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An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine

Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding
Drug Metabolism and Disposition March 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429

Article Information

vol. 37 no. 3 651-657
DOI 
https://doi.org/10.1124/dmd.108.025429
PubMed 
19056912
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received October 27, 2008
  • Accepted December 2, 2008
  • Published online February 18, 2009.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Qing-Yu Zhang,
  2. Cheng Fang,
  3. Jin Zhang,
  4. Deborah Dunbar,
  5. Laurence Kaminsky and
  6. Xinxin Ding
  1. Wadsworth Center, New York State Department of Health, and School of Public Health, State University of New York at Albany, Albany, New York
  1. Address correspondence to:
    Qing-Yu Zhang, Wadsworth Center, New York State Department of Health, Empire State Plaza, Box 509, Albany, NY 12201-0509. E-mail: zhangq{at}wadsworth.org
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Research ArticleArticle

An Intestinal Epithelium-Specific Cytochrome P450 (P450) Reductase-Knockout Mouse Model: Direct Evidence for a Role of Intestinal P450s in First-Pass Clearance of Oral Nifedipine

Qing-Yu Zhang, Cheng Fang, Jin Zhang, Deborah Dunbar, Laurence Kaminsky and Xinxin Ding
Drug Metabolism and Disposition March 1, 2009, 37 (3) 651-657; DOI: https://doi.org/10.1124/dmd.108.025429
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