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Research ArticleArticle

Metabolism and Excretion of an Oral Taxane Analog, [14C]3′-tert-Butyl-3′-N-tert-butyloxycarbonyl-4-deacetyl-3′-dephenyl-3′-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in Rats and Dogs

Van T. Ly, Janet Caceres-Cortes, Donglu Zhang, W. Griffith Humphreys, Ihoezo V. Ekhato, Donald Everett and S. Nilgün Çömezoğlu
Drug Metabolism and Disposition May 2009, 37 (5) 1115-1128; DOI: https://doi.org/10.1124/dmd.108.025809

Article Information

vol. 37 no. 5 1115-1128
DOI 
https://doi.org/10.1124/dmd.108.025809
PubMed 
19196843
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received November 24, 2008
  • Accepted February 4, 2009
  • Published online April 17, 2009.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Van T. Ly,
  2. Janet Caceres-Cortes,
  3. Donglu Zhang,
  4. W. Griffith Humphreys,
  5. Ihoezo V. Ekhato,
  6. Donald Everett and
  7. S. Nilgün Çömezoğlu
  1. Departments of Biotransformation (V.T.L., D.Z., W.G.H., D.E., S.N.C.), Bioanalytical and Discovery Sciences (J.C.C.), and Chemical Synthesis (I.V.E.), Bristol-Myers Squibb Research and Development, Princeton, New Jersey
  1. Address correspondence to:
    Dr. S. Nilgün Çömezoğlu, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb, Research and Development, P.O. Box 4000, Princeton, NJ 08543. E-mail: s.nilgun.comezoglu{at}bms.com
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Research ArticleArticle

Metabolism and Excretion of an Oral Taxane Analog, [14C]3′-tert-Butyl-3′-N-tert-butyloxycarbonyl-4-deacetyl-3′-dephenyl-3′-N-debenzoyl-4-O-methoxy-paclitaxel (BMS-275183), in Rats and Dogs

Van T. Ly, Janet Caceres-Cortes, Donglu Zhang, W. Griffith Humphreys, Ihoezo V. Ekhato, Donald Everett and S. Nilgün Çömezoğlu
Drug Metabolism and Disposition May 1, 2009, 37 (5) 1115-1128; DOI: https://doi.org/10.1124/dmd.108.025809
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