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Drug Metabolism & Disposition

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Table of Contents

January 01, 2010; Volume 38,Issue 1

Short Communication

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    Characterization of Human Organic Cation Transporter 1 (OCT1/SLC22A1)- and OCT2 (SLC22A2)-Mediated Transport of 1-(2-Methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)- 4,9-dihydro-1H-naphtho[2,3-d]imidazolium Bromide (YM155 Monobromide), a Novel Small Molecule Survivin Suppressant
    Tsuyoshi Minematsu, Megumi Iwai, Ken-ichi Umehara, Takashi Usui and Hidetaka Kamimura
    Drug Metabolism and Disposition January 2010, 38 (1) 1-4; DOI: https://doi.org/10.1124/dmd.109.028142

Articles

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    Comparative Biotransformation of Pyrazinone-Containing Corticotropin-Releasing Factor Receptor-1 Antagonists: Minimizing the Reactive Metabolite Formation
    Xiaoliang Zhuo, Richard A. Hartz, Joanne J. Bronson, Harvey Wong, Vijay T. Ahuja, Vivekana M. Vrudhula, John E. Leet, Stella Huang, John E. Macor and Yue-Zhong Shu
    Drug Metabolism and Disposition January 2010, 38 (1) 5-15; DOI: https://doi.org/10.1124/dmd.109.028910
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    Evaluation of Cynomolgus Monkey Pregnane X Receptor, Primary Hepatocyte, and in Vivo Pharmacokinetic Changes in Predicting Human CYP3A4 Induction
    Sean Kim, Joseph E. Dinchuk, Monique N. Anthony, Tami Orcutt, Mary E. Zoeckler, Mary B. Sauer, Kathleen W. Mosure, Ragini Vuppugalla, James E. Grace, Jean Simmermacher, Heidi A. Dulac, Jennifer Pizzano and Michael Sinz
    Drug Metabolism and Disposition January 2010, 38 (1) 16-24; DOI: https://doi.org/10.1124/dmd.109.029637
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    In Vitro Hepatic Metabolism Explains Higher Clearance of Voriconazole in Children versus Adults: Role of CYP2C19 and Flavin-Containing Monooxygenase 3
    Souzan B. Yanni, Pieter P. Annaert, Patrick Augustijns, Joseph G. Ibrahim, Daniel K. Benjamin and Dhiren R. Thakker
    Drug Metabolism and Disposition January 2010, 38 (1) 25-31; DOI: https://doi.org/10.1124/dmd.109.029769
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    Comparison of the Drug-Drug Interactions Potential of Erlotinib and Gefitinib via Inhibition of UDP-Glucuronosyltransferases
    Yong Liu, Jacqueline Ramírez, Larry House and Mark J. Ratain
    Drug Metabolism and Disposition January 2010, 38 (1) 32-39; DOI: https://doi.org/10.1124/dmd.109.029660
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    Contribution of the Different UDP-Glucuronosyltransferase (UGT) Isoforms to Buprenorphine and Norbuprenorphine Metabolism and Relationship with the Main UGT Polymorphisms in a Bank of Human Liver Microsomes
    Koukeb Rouguieg, Nicolas Picard, François-Ludovic Sauvage, Jean-Michel Gaulier and Pierre Marquet
    Drug Metabolism and Disposition January 2010, 38 (1) 40-45; DOI: https://doi.org/10.1124/dmd.109.029546
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    Identification of Multiple Glutathione Conjugates of 8-Amino- 2-methyl-4-phenyl-1,2,3,4-tetrahydroisoquinoline maleate (Nomifensine) in Liver Microsomes and Hepatocyte Preparations: Evidence of the Bioactivation of Nomifensine
    Jian Yu, Donald E. Mathisen, Doug Burdette, Dean G. Brown, Christopher Becker and David Aharony
    Drug Metabolism and Disposition January 2010, 38 (1) 46-60; DOI: https://doi.org/10.1124/dmd.109.028803
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    Inhibition of CYP3A by Erythromycin: In Vitro-In Vivo Correlation in Rats
    Xin Zhang, Raymond E. Galinsky, Robert E. Kimura, Sara K. Quinney, David R. Jones and Stephen D. Hall
    Drug Metabolism and Disposition January 2010, 38 (1) 61-72; DOI: https://doi.org/10.1124/dmd.109.028290
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    In Vitro Metabolism of Haloperidol and Sila-Haloperidol: New Metabolic Pathways Resulting from Carbon/Silicon Exchange
    Tove Johansson, Lars Weidolf, Friedrich Popp, Reinhold Tacke and Ulrik Jurva
    Drug Metabolism and Disposition January 2010, 38 (1) 73-83; DOI: https://doi.org/10.1124/dmd.109.028449
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    Impact of Molecular Processing in the Hinge Region of Therapeutic IgG4 Antibodies on Disposition Profiles in Cynomolgus Monkeys
    Kay Stubenrauch, Uwe Wessels, Joerg Thomas Regula, Hubert Kettenberger, Julia Schleypen and Ulrich Kohnert
    Drug Metabolism and Disposition January 2010, 38 (1) 84-91; DOI: https://doi.org/10.1124/dmd.109.029751
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    Identification of the Human Cytochrome P450 Enzymes Involved in the Two Oxidative Steps in the Bioactivation of Clopidogrel to Its Pharmacologically Active Metabolite
    Miho Kazui, Yumi Nishiya, Tomoko Ishizuka, Katsunobu Hagihara, Nagy A. Farid, Osamu Okazaki, Toshihiko Ikeda and Atsushi Kurihara
    Drug Metabolism and Disposition January 2010, 38 (1) 92-99; DOI: https://doi.org/10.1124/dmd.109.029132
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    Gene Regulation of CYP4F11 in Human Keratinocyte HaCaT Cells
    Ying Wang, Jordan C. Bell, Diane S. Keeney and Henry W. Strobel
    Drug Metabolism and Disposition January 2010, 38 (1) 100-107; DOI: https://doi.org/10.1124/dmd.109.029025
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    Glutathione S-Transferase Catalyzed Desulfonylation of a Sulfonylfuropyridine
    Thomas J. Bateman, John S. Debenham, Christina Madsen-Duggan, Richard B. Toupence, Thomas F. Walsh, Quang Truong, Scott A. Bradley, George A. Doss, Sanjeev Kumar and Vijay Bhasker G. Reddy
    Drug Metabolism and Disposition January 2010, 38 (1) 108-114; DOI: https://doi.org/10.1124/dmd.109.029801
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    Prediction of Vss from In Vitro Tissue-Binding Studies
    Loren M. Berry, Jonathan Roberts, Xuhai Be, Zhiyang Zhao and Min-Hwa Jasmine Lin
    Drug Metabolism and Disposition January 2010, 38 (1) 115-121; DOI: https://doi.org/10.1124/dmd.109.029629
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    Quantifying the Metabolic Activation of Nevirapine in Patients by Integrated Applications of NMR and Mass Spectrometries
    Abhishek Srivastava, Lu-Yun Lian, James L. Maggs, Masautso Chaponda, Munir Pirmohamed, Dominic P. Williams and B. Kevin Park
    Drug Metabolism and Disposition January 2010, 38 (1) 122-132; DOI: https://doi.org/10.1124/dmd.109.028688
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    Stereoselective Flunoxaprofen-S-acyl-glutathione Thioester Formation Mediated by Acyl-CoA Formation in Rat Hepatocytes
    Mark P. Grillo, Jill C. M. Wait, Michelle Tadano Lohr, Smriti Khera and Leslie Z. Benet
    Drug Metabolism and Disposition January 2010, 38 (1) 133-142; DOI: https://doi.org/10.1124/dmd.109.029371
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    Intestinal Detoxification Limits the Activation of Hepatic Pregnane X Receptor by Lithocholic Acid
    Bryn M. Owen, Alexandra Milona, Saskia van Mil, Peter Clements, Julie Holder, Mohamed Boudjelal, William Cairns, Malcolm Parker, Roger White and Catherine Williamson
    Drug Metabolism and Disposition January 2010, 38 (1) 143-149; DOI: https://doi.org/10.1124/dmd.109.029306
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    A Possible Mechanism for the Decrease in Serum Thyroxine Level by a 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Like Polychlorinated Biphenyl Congener, 3,3′,4,4′,5-Pentachlorobiphenyl in Mice
    Yoshihisa Kato, Koichi Haraguchi, Makiko Kubota, Yoshiki Seto, Takashi Okura, Shin-ichi Ikushiro, Nobuyuki Koga, Shizuo Yamada and Masakuni Degawa
    Drug Metabolism and Disposition January 2010, 38 (1) 150-156; DOI: https://doi.org/10.1124/dmd.109.029348
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    Regulation of Gene Expression in Brain Tissues of Rats Repeatedly Treated by the Highly Abused Opioid Agonist, Oxycodone: Microarray Profiling and Gene Mapping Analysis
    Hazem E. Hassan, Alan L. Myers, Insong J. Lee, Hegang Chen, Andrew Coop and Natalie D. Eddington
    Drug Metabolism and Disposition January 2010, 38 (1) 157-167; DOI: https://doi.org/10.1124/dmd.109.029199
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    Functional Characterization of Mouse Organic Anion Transporting Peptide 1a4 in the Uptake and Efflux of Drugs Across the Blood-Brain Barrier
    Atsushi Ose, Hiroyuki Kusuhara, Chihiro Endo, Kimio Tohyama, Mari Miyajima, Satoshi Kitamura and Yuichi Sugiyama
    Drug Metabolism and Disposition January 2010, 38 (1) 168-176; DOI: https://doi.org/10.1124/dmd.109.029454
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    Induction of UGT1A1 and CYP2B6 by an Antimitogenic Factor in HepG2 Cells Is Mediated through Suppression of Cyclin-Dependent Kinase 2 Activity: Cell Cycle-Dependent Expression
    Junko Sugatani, Makoto Osabe, Masatoshi Kurosawa, Naomi Kitamura, Akira Ikari and Masao Miwa
    Drug Metabolism and Disposition January 2010, 38 (1) 177-186; DOI: https://doi.org/10.1124/dmd.109.029785
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    Exploration of Catalytic Properties of CYP2D6 and CYP3A4 Through Metabolic Studies of Levorphanol and Levallorphan
    Britta Bonn, Collen M. Masimirembwa and Neal Castagnoli
    Drug Metabolism and Disposition January 2010, 38 (1) 187-199; DOI: https://doi.org/10.1124/dmd.109.028670
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    Tamoxifen-Induced Adduct Formation and Cell Stress in Human Endometrial Glands
    Helén Andersson, Malin Helmestam, Anna Zebrowska, Matts Olovsson and Eva Brittebo
    Drug Metabolism and Disposition January 2010, 38 (1) 200-207; DOI: https://doi.org/10.1124/dmd.109.029488
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In this issue

Drug Metabolism and Disposition: 38 (1)
Drug Metabolism and Disposition
Vol. 38, Issue 1
1 Jan 2010
  • Table of Contents
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  • Index by author
  • Back Matter (PDF)
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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