The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

AstraZeneca Pharmaceuticals, Wilmington, Delaware (S.W.G.); Allergan Inc., Irvine, California (K.-H.J.L.); Amgen Inc., South San Francisco, California (G.R.T.); Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (E.S.); Bristol-Myers Squibb Co., Princeton, New Jersey (K.H.); Eisai Research Institute, Andover, Massachusetts (Y.N.W.); Eli Lilly and Company, Indianapolis, Indiana (S.D.H.); GlaxoSmithKline, King of Prussia, Pennsylvania (K.W.S.); Hoffmann-La Roche, Nutley, New Jersey (T.J.Y.); Johnson & Johnson Pharmaceutical Research Institute, Raritan, New Jersey (H.-K.L.); Merck Research Laboratories, Rahway, New Jersey (R.W.W.); Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts (C.L.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.J.E.); Pfizer Inc., Groton, Connecticut (R.S.O.); Sanofi-Aventis, Malvern, Pennsylvania (R.V.H.); and Schering-Plough Research Institute, Kenilworth, New Jersey (A.A.N.)

Address correspondence to:
R. Scott Obach, Pfizer Inc., Groton, CT 06340. E-mail: r.scott.obach{at}pfizer.com

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