Advertisement

Index by author

July 01, 2009; Volume 37,Issue 7

A

  1. Akiyama, Y.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  2. Almeida, Bruno

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  3. Ando, Y.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  4. Anraku, Makoto

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

  5. Aoki, Yasuhiro

    1. Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567

  6. Apparsundaram, Subbu

    1. Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674

  7. Araki, K.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

B

  1. Baldwin, R. Michael

    1. Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963

  2. Beaune, Philippe

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  3. Bièche, Ivan

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  4. Blomgren, Anders L.

    1. Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039

  5. Bratton, Stacie M.

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

C

  1. Calle, Ángela P.

    1. Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229

  2. Carlerös, Margareta

    1. Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963

  3. Chen, Yuan

    1. Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
      Bo Wen, Yuan Chen and William L. Fitch
      Drug Metabolism and Disposition July 2009, 37 (7) 1557-1562; DOI: https://doi.org/10.1124/dmd.108.024851

  4. Chu, Valeria

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029

  5. Cloarec, Olivier

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  6. Cole, Susan P. C.

    1. Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633

  7. Conseil, Gwenaëlle

    1. Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633

  8. Cui, Dapeng

    1. The Drug of Abuse γ-Hydroxybutyrate Is a Substrate for Sodium-Coupled Monocarboxylate Transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-Mediated Uptake and Inhibition
      Dapeng Cui and Marilyn E. Morris
      Drug Metabolism and Disposition July 2009, 37 (7) 1404-1410; DOI: https://doi.org/10.1124/dmd.109.027169

  9. Cuyàs, Elisabet

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

D

  1. Dauchy, Sandrine

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  2. Declèves, Xavier

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  3. Deeley, Roger G.

    1. Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633

  4. de la Torre, Rafael

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  5. de Waziers, Isabelle

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  6. Diez, M. José

    1. Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229

  7. Diry, Monique

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  8. Döhrel, Juliane

    1. Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
      Simone Helmig, Bahar Hadzaad, Juliane Döhrel and Joachim Schneider
      Drug Metabolism and Disposition July 2009, 37 (7) 1490-1495; DOI: https://doi.org/10.1124/dmd.109.027060

  9. Dutheil, Fabien

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  10. Duyckaerts, Charles

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

E

  1. Edsbaecker, Staffan

    1. Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039

  2. Einolf, Heidi J.

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
    2. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  3. Ekholm, Kjell

    1. Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039

  4. Endo, H.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  5. Evers, Raymond

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029

F

  1. Farré, Magí

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  2. Fernández, Nélida

    1. Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229

  3. Finel, Moshe

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

  4. Fitch, William L.

    1. Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
      Bo Wen, Yuan Chen and William L. Fitch
      Drug Metabolism and Disposition July 2009, 37 (7) 1557-1562; DOI: https://doi.org/10.1124/dmd.108.024851

  5. Flinois, Jean-Pierre

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  6. Fransson-Steen, Ronny

    1. Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963

  7. Fujita, K.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  8. Fukami, Tatsuki

    1. Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567

G

  1. Gallus-Zawada, Anna

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

  2. García, Juan J.

    1. Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229

  3. Gavrilova, Olga

    1. The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride
      Joachim Geyer, Olga Gavrilova and Ernst Petzinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1371-1374; DOI: https://doi.org/10.1124/dmd.109.027144

  4. Geyer, Joachim

    1. The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride
      Joachim Geyer, Olga Gavrilova and Ernst Petzinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1371-1374; DOI: https://doi.org/10.1124/dmd.109.027144

  5. Grimm, Scott W.

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

H

  1. Hadzaad, Bahar

    1. Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
      Simone Helmig, Bahar Hadzaad, Juliane Döhrel and Joachim Schneider
      Drug Metabolism and Disposition July 2009, 37 (7) 1490-1495; DOI: https://doi.org/10.1124/dmd.109.027060

  2. Hall, Steven D.

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  3. Hayashi, Mike

    1. In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

  4. He, Kan

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  5. Helmig, Simone

    1. Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
      Simone Helmig, Bahar Hadzaad, Juliane Döhrel and Joachim Schneider
      Drug Metabolism and Disposition July 2009, 37 (7) 1490-1495; DOI: https://doi.org/10.1124/dmd.109.027060

  6. Henne, Ilana K.

    1. Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037

  7. Hickman, Dean

    1. In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

  8. Hirose, T.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  9. Hochhaus, Günther

    1. Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039

  10. Horie, Toshiharu

    1. Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
      Takafumi Nakano, Shuichi Sekine, Kousei Ito and Toshiharu Horie
      Drug Metabolism and Disposition July 2009, 37 (7) 1521-1527; DOI: https://doi.org/10.1124/dmd.108.024836

  11. Horinouchi, Hirohisa

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

  12. Horita, Shigeru

    1. Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062

I

  1. Ichikawa, W.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  2. Ingelman-Sundberg, Magnus

    1. Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963
    2. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  3. Ishida, H.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  4. Ito, Kousei

    1. Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
      Takafumi Nakano, Shuichi Sekine, Kousei Ito and Toshiharu Horie
      Drug Metabolism and Disposition July 2009, 37 (7) 1521-1527; DOI: https://doi.org/10.1124/dmd.108.024836

  5. Iwatsubo, Takafumi

    1. Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385

J

  1. Joglar, Jesús

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  2. Jung, Hyun-Ju

    1. Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368

K

  1. Kai, Toshiya

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

  2. Kamimura, Hidetaka

    1. Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385

  3. Kawara, K.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  4. Khymenets, Olha

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  5. Kim, Ho-Sook

    1. Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368

  6. Knights, Kathleen M.

    1. Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
      Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
      Drug Metabolism and Disposition July 2009, 37 (7) 1395-1403; DOI: https://doi.org/10.1124/dmd.109.027656

  7. Kobayashi, Koichi

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

  8. Kondo, Tsunenori

    1. Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062

  9. Kuchimanchi, Mita

    1. In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

  10. Kumar, Gondi

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029
    2. In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

  11. Kusuhara, Hiroyuki

    1. Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062

  12. Kwan, Joyce

    1. Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674

L

  1. Lai, Yurong

    1. Evaluation of in Vitro Models for Screening Alkaline Phosphatase-Mediated Bioconversion of Phosphate Ester Prodrugs
      Haodan Yuan, Na Li and Yurong Lai
      Drug Metabolism and Disposition July 2009, 37 (7) 1443-1447; DOI: https://doi.org/10.1124/dmd.108.026245

  2. Lau, Serrine S.

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  3. Lee, Sang Seop

    1. Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368

  4. Lee, Su-Jun

    1. Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368

  5. Li, Chun

    1. In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

  6. Li, Na

    1. Evaluation of in Vitro Models for Screening Alkaline Phosphatase-Mediated Bioconversion of Phosphate Ester Prodrugs
      Haodan Yuan, Na Li and Yurong Lai
      Drug Metabolism and Disposition July 2009, 37 (7) 1443-1447; DOI: https://doi.org/10.1124/dmd.108.026245

  7. Lichti, Cheryl F.

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

  8. Lim, Heng-Keang

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  9. Ling, Kah-Hiing John

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  10. Liu, Xingrong

    1. Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674

  11. Löfgren, Susanne

    1. Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963

  12. Loriot, Marie-Anne

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  13. Lu, Chuang

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

M

  1. Mackenzie, Peter I.

    1. Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
      Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
      Drug Metabolism and Disposition July 2009, 37 (7) 1395-1403; DOI: https://doi.org/10.1124/dmd.109.027656

  2. Maeda, Kazuya

    1. Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062

  3. Maeno, Kazuma

    1. Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633

  4. Maruyama, Toru

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

  5. Mazur, Anna

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

  6. Mellottée, Lucille

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  7. Miller, Grover P.

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

  8. Miners, John O.

    1. Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
      Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
      Drug Metabolism and Disposition July 2009, 37 (7) 1395-1403; DOI: https://doi.org/10.1124/dmd.109.027656

  9. Miwa, K.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  10. Miya, T.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  11. Mizuno, K.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  12. Monks, Terrence J.

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  13. Moore, David

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029

  14. Moran, Jeffery H.

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

  15. Morris, Marilyn E.

    1. The Drug of Abuse γ-Hydroxybutyrate Is a Substrate for Sodium-Coupled Monocarboxylate Transporter (SMCT) 1 (SLC5A8): Characterization of SMCT-Mediated Uptake and Inhibition
      Dapeng Cui and Marilyn E. Morris
      Drug Metabolism and Disposition July 2009, 37 (7) 1404-1410; DOI: https://doi.org/10.1124/dmd.109.027169

  16. Mwinyi, Jessica

    1. Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963

N

  1. Nagashima, F.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  2. Nakajima, Akio

    1. Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633

  3. Nakajima, Miki

    1. Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567

  4. Nakano, Takafumi

    1. Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
      Takafumi Nakano, Shuichi Sekine, Kousei Ito and Toshiharu Horie
      Drug Metabolism and Disposition July 2009, 37 (7) 1521-1527; DOI: https://doi.org/10.1124/dmd.108.024836

  5. Nakayama, H.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  6. Nakayama, Hideki

    1. Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062

  7. Narabayashi, M.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  8. Noguchi, Kiyoshi

    1. Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385

  9. Nomeir, Amin A.

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

O

  1. O'Connell, Thomas N.

    1. Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037

  2. O'Mathúna, Brian

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  3. Obach, R. Scott

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  4. Otagiri, Masaki

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

P

  1. Park, Soo-Jin

    1. Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368

  2. Pascual, Jose Antonio

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  3. Pellegrini, Manuela

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  4. Perfetti, Ximena

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  5. Petzinger, Ernst

    1. The Role of P-Glycoprotein in Limiting Brain Penetration of the Peripherally Acting Anticholinergic Overactive Bladder Drug Trospium Chloride
      Joachim Geyer, Olga Gavrilova and Ernst Petzinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1371-1374; DOI: https://doi.org/10.1124/dmd.109.027144

  6. Pichini, Simona

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  7. Pizarro, Nieves

    1. Neurotoxic Thioether Adducts of 3,4-Methylenedioxymethamphetamine Identified in Human Urine After Ecstasy Ingestion
      Ximena Perfetti, Brian O'Mathúna, Nieves Pizarro, Elisabet Cuyàs, Olha Khymenets, Bruno Almeida, Manuela Pellegrini, Simona Pichini, Serrine S. Lau, Terrence J. Monks, Magí Farré, Jose Antonio Pascual, Jesús Joglar and Rafael de la Torre
      Drug Metabolism and Disposition July 2009, 37 (7) 1448-1455; DOI: https://doi.org/10.1124/dmd.108.026393

  8. Poppe, Leszek

    1. In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

  9. Prather, Paul L.

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

R

  1. Radomińska-Pandya, Anna

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898

  2. Ripp, Sharon

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029

  3. Rothnie, Alice

    1. Molecular Basis for Reduced Estrone Sulfate Transport and Altered Modulator Sensitivity of Transmembrane Helix (TM) 6 and TM17 Mutants of Multidrug Resistance Protein 1 (ABCC1)
      Kazuma Maeno, Akio Nakajima, Gwenaëlle Conseil, Alice Rothnie, Roger G. Deeley and Susan P. C. Cole
      Drug Metabolism and Disposition July 2009, 37 (7) 1411-1420; DOI: https://doi.org/10.1124/dmd.109.026633

  4. Rowland, Andrew

    1. Characterization of the Binding of Drugs to Human Intestinal Fatty Acid Binding Protein (IFABP): Potential Role of IFABP as an Alternative to Albumin for in Vitro-in Vivo Extrapolation of Drug Kinetic Parameters
      Andrew Rowland, Kathleen M. Knights, Peter I. Mackenzie and John O. Miners
      Drug Metabolism and Disposition July 2009, 37 (7) 1395-1403; DOI: https://doi.org/10.1124/dmd.109.027656

  5. Ryder, Tim F.

    1. Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037

S

  1. Sahagún, Ana

    1. Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229

  2. Sakai, Hiromi

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

  3. Sasaki, Y.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  4. Sazdovitch, Véronique

    1. Xenobiotic-Metabolizing Enzymes and Transporters in the Normal Human Brain: Regional and Cellular Mapping as a Basis for Putative Roles in Cerebral Function
      Fabien Dutheil, Sandrine Dauchy, Monique Diry, Véronique Sazdovitch, Olivier Cloarec, Lucille Mellottée, Ivan Bièche, Magnus Ingelman-Sundberg, Jean-Pierre Flinois, Isabelle de Waziers, Philippe Beaune, Xavier Declèves, Charles Duyckaerts and Marie-Anne Loriot
      Drug Metabolism and Disposition July 2009, 37 (7) 1528-1538; DOI: https://doi.org/10.1124/dmd.109.027011

  5. Schneider, Joachim

    1. Influence of the Cyp1B1 L432V Gene Polymorphism and Exposure to Tobacco Smoke on Cyp1B1 mRNA Expression in Human Leukocytes
      Simone Helmig, Bahar Hadzaad, Juliane Döhrel and Joachim Schneider
      Drug Metabolism and Disposition July 2009, 37 (7) 1490-1495; DOI: https://doi.org/10.1124/dmd.109.027060

  6. Seibert, Eleanore

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  7. Sekine, Shuichi

    1. Correlation between Apical Localization of Abcc2/Mrp2 and Phosphorylation Status of Ezrin in Rat Intestine
      Takafumi Nakano, Shuichi Sekine, Kousei Ito and Toshiharu Horie
      Drug Metabolism and Disposition July 2009, 37 (7) 1521-1527; DOI: https://doi.org/10.1124/dmd.108.024836

  8. Shaffer, Christopher L.

    1. Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037

  9. Shin, Jae-Gook

    1. Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368

  10. Sierra, Matilde

    1. Effects of Plantago ovata Husk on Levodopa (with Carbidopa) Bioavailability in Rabbits with Autonomic Gastrointestinal Disorders
      Juan J. García, Nélida Fernández, Ángela P. Calle, M. José Diez, Ana Sahagún and Matilde Sierra
      Drug Metabolism and Disposition July 2009, 37 (7) 1434-1442; DOI: https://doi.org/10.1124/dmd.108.026229

  11. Silva, Jose

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029

  12. Sinha, Vikram

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029

  13. Sinz, Michael

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029

  14. Skerjanec, Andrej

    1. In Vitro and in Vivo Induction of Cytochrome P450: A Survey of the Current Practices and Recommendations: A Pharmaceutical Research and Manufacturers of America Perspective
      Valeria Chu, Heidi J. Einolf, Raymond Evers, Gondi Kumar, David Moore, Sharon Ripp, Jose Silva, Vikram Sinha, Michael Sinz and Andrej Skerjanec
      Drug Metabolism and Disposition July 2009, 37 (7) 1339-1354; DOI: https://doi.org/10.1124/dmd.109.027029

  15. Skordos, Konstantine W.

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  16. Staudinger, Jeff L.

    1. Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor
      Chenshu Xu, Xinkun Wang and Jeff L. Staudinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1539-1547; DOI: https://doi.org/10.1124/dmd.109.026989

  17. Subramanian, Raju

    1. In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

  18. Sugiyama, Yuichi

    1. Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062

  19. Sunakawa, Y.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  20. Surapaneni, Sekhar

    1. In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

T

  1. Taguchi, Kazuaki

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

  2. Takamiya, Masataka

    1. Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567

  3. Tanaka, R.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  4. Terelius, Ylva

    1. Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963

  5. Tonn, George R.

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  6. Tsuchida, Eishun

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

U

  1. Umehara, Ken-ichi

    1. Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385

  2. Urata, Yukino

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

  3. Usui, Takashi

    1. Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385

V

  1. Van Horn, Robert

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  2. Venkatakrishnan, Karthik

    1. Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite
      Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
      Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037

  3. Vilenski, Olga

    1. Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674

W

  1. Wada, Kouichi

    1. Relationship between Exposure of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a “Funny” If Current Channel Inhibitor, and Heart Rate Reduction in Tachycardia-Induced Beagle Dogs
      Ken-ichi Umehara, Kouichi Wada, Kiyoshi Noguchi, Takafumi Iwatsubo, Takashi Usui and Hidetaka Kamimura
      Drug Metabolism and Disposition July 2009, 37 (7) 1427-1433; DOI: https://doi.org/10.1124/dmd.108.026385

  2. Wang, Regina W.

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  3. Wang, Xinkun

    1. Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor
      Chenshu Xu, Xinkun Wang and Jeff L. Staudinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1539-1547; DOI: https://doi.org/10.1124/dmd.109.026989

  4. Watanabe, Akinobu

    1. Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567

  5. Watanabe, Hiroshi

    1. Pharmacokinetic Study of Enclosed Hemoglobin and Outer Lipid Component after the Administration of Hemoglobin Vesicles as an Artificial Oxygen Carrier
      Kazuaki Taguchi, Yukino Urata, Makoto Anraku, Toru Maruyama, Hiroshi Watanabe, Hiromi Sakai, Hirohisa Horinouchi, Koichi Kobayashi, Eishun Tsuchida, Toshiya Kai and Masaki Otagiri
      Drug Metabolism and Disposition July 2009, 37 (7) 1456-1463; DOI: https://doi.org/10.1124/dmd.109.027094

  6. Watanabe, Tomoko

    1. Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments
      Tomoko Watanabe, Kazuya Maeda, Tsunenori Kondo, Hideki Nakayama, Shigeru Horita, Hiroyuki Kusuhara and Yuichi Sugiyama
      Drug Metabolism and Disposition July 2009, 37 (7) 1471-1479; DOI: https://doi.org/10.1124/dmd.108.026062

  7. Waxman, David J.

    1. Regulation of Human CYP2C18 and CYP2C19 in Transgenic Mice: Influence of Castration, Testosterone, and Growth Hormone
      Susanne Löfgren, R. Michael Baldwin, Margareta Carlerös, Ylva Terelius, Ronny Fransson-Steen, Jessica Mwinyi, David J. Waxman and Magnus Ingelman-Sundberg
      Drug Metabolism and Disposition July 2009, 37 (7) 1505-1512; DOI: https://doi.org/10.1124/dmd.109.026963

  8. Weber, Benjamin

    1. Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039

  9. Weikert, Robert

    1. Unbound Brain Concentration Determines Receptor Occupancy: A Correlation of Drug Concentration and Brain Serotonin and Dopamine Reuptake Transporter Occupancy for Eighteen Compounds in Rats
      Xingrong Liu, Olga Vilenski, Joyce Kwan, Subbu Apparsundaram and Robert Weikert
      Drug Metabolism and Disposition July 2009, 37 (7) 1548-1556; DOI: https://doi.org/10.1124/dmd.109.026674

  10. Wen, Bo

    1. Metabolic Activation of Nevirapine in Human Liver Microsomes: Dehydrogenation and Inactivation of Cytochrome P450 3A4
      Bo Wen, Yuan Chen and William L. Fitch
      Drug Metabolism and Disposition July 2009, 37 (7) 1557-1562; DOI: https://doi.org/10.1124/dmd.108.024851

  11. Wong, Y. Nancy

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  12. Wu, Kai

    1. Budesonide and Ciclesonide: Effect of Tissue Binding on Pulmonary Receptor Binding
      Kai Wu, Anders L. Blomgren, Kjell Ekholm, Benjamin Weber, Staffan Edsbaecker and Günther Hochhaus
      Drug Metabolism and Disposition July 2009, 37 (7) 1421-1426; DOI: https://doi.org/10.1124/dmd.108.026039

X

  1. Xu, Chenshu

    1. Regulation of Tissue-Specific Carboxylesterase Expression by Pregnane X Receptor and Constitutive Androstane Receptor
      Chenshu Xu, Xinkun Wang and Jeff L. Staudinger
      Drug Metabolism and Disposition July 2009, 37 (7) 1539-1547; DOI: https://doi.org/10.1124/dmd.109.026989

Y

  1. Yamamoto, W.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  2. Yamashita, K.

    1. Pharmacokinetics of 5-Fluorouracil in Elderly Japanese Patients with Cancer Treated with S-1 (a Combination of Tegafur and Dihydropyrimidine Dehydrogenase Inhibitor 5-Chloro-2,4-dihydroxypyridine)
      K. Fujita, H. Nakayama, W. Ichikawa, W. Yamamoto, H. Endo, F. Nagashima, R. Tanaka, T. Miya, Y. Sunakawa, K. Yamashita, K. Mizuno, H. Ishida, K. Araki, M. Narabayashi, K. Miwa, Y. Ando, Y. Akiyama, K. Kawara, T. Hirose and Y. Sasaki
      Drug Metabolism and Disposition July 2009, 37 (7) 1375-1377; DOI: https://doi.org/10.1124/dmd.109.027052

  3. Yang, Tian J.

    1. The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America
      Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
      Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

  4. Yeo, Chang-Woo

    1. Discovery of Novel Functional Variants and Extensive Evaluation of CYP2D6 Genetic Polymorphisms in Koreans
      Su-Jun Lee, Sang Seop Lee, Hyun-Ju Jung, Ho-Sook Kim, Soo-Jin Park, Chang-Woo Yeo and Jae-Gook Shin
      Drug Metabolism and Disposition July 2009, 37 (7) 1464-1470; DOI: https://doi.org/10.1124/dmd.108.022368

  5. Yokoi, Tsuyoshi

    1. Human Arylacetamide Deacetylase Is a Principal Enzyme in Flutamide Hydrolysis
      Akinobu Watanabe, Tatsuki Fukami, Miki Nakajima, Masataka Takamiya, Yasuhiro Aoki and Tsuyoshi Yokoi
      Drug Metabolism and Disposition July 2009, 37 (7) 1513-1520; DOI: https://doi.org/10.1124/dmd.109.026567

  6. Yuan, Haodan

    1. Evaluation of in Vitro Models for Screening Alkaline Phosphatase-Mediated Bioconversion of Phosphate Ester Prodrugs
      Haodan Yuan, Na Li and Yurong Lai
      Drug Metabolism and Disposition July 2009, 37 (7) 1443-1447; DOI: https://doi.org/10.1124/dmd.108.026245

Z

  1. Zhou, Yihong

    1. In Vitro Metabolism of the Novel, Highly Selective Oral Angiogenesis Inhibitor Motesanib Diphosphate in Preclinical Species and in Humans
      Chun Li, Mita Kuchimanchi, Dean Hickman, Leszek Poppe, Mike Hayashi, Yihong Zhou, Raju Subramanian, Gondi Kumar and Sekhar Surapaneni
      Drug Metabolism and Disposition July 2009, 37 (7) 1378-1394; DOI: https://doi.org/10.1124/dmd.108.025742

  2. Zielinska, Agnieszka K.

    1. Characterization of Human Hepatic and Extrahepatic UDP-Glucuronosyltransferase Enzymes Involved in the Metabolism of Classic Cannabinoids
      Anna Mazur, Cheryl F. Lichti, Paul L. Prather, Agnieszka K. Zielinska, Stacie M. Bratton, Anna Gallus-Zawada, Moshe Finel, Grover P. Miller, Anna Radomińska-Pandya and Jeffery H. Moran
      Drug Metabolism and Disposition July 2009, 37 (7) 1496-1504; DOI: https://doi.org/10.1124/dmd.109.026898
Back to top

In this issue