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Research ArticleArticle

A Predominate Role of CYP1A2 for the Metabolism of Nabumetone to the Active Metabolite, 6-Methoxy-2-naphthylacetic Acid, in Human Liver Microsomes

Miia Turpeinen, Ute Hofmann, Kathrin Klein, Thomas Mürdter, Matthias Schwab and Ulrich M. Zanger
Drug Metabolism and Disposition May 2009, 37 (5) 1017-1024; DOI: https://doi.org/10.1124/dmd.108.025700

Article Information

vol. 37 no. 5 1017-1024
DOI 
https://doi.org/10.1124/dmd.108.025700
PubMed 
19204080
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 17, 2008
  • Accepted February 5, 2009
  • Published online April 17, 2009.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Miia Turpeinen,
  2. Ute Hofmann,
  3. Kathrin Klein,
  4. Thomas Mürdter,
  5. Matthias Schwab and
  6. Ulrich M. Zanger
  1. Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Stuttgart, Germany (M.T., U.H., K.K., T.M., M.S., U.M.Z.); Department of Clinical Pharmacology, University Hospital Tuebingen, Tuebingen, Germany (M.S.); and Department of Pharmacology and Toxicology, University of Oulu, Oulu, Finland (M.T.)
  1. Address correspondence to:
    Miia Turpeinen, Dr. Margarete Fischer-Bosch Institute of Clinical Pharmacology, Auerbachstrasse 112, D-70376 Stuttgart, Germany. E-mail: miia.turpeinen{at}ikp-stuttgart.de
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Research ArticleArticle

A Predominate Role of CYP1A2 for the Metabolism of Nabumetone to the Active Metabolite, 6-Methoxy-2-naphthylacetic Acid, in Human Liver Microsomes

Miia Turpeinen, Ute Hofmann, Kathrin Klein, Thomas Mürdter, Matthias Schwab and Ulrich M. Zanger
Drug Metabolism and Disposition May 1, 2009, 37 (5) 1017-1024; DOI: https://doi.org/10.1124/dmd.108.025700
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