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Research ArticleArticle

Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite

Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
Drug Metabolism and Disposition July 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037

Article Information

vol. 37 no. 7 1480-1489
DOI 
https://doi.org/10.1124/dmd.109.027037
PubMed 
19339375
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Accepted March 27, 2009
  • Received February 2, 2009
  • Published online June 18, 2009.

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Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Christopher L. Shaffer,
  2. Tim F. Ryder,
  3. Karthik Venkatakrishnan1,
  4. Ilana K. Henne2 and
  5. Thomas N. O'Connell
  1. Departments of Pharmacokinetics, Pharmacodynamics, and Metabolism (C.L.S., T.F.R., K.V., I.K.H.) and Exploratory Medicinal Sciences (T.N.O.), Pfizer Global Research and Development, Groton/New London Laboratories, Pfizer Inc., Groton, Connecticut
  1. Address correspondence to:
    Dr. Christopher L. Shaffer, Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton/New London Laboratories, Pfizer Inc., Eastern Point Road, MS 8220-4186, Groton, CT 06340. E-mail: christopher.l.shaffer{at}pfizer.com
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Research ArticleArticle

Biotransformation of an α4β2 Nicotinic Acetylcholine Receptor Partial Agonist in Sprague-Dawley Rats and the Dispositional Characterization of Its N-Carbamoyl Glucuronide Metabolite

Christopher L. Shaffer, Tim F. Ryder, Karthik Venkatakrishnan, Ilana K. Henne and Thomas N. O'Connell
Drug Metabolism and Disposition July 1, 2009, 37 (7) 1480-1489; DOI: https://doi.org/10.1124/dmd.109.027037
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