Table of Contents

Articles

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  Bioactivation of Minocycline to Reactive Intermediates by Myeloperoxidase, Horseradish Peroxidase, and Hepatic Microsomes: Implications for Minocycline-Induced Lupus and Hepatitis

  Baskar Mannargudi, David McNally, William Reynolds and Jack Uetrecht

  Drug Metabolism and Disposition September 2009, 37 (9) 1806-1818; DOI: https://doi.org/10.1124/dmd.109.027292
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  Age- and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver

  Hao-Jie Zhu, David I. Appel, Yan Jiang and John S. Markowitz

  Drug Metabolism and Disposition September 2009, 37 (9) 1819-1825; DOI: https://doi.org/10.1124/dmd.109.028209
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  Identification and Profiling of Circulating Metabolites of Atazanavir, a HIV Protease Inhibitor

  R. ter Heine, M. J. X. Hillebrand, H. Rosing, E. C. M. van Gorp, J. W. Mulder, J. H. Beijnen and A. D. R. Huitema

  Drug Metabolism and Disposition September 2009, 37 (9) 1826-1840; DOI: https://doi.org/10.1124/dmd.109.028258
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  Up-Regulation of UDP-Glucuronosyltransferase (UGT) 1A4 by 17β-Estradiol: A Potential Mechanism of Increased Lamotrigine Elimination in Pregnancy

  Huiqing Chen, Kyunghee Yang, Suyoung Choi, James H. Fischer and Hyunyoung Jeong

  Drug Metabolism and Disposition September 2009, 37 (9) 1841-1847; DOI: https://doi.org/10.1124/dmd.109.026609
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  In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract

  Robert S. Foti, Josh T. Pearson, Dan A. Rock, Jan L. Wahlstrom and Larry C. Wienkers

  Drug Metabolism and Disposition September 2009, 37 (9) 1848-1855; DOI: https://doi.org/10.1124/dmd.109.028043
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  Involvement of Human Organic Cation Transporter 1 in the Hepatic Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel, Small Molecule Survivin Suppressant

  Megumi Iwai, Tsuyoshi Minematsu, Shinichi Narikawa, Takashi Usui and Hidetaka Kamimura

  Drug Metabolism and Disposition September 2009, 37 (9) 1856-1863; DOI: https://doi.org/10.1124/dmd.109.027359
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  Modulation of the Partition Coefficient between Octanol and Buffer at pH 7.4 and pK_a to Achieve the Optimum Balance of Blood Clearance and Volume of Distribution for a Series of Tetrahydropyran Histamine Type 3 Receptor Antagonists

  Tanya Hay, Rhys Jones, Kevin Beaumont and Mark Kemp

  Drug Metabolism and Disposition September 2009, 37 (9) 1864-1870; DOI: https://doi.org/10.1124/dmd.109.027888
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  Changes in mRNA Expression Levels of Solute Carrier Transporters in Inflammatory Bowel Disease Patients

  Kacper A. Wojtal, Jyrki J. Eloranta, Petr Hruz, Heike Gutmann, Jürgen Drewe, Alex Staumann, Christoph Beglinger, Michael Fried, Gerd A. Kullak-Ublick and Stephan R. Vavricka

  Drug Metabolism and Disposition September 2009, 37 (9) 1871-1877; DOI: https://doi.org/10.1124/dmd.109.027367
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  Effect of Membrane Cholesterol on BSEP/Bsep Activity: Species Specificity Studies for Substrates and Inhibitors

  Emese Kis, Enikő Ioja, Tunde Nagy, Lajos Szente, Krisztina Herédi-Szabó and Péter Krajcsi

  Drug Metabolism and Disposition September 2009, 37 (9) 1878-1886; DOI: https://doi.org/10.1124/dmd.108.024778
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  Methadone Induces the Expression of Hepatic Drug-Metabolizing Enzymes through the Activation of Pregnane X Receptor and Constitutive Androstane Receptor

  Antonia H. Tolson, Haishan Li, Natalie D. Eddington and Hongbing Wang

  Drug Metabolism and Disposition September 2009, 37 (9) 1887-1894; DOI: https://doi.org/10.1124/dmd.109.027854
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  Substrate-Dependent Functional Alterations of Seven CYP2C9 Variants Found in Japanese Subjects

  Keiko Maekawa, Noriko Harakawa, Emiko Sugiyama, Masahiro Tohkin, Su-Ryang Kim, Nahoko Kaniwa, Noriko Katori, Ryuichi Hasegawa, Kazuki Yasuda, Kei Kamide, Toshiyuki Miyata, Yoshiro Saito and Jun-ichi Sawada

  Drug Metabolism and Disposition September 2009, 37 (9) 1895-1903; DOI: https://doi.org/10.1124/dmd.109.027003
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  Metabolism of Ticlopidine in Rats: Identification of the Main Biliary Metabolite as a Glutathione Conjugate of Ticlopidine S-Oxide

  Shinji Shimizu, Ryo Atsumi, Tsunenori Nakazawa, Yuko Fujimaki, Kenichi Sudo and Osamu Okazaki

  Drug Metabolism and Disposition September 2009, 37 (9) 1904-1915; DOI: https://doi.org/10.1124/dmd.109.027524
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  Sex-Dependent Disposition of Acetaminophen Sulfate and Glucuronide in the in Situ Perfused Mouse Liver

  Jin Kyung Lee, Koji Abe, Arlene S. Bridges, Nita J. Patel, Thomas J. Raub, Gary M. Pollack and Kim L. R. Brouwer

  Drug Metabolism and Disposition September 2009, 37 (9) 1916-1921; DOI: https://doi.org/10.1124/dmd.109.026815
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  An in Vitro Evaluation of the Victim and Perpetrator Potential of the Anticancer Agent Laromustine (VNP40101M), Based on Reaction Phenotyping and Inhibition and Induction of Cytochrome P450 Enzymes

  Alaa-Eldin F. Nassar, Ivan King, Brandy L. Paris, Lois Haupt, Florence Ndikum-Moffor, Rebecca Campbell, Etsuko Usuki, Jennifer Skibbe, Dan Brobst, Brian W. Ogilvie and Andrew Parkinson

  Drug Metabolism and Disposition September 2009, 37 (9) 1922-1930; DOI: https://doi.org/10.1124/dmd.109.027516
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  Inhibition of Human CYP2B6-Catalyzed Bupropion Hydroxylation by Ginkgo biloba Extract: Effect of Terpene Trilactones and Flavonols

  Aik Jiang Lau and Thomas K. H. Chang

  Drug Metabolism and Disposition September 2009, 37 (9) 1931-1937; DOI: https://doi.org/10.1124/dmd.109.028118
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  3-Ketocholanoic Acid Is the Major in Vitro Human Hepatic Microsomal Metabolite of Lithocholic Acid

  Anand K. Deo and Stelvio M. Bandiera

  Drug Metabolism and Disposition September 2009, 37 (9) 1938-1947; DOI: https://doi.org/10.1124/dmd.109.027763
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  Influence of N-Terminal Domain Histidine and Proline Residues on the Substrate Selectivities of Human UDP-Glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10

  Oranun Kerdpin, Peter I. Mackenzie, Kushari Bowalgaha, Moshe Finel and John O. Miners

  Drug Metabolism and Disposition September 2009, 37 (9) 1948-1955; DOI: https://doi.org/10.1124/dmd.109.028225
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  Culture Period-Dependent Change of Function and Expression of ATP-Binding Cassette Transporters in Caco-2 Cells

  Emi Kamiyama, Daisuke Sugiyama, Daisuke Nakai, Shin-ichi Miura and Osamu Okazaki

  Drug Metabolism and Disposition September 2009, 37 (9) 1956-1962; DOI: https://doi.org/10.1124/dmd.109.027490
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  Thyroid Hormone Is Necessary for Expression of Constitutive Androstane Receptor in Rat Hepatocytes

  Hidekazu Ooe, Junko Kon, Hideki Oshima and Toshihiro Mitaka

  Drug Metabolism and Disposition September 2009, 37 (9) 1963-1969; DOI: https://doi.org/10.1124/dmd.108.022905
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  A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding

  Shintaro Nakayama, Ryo Atsumi, Hideo Takakusa, Yoshimasa Kobayashi, Atsushi Kurihara, Yoko Nagai, Daisuke Nakai and Osamu Okazaki

  Drug Metabolism and Disposition September 2009, 37 (9) 1970-1977; DOI: https://doi.org/10.1124/dmd.109.027797
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  Genetic Polymorphisms in the TATA Box and Upstream Phenobarbital-Responsive Enhancer Module of the UGT1A1 Promoter Have Combined Effects on UDP-Glucuronosyltransferase 1A1 Transcription Mediated by Constitutive Androstane Receptor, Pregnane X Receptor, or Glucocorticoid Receptor in Human Liver

  Ye Li, David Buckley, Shuang Wang, Curtis D. Klaassen and Xiao-bo Zhong

  Drug Metabolism and Disposition September 2009, 37 (9) 1978-1986; DOI: https://doi.org/10.1124/dmd.109.027409