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Research ArticleArticle

Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

Odette A. Fahmi, Susan Hurst, David Plowchalk, Jack Cook, Feng Guo, Kuresh Youdim, Maurice Dickins, Alex Phipps, Amanda Darekar, Ruth Hyland and R. Scott Obach
Drug Metabolism and Disposition August 2009, 37 (8) 1658-1666; DOI: https://doi.org/10.1124/dmd.108.026252

Article Information

vol. 37 no. 8 1658-1666
DOI 
https://doi.org/10.1124/dmd.108.026252
PubMed 
19406954
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Accepted April 28, 2009
  • Received December 18, 2008
  • Published online July 17, 2009.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Odette A. Fahmi,
  2. Susan Hurst,
  3. David Plowchalk,
  4. Jack Cook,
  5. Feng Guo,
  6. Kuresh Youdim,
  7. Maurice Dickins,
  8. Alex Phipps,
  9. Amanda Darekar,
  10. Ruth Hyland and
  11. R. Scott Obach
  1. Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Groton, Connecticut (O.A.F., S.H., R.S.O.); Pharmacokinetics, Dynamics and Metabolism, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom (K.Y., M.D., R.H.); Clinical Research and Development, Pfizer Global Research and Development, Groton, Connecticut (D.P., J.C., F.G.); Clinical Research and Development, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom (A.P.); and Clinical Research and Development Statistics, Pfizer Global Research and Development, Sandwich, Kent, United Kingdom (A.D.)
  1. Address correspondence to:
    Dr. Odette A. Fahmi, Pfizer Global Research and Development, Groton, CT 06340. E-mail: odette.a.fahmi{at}pfizer.com
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Research ArticleArticle

Comparison of Different Algorithms for Predicting Clinical Drug-Drug Interactions, Based on the Use of CYP3A4 in Vitro Data: Predictions of Compounds as Precipitants of Interaction

Odette A. Fahmi, Susan Hurst, David Plowchalk, Jack Cook, Feng Guo, Kuresh Youdim, Maurice Dickins, Alex Phipps, Amanda Darekar, Ruth Hyland and R. Scott Obach
Drug Metabolism and Disposition August 1, 2009, 37 (8) 1658-1666; DOI: https://doi.org/10.1124/dmd.108.026252
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