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Research ArticlePerspective

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
Drug Metabolism and Disposition July 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
Scott W. Grimm
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Heidi J. Einolf
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Steven D. Hall
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Kan He
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Heng-Keang Lim
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Kah-Hiing John Ling
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Chuang Lu
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Amin A. Nomeir
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Eleanore Seibert
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Konstantine W. Skordos
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Regina W. Wang
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Y. Nancy Wong
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Tian J. Yang
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Article Information

vol. 37 no. 7 1355-1370
DOI 
https://doi.org/10.1124/dmd.109.026716
PubMed 
19359406

Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Accepted April 7, 2009
  • Received January 13, 2009
  • Published online June 18, 2009.

Article Versions

  • Earlier version (April 9, 2009 - 08:52).
  • You are viewing the most recent version of this article.
Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Scott W. Grimm,
  2. Heidi J. Einolf,
  3. Steven D. Hall,
  4. Kan He,
  5. Heng-Keang Lim,
  6. Kah-Hiing John Ling,
  7. Chuang Lu,
  8. Amin A. Nomeir,
  9. Eleanore Seibert,
  10. Konstantine W. Skordos,
  11. George R. Tonn,
  12. Robert Van Horn,
  13. Regina W. Wang,
  14. Y. Nancy Wong,
  15. Tian J. Yang and
  16. R. Scott Obach
  1. AstraZeneca Pharmaceuticals, Wilmington, Delaware (S.W.G.); Allergan Inc., Irvine, California (K.-H.J.L.); Amgen Inc., South San Francisco, California (G.R.T.); Boehringer Ingelheim Pharmaceuticals, Inc., Ridgefield, Connecticut (E.S.); Bristol-Myers Squibb Co., Princeton, New Jersey (K.H.); Eisai Research Institute, Andover, Massachusetts (Y.N.W.); Eli Lilly and Company, Indianapolis, Indiana (S.D.H.); GlaxoSmithKline, King of Prussia, Pennsylvania (K.W.S.); Hoffmann-La Roche, Nutley, New Jersey (T.J.Y.); Johnson & Johnson Pharmaceutical Research Institute, Raritan, New Jersey (H.-K.L.); Merck Research Laboratories, Rahway, New Jersey (R.W.W.); Millennium Pharmaceuticals, Inc., Cambridge, Massachusetts (C.L.); Novartis Pharmaceuticals Corporation, East Hanover, New Jersey (H.J.E.); Pfizer Inc., Groton, Connecticut (R.S.O.); Sanofi-Aventis, Malvern, Pennsylvania (R.V.H.); and Schering-Plough Research Institute, Kenilworth, New Jersey (A.A.N.)
  1. Address correspondence to:
    R. Scott Obach, Pfizer Inc., Groton, CT 06340. E-mail: r.scott.obach{at}pfizer.com
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Drug Metabolism and Disposition: 37 (7)
Drug Metabolism and Disposition
Vol. 37, Issue 7
1 Jul 2009
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Research ArticlePerspective

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
Drug Metabolism and Disposition July 1, 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716

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Research ArticlePerspective

The Conduct of in Vitro Studies to Address Time-Dependent Inhibition of Drug-Metabolizing Enzymes: A Perspective of the Pharmaceutical Research and Manufacturers of America

Scott W. Grimm, Heidi J. Einolf, Steven D. Hall, Kan He, Heng-Keang Lim, Kah-Hiing John Ling, Chuang Lu, Amin A. Nomeir, Eleanore Seibert, Konstantine W. Skordos, George R. Tonn, Robert Van Horn, Regina W. Wang, Y. Nancy Wong, Tian J. Yang and R. Scott Obach
Drug Metabolism and Disposition July 1, 2009, 37 (7) 1355-1370; DOI: https://doi.org/10.1124/dmd.109.026716
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