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Drug Metabolism & Disposition

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Table of Contents

August 01, 2009; Volume 37,Issue 8

MINIREVIEW

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    The Ontogeny, Distribution, and Regulation of Alcohol Dehydrogenase 3: Implications for Pulmonary Physiology
    Chad M. Thompson, Babasaheb Sonawane and Roland C. Grafström
    Drug Metabolism and Disposition August 2009, 37 (8) 1565-1571; DOI: https://doi.org/10.1124/dmd.109.027904

Short Communications

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    Binding of Lopinavir to Human α1-Acid Glycoprotein and Serum Albumin
    Abhishek Gulati, F. Douglas Boudinot and Phillip M. Gerk
    Drug Metabolism and Disposition August 2009, 37 (8) 1572-1575; DOI: https://doi.org/10.1124/dmd.109.026708
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    The Glycogen Synthase Kinase Inhibitor 3-(2,4-Dichlorophenyl)-4-(1-methyl-1H-indol-3-yl)-1H-pyrrole-2,5-dione (SB216763) Is a Partial Agonist of the Aryl Hydrocarbon Receptor
    Albert Braeuning and Albrecht Buchmann
    Drug Metabolism and Disposition August 2009, 37 (8) 1576-1580; DOI: https://doi.org/10.1124/dmd.109.027821
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    Glycerolysis of Acyl Glucuronides as an Artifact of in Vitro Drug Metabolism Incubations
    R. Scott Obach
    Drug Metabolism and Disposition August 2009, 37 (8) 1581-1586; DOI: https://doi.org/10.1124/dmd.109.027953

Articles

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    Semiphysiologically Based Pharmacokinetic Models for the Inhibition of Midazolam Clearance by Diltiazem and Its Major Metabolite
    Xin Zhang, Sara K. Quinney, J. Christopher Gorski, David R. Jones and Stephen D. Hall
    Drug Metabolism and Disposition August 2009, 37 (8) 1587-1597; DOI: https://doi.org/10.1124/dmd.109.026658
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    Evaluation of Luciferin-Isopropyl Acetal as a CYP3A4 Substrate for Human Hepatocytes: Effects of Organic Solvents, Cytochrome P450 (P450) Inhibitors, and P450 Inducers
    Albert P. Li
    Drug Metabolism and Disposition August 2009, 37 (8) 1598-1603; DOI: https://doi.org/10.1124/dmd.109.027268
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    Involvement of Vitamin D Receptor in the Intestinal Induction of Human ABCB1
    Shuko Tachibana, Kouichi Yoshinari, Tsubasa Chikada, Takayoshi Toriyabe, Kiyoshi Nagata and Yasushi Yamazoe
    Drug Metabolism and Disposition August 2009, 37 (8) 1604-1610; DOI: https://doi.org/10.1124/dmd.109.027219
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    Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity
    Jie Cheng, Xiaochao Ma, Kristopher W. Krausz, Jeffrey R. Idle and Frank J. Gonzalez
    Drug Metabolism and Disposition August 2009, 37 (8) 1611-1621; DOI: https://doi.org/10.1124/dmd.109.027565
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    Disposition and Metabolism of a Novel Prostanoid Antiglaucoma Medication, Tafluprost, Following Ocular Administration to Rats
    Y. Fukano and K. Kawazu
    Drug Metabolism and Disposition August 2009, 37 (8) 1622-1634; DOI: https://doi.org/10.1124/dmd.108.024885
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    Disposition and Metabolism of Radiolabeled Casopitant in Humans
    Mario Pellegatti, Ellenia Bordini, Patrizia Fizzotti, Andy Roberts and Brendan M. Johnson
    Drug Metabolism and Disposition August 2009, 37 (8) 1635-1645; DOI: https://doi.org/10.1124/dmd.109.026781
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    Identification of Human Metabolites of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, and Investigation of the Transporter-Mediated Renal and Hepatic Excretion of These Metabolites
    Ken-ichi Umehara, Nobuaki Shirai, Takafumi Iwatsubo, Kiyoshi Noguchi, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition August 2009, 37 (8) 1646-1657; DOI: https://doi.org/10.1124/dmd.108.026294
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    Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction
    Odette A. Fahmi, Susan Hurst, David Plowchalk, Jack Cook, Feng Guo, Kuresh Youdim, Maurice Dickins, Alex Phipps, Amanda Darekar, Ruth Hyland and R. Scott Obach
    Drug Metabolism and Disposition August 2009, 37 (8) 1658-1666; DOI: https://doi.org/10.1124/dmd.108.026252
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    Further Assessment of 17α-Ethinyl Estradiol as an Inhibitor of Different Human Cytochrome P450 Forms in Vitro
    Shu-Ying Chang, Cliff Chen, Zheng Yang and A. David Rodrigues
    Drug Metabolism and Disposition August 2009, 37 (8) 1667-1675; DOI: https://doi.org/10.1124/dmd.109.026997
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    Oseltamivir (Tamiflu) Is a Substrate of Peptide Transporter 1
    Takuo Ogihara, Takashi Kano, Tamae Wagatsuma, Sho Wada, Hikaru Yabuuchi, Shigeki Enomoto, Kaori Morimoto, Yoshiyuki Shirasaka, Shoko Kobayashi and Ikumi Tamai
    Drug Metabolism and Disposition August 2009, 37 (8) 1676-1681; DOI: https://doi.org/10.1124/dmd.109.026922
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    CYP2D6-CYP2C9 Protein-Protein Interactions and Isoform-Selective Effects on Substrate Binding and Catalysis
    Murali Subramanian, Michael Low, Charles W. Locuson and Timothy S. Tracy
    Drug Metabolism and Disposition August 2009, 37 (8) 1682-1689; DOI: https://doi.org/10.1124/dmd.109.026500
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    Identification of New 2-Amino-3-methylimidazo[4,5-f]quinoline Urinary Metabolites from β-Naphthoflavone-Treated Mice
    Vijaya M. Lakshmi, Fong-Fu Hsu and Terry V. Zenser
    Drug Metabolism and Disposition August 2009, 37 (8) 1690-1697; DOI: https://doi.org/10.1124/dmd.109.027342
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    Complex Pharmacokinetic Behavior of Ezetimibe Depends on Abcc2, Abcc3, and Abcg2
    Dirk R. de Waart, Maria L. H. Vlaming, Cindy Kunne, Alfred H. Schinkel and Ronald P. J. Oude Elferink
    Drug Metabolism and Disposition August 2009, 37 (8) 1698-1702; DOI: https://doi.org/10.1124/dmd.108.026146
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    The Importance of Heterogeneous Nuclear Ribonucleoprotein K on Cytochrome P450 2D2 Gene Regulation: Its Binding Is Reduced in Dark Agouti Rats
    Noriaki Sakai, Kentaro Q. Sakamoto, Shoichi Fujita and Mayumi Ishizuka
    Drug Metabolism and Disposition August 2009, 37 (8) 1703-1710; DOI: https://doi.org/10.1124/dmd.109.027284
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    Selective Role of Sulfotransferase 2A1 (SULT2A1) in the N-Sulfoconjugation of Quinolone Drugs in Humans
    Laddawan Senggunprai, Kouichi Yoshinari and Yasushi Yamazoe
    Drug Metabolism and Disposition August 2009, 37 (8) 1711-1717; DOI: https://doi.org/10.1124/dmd.109.027441
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    Vitreal Kinetics of Quinidine in Rabbits in the Presence of Topically Coadministered P-Glycoprotein Substrates/Modulators
    Soumyajit Majumdar, Ketan Hippalgaonkar and Ramesh Srirangam
    Drug Metabolism and Disposition August 2009, 37 (8) 1718-1725; DOI: https://doi.org/10.1124/dmd.108.026450
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    Characterizing the Effects of Common UDP Glucuronosyltransferase (UGT) 1A6 and UGT1A1 Polymorphisms on cis- and trans-Resveratrol Glucuronidation
    Otito Frances Iwuchukwu, Jumoke Ajetunmobi, Din Ung and Swati Nagar
    Drug Metabolism and Disposition August 2009, 37 (8) 1726-1732; DOI: https://doi.org/10.1124/dmd.109.027391
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    Cannabidiol-2′,6′-Dimethyl Ether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor
    Shuso Takeda, Noriyuki Usami, Ikuo Yamamoto and Kazuhito Watanabe
    Drug Metabolism and Disposition August 2009, 37 (8) 1733-1737; DOI: https://doi.org/10.1124/dmd.109.026930
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    Comparative Metabolism of 14C-Labeled Apixaban in Mice, Rats, Rabbits, Dogs, and Humans
    Donglu Zhang, Kan He, Nirmala Raghavan, Lifei Wang, James Mitroka, Brad D. Maxwell, Robert M. Knabb, Charles Frost, Alan Schuster, Feng Hao, Zheming Gu, W. Griffith Humphreys and Scott J. Grossman
    Drug Metabolism and Disposition August 2009, 37 (8) 1738-1748; DOI: https://doi.org/10.1124/dmd.108.025981
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    Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption
    Angélique Stalmach, William Mullen, Denis Barron, Kenichi Uchida, Takao Yokota, Christophe Cavin, Heike Steiling, Gary Williamson and Alan Crozier
    Drug Metabolism and Disposition August 2009, 37 (8) 1749-1758; DOI: https://doi.org/10.1124/dmd.109.028019
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    Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers
    Takeshi Izukawa, Miki Nakajima, Ryoichi Fujiwara, Hiroyuki Yamanaka, Tatsuki Fukami, Masataka Takamiya, Yasuhiro Aoki, Shin-ichi Ikushiro, Toshiyuki Sakaki and Tsuyoshi Yokoi
    Drug Metabolism and Disposition August 2009, 37 (8) 1759-1768; DOI: https://doi.org/10.1124/dmd.109.027227
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    Use of Human Microsomes and Deuterated Substrates: An Alternative Approach for the Identification of Novel Metabolites of Ketamine by Mass Spectrometry
    Sophie C. Turfus, Mark C. Parkin, David A. Cowan, John M. Halket, Norman W. Smith, Robin A. Braithwaite, Simon P. Elliot, Glyn B. Steventon and Andrew T. Kicman
    Drug Metabolism and Disposition August 2009, 37 (8) 1769-1778; DOI: https://doi.org/10.1124/dmd.108.026328
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    Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure
    Laura P. James, Lynda Letzig, Pippa M. Simpson, Edmund Capparelli, Dean W. Roberts, Jack A. Hinson, Timothy J. Davern and William M. Lee
    Drug Metabolism and Disposition August 2009, 37 (8) 1779-1784; DOI: https://doi.org/10.1124/dmd.108.026195
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    Characterization of Sulfoxygenation and Structural Implications of Human Flavin-Containing Monooxygenase Isoform 2 (FMO2.1) Variants S195L and N413K
    Sharon K. Krueger, Marilyn C. Henderson, Lisbeth K. Siddens, Jonathan E. VanDyke, Abby D. Benninghoff, P. Andrew Karplus, Bjarte Furnes, Daniel Schlenk and David E. Williams
    Drug Metabolism and Disposition August 2009, 37 (8) 1785-1791; DOI: https://doi.org/10.1124/dmd.109.027201
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Drug Metabolism and Disposition: 37 (8)
Drug Metabolism and Disposition
Vol. 37, Issue 8
1 Aug 2009
  • Table of Contents
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  • MINIREVIEW
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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