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Research ArticleArticle

Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
Drug Metabolism and Disposition March 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745

Article Information

vol. 37 no. 3 635-643
DOI 
https://doi.org/10.1124/dmd.108.024745
PubMed 
19047468
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 7, 2008
  • Accepted November 24, 2008
  • Published online February 18, 2009.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Stina Syvänen,
  2. Örjan Lindhe,
  3. Mikael Palner,
  4. Birgitte R. Kornum,
  5. Obaidur Rahman,
  6. Bengt Långström,
  7. Gitte M. Knudsen and
  8. Margareta Hammarlund-Udenaes
  1. Department of Pharmaceutical Biosciences, Uppsala University, Uppsala, Sweden (S.S., M.H.-U.); Uppsala Imanet, GE Healthcare, Uppsala, Sweden (S.S., Ö.L.); Uppsala Applied Science Lab, GEMS PET Systems, GE Healthcare, Uppsala, Sweden (O.R., B.L.); Neurobiology Research Unit, Department of Neurology, Copenhagen University Hospital, Copenhagen, Denmark (M.P., B.R.K., G.M.K.); and Department of Biochemistry and Organic Chemistry, Uppsala University, Uppsala, Sweden (B.L.)
  1. Address correspondence to:
    Dr. Stina Syvänen, Division of Pharmacology, Leiden University, Leiden-Amsterdam Center for Drug Research (LACDR), Box 9502, 2300 RA Leiden, The Netherlands. E-mail: s.syvanen{at}lacdr.leidenuniv.nl
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Research ArticleArticle

Species Differences in Blood-Brain Barrier Transport of Three Positron Emission Tomography Radioligands with Emphasis on P-Glycoprotein Transport

Stina Syvänen, Örjan Lindhe, Mikael Palner, Birgitte R. Kornum, Obaidur Rahman, Bengt Långström, Gitte M. Knudsen and Margareta Hammarlund-Udenaes
Drug Metabolism and Disposition March 1, 2009, 37 (3) 635-643; DOI: https://doi.org/10.1124/dmd.108.024745
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