1 Mar 2009
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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