Table of Contents

Articles

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  Application of Stable Isotope Methodology in the Evaluation of the Pharmacokinetics of (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride in Rats

  Shinji Yamazaki, Lisa N. Toth, Emi Kimoto, Janice Bower, Judith Skaptason, David Romero and Timothy G. Heath

  Drug Metabolism and Disposition May 2009, 37 (5) 937-945; DOI: https://doi.org/10.1124/dmd.108.025478
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  The Effect of Breast Cancer Resistance Protein and P-Glycoprotein on the Brain Penetration of Flavopiridol, Imatinib Mesylate (Gleevec), Prazosin, and 2-Methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic Acid (PF-407288) in Mice

  Lin Zhou, Kari Schmidt, Frederick R. Nelson, Veronica Zelesky, Matthew D. Troutman and Bo Feng

  Drug Metabolism and Disposition May 2009, 37 (5) 946-955; DOI: https://doi.org/10.1124/dmd.108.024489
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  Different Inhibitory Effects in Rat and Human Carboxylesterases

  Shiori Takahashi, Miki Katoh, Takashi Saitoh, Miki Nakajima and Tsuyoshi Yokoi

  Drug Metabolism and Disposition May 2009, 37 (5) 956-961; DOI: https://doi.org/10.1124/dmd.108.024331
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  Transplacental Pharmacokinetics of Diclofenac in Perfused Human Placenta

  Kyohei Shintaku, Satoko Hori, Masayuki Tsujimoto, Hideaki Nagata, Shoji Satoh, Kiyomi Tsukimori, Hitoo Nakano, Tomoyuki Fujii, Yuji Taketani, Hisakazu Ohtani and Yasufumi Sawada

  Drug Metabolism and Disposition May 2009, 37 (5) 962-968; DOI: https://doi.org/10.1124/dmd.108.024349
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  Characterization of Sandwich-Cultured Hepatocytes As an in Vitro Model to Assess the Hepatobiliary Disposition of Copper

  John H. Ansede, Matthew R. Wright, Robert L. St. Claire, Robert W. Hart, Holly A. Gefroh and Kenneth R. Brouwer

  Drug Metabolism and Disposition May 2009, 37 (5) 969-976; DOI: https://doi.org/10.1124/dmd.108.024638
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  A Bioinformatics Approach for the Phenotype Prediction of Nonsynonymous Single Nucleotide Polymorphisms in Human Cytochromes P450

  Lin-Lin Wang, Yong Li and Shu-Feng Zhou

  Drug Metabolism and Disposition May 2009, 37 (5) 977-991; DOI: https://doi.org/10.1124/dmd.108.026047
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  Characterization of Human Corneal Epithelial Cell Model As a Surrogate for Corneal Permeability Assessment: Metabolism and Transport

  Cathie D. Xiang, Minerva Batugo, David C. Gale, Tao Zhang, Jingjing Ye, Chunze Li, Sue Zhou, Ellen Y. Wu and Eric Y. Zhang

  Drug Metabolism and Disposition May 2009, 37 (5) 992-998; DOI: https://doi.org/10.1124/dmd.108.026286
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  Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide

  David Boyer, Jonathan N. Bauman, Daniel P. Walker, Brendon Kapinos, Kapil Karki and Amit S. Kalgutkar

  Drug Metabolism and Disposition May 2009, 37 (5) 999-1008; DOI: https://doi.org/10.1124/dmd.108.026112
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  Carnitine/Organic Cation Transporter OCTN2 (Slc22a5) Is Responsible for Renal Secretion of Cephaloridine in Mice

  Takashi Kano, Yukio Kato, Kimihiro Ito, Takuo Ogihara, Yoshiyuki Kubo and Akira Tsuji

  Drug Metabolism and Disposition May 2009, 37 (5) 1009-1016; DOI: https://doi.org/10.1124/dmd.108.025015
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  A Predominate Role of CYP1A2 for the Metabolism of Nabumetone to the Active Metabolite, 6-Methoxy-2-naphthylacetic Acid, in Human Liver Microsomes

  Miia Turpeinen, Ute Hofmann, Kathrin Klein, Thomas Mürdter, Matthias Schwab and Ulrich M. Zanger

  Drug Metabolism and Disposition May 2009, 37 (5) 1017-1024; DOI: https://doi.org/10.1124/dmd.108.025700
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  Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions

  Rowan A. Stringer, Claire Strain-Damerell, Paul Nicklin and J. Brian Houston

  Drug Metabolism and Disposition May 2009, 37 (5) 1025-1034; DOI: https://doi.org/10.1124/dmd.108.024810
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  Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice

  Lisa D. Beilke, Lauren M. Aleksunes, Ricky D. Holland, David G. Besselsen, Rick D. Beger, Curtis D. Klaassen and Nathan J. Cherrington

  Drug Metabolism and Disposition May 2009, 37 (5) 1035-1045; DOI: https://doi.org/10.1124/dmd.108.023317
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  In Vitro Metabolism of Rivaroxaban, an Oral, Direct Factor Xa Inhibitor, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans

  D. Lang, C. Freudenberger and C. Weinz

  Drug Metabolism and Disposition May 2009, 37 (5) 1046-1055; DOI: https://doi.org/10.1124/dmd.108.025551
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  Metabolism and Excretion of Rivaroxaban, an Oral, Direct Factor Xa Inhibitor, in Rats, Dogs, and Humans

  C. Weinz, T. Schwarz, D. Kubitza, W. Mueck and D. Lang

  Drug Metabolism and Disposition May 2009, 37 (5) 1056-1064; DOI: https://doi.org/10.1124/dmd.108.025569
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  Structure-Activity Relationships for Hydroxylated Polychlorinated Biphenyls as Substrates and Inhibitors of Rat Sulfotransferases and Modification of These Relationships by Changes in Thiol Status

  Yungang Liu, Jason T. Smart, Yang Song, Hans-Joachim Lehmler, Larry W. Robertson and Michael W. Duffel

  Drug Metabolism and Disposition May 2009, 37 (5) 1065-1072; DOI: https://doi.org/10.1124/dmd.108.026021
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  Covalent Binding of Phenylacetic Acid to Protein in Incubations with Freshly Isolated Rat Hepatocytes

  Mark P. Grillo and Michelle Tadano Lohr

  Drug Metabolism and Disposition May 2009, 37 (5) 1073-1082; DOI: https://doi.org/10.1124/dmd.108.026153
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  Dimerization Is Responsible for the Structural Stability of Human Sulfotransferase 1A1

  Lu-Yi Lu, Han-Ping Chiang, Wei-Ti Chen and Yuh-Shyong Yang

  Drug Metabolism and Disposition May 2009, 37 (5) 1083-1088; DOI: https://doi.org/10.1124/dmd.108.025395
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  Identification of [¹⁴C]Fluasterone Metabolites in Urine and Feces Collected from Dogs after Subcutaneous and Oral Administration of [¹⁴C]Fluasterone

  Jason P. Burgess, Jonathan S. Green, Judith M. Hill, Qiao Zhan, Matthew Lindeblad, Alexander Lyubimov, Izet M. Kapetanovic, Arthur Schwartz and Brian F. Thomas

  Drug Metabolism and Disposition May 2009, 37 (5) 1089-1097; DOI: https://doi.org/10.1124/dmd.108.023614
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  Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes

  Haishan Li, Tao Chen, John Cottrell and Hongbing Wang

  Drug Metabolism and Disposition May 2009, 37 (5) 1098-1106; DOI: https://doi.org/10.1124/dmd.108.026005
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  Two Nonsynonymous Single Nucleotide Polymorphisms of Human Carbonyl Reductase 1 Demonstrate Reduced in Vitro Metabolism of Daunorubicin and Doxorubicin

  Onkar S. Bains, Morgan J. Karkling, Thomas A. Grigliatti, Ronald E. Reid and K. Wayne Riggs

  Drug Metabolism and Disposition May 2009, 37 (5) 1107-1114; DOI: https://doi.org/10.1124/dmd.108.024711
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  Metabolism and Excretion of an Oral Taxane Analog, [¹⁴C]3′-tert-Butyl-3′-N-tert-butyloxycarbonyl-4-deacetyl-3′-dephenyl-3′-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in Rats and Dogs

  Van T. Ly, Janet Caceres-Cortes, Donglu Zhang, W. Griffith Humphreys, Ihoezo V. Ekhato, Donald Everett and S. Nilgün Çömezoğlu

  Drug Metabolism and Disposition May 2009, 37 (5) 1115-1128; DOI: https://doi.org/10.1124/dmd.108.025809
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  Human Platelets Express Organic Anion-Transporting Peptide 2B1, an Uptake Transporter for Atorvastatin

  Juliane Niessen, Gabriele Jedlitschky, Markus Grube, Sandra Bien, Hansjörg Schwertz, Sumio Ohtsuki, Hirotaka Kawakami, Junichi Kamiie, Stefan Oswald, Katharina Starke, Ulrike Strobel, Werner Siegmund, Dieter Rosskopf, Andreas Greinacher, Tetsuya Terasaki and Heyo K. Kroemer

  Drug Metabolism and Disposition May 2009, 37 (5) 1129-1137; DOI: https://doi.org/10.1124/dmd.108.024570
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  Inducibility of Drug-Metabolizing Enzymes by Xenobiotics in Mice with Liver-Specific Knockout of Ctnnb1

  Albert Braeuning, Riccardo Sanna, Joerg Huelsken and Michael Schwarz

  Drug Metabolism and Disposition May 2009, 37 (5) 1138-1145; DOI: https://doi.org/10.1124/dmd.108.026179