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Research ArticleArticle

Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection

Santosh Kumar, Huan Qiu, Numan Oezguen, Holger Herlyn, James R. Halpert and Leszek Wojnowski
Drug Metabolism and Disposition June 2009, 37 (6) 1328-1333; DOI: https://doi.org/10.1124/dmd.108.024372
Santosh Kumar
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Huan Qiu
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Numan Oezguen
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Holger Herlyn
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James R. Halpert
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Leszek Wojnowski
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Article Information

vol. 37 no. 6 1328-1333
DOI 
https://doi.org/10.1124/dmd.108.024372
PubMed 
19299527

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Received September 3, 2008
  • Accepted March 16, 2009
  • Published online May 15, 2009.

Article Versions

  • Earlier version (March 19, 2009 - 09:52).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Santosh Kumar,
  2. Huan Qiu,
  3. Numan Oezguen,
  4. Holger Herlyn,
  5. James R. Halpert and
  6. Leszek Wojnowski
  1. Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California-San Diego, La Jolla, California (S.K., J.R.H.); Division of Pharmacology and Toxicology, School of Pharmacy, University of Missouri-Kansas City, Kansas City, Missouri (S.K.); Department of Pharmacology, Johannes Gutenberg University Mainz, Mainz, Germany (H.Q., L.W.); Department of Biochemistry and Molecular Biology and the Sealy Center for Structural Biology and Molecular Biophysics, University of Texas Medical Branch, Galveston, Texas (N.O.); and Institute of Anthropology, Johannes Gutenberg University Mainz, Mainz, Germany (H.H.)
  1. Address correspondence to:
    Dr. Leszek Wojnowski, Department of Pharmacology, Johannes Gutenberg University Mainz, Obere Zahlbacher Str. 67, D-55101 Mainz, Germany. E-mail: wojnowski{at}uni-mainz.de
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Drug Metabolism and Disposition: 37 (6)
Drug Metabolism and Disposition
Vol. 37, Issue 6
1 Jun 2009
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Research ArticleArticle

Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection

Santosh Kumar, Huan Qiu, Numan Oezguen, Holger Herlyn, James R. Halpert and Leszek Wojnowski
Drug Metabolism and Disposition June 1, 2009, 37 (6) 1328-1333; DOI: https://doi.org/10.1124/dmd.108.024372

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Research ArticleArticle

Ligand Diversity of Human and Chimpanzee CYP3A4: Activation of Human CYP3A4 by Lithocholic Acid Results from Positive Selection

Santosh Kumar, Huan Qiu, Numan Oezguen, Holger Herlyn, James R. Halpert and Leszek Wojnowski
Drug Metabolism and Disposition June 1, 2009, 37 (6) 1328-1333; DOI: https://doi.org/10.1124/dmd.108.024372
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