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Research ArticleArticle

The Effect of Breast Cancer Resistance Protein and P-Glycoprotein on the Brain Penetration of Flavopiridol, Imatinib Mesylate (Gleevec), Prazosin, and 2-Methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic Acid (PF-407288) in Mice

Lin Zhou, Kari Schmidt, Frederick R. Nelson, Veronica Zelesky, Matthew D. Troutman and Bo Feng
Drug Metabolism and Disposition May 2009, 37 (5) 946-955; DOI: https://doi.org/10.1124/dmd.108.024489

Article Information

vol. 37 no. 5 946-955
DOI 
https://doi.org/10.1124/dmd.108.024489
PubMed 
19225039
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 9, 2008
  • Accepted February 12, 2009
  • Published online April 17, 2009.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Lin Zhou,
  2. Kari Schmidt,
  3. Frederick R. Nelson,
  4. Veronica Zelesky,
  5. Matthew D. Troutman and
  6. Bo Feng
  1. Department of Pharmaceutics, University of Washington, Seattle, Washington (L.Z.); and Department of Pharmacokinetics, Dynamics, and Drug Metabolism, Pfizer Global Research and Development, Groton, Connecticut (K.S., F.R.N., V.Z., M.D.T., B.F.)
  1. Address correspondence to:
    Dr. Bo Feng, Pfizer Inc., Eastern Point Road, MS 8118W-131, Groton, CT 06340. E-mail: bo.feng2{at}pfizer.com
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Research ArticleArticle

The Effect of Breast Cancer Resistance Protein and P-Glycoprotein on the Brain Penetration of Flavopiridol, Imatinib Mesylate (Gleevec), Prazosin, and 2-Methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic Acid (PF-407288) in Mice

Lin Zhou, Kari Schmidt, Frederick R. Nelson, Veronica Zelesky, Matthew D. Troutman and Bo Feng
Drug Metabolism and Disposition May 1, 2009, 37 (5) 946-955; DOI: https://doi.org/10.1124/dmd.108.024489
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