Table of Contents

Articles

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  Comparative Biotransformation of Pyrazinone-Containing Corticotropin-Releasing Factor Receptor-1 Antagonists: Minimizing the Reactive Metabolite Formation

  Xiaoliang Zhuo, Richard A. Hartz, Joanne J. Bronson, Harvey Wong, Vijay T. Ahuja, Vivekana M. Vrudhula, John E. Leet, Stella Huang, John E. Macor and Yue-Zhong Shu

  Drug Metabolism and Disposition January 2010, 38 (1) 5-15; DOI: https://doi.org/10.1124/dmd.109.028910
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  Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction

  Sean Kim, Joseph E. Dinchuk, Monique N. Anthony, Tami Orcutt, Mary E. Zoeckler, Mary B. Sauer, Kathleen W. Mosure, Ragini Vuppugalla, James E. Grace, Jean Simmermacher, Heidi A. Dulac, Jennifer Pizzano and Michael Sinz

  Drug Metabolism and Disposition January 2010, 38 (1) 16-24; DOI: https://doi.org/10.1124/dmd.109.029637
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  In Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3

  Souzan B. Yanni, Pieter P. Annaert, Patrick Augustijns, Joseph G. Ibrahim, Daniel K. Benjamin and Dhiren R. Thakker

  Drug Metabolism and Disposition January 2010, 38 (1) 25-31; DOI: https://doi.org/10.1124/dmd.109.029769
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  Comparison of the Drug-Drug Interactions Potential of Erlotinib and Gefitinib via Inhibition of UDP-Glucuronosyltransferases

  Yong Liu, Jacqueline Ramírez, Larry House and Mark J. Ratain

  Drug Metabolism and Disposition January 2010, 38 (1) 32-39; DOI: https://doi.org/10.1124/dmd.109.029660
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  Contribution of the Different UDP-Glucuronosyltransferase (UGT) Isoforms to Buprenorphine and Norbuprenorphine Metabolism and Relationship with the Main UGT Polymorphisms in a Bank of Human Liver Microsomes

  Koukeb Rouguieg, Nicolas Picard, François-Ludovic Sauvage, Jean-Michel Gaulier and Pierre Marquet

  Drug Metabolism and Disposition January 2010, 38 (1) 40-45; DOI: https://doi.org/10.1124/dmd.109.029546
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  Identification of Multiple Glutathione Conjugates of 8-Amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (Nomifensine) in Liver Microsomes and Hepatocyte Preparations: Evidence of the Bioactivation of Nomifensine

  Jian Yu, Donald E. Mathisen, Doug Burdette, Dean G. Brown, Christopher Becker and David Aharony

  Drug Metabolism and Disposition January 2010, 38 (1) 46-60; DOI: https://doi.org/10.1124/dmd.109.028803
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  Inhibition of CYP3A by Erythromycin: In Vitro-In Vivo Correlation in Rats

  Xin Zhang, Raymond E. Galinsky, Robert E. Kimura, Sara K. Quinney, David R. Jones and Stephen D. Hall

  Drug Metabolism and Disposition January 2010, 38 (1) 61-72; DOI: https://doi.org/10.1124/dmd.109.028290
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  In Vitro Metabolism of Haloperidol and Sila-Haloperidol: New Metabolic Pathways Resulting from Carbon/Silicon Exchange

  Tove Johansson, Lars Weidolf, Friedrich Popp, Reinhold Tacke and Ulrik Jurva

  Drug Metabolism and Disposition January 2010, 38 (1) 73-83; DOI: https://doi.org/10.1124/dmd.109.028449
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  Impact of Molecular Processing in the Hinge Region of Therapeutic IgG4 Antibodies on Disposition Profiles in Cynomolgus Monkeys

  Kay Stubenrauch, Uwe Wessels, Joerg Thomas Regula, Hubert Kettenberger, Julia Schleypen and Ulrich Kohnert

  Drug Metabolism and Disposition January 2010, 38 (1) 84-91; DOI: https://doi.org/10.1124/dmd.109.029751
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  Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite

  Miho Kazui, Yumi Nishiya, Tomoko Ishizuka, Katsunobu Hagihara, Nagy A. Farid, Osamu Okazaki, Toshihiko Ikeda and Atsushi Kurihara

  Drug Metabolism and Disposition January 2010, 38 (1) 92-99; DOI: https://doi.org/10.1124/dmd.109.029132
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  Gene Regulation of CYP4F11 in Human Keratinocyte HaCaT Cells

  Ying Wang, Jordan C. Bell, Diane S. Keeney and Henry W. Strobel

  Drug Metabolism and Disposition January 2010, 38 (1) 100-107; DOI: https://doi.org/10.1124/dmd.109.029025
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  Glutathione S-Transferase Catalyzed Desulfonylation of a Sulfonylfuropyridine

  Thomas J. Bateman, John S. Debenham, Christina Madsen-Duggan, Richard B. Toupence, Thomas F. Walsh, Quang Truong, Scott A. Bradley, George A. Doss, Sanjeev Kumar and Vijay Bhasker G. Reddy

  Drug Metabolism and Disposition January 2010, 38 (1) 108-114; DOI: https://doi.org/10.1124/dmd.109.029801
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  Prediction of V_ss from In Vitro Tissue-Binding Studies

  Loren M. Berry, Jonathan Roberts, Xuhai Be, Zhiyang Zhao and Min-Hwa Jasmine Lin

  Drug Metabolism and Disposition January 2010, 38 (1) 115-121; DOI: https://doi.org/10.1124/dmd.109.029629
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  Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries

  Abhishek Srivastava, Lu-Yun Lian, James L. Maggs, Masautso Chaponda, Munir Pirmohamed, Dominic P. Williams and B. Kevin Park

  Drug Metabolism and Disposition January 2010, 38 (1) 122-132; DOI: https://doi.org/10.1124/dmd.109.028688
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  Stereoselective Flunoxaprofen-S-acyl-glutathione Thioester Formation Mediated by Acyl-CoA Formation in Rat Hepatocytes

  Mark P. Grillo, Jill C. M. Wait, Michelle Tadano Lohr, Smriti Khera and Leslie Z. Benet

  Drug Metabolism and Disposition January 2010, 38 (1) 133-142; DOI: https://doi.org/10.1124/dmd.109.029371
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  Intestinal Detoxification Limits the Activation of Hepatic Pregnane X Receptor by Lithocholic Acid

  Bryn M. Owen, Alexandra Milona, Saskia van Mil, Peter Clements, Julie Holder, Mohamed Boudjelal, William Cairns, Malcolm Parker, Roger White and Catherine Williamson

  Drug Metabolism and Disposition January 2010, 38 (1) 143-149; DOI: https://doi.org/10.1124/dmd.109.029306
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  A Possible Mechanism for the Decrease in Serum Thyroxine Level by a 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Like Polychlorinated Biphenyl Congener, 3,3′,4,4′,5-Pentachlorobiphenyl in Mice

  Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Yoshiki Seto, Takashi Okura, Shin-ichi Ikushiro, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa

  Drug Metabolism and Disposition January 2010, 38 (1) 150-156; DOI: https://doi.org/10.1124/dmd.109.029348
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  Regulation of Gene Expression in Brain Tissues of Rats Repeatedly Treated by the Highly Abused Opioid Agonist, Oxycodone: Microarray Profiling and Gene Mapping Analysis

  Hazem E. Hassan, Alan L. Myers, Insong J. Lee, Hegang Chen, Andrew Coop and Natalie D. Eddington

  Drug Metabolism and Disposition January 2010, 38 (1) 157-167; DOI: https://doi.org/10.1124/dmd.109.029199
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  Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier

  Atsushi Ose, Hiroyuki Kusuhara, Chihiro Endo, Kimio Tohyama, Mari Miyajima, Satoshi Kitamura and Yuichi Sugiyama

  Drug Metabolism and Disposition January 2010, 38 (1) 168-176; DOI: https://doi.org/10.1124/dmd.109.029454
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  Induction of UGT1A1 and CYP2B6 by an Antimitogenic Factor in HepG2 Cells Is Mediated through Suppression of Cyclin-Dependent Kinase 2 Activity: Cell Cycle-Dependent Expression

  Junko Sugatani, Makoto Osabe, Masatoshi Kurosawa, Naomi Kitamura, Akira Ikari and Masao Miwa

  Drug Metabolism and Disposition January 2010, 38 (1) 177-186; DOI: https://doi.org/10.1124/dmd.109.029785
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  Exploration of Catalytic Properties of CYP2D6 and CYP3A4 Through Metabolic Studies of Levorphanol and Levallorphan

  Britta Bonn, Collen M. Masimirembwa and Neal Castagnoli

  Drug Metabolism and Disposition January 2010, 38 (1) 187-199; DOI: https://doi.org/10.1124/dmd.109.028670
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  Tamoxifen-Induced Adduct Formation and Cell Stress in Human Endometrial Glands

  Helén Andersson, Malin Helmestam, Anna Zebrowska, Matts Olovsson and Eva Brittebo

  Drug Metabolism and Disposition January 2010, 38 (1) 200-207; DOI: https://doi.org/10.1124/dmd.109.029488