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Research ArticleArticle

Comparative Metabolism of 14C-Labeled Apixaban in Mice, Rats, Rabbits, Dogs, and Humans

Donglu Zhang, Kan He, Nirmala Raghavan, Lifei Wang, James Mitroka, Brad D. Maxwell, Robert M. Knabb, Charles Frost, Alan Schuster, Feng Hao, Zheming Gu, W. Griffith Humphreys and Scott J. Grossman
Drug Metabolism and Disposition August 2009, 37 (8) 1738-1748; DOI: https://doi.org/10.1124/dmd.108.025981

Article Information

vol. 37 no. 8 1738-1748
DOI 
https://doi.org/10.1124/dmd.108.025981
PubMed 
19420130
Published By 
American Society for Pharmacology and Experimental Therapeutics
Print ISSN 
0090-9556
Online ISSN 
1521-009X
History 
  • Accepted May 1, 2009
  • Received December 4, 2008
  • Published online July 17, 2009.

Article Versions

Copyright & Usage 
The American Society for Pharmacology and Experimental Therapeutics

Author Information

  1. Donglu Zhang,
  2. Kan He1,
  3. Nirmala Raghavan,
  4. Lifei Wang,
  5. James Mitroka,
  6. Brad D. Maxwell,
  7. Robert M. Knabb,
  8. Charles Frost,
  9. Alan Schuster,
  10. Feng Hao,
  11. Zheming Gu,
  12. W. Griffith Humphreys and
  13. Scott J. Grossman
  1. Bristol-Myers Squibb Research and Development, Princeton, New Jersey (D.Z., K.H., N.R., L.W., J.M., B.D.M., R.M.K., C.F, A.S., W.G.H., S.J.G.); and Xenobiotic Laboratories, Plainsboro, New Jersey (F.H., Z.G.)
  1. Address correspondence to:
    Dr. Donglu Zhang, PO Box 4000, Pharmaceutical Candidate Optimization, Bristol-Myers Squibb Research and Development, Princeton, NJ 08543-4000. E-mail: donglu.zhang{at}bms.com
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Research ArticleArticle

Comparative Metabolism of 14C-Labeled Apixaban in Mice, Rats, Rabbits, Dogs, and Humans

Donglu Zhang, Kan He, Nirmala Raghavan, Lifei Wang, James Mitroka, Brad D. Maxwell, Robert M. Knabb, Charles Frost, Alan Schuster, Feng Hao, Zheming Gu, W. Griffith Humphreys and Scott J. Grossman
Drug Metabolism and Disposition August 1, 2009, 37 (8) 1738-1748; DOI: https://doi.org/10.1124/dmd.108.025981
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