Drug Metabolism and Disposition: 37 (7)

July 01, 2009; Volume 37,Issue 7

Perspectives

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In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec

Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
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The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach

Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

Short Communications

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The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride
Joachim Geyer, Olga Gavrilova and Ernst Petzinger

Drug Metabolism and Disposition July 2009, 37 (7) 1371-1374; DOI: https://doi.org/10.1124/dmd.109.027144
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Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki

Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

Articles

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In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni

Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742
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Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners

Drug Metabolism and Disposition July 2009, 37 (7) 1395-1403; DOI: https://doi.org/10.1124/dmd.109.027656
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The Drug of Abuse γ-Hydroxybutyrate Is a Substrate for Sodium-Coupled Monocarboxylate Transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-Mediated Uptake and Inhibition
Dapeng Cui and Marilyn E. Morris

Drug Metabolism and Disposition July 2009, 37 (7) 1404-1410; DOI: https://doi.org/10.1124/dmd.109.027169
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Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole

Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633
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Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus

Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039
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Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura

Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385
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Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra

Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229
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Evaluation of in Vitro Models for Screening Alkaline Phosphatase-Mediated Bioconversion of Phosphate Ester Prodrugs
Haodan Yuan, Na Li and Yurong Lai

Drug Metabolism and Disposition July 2009, 37 (7) 1443-1447; DOI: https://doi.org/10.1124/dmd.108.026245
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Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre

Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
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Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri

Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
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Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin

Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368
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Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama

Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062
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Biotransformation of an α₄β₂ Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell

Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037
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Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
Simone Helmig, Bahar Hadzaad, Juliane Döhrel and Joachim Schneider

Drug Metabolism and Disposition July 2009, 37 (7) 1490-1495; DOI: https://doi.org/10.1124/dmd.109.027060
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Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran

Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
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Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg

Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963
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Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi

Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567
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Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
Takafumi Nakano, Shuichi Sekine, Kousei Ito and Toshiharu Horie

Drug Metabolism and Disposition July 2009, 37 (7) 1521-1527; DOI: https://doi.org/10.1124/dmd.108.024836
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Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot

Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
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Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor
Chenshu Xu, Xinkun Wang and Jeff L. Staudinger

Drug Metabolism and Disposition July 2009, 37 (7) 1539-1547; DOI: https://doi.org/10.1124/dmd.109.026989
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Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert

Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674

Accelerated Communication

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Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
Bo Wen, Yuan Chen and William L. Fitch

Drug Metabolism and Disposition July 2009, 37 (7) 1557-1562; DOI: https://doi.org/10.1124/dmd.108.024851

Erratum

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CORRECTION TO “CYTOCHROME P450 EXPRESSION AND REGULATION IN CYP3A4/CYP2D6 DOUBLE TRANSGENIC HUMANIZED MICE”
Drug Metabolism and Disposition July 2009, 37 (7) 1563; DOI: https://doi.org/10.1124/dmd.37.7.1563

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