Table of Contents

Articles

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  Semiphysiologically Based Pharmacokinetic Models for the Inhibition of Midazolam Clearance by Diltiazem and Its Major Metabolite

  Xin Zhang, Sara K. Quinney, J. Christopher Gorski, David R. Jones and Stephen D. Hall

  Drug Metabolism and Disposition August 2009, 37 (8) 1587-1597; DOI: https://doi.org/10.1124/dmd.109.026658
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  Evaluation of Luciferin-Isopropyl Acetal as a CYP3A4 Substrate for Human Hepatocytes: Effects of Organic Solvents, Cytochrome P450 (P450) Inhibitors, and P450 Inducers

  Albert P. Li

  Drug Metabolism and Disposition August 2009, 37 (8) 1598-1603; DOI: https://doi.org/10.1124/dmd.109.027268
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  Involvement of Vitamin D Receptor in the Intestinal Induction of Human ABCB1

  Shuko Tachibana, Kouichi Yoshinari, Tsubasa Chikada, Takayoshi Toriyabe, Kiyoshi Nagata and Yasushi Yamazoe

  Drug Metabolism and Disposition August 2009, 37 (8) 1604-1610; DOI: https://doi.org/10.1124/dmd.109.027219
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  Rifampicin-Activated Human Pregnane X Receptor and CYP3A4 Induction Enhance Acetaminophen-Induced Toxicity

  Jie Cheng, Xiaochao Ma, Kristopher W. Krausz, Jeffrey R. Idle and Frank J. Gonzalez

  Drug Metabolism and Disposition August 2009, 37 (8) 1611-1621; DOI: https://doi.org/10.1124/dmd.109.027565
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  Disposition and Metabolism of a Novel Prostanoid Antiglaucoma Medication, Tafluprost, Following Ocular Administration to Rats

  Y. Fukano and K. Kawazu

  Drug Metabolism and Disposition August 2009, 37 (8) 1622-1634; DOI: https://doi.org/10.1124/dmd.108.024885
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  Disposition and Metabolism of Radiolabeled Casopitant in Humans

  Mario Pellegatti, Ellenia Bordini, Patrizia Fizzotti, Andy Roberts and Brendan M. Johnson

  Drug Metabolism and Disposition August 2009, 37 (8) 1635-1645; DOI: https://doi.org/10.1124/dmd.109.026781
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  Identification of Human Metabolites of (–)-N-{2-[(R)-3-(6,7-Dimethoxy-1,2,3,4-tetrahydroisoquinoline-2-carbonyl)piperidino]ethyl}-4-fluorobenzamide (YM758), a Novel If Channel Inhibitor, and Investigation of the Transporter-Mediated Renal and Hepatic Excretion of These Metabolites

  Ken-ichi Umehara, Nobuaki Shirai, Takafumi Iwatsubo, Kiyoshi Noguchi, Takashi Usui and Hidetaka Kamimura

  Drug Metabolism and Disposition August 2009, 37 (8) 1646-1657; DOI: https://doi.org/10.1124/dmd.108.026294
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  Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

  Odette A. Fahmi, Susan Hurst, David Plowchalk, Jack Cook, Feng Guo, Kuresh Youdim, Maurice Dickins, Alex Phipps, Amanda Darekar, Ruth Hyland and R. Scott Obach

  Drug Metabolism and Disposition August 2009, 37 (8) 1658-1666; DOI: https://doi.org/10.1124/dmd.108.026252
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  Further Assessment of 17α-Ethinyl Estradiol as an Inhibitor of Different Human Cytochrome P450 Forms in Vitro

  Shu-Ying Chang, Cliff Chen, Zheng Yang and A. David Rodrigues

  Drug Metabolism and Disposition August 2009, 37 (8) 1667-1675; DOI: https://doi.org/10.1124/dmd.109.026997
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  Oseltamivir (Tamiflu) Is a Substrate of Peptide Transporter 1

  Takuo Ogihara, Takashi Kano, Tamae Wagatsuma, Sho Wada, Hikaru Yabuuchi, Shigeki Enomoto, Kaori Morimoto, Yoshiyuki Shirasaka, Shoko Kobayashi and Ikumi Tamai

  Drug Metabolism and Disposition August 2009, 37 (8) 1676-1681; DOI: https://doi.org/10.1124/dmd.109.026922
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  CYP2D6-CYP2C9 Protein-Protein Interactions and Isoform-Selective Effects on Substrate Binding and Catalysis

  Murali Subramanian, Michael Low, Charles W. Locuson and Timothy S. Tracy

  Drug Metabolism and Disposition August 2009, 37 (8) 1682-1689; DOI: https://doi.org/10.1124/dmd.109.026500
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  Identification of New 2-Amino-3-methylimidazo[4,5-f]quinoline Urinary Metabolites from β-Naphthoflavone-Treated Mice

  Vijaya M. Lakshmi, Fong-Fu Hsu and Terry V. Zenser

  Drug Metabolism and Disposition August 2009, 37 (8) 1690-1697; DOI: https://doi.org/10.1124/dmd.109.027342
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  Complex Pharmacokinetic Behavior of Ezetimibe Depends on Abcc2, Abcc3, and Abcg2

  Dirk R. de Waart, Maria L. H. Vlaming, Cindy Kunne, Alfred H. Schinkel and Ronald P. J. Oude Elferink

  Drug Metabolism and Disposition August 2009, 37 (8) 1698-1702; DOI: https://doi.org/10.1124/dmd.108.026146
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  The Importance of Heterogeneous Nuclear Ribonucleoprotein K on Cytochrome P450 2D2 Gene Regulation: Its Binding Is Reduced in Dark Agouti Rats

  Noriaki Sakai, Kentaro Q. Sakamoto, Shoichi Fujita and Mayumi Ishizuka

  Drug Metabolism and Disposition August 2009, 37 (8) 1703-1710; DOI: https://doi.org/10.1124/dmd.109.027284
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  Selective Role of Sulfotransferase 2A1 (SULT2A1) in the N-Sulfoconjugation of Quinolone Drugs in Humans

  Laddawan Senggunprai, Kouichi Yoshinari and Yasushi Yamazoe

  Drug Metabolism and Disposition August 2009, 37 (8) 1711-1717; DOI: https://doi.org/10.1124/dmd.109.027441
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  Vitreal Kinetics of Quinidine in Rabbits in the Presence of Topically Coadministered P-Glycoprotein Substrates/Modulators

  Soumyajit Majumdar, Ketan Hippalgaonkar and Ramesh Srirangam

  Drug Metabolism and Disposition August 2009, 37 (8) 1718-1725; DOI: https://doi.org/10.1124/dmd.108.026450
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  Characterizing the Effects of Common UDP Glucuronosyltransferase (UGT) 1A6 and UGT1A1 Polymorphisms on cis- and trans-Resveratrol Glucuronidation

  Otito Frances Iwuchukwu, Jumoke Ajetunmobi, Din Ung and Swati Nagar

  Drug Metabolism and Disposition August 2009, 37 (8) 1726-1732; DOI: https://doi.org/10.1124/dmd.109.027391
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  Cannabidiol-2′,6′-Dimethyl Ether, a Cannabidiol Derivative, Is a Highly Potent and Selective 15-Lipoxygenase Inhibitor

  Shuso Takeda, Noriyuki Usami, Ikuo Yamamoto and Kazuhito Watanabe

  Drug Metabolism and Disposition August 2009, 37 (8) 1733-1737; DOI: https://doi.org/10.1124/dmd.109.026930
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  Comparative Metabolism of ¹⁴C-Labeled Apixaban in Mice, Rats, Rabbits, Dogs, and Humans

  Donglu Zhang, Kan He, Nirmala Raghavan, Lifei Wang, James Mitroka, Brad D. Maxwell, Robert M. Knabb, Charles Frost, Alan Schuster, Feng Hao, Zheming Gu, W. Griffith Humphreys and Scott J. Grossman

  Drug Metabolism and Disposition August 2009, 37 (8) 1738-1748; DOI: https://doi.org/10.1124/dmd.108.025981
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  Metabolite Profiling of Hydroxycinnamate Derivatives in Plasma and Urine after the Ingestion of Coffee by Humans: Identification of Biomarkers of Coffee Consumption

  Angélique Stalmach, William Mullen, Denis Barron, Kenichi Uchida, Takao Yokota, Christophe Cavin, Heike Steiling, Gary Williamson and Alan Crozier

  Drug Metabolism and Disposition August 2009, 37 (8) 1749-1758; DOI: https://doi.org/10.1124/dmd.109.028019
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  Quantitative Analysis of UDP-Glucuronosyltransferase (UGT) 1A and UGT2B Expression Levels in Human Livers

  Takeshi Izukawa, Miki Nakajima, Ryoichi Fujiwara, Hiroyuki Yamanaka, Tatsuki Fukami, Masataka Takamiya, Yasuhiro Aoki, Shin-ichi Ikushiro, Toshiyuki Sakaki and Tsuyoshi Yokoi

  Drug Metabolism and Disposition August 2009, 37 (8) 1759-1768; DOI: https://doi.org/10.1124/dmd.109.027227
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  Use of Human Microsomes and Deuterated Substrates: An Alternative Approach for the Identification of Novel Metabolites of Ketamine by Mass Spectrometry

  Sophie C. Turfus, Mark C. Parkin, David A. Cowan, John M. Halket, Norman W. Smith, Robin A. Braithwaite, Simon P. Elliot, Glyn B. Steventon and Andrew T. Kicman

  Drug Metabolism and Disposition August 2009, 37 (8) 1769-1778; DOI: https://doi.org/10.1124/dmd.108.026328
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  Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure

  Laura P. James, Lynda Letzig, Pippa M. Simpson, Edmund Capparelli, Dean W. Roberts, Jack A. Hinson, Timothy J. Davern and William M. Lee

  Drug Metabolism and Disposition August 2009, 37 (8) 1779-1784; DOI: https://doi.org/10.1124/dmd.108.026195
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  Characterization of Sulfoxygenation and Structural Implications of Human Flavin-Containing Monooxygenase Isoform 2 (FMO2.1) Variants S195L and N413K

  Sharon K. Krueger, Marilyn C. Henderson, Lisbeth K. Siddens, Jonathan E. VanDyke, Abby D. Benninghoff, P. Andrew Karplus, Bjarte Furnes, Daniel Schlenk and David E. Williams

  Drug Metabolism and Disposition August 2009, 37 (8) 1785-1791; DOI: https://doi.org/10.1124/dmd.109.027201