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Index by author

March 01, 2009; Volume 37,Issue 3

A

  1. Abe, Koji

    1. Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors
      Koji Abe, Arlene S. Bridges and Kim L. R. Brouwer
      Drug Metabolism and Disposition March 2009, 37 (3) 447-452; DOI: https://doi.org/10.1124/dmd.108.023465

  2. Agarwal, Sagar

    1. Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design
      Nagdeep Giri, Sagar Agarwal, Naveed Shaik, Guoyu Pan, Ying Chen and William F. Elmquist
      Drug Metabolism and Disposition March 2009, 37 (3) 560-570; DOI: https://doi.org/10.1124/dmd.108.022046

  3. Allen, Darin

    1. Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent
      Marc J. Evanchik, Darin Allen, Josh C. Yoburn, Jeffrey A. Silverman and Ute Hoch
      Drug Metabolism and Disposition March 2009, 37 (3) 594-601; DOI: https://doi.org/10.1124/dmd.108.023432

  4. Anderson, Alan

    1. Dexamethasone Induction of Murine CYP2B Genes Requires the Glucocorticoid Receptor
      Étienne Audet-Walsh and Alan Anderson
      Drug Metabolism and Disposition March 2009, 37 (3) 580-588; DOI: https://doi.org/10.1124/dmd.108.022772

  5. Audet-Walsh, Étienne

    1. Dexamethasone Induction of Murine CYP2B Genes Requires the Glucocorticoid Receptor
      Étienne Audet-Walsh and Alan Anderson
      Drug Metabolism and Disposition March 2009, 37 (3) 580-588; DOI: https://doi.org/10.1124/dmd.108.022772

B

  1. Bandiera, Stelvio M.

    1. Developmental Expression and Endocrine Regulation of CYP1B1 in Rat Testis
      Grace S. Leung, Masahiko Kawai, Jenny K. Tai, Jie Chen, Stelvio M. Bandiera and Thomas K. H. Chang
      Drug Metabolism and Disposition March 2009, 37 (3) 523-528; DOI: https://doi.org/10.1124/dmd.108.025635

  2. Batard, Yannick

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010

  3. Bednarski, Patrick J.

    1. Investigation of the in Vitro Metabolism of the Analgesic Flupirtine
      Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski
      Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364

  4. Berg, Jeannette Zinggeler

    1. Effect of CYP2A13 Active Site Mutation N297A on Metabolism of Coumarin and Tobacco-Specific Nitrosamines
      Kari E. Schlicht, Jeannette Zinggeler Berg and Sharon E. Murphy
      Drug Metabolism and Disposition March 2009, 37 (3) 665-671; DOI: https://doi.org/10.1124/dmd.108.025072

  5. Berry, Karen

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  6. Bridges, Arlene S.

    1. Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors
      Koji Abe, Arlene S. Bridges and Kim L. R. Brouwer
      Drug Metabolism and Disposition March 2009, 37 (3) 447-452; DOI: https://doi.org/10.1124/dmd.108.023465
    2. Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration
      Rong Zhao, J. Cory Kalvass, Souzan B. Yanni, Arlene S. Bridges and Gary M. Pollack
      Drug Metabolism and Disposition March 2009, 37 (3) 529-535; DOI: https://doi.org/10.1124/dmd.107.019893

  7. Brouwer, Kim L. R.

    1. Use of Sandwich-Cultured Human Hepatocytes to Predict Biliary Clearance of Angiotensin II Receptor Blockers and HMG-CoA Reductase Inhibitors
      Koji Abe, Arlene S. Bridges and Kim L. R. Brouwer
      Drug Metabolism and Disposition March 2009, 37 (3) 447-452; DOI: https://doi.org/10.1124/dmd.108.023465

C

  1. Carrizosa, Daniel R.

    1. Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans
      Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968

  2. Cashman, John R.

    1. Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models
      Jun Zhang, Madhusudana R. Chaluvadi, Rob Reddy, Meike S. Motika, Terrilyn A. Richardson, John R. Cashman and Edward T. Morgan
      Drug Metabolism and Disposition March 2009, 37 (3) 462-468; DOI: https://doi.org/10.1124/dmd.108.025338

  3. Chaluvadi, Madhusudana R.

    1. Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models
      Jun Zhang, Madhusudana R. Chaluvadi, Rob Reddy, Meike S. Motika, Terrilyn A. Richardson, John R. Cashman and Edward T. Morgan
      Drug Metabolism and Disposition March 2009, 37 (3) 462-468; DOI: https://doi.org/10.1124/dmd.108.025338

  4. Chang, Thomas K. H.

    1. Developmental Expression and Endocrine Regulation of CYP1B1 in Rat Testis
      Grace S. Leung, Masahiko Kawai, Jenny K. Tai, Jie Chen, Stelvio M. Bandiera and Thomas K. H. Chang
      Drug Metabolism and Disposition March 2009, 37 (3) 523-528; DOI: https://doi.org/10.1124/dmd.108.025635

  5. Chen, Jie

    1. Developmental Expression and Endocrine Regulation of CYP1B1 in Rat Testis
      Grace S. Leung, Masahiko Kawai, Jenny K. Tai, Jie Chen, Stelvio M. Bandiera and Thomas K. H. Chang
      Drug Metabolism and Disposition March 2009, 37 (3) 523-528; DOI: https://doi.org/10.1124/dmd.108.025635

  6. Chen, Ying

    1. Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design
      Nagdeep Giri, Sagar Agarwal, Naveed Shaik, Guoyu Pan, Ying Chen and William F. Elmquist
      Drug Metabolism and Disposition March 2009, 37 (3) 560-570; DOI: https://doi.org/10.1124/dmd.108.022046

  7. Chiang, John Y. L.

    1. Mechanism of Vitamin D Receptor Inhibition of Cholesterol 7α-Hydroxylase Gene Transcription in Human Hepatocytes
      Shuxin Han and John Y. L. Chiang
      Drug Metabolism and Disposition March 2009, 37 (3) 469-478; DOI: https://doi.org/10.1124/dmd.108.025155

  8. Cho, Robert

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

D

  1. Dansette, Patrick M.

    1. Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions
      Hao Sun, Chad Moore, Patrick M. Dansette, Santosh Kumar, James R. Halpert and Garold S. Yost
      Drug Metabolism and Disposition March 2009, 37 (3) 672-684; DOI: https://doi.org/10.1124/dmd.108.022707

  2. Dees, E. Claire

    1. Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans
      Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968

  3. Ding, Xinxin

    1. An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine
      Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding
      Drug Metabolism and Disposition March 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429

  4. Dunbar, Deborah

    1. An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine
      Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding
      Drug Metabolism and Disposition March 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429

E

  1. Einolf, Heidi

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010

  2. Elmquist, William F.

    1. Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design
      Nagdeep Giri, Sagar Agarwal, Naveed Shaik, Guoyu Pan, Ying Chen and William F. Elmquist
      Drug Metabolism and Disposition March 2009, 37 (3) 560-570; DOI: https://doi.org/10.1124/dmd.108.022046

  3. Ethell, Brian T.

    1. Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase
      Charles W. Locuson, Brian T. Ethell, Michael Voice, David Lee and Kenneth L. Feenstra
      Drug Metabolism and Disposition March 2009, 37 (3) 457-461; DOI: https://doi.org/10.1124/dmd.108.025312

  4. Evanchik, Marc J.

    1. Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent
      Marc J. Evanchik, Darin Allen, Josh C. Yoburn, Jeffrey A. Silverman and Ute Hoch
      Drug Metabolism and Disposition March 2009, 37 (3) 594-601; DOI: https://doi.org/10.1124/dmd.108.023432

F

  1. Fang, Cheng

    1. An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine
      Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding
      Drug Metabolism and Disposition March 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429

  2. Fardel, Olivier

    1. Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-α or Interleukin-6
      Marc Le Vee, Valérie Lecureur, Bruno Stieger and Olivier Fardel
      Drug Metabolism and Disposition March 2009, 37 (3) 685-693; DOI: https://doi.org/10.1124/dmd.108.023630

  3. Farhadi, Ashkan

    1. SIMDOT-AbMe: Microphysiologically Based Simulation Tool for Quantitative Prediction of Systemic and Local Bioavailability of Targeted Oral Delivery Formulations
      Nahor Haddish-Berhane, Ashkan Farhadi, Chell Nyquist, Kamyar Haghighi and Ali Keshavarzian
      Drug Metabolism and Disposition March 2009, 37 (3) 608-618; DOI: https://doi.org/10.1124/dmd.108.021949

  4. Farid, Nagy A.

    1. Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
      Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda
      Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988

  5. Fawcett, J. Paul

    1. Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
      Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett
      Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416

  6. Feenstra, Kenneth L.

    1. Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase
      Charles W. Locuson, Brian T. Ethell, Michael Voice, David Lee and Kenneth L. Feenstra
      Drug Metabolism and Disposition March 2009, 37 (3) 457-461; DOI: https://doi.org/10.1124/dmd.108.025312

  7. Filipeck, Ron

    1. Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002

  8. Fischer, Volker

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010
    2. Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002

  9. Flood, Dennis

    1. Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002

  10. Floren, Leslie C.

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

G

  1. Giri, Nagdeep

    1. Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design
      Nagdeep Giri, Sagar Agarwal, Naveed Shaik, Guoyu Pan, Ying Chen and William F. Elmquist
      Drug Metabolism and Disposition March 2009, 37 (3) 560-570; DOI: https://doi.org/10.1124/dmd.108.022046

  2. Graf, Tyler N.

    1. Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans
      Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968

  3. Grönberg, Gunnar

    1. Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry, and NMR
      Tove Johansson, Ulrik Jurva, Gunnar Grönberg, Lars Weidolf and Collen Masimirembwa
      Drug Metabolism and Disposition March 2009, 37 (3) 571-579; DOI: https://doi.org/10.1124/dmd.108.025171

  4. Gu, Helen

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010

  5. Guo, Yingjie

    1. Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
      Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett
      Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416

H

  1. Haddish-Berhane, Nahor

    1. SIMDOT-AbMe: Microphysiologically Based Simulation Tool for Quantitative Prediction of Systemic and Local Bioavailability of Targeted Oral Delivery Formulations
      Nahor Haddish-Berhane, Ashkan Farhadi, Chell Nyquist, Kamyar Haghighi and Ali Keshavarzian
      Drug Metabolism and Disposition March 2009, 37 (3) 608-618; DOI: https://doi.org/10.1124/dmd.108.021949

  2. Haghighi, Kamyar

    1. SIMDOT-AbMe: Microphysiologically Based Simulation Tool for Quantitative Prediction of Systemic and Local Bioavailability of Targeted Oral Delivery Formulations
      Nahor Haddish-Berhane, Ashkan Farhadi, Chell Nyquist, Kamyar Haghighi and Ali Keshavarzian
      Drug Metabolism and Disposition March 2009, 37 (3) 608-618; DOI: https://doi.org/10.1124/dmd.108.021949

  3. Hagihara, Katsunobu

    1. Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
      Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda
      Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988

  4. Halpert, James R.

    1. Decreased Susceptibility of the Cytochrome P450 2B6 Variant K262R to Inhibition by Several Clinically Important Drugs
      Jyothi C. Talakad, Santosh Kumar and James R. Halpert
      Drug Metabolism and Disposition March 2009, 37 (3) 644-650; DOI: https://doi.org/10.1124/dmd.108.023655
    2. Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions
      Hao Sun, Chad Moore, Patrick M. Dansette, Santosh Kumar, James R. Halpert and Garold S. Yost
      Drug Metabolism and Disposition March 2009, 37 (3) 672-684; DOI: https://doi.org/10.1124/dmd.108.022707

  5. Hammarlund-Udenaes, Margareta

    1. Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
      Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745

  6. Han, Shuxin

    1. Mechanism of Vitamin D Receptor Inhibition of Cholesterol 7α-Hydroxylase Gene Transcription in Human Hepatocytes
      Shuxin Han and John Y. L. Chiang
      Drug Metabolism and Disposition March 2009, 37 (3) 469-478; DOI: https://doi.org/10.1124/dmd.108.025155

  7. Harada, Akihiro

    1. Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice
      Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji
      Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689

  8. He, Handan

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010
    2. Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002

  9. Hoch, Ute

    1. Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent
      Marc J. Evanchik, Darin Allen, Josh C. Yoburn, Jeffrey A. Silverman and Ute Hoch
      Drug Metabolism and Disposition March 2009, 37 (3) 594-601; DOI: https://doi.org/10.1124/dmd.108.023432

  10. Horita, Shigeru

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

  11. Howard, Dan

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010
    2. Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002

I

  1. Ikeda, Toshihiko

    1. Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
      Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda
      Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988

  2. Inoue, Katsuhisa

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

  3. Ito, Takashi

    1. Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
      Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda
      Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988

  4. Iwai, Megumi

    1. Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells
      Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition March 2009, 37 (3) 619-628; DOI: https://doi.org/10.1124/dmd.108.025254

J

  1. Jasko, Maxim V.

    1. 5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
      Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
      Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269

  2. Jiang, Xi-Ling

    1. Pinoline May be Used as a Probe for CYP2D6 Activity
      Xi-Ling Jiang, Hong-Wu Shen and Ai-Ming Yu
      Drug Metabolism and Disposition March 2009, 37 (3) 443-446; DOI: https://doi.org/10.1124/dmd.108.025056

  3. Johansson, Tove

    1. Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry, and NMR
      Tove Johansson, Ulrik Jurva, Gunnar Grönberg, Lars Weidolf and Collen Masimirembwa
      Drug Metabolism and Disposition March 2009, 37 (3) 571-579; DOI: https://doi.org/10.1124/dmd.108.025171

  4. Johnson, Michael G.

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  5. Jørgensen, Flemming Steen

    1. Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques
      Poongavanam Vasanthanathan, Olivier Taboureau, Chris Oostenbrink, Nico P. E. Vermeulen, Lars Olsen and Flemming Steen Jørgensen
      Drug Metabolism and Disposition March 2009, 37 (3) 658-664; DOI: https://doi.org/10.1124/dmd.108.023507

  6. Jurva, Ulrik

    1. Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry, and NMR
      Tove Johansson, Ulrik Jurva, Gunnar Grönberg, Lars Weidolf and Collen Masimirembwa
      Drug Metabolism and Disposition March 2009, 37 (3) 571-579; DOI: https://doi.org/10.1124/dmd.108.025171

K

  1. Kalvass, J. Cory

    1. Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration
      Rong Zhao, J. Cory Kalvass, Souzan B. Yanni, Arlene S. Bridges and Gary M. Pollack
      Drug Metabolism and Disposition March 2009, 37 (3) 529-535; DOI: https://doi.org/10.1124/dmd.107.019893

  2. Kamataki, Tetsuya

    1. Sex-Related Differences in the Expression of mfGSTA2, a Novel GST Identified in Cynomolgus Monkey (Macaca fascicularis)
      Yasuhiro Uno, Tsukasa Ohuchi, Shotaro Uehara, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition March 2009, 37 (3) 453-456; DOI: https://doi.org/10.1124/dmd.108.023747

  3. Kamimura, Hidetaka

    1. Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells
      Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition March 2009, 37 (3) 619-628; DOI: https://doi.org/10.1124/dmd.108.025254

  4. Kaminsky, Laurence

    1. An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine
      Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding
      Drug Metabolism and Disposition March 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429

  5. Kashuba, Angela D. M.

    1. Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans
      Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968

  6. Kato, Yukio

    1. Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice
      Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji
      Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689

  7. Kawai, Masahiko

    1. Developmental Expression and Endocrine Regulation of CYP1B1 in Rat Testis
      Grace S. Leung, Masahiko Kawai, Jenny K. Tai, Jie Chen, Stelvio M. Bandiera and Thomas K. H. Chang
      Drug Metabolism and Disposition March 2009, 37 (3) 523-528; DOI: https://doi.org/10.1124/dmd.108.025635

  8. Kersey, Kathryn

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  9. Keshavarzian, Ali

    1. SIMDOT-AbMe: Microphysiologically Based Simulation Tool for Quantitative Prediction of Systemic and Local Bioavailability of Targeted Oral Delivery Formulations
      Nahor Haddish-Berhane, Ashkan Farhadi, Chell Nyquist, Kamyar Haghighi and Ali Keshavarzian
      Drug Metabolism and Disposition March 2009, 37 (3) 608-618; DOI: https://doi.org/10.1124/dmd.108.021949

  10. Khalizev, Vsevolod A.

    1. 5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
      Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
      Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269

  11. Khandazhinskaya, Anastasia L.

    1. 5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
      Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
      Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269

  12. Kito, Go

    1. Sex-Related Differences in the Expression of mfGSTA2, a Novel GST Identified in Cynomolgus Monkey (Macaca fascicularis)
      Yasuhiro Uno, Tsukasa Ohuchi, Shotaro Uehara, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition March 2009, 37 (3) 453-456; DOI: https://doi.org/10.1124/dmd.108.023747

  13. Knudsen, Gitte M.

    1. Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
      Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745

  14. Kondo, Tsunenori

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

  15. Kornum, Birgitte R.

    1. Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
      Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745

  16. Kramp, Roger

    1. Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002

  17. Kubo, Yoshiyuki

    1. Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice
      Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji
      Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689

  18. Kukhanova, Marina K.

    1. 5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
      Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
      Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269

  19. Kumar, Santosh

    1. Decreased Susceptibility of the Cytochrome P450 2B6 Variant K262R to Inhibition by Several Clinically Important Drugs
      Jyothi C. Talakad, Santosh Kumar and James R. Halpert
      Drug Metabolism and Disposition March 2009, 37 (3) 644-650; DOI: https://doi.org/10.1124/dmd.108.023655
    2. Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions
      Hao Sun, Chad Moore, Patrick M. Dansette, Santosh Kumar, James R. Halpert and Garold S. Yost
      Drug Metabolism and Disposition March 2009, 37 (3) 672-684; DOI: https://doi.org/10.1124/dmd.108.022707

  20. Kurihara, Atsushi

    1. Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
      Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda
      Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988

  21. Kusuhara, Hiroyuki

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

L

  1. Lalk, Michael

    1. Investigation of the in Vitro Metabolism of the Analgesic Flupirtine
      Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski
      Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364

  2. Långström, Bengt

    1. Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
      Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745

  3. Lecureur, Valérie

    1. Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-α or Interleukin-6
      Marc Le Vee, Valérie Lecureur, Bruno Stieger and Olivier Fardel
      Drug Metabolism and Disposition March 2009, 37 (3) 685-693; DOI: https://doi.org/10.1124/dmd.108.023630

  4. Lee, David

    1. Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase
      Charles W. Locuson, Brian T. Ethell, Michael Voice, David Lee and Kenneth L. Feenstra
      Drug Metabolism and Disposition March 2009, 37 (3) 457-461; DOI: https://doi.org/10.1124/dmd.108.025312

  5. Leung, Grace S.

    1. Developmental Expression and Endocrine Regulation of CYP1B1 in Rat Testis
      Grace S. Leung, Masahiko Kawai, Jenny K. Tai, Jie Chen, Stelvio M. Bandiera and Thomas K. H. Chang
      Drug Metabolism and Disposition March 2009, 37 (3) 523-528; DOI: https://doi.org/10.1124/dmd.108.025635

  6. Li, Ze-Sheng

    1. Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
      Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett
      Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416

  7. Lindhe, Örjan

    1. Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
      Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745

  8. Locuson, Charles W.

    1. Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase
      Charles W. Locuson, Brian T. Ethell, Michael Voice, David Lee and Kenneth L. Feenstra
      Drug Metabolism and Disposition March 2009, 37 (3) 457-461; DOI: https://doi.org/10.1124/dmd.108.025312

M

  1. Ma, Ji

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  2. Maeda, Kazuya

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

  3. Mangold, James B.

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010

  4. Marcus, Andrew P.

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  5. Masimirembwa, Collen

    1. Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry, and NMR
      Tove Johansson, Ulrik Jurva, Gunnar Grönberg, Lars Weidolf and Collen Masimirembwa
      Drug Metabolism and Disposition March 2009, 37 (3) 571-579; DOI: https://doi.org/10.1124/dmd.108.025171

  6. Matsushima, Soichiro

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

  7. Medina, Julio C.

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  8. Methling, Karen

    1. Investigation of the in Vitro Metabolism of the Analgesic Flupirtine
      Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski
      Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364

  9. Minematsu, Tsuyoshi

    1. Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells
      Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition March 2009, 37 (3) 619-628; DOI: https://doi.org/10.1124/dmd.108.025254

  10. Miura, Shin-ichi

    1. Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
      Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda
      Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988

  11. Moore, Chad

    1. Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions
      Hao Sun, Chad Moore, Patrick M. Dansette, Santosh Kumar, James R. Halpert and Garold S. Yost
      Drug Metabolism and Disposition March 2009, 37 (3) 672-684; DOI: https://doi.org/10.1124/dmd.108.022707

  12. Morgan, Edward T.

    1. Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models
      Jun Zhang, Madhusudana R. Chaluvadi, Rob Reddy, Meike S. Motika, Terrilyn A. Richardson, John R. Cashman and Edward T. Morgan
      Drug Metabolism and Disposition March 2009, 37 (3) 462-468; DOI: https://doi.org/10.1124/dmd.108.025338

  13. Motika, Meike S.

    1. Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models
      Jun Zhang, Madhusudana R. Chaluvadi, Rob Reddy, Meike S. Motika, Terrilyn A. Richardson, John R. Cashman and Edward T. Morgan
      Drug Metabolism and Disposition March 2009, 37 (3) 462-468; DOI: https://doi.org/10.1124/dmd.108.025338

  14. Murphy, Sharon E.

    1. Effect of CYP2A13 Active Site Mutation N297A on Metabolism of Coumarin and Tobacco-Specific Nitrosamines
      Kari E. Schlicht, Jeannette Zinggeler Berg and Sharon E. Murphy
      Drug Metabolism and Disposition March 2009, 37 (3) 665-671; DOI: https://doi.org/10.1124/dmd.108.025072

N

  1. Nagata, Ryoichi

    1. Sex-Related Differences in the Expression of mfGSTA2, a Novel GST Identified in Cynomolgus Monkey (Macaca fascicularis)
      Yasuhiro Uno, Tsukasa Ohuchi, Shotaro Uehara, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition March 2009, 37 (3) 453-456; DOI: https://doi.org/10.1124/dmd.108.023747

  2. Nakadera, Yasuhito

    1. Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice
      Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji
      Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689

  3. Nakahara, Takahito

    1. Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells
      Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition March 2009, 37 (3) 619-628; DOI: https://doi.org/10.1124/dmd.108.025254

  4. Nakayama, Hideki

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

  5. Ngo, Ngoc

    1. Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans
      Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968

  6. Nishiya, Yumi

    1. Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
      Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda
      Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988

  7. Nyquist, Chell

    1. SIMDOT-AbMe: Microphysiologically Based Simulation Tool for Quantitative Prediction of Systemic and Local Bioavailability of Targeted Oral Delivery Formulations
      Nahor Haddish-Berhane, Ashkan Farhadi, Chell Nyquist, Kamyar Haghighi and Ali Keshavarzian
      Drug Metabolism and Disposition March 2009, 37 (3) 608-618; DOI: https://doi.org/10.1124/dmd.108.021949

O

  1. Oberlies, Nicholas H.

    1. Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans
      Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968

  2. Ohta, Kin-ya

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

  3. Ohuchi, Tsukasa

    1. Sex-Related Differences in the Expression of mfGSTA2, a Novel GST Identified in Cynomolgus Monkey (Macaca fascicularis)
      Yasuhiro Uno, Tsukasa Ohuchi, Shotaro Uehara, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition March 2009, 37 (3) 453-456; DOI: https://doi.org/10.1124/dmd.108.023747

  4. Olsen, Lars

    1. Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques
      Poongavanam Vasanthanathan, Olivier Taboureau, Chris Oostenbrink, Nico P. E. Vermeulen, Lars Olsen and Flemming Steen Jørgensen
      Drug Metabolism and Disposition March 2009, 37 (3) 658-664; DOI: https://doi.org/10.1124/dmd.108.023507

  5. Oostenbrink, Chris

    1. Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques
      Poongavanam Vasanthanathan, Olivier Taboureau, Chris Oostenbrink, Nico P. E. Vermeulen, Lars Olsen and Flemming Steen Jørgensen
      Drug Metabolism and Disposition March 2009, 37 (3) 658-664; DOI: https://doi.org/10.1124/dmd.108.023507

P

  1. Paine, Mary F.

    1. Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans
      Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968

  2. Palner, Mikael

    1. Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
      Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745

  3. Pan, Guoyu

    1. Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design
      Nagdeep Giri, Sagar Agarwal, Naveed Shaik, Guoyu Pan, Ying Chen and William F. Elmquist
      Drug Metabolism and Disposition March 2009, 37 (3) 560-570; DOI: https://doi.org/10.1124/dmd.108.022046

  4. Pearson, Paul G.

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  5. Pollack, Gary M.

    1. Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration
      Rong Zhao, J. Cory Kalvass, Souzan B. Yanni, Arlene S. Bridges and Gary M. Pollack
      Drug Metabolism and Disposition March 2009, 37 (3) 529-535; DOI: https://doi.org/10.1124/dmd.107.019893

R

  1. Rahman, Obaidur

    1. Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
      Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745

  2. Reddy, Rob

    1. Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models
      Jun Zhang, Madhusudana R. Chaluvadi, Rob Reddy, Meike S. Motika, Terrilyn A. Richardson, John R. Cashman and Edward T. Morgan
      Drug Metabolism and Disposition March 2009, 37 (3) 462-468; DOI: https://doi.org/10.1124/dmd.108.025338

  3. Reszka, Przyemslaw

    1. Investigation of the in Vitro Metabolism of the Analgesic Flupirtine
      Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski
      Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364

  4. Richardson, Terrilyn A.

    1. Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models
      Jun Zhang, Madhusudana R. Chaluvadi, Rob Reddy, Meike S. Motika, Terrilyn A. Richardson, John R. Cashman and Edward T. Morgan
      Drug Metabolism and Disposition March 2009, 37 (3) 462-468; DOI: https://doi.org/10.1124/dmd.108.025338

S

  1. Sato, Takashi

    1. Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice
      Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji
      Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689

  2. Scheuch, Eberhard

    1. Investigation of the in Vitro Metabolism of the Analgesic Flupirtine
      Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski
      Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364

  3. Schlicht, Kari E.

    1. Effect of CYP2A13 Active Site Mutation N297A on Metabolism of Coumarin and Tobacco-Specific Nitrosamines
      Kari E. Schlicht, Jeannette Zinggeler Berg and Sharon E. Murphy
      Drug Metabolism and Disposition March 2009, 37 (3) 665-671; DOI: https://doi.org/10.1124/dmd.108.025072

  4. Shaik, Naveed

    1. Substrate-Dependent Breast Cancer Resistance Protein (Bcrp1/Abcg2)-Mediated Interactions: Consideration of Multiple Binding Sites in in Vitro Assay Design
      Nagdeep Giri, Sagar Agarwal, Naveed Shaik, Guoyu Pan, Ying Chen and William F. Elmquist
      Drug Metabolism and Disposition March 2009, 37 (3) 560-570; DOI: https://doi.org/10.1124/dmd.108.022046

  5. Shen, Hong-Wu

    1. Pinoline May be Used as a Probe for CYP2D6 Activity
      Xi-Ling Jiang, Hong-Wu Shen and Ai-Ming Yu
      Drug Metabolism and Disposition March 2009, 37 (3) 443-446; DOI: https://doi.org/10.1124/dmd.108.025056

  6. Shipitsin, Alexander V.

    1. 5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
      Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
      Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269

  7. Shirai, Nobuaki

    1. Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells
      Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition March 2009, 37 (3) 619-628; DOI: https://doi.org/10.1124/dmd.108.025254

  8. Shirokova, Elena A.

    1. 5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
      Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
      Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269

  9. Shram, Stanislav I.

    1. 5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
      Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
      Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269

  10. Si, Dayong

    1. Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
      Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett
      Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416

  11. Siegmund, Werner

    1. Investigation of the in Vitro Metabolism of the Analgesic Flupirtine
      Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski
      Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364

  12. Silverman, Jeffrey A.

    1. Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent
      Marc J. Evanchik, Darin Allen, Josh C. Yoburn, Jeffrey A. Silverman and Ute Hoch
      Drug Metabolism and Disposition March 2009, 37 (3) 594-601; DOI: https://doi.org/10.1124/dmd.108.023432

  13. Skoblov, Yuriy S.

    1. 5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
      Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
      Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269

  14. Smith, Harold

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010
    2. Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002

  15. Stieger, Bruno

    1. Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-α or Interleukin-6
      Marc Le Vee, Valérie Lecureur, Bruno Stieger and Olivier Fardel
      Drug Metabolism and Disposition March 2009, 37 (3) 685-693; DOI: https://doi.org/10.1124/dmd.108.023630

  16. Sugimoto, Kenji

    1. Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells
      Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition March 2009, 37 (3) 619-628; DOI: https://doi.org/10.1124/dmd.108.025254

  17. Sugiura, Mikihiro

    1. Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice
      Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji
      Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689

  18. Sugiura, Tomoko

    1. Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice
      Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji
      Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689

  19. Sugiyama, Yuichi

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

  20. Sun, Hao

    1. Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions
      Hao Sun, Chad Moore, Patrick M. Dansette, Santosh Kumar, James R. Halpert and Garold S. Yost
      Drug Metabolism and Disposition March 2009, 37 (3) 672-684; DOI: https://doi.org/10.1124/dmd.108.022707

  21. Syvänen, Stina

    1. Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport
      Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
      Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745

T

  1. Taboureau, Olivier

    1. Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques
      Poongavanam Vasanthanathan, Olivier Taboureau, Chris Oostenbrink, Nico P. E. Vermeulen, Lars Olsen and Flemming Steen Jørgensen
      Drug Metabolism and Disposition March 2009, 37 (3) 658-664; DOI: https://doi.org/10.1124/dmd.108.023507

  2. Tai, Jenny K.

    1. Developmental Expression and Endocrine Regulation of CYP1B1 in Rat Testis
      Grace S. Leung, Masahiko Kawai, Jenny K. Tai, Jie Chen, Stelvio M. Bandiera and Thomas K. H. Chang
      Drug Metabolism and Disposition March 2009, 37 (3) 523-528; DOI: https://doi.org/10.1124/dmd.108.025635

  3. Tajima, Masami

    1. Mechanism-Based Inhibition of Human Cytochrome P450 2B6 by Ticlopidine, Clopidogrel, and the Thiolactone Metabolite of Prasugrel
      Yumi Nishiya, Katsunobu Hagihara, Takashi Ito, Masami Tajima, Shin-ichi Miura, Atsushi Kurihara, Nagy A. Farid and Toshihiko Ikeda
      Drug Metabolism and Disposition March 2009, 37 (3) 589-593; DOI: https://doi.org/10.1124/dmd.108.022988

  4. Talakad, Jyothi C.

    1. Decreased Susceptibility of the Cytochrome P450 2B6 Variant K262R to Inhibition by Several Clinically Important Drugs
      Jyothi C. Talakad, Santosh Kumar and James R. Halpert
      Drug Metabolism and Disposition March 2009, 37 (3) 644-650; DOI: https://doi.org/10.1124/dmd.108.023655

  5. Terhaag, Bernd

    1. Investigation of the in Vitro Metabolism of the Analgesic Flupirtine
      Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski
      Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364

  6. Tonn, George R.

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  7. Tran, Phi

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010
    2. Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002

  8. Tsuji, Akira

    1. Investigation of the Role of Oligopeptide Transporter PEPT1 and Sodium/Glucose Cotransporter SGLT1 in Intestinal Absorption of Their Substrates Using Small GTP-Binding Protein Rab8-Null Mice
      Yukio Kato, Tomoko Sugiura, Yasuhito Nakadera, Mikihiro Sugiura, Yoshiyuki Kubo, Takashi Sato, Akihiro Harada and Akira Tsuji
      Drug Metabolism and Disposition March 2009, 37 (3) 602-607; DOI: https://doi.org/10.1124/dmd.108.023689

U

  1. Uehara, Shotaro

    1. Sex-Related Differences in the Expression of mfGSTA2, a Novel GST Identified in Cynomolgus Monkey (Macaca fascicularis)
      Yasuhiro Uno, Tsukasa Ohuchi, Shotaro Uehara, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition March 2009, 37 (3) 453-456; DOI: https://doi.org/10.1124/dmd.108.023747

  2. Uno, Yasuhiro

    1. Sex-Related Differences in the Expression of mfGSTA2, a Novel GST Identified in Cynomolgus Monkey (Macaca fascicularis)
      Yasuhiro Uno, Tsukasa Ohuchi, Shotaro Uehara, Go Kito, Tetsuya Kamataki and Ryoichi Nagata
      Drug Metabolism and Disposition March 2009, 37 (3) 453-456; DOI: https://doi.org/10.1124/dmd.108.023747

  3. Usui, Takashi

    1. Carrier-Mediated Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small-Molecule Survivin Suppressant, into Human Solid Tumor and Lymphoma Cells
      Tsuyoshi Minematsu, Megumi Iwai, Kenji Sugimoto, Nobuaki Shirai, Takahito Nakahara, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition March 2009, 37 (3) 619-628; DOI: https://doi.org/10.1124/dmd.108.025254

V

  1. Van Lengerich, Bettina

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  2. Vasanthanathan, Poongavanam

    1. Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques
      Poongavanam Vasanthanathan, Olivier Taboureau, Chris Oostenbrink, Nico P. E. Vermeulen, Lars Olsen and Flemming Steen Jørgensen
      Drug Metabolism and Disposition March 2009, 37 (3) 658-664; DOI: https://doi.org/10.1124/dmd.108.023507

  3. Vee, Marc Le

    1. Regulation of Drug Transporter Expression in Human Hepatocytes Exposed to the Proinflammatory Cytokines Tumor Necrosis Factor-α or Interleukin-6
      Marc Le Vee, Valérie Lecureur, Bruno Stieger and Olivier Fardel
      Drug Metabolism and Disposition March 2009, 37 (3) 685-693; DOI: https://doi.org/10.1124/dmd.108.023630

  4. Vermeulen, Nico P. E.

    1. Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques
      Poongavanam Vasanthanathan, Olivier Taboureau, Chris Oostenbrink, Nico P. E. Vermeulen, Lars Olsen and Flemming Steen Jørgensen
      Drug Metabolism and Disposition March 2009, 37 (3) 658-664; DOI: https://doi.org/10.1124/dmd.108.023507

  5. Voice, Michael

    1. Evaluation of Escherichia coli Membrane Preparations of Canine CYP1A1, 2B11, 2C21, 2C41, 2D15, 3A12, and 3A26 with Coexpressed Canine Cytochrome P450 Reductase
      Charles W. Locuson, Brian T. Ethell, Michael Voice, David Lee and Kenneth L. Feenstra
      Drug Metabolism and Disposition March 2009, 37 (3) 457-461; DOI: https://doi.org/10.1124/dmd.108.025312

  6. Vrana, Oldrich

    1. Investigation of the in Vitro Metabolism of the Analgesic Flupirtine
      Karen Methling, Przyemslaw Reszka, Michael Lalk, Oldrich Vrana, Eberhard Scheuch, Werner Siegmund, Bernd Terhaag and Patrick J. Bednarski
      Drug Metabolism and Disposition March 2009, 37 (3) 479-493; DOI: https://doi.org/10.1124/dmd.108.024364

W

  1. Wang, Juan

    1. Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
      Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett
      Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416

  2. Wang, Lai

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010

  3. Wang, Xuemei

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  4. Wang, Ying

    1. Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
      Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett
      Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416

  5. Weidolf, Lars

    1. Novel Metabolites of Amodiaquine Formed by CYP1A1 and CYP1B1: Structure Elucidation Using Electrochemistry, Mass Spectrometry, and NMR
      Tove Johansson, Ulrik Jurva, Gunnar Grönberg, Lars Weidolf and Collen Masimirembwa
      Drug Metabolism and Disposition March 2009, 37 (3) 571-579; DOI: https://doi.org/10.1124/dmd.108.025171

  6. Wong, Bradley K.

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  7. Wong, Simon G.

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

  8. Wong, Sylvia C.

    1. An Inhibitory Metabolite Leads to Dose- and Time-Dependent Pharmacokinetics of (R)-N-{1-[3-(4-Ethoxy-phenyl)-4-oxo-3,4-dihydro-pyrido[2,3-d]pyrimidin-2-yl]-ethyl}-N-pyridin-3-yl-methyl-2-(4-trifluoromethoxy-phenyl)-acetamide (AMG 487) in Human Subjects After Multiple Dosing
      George R. Tonn, Simon G. Wong, Sylvia C. Wong, Michael G. Johnson, Ji Ma, Robert Cho, Leslie C. Floren, Kathryn Kersey, Karen Berry, Andrew P. Marcus, Xuemei Wang, Bettina Van Lengerich, Julio C. Medina, Paul G. Pearson and Bradley K. Wong
      Drug Metabolism and Disposition March 2009, 37 (3) 502-513; DOI: https://doi.org/10.1124/dmd.108.021931

Y

  1. Yan, Zhixia

    1. Identification of a Cranberry Juice Product that Inhibits Enteric CYP3A-Mediated First-Pass Metabolism in Humans
      Ngoc Ngo, Zhixia Yan, Tyler N. Graf, Daniel R. Carrizosa, Angela D. M. Kashuba, E. Claire Dees, Nicholas H. Oberlies and Mary F. Paine
      Drug Metabolism and Disposition March 2009, 37 (3) 514-522; DOI: https://doi.org/10.1124/dmd.108.024968

  2. Yanni, Souzan B.

    1. Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration
      Rong Zhao, J. Cory Kalvass, Souzan B. Yanni, Arlene S. Bridges and Gary M. Pollack
      Drug Metabolism and Disposition March 2009, 37 (3) 529-535; DOI: https://doi.org/10.1124/dmd.107.019893

  3. Yanvarev, Dmitry V.

    1. 5′-Aminocarbonyl Phosphonates as New Zidovudine Depot Forms: Antiviral Properties, Intracellular Transformations, and Pharmacokinetic Parameters
      Anastasia L. Khandazhinskaya, Dmitry V. Yanvarev, Maxim V. Jasko, Alexander V. Shipitsin, Vsevolod A. Khalizev, Stanislav I. Shram, Yuriy S. Skoblov, Elena A. Shirokova and Marina K. Kukhanova
      Drug Metabolism and Disposition March 2009, 37 (3) 494-501; DOI: https://doi.org/10.1124/dmd.108.022269

  4. Yin, Hequn

    1. Absorption, Metabolism, and Excretion of [14C]Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Humans
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Yannick Batard, Lai Wang, Heidi Einolf, Helen Gu, James B. Mangold, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 536-544; DOI: https://doi.org/10.1124/dmd.108.023010
    2. Disposition of Vildagliptin, a Novel Dipeptidyl Peptidase 4 Inhibitor, in Rats and Dogs
      Handan He, Phi Tran, Hequn Yin, Harold Smith, Dennis Flood, Roger Kramp, Ron Filipeck, Volker Fischer and Dan Howard
      Drug Metabolism and Disposition March 2009, 37 (3) 545-554; DOI: https://doi.org/10.1124/dmd.108.023002

  5. Yoburn, Josh C.

    1. Metabolism of (+)-1,4-Dihydro-7-(trans-3-methoxy-4-methylamino-1-pyrrolidinyl)-4-oxo-1-(2-thiazolyl)-1,8-naphthyridine-3-carboxylic Acid (Voreloxin; Formerly SNS-595), a Novel Replication-Dependent DNA-Damaging Agent
      Marc J. Evanchik, Darin Allen, Josh C. Yoburn, Jeffrey A. Silverman and Ute Hoch
      Drug Metabolism and Disposition March 2009, 37 (3) 594-601; DOI: https://doi.org/10.1124/dmd.108.023432

  6. Yost, Garold S.

    1. Dehydrogenation of the Indoline-Containing Drug 4-Chloro-N-(2-methyl-1-indolinyl)-3-sulfamoylbenzamide (Indapamide) by CYP3A4: Correlation with in Silico Predictions
      Hao Sun, Chad Moore, Patrick M. Dansette, Santosh Kumar, James R. Halpert and Garold S. Yost
      Drug Metabolism and Disposition March 2009, 37 (3) 672-684; DOI: https://doi.org/10.1124/dmd.108.022707

  7. Yu, Ai-Ming

    1. Pinoline May be Used as a Probe for CYP2D6 Activity
      Xi-Ling Jiang, Hong-Wu Shen and Ai-Ming Yu
      Drug Metabolism and Disposition March 2009, 37 (3) 443-446; DOI: https://doi.org/10.1124/dmd.108.025056

  8. Yuasa, Hiroaki

    1. The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine
      Soichiro Matsushima, Kazuya Maeda, Katsuhisa Inoue, Kin-ya Ohta, Hiroaki Yuasa, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition March 2009, 37 (3) 555-559; DOI: https://doi.org/10.1124/dmd.108.023911

Z

  1. Zhang, Jin

    1. An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine
      Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding
      Drug Metabolism and Disposition March 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429

  2. Zhang, Jun

    1. Hepatic Flavin-Containing Monooxygenase Gene Regulation in Different Mouse Inflammation Models
      Jun Zhang, Madhusudana R. Chaluvadi, Rob Reddy, Meike S. Motika, Terrilyn A. Richardson, John R. Cashman and Edward T. Morgan
      Drug Metabolism and Disposition March 2009, 37 (3) 462-468; DOI: https://doi.org/10.1124/dmd.108.025338

  3. Zhang, Qing-Yu

    1. An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine
      Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding
      Drug Metabolism and Disposition March 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429

  4. Zhao, Rong

    1. Fexofenadine Brain Exposure and the Influence of Blood-Brain Barrier P-Glycoprotein After Fexofenadine and Terfenadine Administration
      Rong Zhao, J. Cory Kalvass, Souzan B. Yanni, Arlene S. Bridges and Gary M. Pollack
      Drug Metabolism and Disposition March 2009, 37 (3) 529-535; DOI: https://doi.org/10.1124/dmd.107.019893

  5. Zhou, Hui

    1. Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
      Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett
      Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416

  6. Zhou, Yi-Han

    1. Mechanism of CYP2C9 Inhibition by Flavones and Flavonols
      Dayong Si, Ying Wang, Yi-Han Zhou, Yingjie Guo, Juan Wang, Hui Zhou, Ze-Sheng Li and J. Paul Fawcett
      Drug Metabolism and Disposition March 2009, 37 (3) 629-634; DOI: https://doi.org/10.1124/dmd.108.023416
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