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Drug Metabolism & Disposition

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Table of Contents

September 01, 2009; Volume 37,Issue 9

Short Communications

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    Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine
    Anne-Sophie Bélanger, Patrick Caron, Mario Harvey, Peter A. Zimmerman, Rajeev K. Mehlotra and Chantal Guillemette
    Drug Metabolism and Disposition September 2009, 37 (9) 1793-1796; DOI: https://doi.org/10.1124/dmd.109.027706
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    Aromatic Substitution Reaction of 2-Chloropyridines Catalyzed by Microsomal Glutathione S-Transferase 1
    Kazuko Inoue, Tomoyuki Ohe, Kenichi Mori, Takeshi Sagara, Yasuyuki Ishii and Masato Chiba
    Drug Metabolism and Disposition September 2009, 37 (9) 1797-1800; DOI: https://doi.org/10.1124/dmd.109.027698
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    Contrasting Influence of NADPH and a NADPH-Regenerating System on the Metabolism of Carbonyl-Containing Compounds in Hepatic Microsomes
    Christopher S. Mazur, John F. Kenneke, Michael-Rock Goldsmith and Cather Brown
    Drug Metabolism and Disposition September 2009, 37 (9) 1801-1805; DOI: https://doi.org/10.1124/dmd.109.027615

Articles

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    Bioactivation of Minocycline to Reactive Intermediates by Myeloperoxidase, Horseradish Peroxidase, and Hepatic Microsomes: Implications for Minocycline-Induced Lupus and Hepatitis
    Baskar Mannargudi, David McNally, William Reynolds and Jack Uetrecht
    Drug Metabolism and Disposition September 2009, 37 (9) 1806-1818; DOI: https://doi.org/10.1124/dmd.109.027292
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    Age- and Sex-Related Expression and Activity of Carboxylesterase 1 and 2 in Mouse and Human Liver
    Hao-Jie Zhu, David I. Appel, Yan Jiang and John S. Markowitz
    Drug Metabolism and Disposition September 2009, 37 (9) 1819-1825; DOI: https://doi.org/10.1124/dmd.109.028209
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    Identification and Profiling of Circulating Metabolites of Atazanavir, a HIV Protease Inhibitor
    R. ter Heine, M. J. X. Hillebrand, H. Rosing, E. C. M. van Gorp, J. W. Mulder, J. H. Beijnen and A. D. R. Huitema
    Drug Metabolism and Disposition September 2009, 37 (9) 1826-1840; DOI: https://doi.org/10.1124/dmd.109.028258
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    Up-Regulation of UDP-Glucuronosyltransferase (UGT) 1A4 by 17β-Estradiol: A Potential Mechanism of Increased Lamotrigine Elimination in Pregnancy
    Huiqing Chen, Kyunghee Yang, Suyoung Choi, James H. Fischer and Hyunyoung Jeong
    Drug Metabolism and Disposition September 2009, 37 (9) 1841-1847; DOI: https://doi.org/10.1124/dmd.109.026609
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    In Vitro Inhibition of Multiple Cytochrome P450 Isoforms by Xanthone Derivatives from Mangosteen Extract
    Robert S. Foti, Josh T. Pearson, Dan A. Rock, Jan L. Wahlstrom and Larry C. Wienkers
    Drug Metabolism and Disposition September 2009, 37 (9) 1848-1855; DOI: https://doi.org/10.1124/dmd.109.028043
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    Involvement of Human Organic Cation Transporter 1 in the Hepatic Uptake of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel, Small Molecule Survivin Suppressant
    Megumi Iwai, Tsuyoshi Minematsu, Shinichi Narikawa, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition September 2009, 37 (9) 1856-1863; DOI: https://doi.org/10.1124/dmd.109.027359
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    Modulation of the Partition Coefficient between Octanol and Buffer at pH 7.4 and pKa to Achieve the Optimum Balance of Blood Clearance and Volume of Distribution for a Series of Tetrahydropyran Histamine Type 3 Receptor Antagonists
    Tanya Hay, Rhys Jones, Kevin Beaumont and Mark Kemp
    Drug Metabolism and Disposition September 2009, 37 (9) 1864-1870; DOI: https://doi.org/10.1124/dmd.109.027888
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    Changes in mRNA Expression Levels of Solute Carrier Transporters in Inflammatory Bowel Disease Patients
    Kacper A. Wojtal, Jyrki J. Eloranta, Petr Hruz, Heike Gutmann, Jürgen Drewe, Alex Staumann, Christoph Beglinger, Michael Fried, Gerd A. Kullak-Ublick and Stephan R. Vavricka
    Drug Metabolism and Disposition September 2009, 37 (9) 1871-1877; DOI: https://doi.org/10.1124/dmd.109.027367
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    Effect of Membrane Cholesterol on BSEP/Bsep Activity: Species Specificity Studies for Substrates and Inhibitors
    Emese Kis, Enikő Ioja, Tunde Nagy, Lajos Szente, Krisztina Herédi-Szabó and Péter Krajcsi
    Drug Metabolism and Disposition September 2009, 37 (9) 1878-1886; DOI: https://doi.org/10.1124/dmd.108.024778
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    Methadone Induces the Expression of Hepatic Drug-Metabolizing Enzymes through the Activation of Pregnane X Receptor and Constitutive Androstane Receptor
    Antonia H. Tolson, Haishan Li, Natalie D. Eddington and Hongbing Wang
    Drug Metabolism and Disposition September 2009, 37 (9) 1887-1894; DOI: https://doi.org/10.1124/dmd.109.027854
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    Substrate-Dependent Functional Alterations of Seven CYP2C9 Variants Found in Japanese Subjects
    Keiko Maekawa, Noriko Harakawa, Emiko Sugiyama, Masahiro Tohkin, Su-Ryang Kim, Nahoko Kaniwa, Noriko Katori, Ryuichi Hasegawa, Kazuki Yasuda, Kei Kamide, Toshiyuki Miyata, Yoshiro Saito and Jun-ichi Sawada
    Drug Metabolism and Disposition September 2009, 37 (9) 1895-1903; DOI: https://doi.org/10.1124/dmd.109.027003
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    Metabolism of Ticlopidine in Rats: Identification of the Main Biliary Metabolite as a Glutathione Conjugate of Ticlopidine S-Oxide
    Shinji Shimizu, Ryo Atsumi, Tsunenori Nakazawa, Yuko Fujimaki, Kenichi Sudo and Osamu Okazaki
    Drug Metabolism and Disposition September 2009, 37 (9) 1904-1915; DOI: https://doi.org/10.1124/dmd.109.027524
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    Sex-Dependent Disposition of Acetaminophen Sulfate and Glucuronide in the in Situ Perfused Mouse Liver
    Jin Kyung Lee, Koji Abe, Arlene S. Bridges, Nita J. Patel, Thomas J. Raub, Gary M. Pollack and Kim L. R. Brouwer
    Drug Metabolism and Disposition September 2009, 37 (9) 1916-1921; DOI: https://doi.org/10.1124/dmd.109.026815
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    An in Vitro Evaluation of the Victim and Perpetrator Potential of the Anticancer Agent Laromustine (VNP40101M), Based on Reaction Phenotyping and Inhibition and Induction of Cytochrome P450 Enzymes
    Alaa-Eldin F. Nassar, Ivan King, Brandy L. Paris, Lois Haupt, Florence Ndikum-Moffor, Rebecca Campbell, Etsuko Usuki, Jennifer Skibbe, Dan Brobst, Brian W. Ogilvie and Andrew Parkinson
    Drug Metabolism and Disposition September 2009, 37 (9) 1922-1930; DOI: https://doi.org/10.1124/dmd.109.027516
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    Inhibition of Human CYP2B6-Catalyzed Bupropion Hydroxylation by Ginkgo biloba Extract: Effect of Terpene Trilactones and Flavonols
    Aik Jiang Lau and Thomas K. H. Chang
    Drug Metabolism and Disposition September 2009, 37 (9) 1931-1937; DOI: https://doi.org/10.1124/dmd.109.028118
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    3-Ketocholanoic Acid Is the Major in Vitro Human Hepatic Microsomal Metabolite of Lithocholic Acid
    Anand K. Deo and Stelvio M. Bandiera
    Drug Metabolism and Disposition September 2009, 37 (9) 1938-1947; DOI: https://doi.org/10.1124/dmd.109.027763
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    Influence of N-Terminal Domain Histidine and Proline Residues on the Substrate Selectivities of Human UDP-Glucuronosyltransferase 1A1, 1A6, 1A9, 2B7, and 2B10
    Oranun Kerdpin, Peter I. Mackenzie, Kushari Bowalgaha, Moshe Finel and John O. Miners
    Drug Metabolism and Disposition September 2009, 37 (9) 1948-1955; DOI: https://doi.org/10.1124/dmd.109.028225
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    Culture Period-Dependent Change of Function and Expression of ATP-Binding Cassette Transporters in Caco-2 Cells
    Emi Kamiyama, Daisuke Sugiyama, Daisuke Nakai, Shin-ichi Miura and Osamu Okazaki
    Drug Metabolism and Disposition September 2009, 37 (9) 1956-1962; DOI: https://doi.org/10.1124/dmd.109.027490
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    Thyroid Hormone Is Necessary for Expression of Constitutive Androstane Receptor in Rat Hepatocytes
    Hidekazu Ooe, Junko Kon, Hideki Oshima and Toshihiro Mitaka
    Drug Metabolism and Disposition September 2009, 37 (9) 1963-1969; DOI: https://doi.org/10.1124/dmd.108.022905
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    A Zone Classification System for Risk Assessment of Idiosyncratic Drug Toxicity Using Daily Dose and Covalent Binding
    Shintaro Nakayama, Ryo Atsumi, Hideo Takakusa, Yoshimasa Kobayashi, Atsushi Kurihara, Yoko Nagai, Daisuke Nakai and Osamu Okazaki
    Drug Metabolism and Disposition September 2009, 37 (9) 1970-1977; DOI: https://doi.org/10.1124/dmd.109.027797
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    Genetic Polymorphisms in the TATA Box and Upstream Phenobarbital-Responsive Enhancer Module of the UGT1A1 Promoter Have Combined Effects on UDP-Glucuronosyltransferase 1A1 Transcription Mediated by Constitutive Androstane Receptor, Pregnane X Receptor, or Glucocorticoid Receptor in Human Liver
    Ye Li, David Buckley, Shuang Wang, Curtis D. Klaassen and Xiao-bo Zhong
    Drug Metabolism and Disposition September 2009, 37 (9) 1978-1986; DOI: https://doi.org/10.1124/dmd.109.027409
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In this issue

Drug Metabolism and Disposition: 37 (9)
Drug Metabolism and Disposition
Vol. 37, Issue 9
1 Sep 2009
  • Table of Contents
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  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
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