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Drug Metabolism & Disposition

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Table of Contents

May 01, 2009; Volume 37,Issue 5

MINIREVIEW

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    Antibodies as a Probe in Cytochrome P450 Research
    Magang Shou and Anthony Y. H. Lu
    Drug Metabolism and Disposition May 2009, 37 (5) 925-931; DOI: https://doi.org/10.1124/dmd.108.025718

Short Communication

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    Generation of the Human Metabolite Piceatannol from the Anticancer-Preventive Agent Resveratrol by Bacterial Cytochrome P450 BM3
    Dong-Hyun Kim, Taeho Ahn, Heung-Chae Jung, Jae-Gu Pan and Chul-Ho Yun
    Drug Metabolism and Disposition May 2009, 37 (5) 932-936; DOI: https://doi.org/10.1124/dmd.108.026484

Articles

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    Application of Stable Isotope Methodology in the Evaluation of the Pharmacokinetics of (S,S)-3-[3-(Methylsulfonyl)phenyl]-1-propylpiperidine Hydrochloride in Rats
    Shinji Yamazaki, Lisa N. Toth, Emi Kimoto, Janice Bower, Judith Skaptason, David Romero and Timothy G. Heath
    Drug Metabolism and Disposition May 2009, 37 (5) 937-945; DOI: https://doi.org/10.1124/dmd.108.025478
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    The Effect of Breast Cancer Resistance Protein and P-Glycoprotein on the Brain Penetration of Flavopiridol, Imatinib Mesylate (Gleevec), Prazosin, and 2-Methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic Acid (PF-407288) in Mice
    Lin Zhou, Kari Schmidt, Frederick R. Nelson, Veronica Zelesky, Matthew D. Troutman and Bo Feng
    Drug Metabolism and Disposition May 2009, 37 (5) 946-955; DOI: https://doi.org/10.1124/dmd.108.024489
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    Different Inhibitory Effects in Rat and Human Carboxylesterases
    Shiori Takahashi, Miki Katoh, Takashi Saitoh, Miki Nakajima and Tsuyoshi Yokoi
    Drug Metabolism and Disposition May 2009, 37 (5) 956-961; DOI: https://doi.org/10.1124/dmd.108.024331
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    Transplacental Pharmacokinetics of Diclofenac in Perfused Human Placenta
    Kyohei Shintaku, Satoko Hori, Masayuki Tsujimoto, Hideaki Nagata, Shoji Satoh, Kiyomi Tsukimori, Hitoo Nakano, Tomoyuki Fujii, Yuji Taketani, Hisakazu Ohtani and Yasufumi Sawada
    Drug Metabolism and Disposition May 2009, 37 (5) 962-968; DOI: https://doi.org/10.1124/dmd.108.024349
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    Characterization of Sandwich-Cultured Hepatocytes As an in Vitro Model to Assess the Hepatobiliary Disposition of Copper
    John H. Ansede, Matthew R. Wright, Robert L. St. Claire, Robert W. Hart, Holly A. Gefroh and Kenneth R. Brouwer
    Drug Metabolism and Disposition May 2009, 37 (5) 969-976; DOI: https://doi.org/10.1124/dmd.108.024638
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    A Bioinformatics Approach for the Phenotype Prediction of Nonsynonymous Single Nucleotide Polymorphisms in Human Cytochromes P450
    Lin-Lin Wang, Yong Li and Shu-Feng Zhou
    Drug Metabolism and Disposition May 2009, 37 (5) 977-991; DOI: https://doi.org/10.1124/dmd.108.026047
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    Characterization of Human Corneal Epithelial Cell Model As a Surrogate for Corneal Permeability Assessment: Metabolism and Transport
    Cathie D. Xiang, Minerva Batugo, David C. Gale, Tao Zhang, Jingjing Ye, Chunze Li, Sue Zhou, Ellen Y. Wu and Eric Y. Zhang
    Drug Metabolism and Disposition May 2009, 37 (5) 992-998; DOI: https://doi.org/10.1124/dmd.108.026286
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    Utility of MetaSite in Improving Metabolic Stability of the Neutral Indomethacin Amide Derivative and Selective Cyclooxygenase-2 Inhibitor 2-(1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl)-N-phenethyl-acetamide
    David Boyer, Jonathan N. Bauman, Daniel P. Walker, Brendon Kapinos, Kapil Karki and Amit S. Kalgutkar
    Drug Metabolism and Disposition May 2009, 37 (5) 999-1008; DOI: https://doi.org/10.1124/dmd.108.026112
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    Carnitine/Organic Cation Transporter OCTN2 (Slc22a5) Is Responsible for Renal Secretion of Cephaloridine in Mice
    Takashi Kano, Yukio Kato, Kimihiro Ito, Takuo Ogihara, Yoshiyuki Kubo and Akira Tsuji
    Drug Metabolism and Disposition May 2009, 37 (5) 1009-1016; DOI: https://doi.org/10.1124/dmd.108.025015
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    A Predominate Role of CYP1A2 for the Metabolism of Nabumetone to the Active Metabolite, 6-Methoxy-2-naphthylacetic Acid, in Human Liver Microsomes
    Miia Turpeinen, Ute Hofmann, Kathrin Klein, Thomas Mürdter, Matthias Schwab and Ulrich M. Zanger
    Drug Metabolism and Disposition May 2009, 37 (5) 1017-1024; DOI: https://doi.org/10.1124/dmd.108.025700
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    Evaluation of Recombinant Cytochrome P450 Enzymes as an in Vitro System for Metabolic Clearance Predictions
    Rowan A. Stringer, Claire Strain-Damerell, Paul Nicklin and J. Brian Houston
    Drug Metabolism and Disposition May 2009, 37 (5) 1025-1034; DOI: https://doi.org/10.1124/dmd.108.024810
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    Constitutive Androstane Receptor-Mediated Changes in Bile Acid Composition Contributes to Hepatoprotection from Lithocholic Acid-Induced Liver Injury in Mice
    Lisa D. Beilke, Lauren M. Aleksunes, Ricky D. Holland, David G. Besselsen, Rick D. Beger, Curtis D. Klaassen and Nathan J. Cherrington
    Drug Metabolism and Disposition May 2009, 37 (5) 1035-1045; DOI: https://doi.org/10.1124/dmd.108.023317
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    In Vitro Metabolism of Rivaroxaban, an Oral, Direct Factor Xa Inhibitor, in Liver Microsomes and Hepatocytes of Rats, Dogs, and Humans
    D. Lang, C. Freudenberger and C. Weinz
    Drug Metabolism and Disposition May 2009, 37 (5) 1046-1055; DOI: https://doi.org/10.1124/dmd.108.025551
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    Metabolism and Excretion of Rivaroxaban, an Oral, Direct Factor Xa Inhibitor, in Rats, Dogs, and Humans
    C. Weinz, T. Schwarz, D. Kubitza, W. Mueck and D. Lang
    Drug Metabolism and Disposition May 2009, 37 (5) 1056-1064; DOI: https://doi.org/10.1124/dmd.108.025569
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    Structure-Activity Relationships for Hydroxylated Polychlorinated Biphenyls as Substrates and Inhibitors of Rat Sulfotransferases and Modification of These Relationships by Changes in Thiol Status
    Yungang Liu, Jason T. Smart, Yang Song, Hans-Joachim Lehmler, Larry W. Robertson and Michael W. Duffel
    Drug Metabolism and Disposition May 2009, 37 (5) 1065-1072; DOI: https://doi.org/10.1124/dmd.108.026021
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    Covalent Binding of Phenylacetic Acid to Protein in Incubations with Freshly Isolated Rat Hepatocytes
    Mark P. Grillo and Michelle Tadano Lohr
    Drug Metabolism and Disposition May 2009, 37 (5) 1073-1082; DOI: https://doi.org/10.1124/dmd.108.026153
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    Dimerization Is Responsible for the Structural Stability of Human Sulfotransferase 1A1
    Lu-Yi Lu, Han-Ping Chiang, Wei-Ti Chen and Yuh-Shyong Yang
    Drug Metabolism and Disposition May 2009, 37 (5) 1083-1088; DOI: https://doi.org/10.1124/dmd.108.025395
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    Identification of [14C]Fluasterone Metabolites in Urine and Feces Collected from Dogs after Subcutaneous and Oral Administration of [14C]Fluasterone
    Jason P. Burgess, Jonathan S. Green, Judith M. Hill, Qiao Zhan, Matthew Lindeblad, Alexander Lyubimov, Izet M. Kapetanovic, Arthur Schwartz and Brian F. Thomas
    Drug Metabolism and Disposition May 2009, 37 (5) 1089-1097; DOI: https://doi.org/10.1124/dmd.108.023614
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    Nuclear Translocation of Adenoviral-Enhanced Yellow Fluorescent Protein-Tagged-Human Constitutive Androstane Receptor (hCAR): A Novel Tool for Screening hCAR Activators in Human Primary Hepatocytes
    Haishan Li, Tao Chen, John Cottrell and Hongbing Wang
    Drug Metabolism and Disposition May 2009, 37 (5) 1098-1106; DOI: https://doi.org/10.1124/dmd.108.026005
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    Two Nonsynonymous Single Nucleotide Polymorphisms of Human Carbonyl Reductase 1 Demonstrate Reduced in Vitro Metabolism of Daunorubicin and Doxorubicin
    Onkar S. Bains, Morgan J. Karkling, Thomas A. Grigliatti, Ronald E. Reid and K. Wayne Riggs
    Drug Metabolism and Disposition May 2009, 37 (5) 1107-1114; DOI: https://doi.org/10.1124/dmd.108.024711
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    Metabolism and Excretion of an Oral Taxane Analog, [14C]3′-tert-Butyl-3′-N-tert-butyloxycarbonyl-4-deacetyl-3′-dephenyl-3′-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in Rats and Dogs
    Van T. Ly, Janet Caceres-Cortes, Donglu Zhang, W. Griffith Humphreys, Ihoezo V. Ekhato, Donald Everett and S. Nilgün Çömezoğlu
    Drug Metabolism and Disposition May 2009, 37 (5) 1115-1128; DOI: https://doi.org/10.1124/dmd.108.025809
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    Human Platelets Express Organic Anion-Transporting Peptide 2B1, an Uptake Transporter for Atorvastatin
    Juliane Niessen, Gabriele Jedlitschky, Markus Grube, Sandra Bien, Hansjörg Schwertz, Sumio Ohtsuki, Hirotaka Kawakami, Junichi Kamiie, Stefan Oswald, Katharina Starke, Ulrike Strobel, Werner Siegmund, Dieter Rosskopf, Andreas Greinacher, Tetsuya Terasaki and Heyo K. Kroemer
    Drug Metabolism and Disposition May 2009, 37 (5) 1129-1137; DOI: https://doi.org/10.1124/dmd.108.024570
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    Inducibility of Drug-Metabolizing Enzymes by Xenobiotics in Mice with Liver-Specific Knockout of Ctnnb1
    Albert Braeuning, Riccardo Sanna, Joerg Huelsken and Michael Schwarz
    Drug Metabolism and Disposition May 2009, 37 (5) 1138-1145; DOI: https://doi.org/10.1124/dmd.108.026179
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Drug Metabolism and Disposition: 37 (5)
Drug Metabolism and Disposition
Vol. 37, Issue 5
1 May 2009
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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