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Drug Metabolism & Disposition

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    • Current Issue
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Index by author

July 01, 2009; Volume 37,Issue 7
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Y
  • Z

A

  1. Akiyama, Y.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  2. Almeida, Bruno

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  3. Ando, Y.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  4. Anraku, Makoto

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
  5. Aoki, Yasuhiro

    1. You have access
      Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567
  6. Apparsundaram, Subbu

    1. You have access
      Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674
  7. Araki, K.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

B

  1. Baldwin, R. Michael

    1. You have access
      Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963
  2. Beaune, Philippe

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  3. Bièche, Ivan

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  4. Blomgren, Anders L.

    1. You have access
      Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039
  5. Bratton, Stacie M.

    1. You have access
      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

C

  1. Calle, Ángela P.

    1. You have access
      Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229
  2. Carlerös, Margareta

    1. You have access
      Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963
  3. Chen, Yuan

    1. You have access
      Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
      Bo Wen, Yuan Chen and William L. Fitch
      Drug Metabolism and Disposition July 2009, 37 (7) 1557-1562; DOI: https://doi.org/10.1124/dmd.108.024851
  4. Chu, Valeria

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
  5. Cloarec, Olivier

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  6. Cole, Susan P. C.

    1. You have access
      Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633
  7. Conseil, Gwenaëlle

    1. You have access
      Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633
  8. Cui, Dapeng

    1. You have access
      The Drug of Abuse γ-Hydroxybutyrate Is a Substrate for Sodium-Coupled Monocarboxylate Transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-Mediated Uptake and Inhibition
      Dapeng Cui and Marilyn E. Morris
      Drug Metabolism and Disposition July 2009, 37 (7) 1404-1410; DOI: https://doi.org/10.1124/dmd.109.027169
  9. Cuyàs, Elisabet

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

D

  1. Dauchy, Sandrine

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  2. Declèves, Xavier

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  3. Deeley, Roger G.

    1. You have access
      Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633
  4. de la Torre, Rafael

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  5. de Waziers, Isabelle

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  6. Diez, M. José

    1. You have access
      Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229
  7. Diry, Monique

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  8. Döhrel, Juliane

    1. You have access
      Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
      Simone Helmig, Bahar Hadzaad, Juliane Döhrel and Joachim Schneider
      Drug Metabolism and Disposition July 2009, 37 (7) 1490-1495; DOI: https://doi.org/10.1124/dmd.109.027060
  9. Dutheil, Fabien

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  10. Duyckaerts, Charles

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

E

  1. Edsbaecker, Staffan

    1. You have access
      Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039
  2. Einolf, Heidi J.

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
    2. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  3. Ekholm, Kjell

    1. You have access
      Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039
  4. Endo, H.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  5. Evers, Raymond

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029

F

  1. Farré, Magí

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  2. Fernández, Nélida

    1. You have access
      Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229
  3. Finel, Moshe

    1. You have access
      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
  4. Fitch, William L.

    1. You have access
      Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
      Bo Wen, Yuan Chen and William L. Fitch
      Drug Metabolism and Disposition July 2009, 37 (7) 1557-1562; DOI: https://doi.org/10.1124/dmd.108.024851
  5. Flinois, Jean-Pierre

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  6. Fransson-Steen, Ronny

    1. You have access
      Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963
  7. Fujita, K.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  8. Fukami, Tatsuki

    1. You have access
      Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567

G

  1. Gallus-Zawada, Anna

    1. You have access
      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
  2. García, Juan J.

    1. You have access
      Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229
  3. Gavrilova, Olga

    1. You have access
      The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride
      Joachim Geyer, Olga Gavrilova and Ernst Petzinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1371-1374; DOI: https://doi.org/10.1124/dmd.109.027144
  4. Geyer, Joachim

    1. You have access
      The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride
      Joachim Geyer, Olga Gavrilova and Ernst Petzinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1371-1374; DOI: https://doi.org/10.1124/dmd.109.027144
  5. Grimm, Scott W.

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

H

  1. Hadzaad, Bahar

    1. You have access
      Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
      Simone Helmig, Bahar Hadzaad, Juliane Döhrel and Joachim Schneider
      Drug Metabolism and Disposition July 2009, 37 (7) 1490-1495; DOI: https://doi.org/10.1124/dmd.109.027060
  2. Hall, Steven D.

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  3. Hayashi, Mike

    1. You have access
      In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742
  4. He, Kan

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  5. Helmig, Simone

    1. You have access
      Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
      Simone Helmig, Bahar Hadzaad, Juliane Döhrel and Joachim Schneider
      Drug Metabolism and Disposition July 2009, 37 (7) 1490-1495; DOI: https://doi.org/10.1124/dmd.109.027060
  6. Henne, Ilana K.

    1. You have access
      Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037
  7. Hickman, Dean

    1. You have access
      In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742
  8. Hirose, T.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  9. Hochhaus, Günther

    1. You have access
      Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039
  10. Horie, Toshiharu

    1. You have access
      Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
      Takafumi Nakano, Shuichi Sekine, Kousei Ito and Toshiharu Horie
      Drug Metabolism and Disposition July 2009, 37 (7) 1521-1527; DOI: https://doi.org/10.1124/dmd.108.024836
  11. Horinouchi, Hirohisa

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
  12. Horita, Shigeru

    1. You have access
      Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062

I

  1. Ichikawa, W.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  2. Ingelman-Sundberg, Magnus

    1. You have access
      Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963
    2. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  3. Ishida, H.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  4. Ito, Kousei

    1. You have access
      Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
      Takafumi Nakano, Shuichi Sekine, Kousei Ito and Toshiharu Horie
      Drug Metabolism and Disposition July 2009, 37 (7) 1521-1527; DOI: https://doi.org/10.1124/dmd.108.024836
  5. Iwatsubo, Takafumi

    1. You have access
      Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385

J

  1. Joglar, Jesús

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  2. Jung, Hyun-Ju

    1. You have access
      Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368

K

  1. Kai, Toshiya

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
  2. Kamimura, Hidetaka

    1. You have access
      Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385
  3. Kawara, K.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  4. Khymenets, Olha

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  5. Kim, Ho-Sook

    1. You have access
      Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368
  6. Knights, Kathleen M.

    1. You have access
      Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
      Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
      Drug Metabolism and Disposition July 2009, 37 (7) 1395-1403; DOI: https://doi.org/10.1124/dmd.109.027656
  7. Kobayashi, Koichi

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
  8. Kondo, Tsunenori

    1. You have access
      Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062
  9. Kuchimanchi, Mita

    1. You have access
      In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742
  10. Kumar, Gondi

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
    2. You have access
      In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742
  11. Kusuhara, Hiroyuki

    1. You have access
      Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062
  12. Kwan, Joyce

    1. You have access
      Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674

L

  1. Lai, Yurong

    1. You have access
      Evaluation of in Vitro Models for Screening Alkaline Phosphatase-Mediated Bioconversion of Phosphate Ester Prodrugs
      Haodan Yuan, Na Li and Yurong Lai
      Drug Metabolism and Disposition July 2009, 37 (7) 1443-1447; DOI: https://doi.org/10.1124/dmd.108.026245
  2. Lau, Serrine S.

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  3. Lee, Sang Seop

    1. You have access
      Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368
  4. Lee, Su-Jun

    1. You have access
      Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368
  5. Li, Chun

    1. You have access
      In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742
  6. Li, Na

    1. You have access
      Evaluation of in Vitro Models for Screening Alkaline Phosphatase-Mediated Bioconversion of Phosphate Ester Prodrugs
      Haodan Yuan, Na Li and Yurong Lai
      Drug Metabolism and Disposition July 2009, 37 (7) 1443-1447; DOI: https://doi.org/10.1124/dmd.108.026245
  7. Lichti, Cheryl F.

    1. You have access
      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
  8. Lim, Heng-Keang

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  9. Ling, Kah-Hiing John

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  10. Liu, Xingrong

    1. You have access
      Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674
  11. Löfgren, Susanne

    1. You have access
      Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963
  12. Loriot, Marie-Anne

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  13. Lu, Chuang

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

M

  1. Mackenzie, Peter I.

    1. You have access
      Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
      Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
      Drug Metabolism and Disposition July 2009, 37 (7) 1395-1403; DOI: https://doi.org/10.1124/dmd.109.027656
  2. Maeda, Kazuya

    1. You have access
      Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062
  3. Maeno, Kazuma

    1. You have access
      Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633
  4. Maruyama, Toru

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
  5. Mazur, Anna

    1. You have access
      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
  6. Mellottée, Lucille

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  7. Miller, Grover P.

    1. You have access
      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
  8. Miners, John O.

    1. You have access
      Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
      Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
      Drug Metabolism and Disposition July 2009, 37 (7) 1395-1403; DOI: https://doi.org/10.1124/dmd.109.027656
  9. Miwa, K.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  10. Miya, T.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  11. Mizuno, K.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  12. Monks, Terrence J.

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  13. Moore, David

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
  14. Moran, Jeffery H.

    1. You have access
      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
  15. Morris, Marilyn E.

    1. You have access
      The Drug of Abuse γ-Hydroxybutyrate Is a Substrate for Sodium-Coupled Monocarboxylate Transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-Mediated Uptake and Inhibition
      Dapeng Cui and Marilyn E. Morris
      Drug Metabolism and Disposition July 2009, 37 (7) 1404-1410; DOI: https://doi.org/10.1124/dmd.109.027169
  16. Mwinyi, Jessica

    1. You have access
      Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963

N

  1. Nagashima, F.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  2. Nakajima, Akio

    1. You have access
      Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633
  3. Nakajima, Miki

    1. You have access
      Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567
  4. Nakano, Takafumi

    1. You have access
      Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
      Takafumi Nakano, Shuichi Sekine, Kousei Ito and Toshiharu Horie
      Drug Metabolism and Disposition July 2009, 37 (7) 1521-1527; DOI: https://doi.org/10.1124/dmd.108.024836
  5. Nakayama, H.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  6. Nakayama, Hideki

    1. You have access
      Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062
  7. Narabayashi, M.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  8. Noguchi, Kiyoshi

    1. You have access
      Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385
  9. Nomeir, Amin A.

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

O

  1. O'Connell, Thomas N.

    1. You have access
      Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037
  2. O'Mathúna, Brian

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  3. Obach, R. Scott

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  4. Otagiri, Masaki

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

P

  1. Park, Soo-Jin

    1. You have access
      Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368
  2. Pascual, Jose Antonio

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  3. Pellegrini, Manuela

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  4. Perfetti, Ximena

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  5. Petzinger, Ernst

    1. You have access
      The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride
      Joachim Geyer, Olga Gavrilova and Ernst Petzinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1371-1374; DOI: https://doi.org/10.1124/dmd.109.027144
  6. Pichini, Simona

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  7. Pizarro, Nieves

    1. You have access
      Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393
  8. Poppe, Leszek

    1. You have access
      In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742
  9. Prather, Paul L.

    1. You have access
      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

R

  1. Radomińska-Pandya, Anna

    1. You have access
      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
  2. Ripp, Sharon

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
  3. Rothnie, Alice

    1. You have access
      Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633
  4. Rowland, Andrew

    1. You have access
      Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
      Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
      Drug Metabolism and Disposition July 2009, 37 (7) 1395-1403; DOI: https://doi.org/10.1124/dmd.109.027656
  5. Ryder, Tim F.

    1. You have access
      Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037

S

  1. Sahagún, Ana

    1. You have access
      Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229
  2. Sakai, Hiromi

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
  3. Sasaki, Y.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  4. Sazdovitch, Véronique

    1. You have access
      Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011
  5. Schneider, Joachim

    1. You have access
      Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
      Simone Helmig, Bahar Hadzaad, Juliane Döhrel and Joachim Schneider
      Drug Metabolism and Disposition July 2009, 37 (7) 1490-1495; DOI: https://doi.org/10.1124/dmd.109.027060
  6. Seibert, Eleanore

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  7. Sekine, Shuichi

    1. You have access
      Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
      Takafumi Nakano, Shuichi Sekine, Kousei Ito and Toshiharu Horie
      Drug Metabolism and Disposition July 2009, 37 (7) 1521-1527; DOI: https://doi.org/10.1124/dmd.108.024836
  8. Shaffer, Christopher L.

    1. You have access
      Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037
  9. Shin, Jae-Gook

    1. You have access
      Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368
  10. Sierra, Matilde

    1. You have access
      Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229
  11. Silva, Jose

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
  12. Sinha, Vikram

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
  13. Sinz, Michael

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
  14. Skerjanec, Andrej

    1. You have access
      In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
  15. Skordos, Konstantine W.

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  16. Staudinger, Jeff L.

    1. You have access
      Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor
      Chenshu Xu, Xinkun Wang and Jeff L. Staudinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1539-1547; DOI: https://doi.org/10.1124/dmd.109.026989
  17. Subramanian, Raju

    1. You have access
      In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742
  18. Sugiyama, Yuichi

    1. You have access
      Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062
  19. Sunakawa, Y.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  20. Surapaneni, Sekhar

    1. You have access
      In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

T

  1. Taguchi, Kazuaki

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
  2. Takamiya, Masataka

    1. You have access
      Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567
  3. Tanaka, R.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  4. Terelius, Ylva

    1. You have access
      Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963
  5. Tonn, George R.

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  6. Tsuchida, Eishun

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

U

  1. Umehara, Ken-ichi

    1. You have access
      Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385
  2. Urata, Yukino

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
  3. Usui, Takashi

    1. You have access
      Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385

V

  1. Van Horn, Robert

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  2. Venkatakrishnan, Karthik

    1. You have access
      Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037
  3. Vilenski, Olga

    1. You have access
      Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674

W

  1. Wada, Kouichi

    1. You have access
      Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385
  2. Wang, Regina W.

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  3. Wang, Xinkun

    1. You have access
      Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor
      Chenshu Xu, Xinkun Wang and Jeff L. Staudinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1539-1547; DOI: https://doi.org/10.1124/dmd.109.026989
  4. Watanabe, Akinobu

    1. You have access
      Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567
  5. Watanabe, Hiroshi

    1. You have access
      Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094
  6. Watanabe, Tomoko

    1. You have access
      Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062
  7. Waxman, David J.

    1. You have access
      Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963
  8. Weber, Benjamin

    1. You have access
      Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039
  9. Weikert, Robert

    1. You have access
      Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674
  10. Wen, Bo

    1. You have access
      Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
      Bo Wen, Yuan Chen and William L. Fitch
      Drug Metabolism and Disposition July 2009, 37 (7) 1557-1562; DOI: https://doi.org/10.1124/dmd.108.024851
  11. Wong, Y. Nancy

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  12. Wu, Kai

    1. You have access
      Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039

X

  1. Xu, Chenshu

    1. You have access
      Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor
      Chenshu Xu, Xinkun Wang and Jeff L. Staudinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1539-1547; DOI: https://doi.org/10.1124/dmd.109.026989

Y

  1. Yamamoto, W.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  2. Yamashita, K.

    1. You have access
      Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052
  3. Yang, Tian J.

    1. You have access
      The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
  4. Yeo, Chang-Woo

    1. You have access
      Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368
  5. Yokoi, Tsuyoshi

    1. You have access
      Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567
  6. Yuan, Haodan

    1. You have access
      Evaluation of in Vitro Models for Screening Alkaline Phosphatase-Mediated Bioconversion of Phosphate Ester Prodrugs
      Haodan Yuan, Na Li and Yurong Lai
      Drug Metabolism and Disposition July 2009, 37 (7) 1443-1447; DOI: https://doi.org/10.1124/dmd.108.026245

Z

  1. Zhou, Yihong

    1. You have access
      In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742
  2. Zielinska, Agnieszka K.

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      Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
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Drug Metabolism and Disposition: 37 (7)
Drug Metabolism and Disposition
Vol. 37, Issue 7
1 Jul 2009
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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