Prediction of the Hepatic and Renal Clearance of Transporter Substrates in Rats Using in Vitro Uptake Experiments

Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, the University of Tokyo, Tokyo, Japan (T.W., K.M., H.K., Y.S.); and Department of Urology, Kidney Center, Tokyo Women's Medical University, Tokyo, Japan (T.K., H.N., S.H.)

Address correspondence to:
Dr. Yuichi Sugiyama, Department of Molecular Pharmacokinetics, Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan. E-mail: sugiyama{at}mol.f.u-tokyo.ac.jp

View Full Text

Statistics from Altmetric.com

Article usage

Article usage: April 2009 to April 2021

	Abstract	Full	Pdf
Apr 2009	102	0	194
May 2009	33	0	102
Jun 2009	100	16	156
Jul 2009	48	38	95
Aug 2009	40	24	71
Sep 2009	46	30	68
Oct 2009	25	33	57
Nov 2009	27	16	37
Dec 2009	64	12	48
Jan 2010	69	25	37
Feb 2010	51	20	24
Mar 2010	69	30	35
Apr 2010	48	11	20
May 2010	44	16	27
Jun 2010	49	18	42
Jul 2010	60	48	57
Aug 2010	72	28	43
Sep 2010	50	31	41
Oct 2010	41	47	40
Nov 2010	46	39	43
Dec 2010	57	35	28
Jan 2011	45	29	41
Feb 2011	36	36	28
Mar 2011	91	50	38
Apr 2011	58	25	36
May 2011	73	30	31
Jun 2011	70	21	31
Jul 2011	79	38	27
Aug 2011	96	40	36
Sep 2011	43	31	23
Oct 2011	31	35	26
Nov 2011	24	43	47
Dec 2011	31	20	43
Jan 2012	49	41	60
Feb 2012	38	25	36
Mar 2012	35	24	28
Apr 2012	15	60	37
May 2012	38	47	34
Jun 2012	42	66	38
Jul 2012	33	31	32
Aug 2012	32	47	27
Sep 2012	22	50	30
Oct 2012	30	53	41
Nov 2012	33	48	39
Dec 2012	32	34	27
Jan 2013	34	55	25
Feb 2013	24	56	27
Mar 2013	21	36	22
Apr 2013	25	30	22
May 2013	20	39	32
Jun 2013	18	36	18
Jul 2013	22	26	11
Aug 2013	26	16	17
Sep 2013	25	35	23
Oct 2013	26	39	17
Nov 2013	20	34	18
Dec 2013	9	21	13
Jan 2014	12	28	15
Feb 2014	24	36	17
Mar 2014	23	46	28
Apr 2014	20	50	21
May 2014	15	42	22
Jun 2014	12	37	21
Jul 2014	11	21	6
Aug 2014	8	31	9
Sep 2014	14	26	11
Oct 2014	14	32	23
Nov 2014	21	25	15
Dec 2014	18	24	17
Jan 2015	8	12	8
Feb 2015	23	19	11
Mar 2015	8	44	24
Apr 2015	19	42	8
May 2015	13	31	9
Jun 2015	20	45	22
Jul 2015	23	31	25
Aug 2015	10	52	27
Sep 2015	6	35	12
Oct 2015	7	28	8
Nov 2015	14	32	10
Dec 2015	14	27	15
Jan 2016	8	35	12
Feb 2016	17	40	17
Mar 2016	11	32	26
Apr 2016	11	32	13
May 2016	8	35	11
Jun 2016	8	38	14
Jul 2016	8	28	21
Aug 2016	15	31	23
Sep 2016	7	28	11
Oct 2016	4	28	13
Nov 2016	2	26	20
Dec 2016	6	22	21
Jan 2017	3	29	15
Feb 2017	4	39	26
Mar 2017	2	51	28
Apr 2017	2	16	17
May 2017	3	20	25
Jun 2017	1	19	26
Jul 2017	1	11	4
Aug 2017	2	25	13
Sep 2017	5	27	16
Oct 2017	3	22	10
Nov 2017	5	32	18
Dec 2017	1	24	17
Jan 2018	2	31	17
Feb 2018	2	46	22
Mar 2018	2	45	14
Apr 2018	1	43	9
May 2018	0	48	26
Jun 2018	2	28	8
Jul 2018	1	16	12
Aug 2018	0	28	21
Sep 2018	0	22	12
Oct 2018	0	37	24
Nov 2018	0	38	23
Dec 2018	21	6	9
Jan 2019	11	6	8
Feb 2019	15	1	1
Mar 2019	27	7	6
Apr 2019	20	13	19
May 2019	9	3	4
Jun 2019	29	5	10
Jul 2019	16	2	4
Aug 2019	23	6	7
Sep 2019	22	4	4
Oct 2019	13	4	6
Nov 2019	30	9	12
Dec 2019	19	5	1
Jan 2020	15	2	11
Feb 2020	13	5	4
Mar 2020	20	10	6
Apr 2020	14	3	10
May 2020	16	9	5
Jun 2020	11	5	3
Jul 2020	11	9	9
Aug 2020	10	2	3
Sep 2020	15	2	2
Oct 2020	38	7	9
Nov 2020	17	2	3
Dec 2020	16	5	2
Jan 2021	24	19	4
Feb 2021	16	30	7
Mar 2021	23	9	3
Apr 2021	13	4	2