Table of Contents

Articles

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  Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats

  John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford

  Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431
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  Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats

  Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Shin-ichi Ikushiro, Toshiyuki Sakaki, Akira Ikari and Masao Miwa

  Drug Metabolism and Disposition October 2010, 38 (10) 1655-1664; DOI: https://doi.org/10.1124/dmd.110.034090
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  Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver

  Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato

  Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763
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  Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis

  Albert Mennone, Carol J. Soroka, Kathy M. Harry and James L. Boyer

  Drug Metabolism and Disposition October 2010, 38 (10) 1673-1678; DOI: https://doi.org/10.1124/dmd.110.034512
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  Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme

  Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou

  Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678
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  In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology

  Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison

  Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159
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  Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats

  Carolin Hamberger, Marco Kellert, Ute M. Schauer, Wolfgang Dekant and Angela Mally

  Drug Metabolism and Disposition October 2010, 38 (10) 1698-1706; DOI: https://doi.org/10.1124/dmd.109.031781
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  Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation

  Yuen Yi Hon, He Sun, André Dejam and Mark T. Gladwin

  Drug Metabolism and Disposition October 2010, 38 (10) 1707-1713; DOI: https://doi.org/10.1124/dmd.110.034355
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  Metabolism of Dicentrine: Identification of the Phase I and Phase II Metabolites in Miniature Pig Urine

  Yi-Chun Lai, Tzong-Fu Kuo, Chien-Kuang Chen, Han-Ju Tsai and Shoei-Sheng Lee

  Drug Metabolism and Disposition October 2010, 38 (10) 1714-1722; DOI: https://doi.org/10.1124/dmd.110.033795
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  Hepatobiliary Disposition of 3α,6α,7α,12α-Tetrahydroxy-Cholanoyl Taurine: A Substrate for Multiple Canalicular Transporters

  Vandana Megaraj, Takashi Iida, Paiboon Jungsuwadee, Alan F. Hofmann and Mary Vore

  Drug Metabolism and Disposition October 2010, 38 (10) 1723-1730; DOI: https://doi.org/10.1124/dmd.110.033480
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  Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship

  Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang

  Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845
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  Significance and Regional Dependency of Peptide Transporter (PEPT) 1 in the Intestinal Permeability of Glycylsarcosine: In Situ Single-Pass Perfusion Studies in Wild-Type and Pept1 Knockout Mice

  Dilara Jappar, Shu-Pei Wu, Yongjun Hu and David E. Smith

  Drug Metabolism and Disposition October 2010, 38 (10) 1740-1746; DOI: https://doi.org/10.1124/dmd.110.034025
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  Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats

  Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang

  Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373
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  Impact of Polyinosinic/Polycytidylic Acid on Placental and Hepatobiliary Drug Transporters in Pregnant Rats

  Vanja Petrovic and Micheline Piquette-Miller

  Drug Metabolism and Disposition October 2010, 38 (10) 1760-1766; DOI: https://doi.org/10.1124/dmd.110.034470
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  In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism

  Jian Yu, Dean G. Brown and Doug Burdette

  Drug Metabolism and Disposition October 2010, 38 (10) 1767-1778; DOI: https://doi.org/10.1124/dmd.110.033910
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  Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats

  Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang

  Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936
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  Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro

  Judith Bellemare, Mélanie Rouleau, Hugo Girard, Mario Harvey and Chantal Guillemette

  Drug Metabolism and Disposition October 2010, 38 (10) 1785-1789; DOI: https://doi.org/10.1124/dmd.110.034835
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  Interaction between Topically and Systemically Coadministered P-Glycoprotein Substrates/Inhibitors: Effect on Vitreal Kinetics

  Ketan Hippalgaonkar, Ramesh Srirangam, Bharathi Avula, Ikhlas A. Khan and Soumyajit Majumdar

  Drug Metabolism and Disposition October 2010, 38 (10) 1790-1797; DOI: https://doi.org/10.1124/dmd.110.032672
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  Adenosine Transport by Plasma Membrane Monoamine Transporter: Reinvestigation and Comparison with Organic Cations

  Mingyan Zhou, Haichuan Duan, Karen Engel, Li Xia and Joanne Wang

  Drug Metabolism and Disposition October 2010, 38 (10) 1798-1805; DOI: https://doi.org/10.1124/dmd.110.032987
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  Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys

  Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume

  Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656
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  Influence of Cytidine Deaminase on Antitumor Activity of 2′-Deoxycytidine Analogs In Vitro and In Vivo

  Takahiro Yoshida, Yoshio Endo, Tohru Obata, Yuri Kosugi, Kazuki Sakamoto and Takuma Sasaki

  Drug Metabolism and Disposition October 2010, 38 (10) 1814-1819; DOI: https://doi.org/10.1124/dmd.110.034397
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  Molecular Cloning, Expression, and Initial Characterization of Members of the CYP3A Family in Horses

  Heather K. DiMaio Knych, Daniel S. McKemie and Scott D. Stanley

  Drug Metabolism and Disposition October 2010, 38 (10) 1820-1827; DOI: https://doi.org/10.1124/dmd.110.032953
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  Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide

  Yusuke Masuo, Kousei Ito, Takehito Yamamoto, Akihiro Hisaka, Masashi Honma and Hiroshi Suzuki

  Drug Metabolism and Disposition October 2010, 38 (10) 1828-1835; DOI: https://doi.org/10.1124/dmd.110.034231
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  Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas

  Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle

  Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579
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  In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats

  Souzan B. Yanni, Patrick F. Augustijns, Daniel K. Benjamin, Kim L. R. Brouwer, Dhiren R. Thakker and Pieter P. Annaert

  Drug Metabolism and Disposition October 2010, 38 (10) 1848-1856; DOI: https://doi.org/10.1124/dmd.110.033811
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  Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide

  Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki

  Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173
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  Effects of Typical Inducers on Olfactory Xenobiotic-Metabolizing Enzyme, Transporter, and Transcription Factor Expression in Rats

  Nicolas Thiebaud, Maud Sigoillot, Joëlle Chevalier, Yves Artur, Jean-Marie Heydel and Anne-Marie Le Bon

  Drug Metabolism and Disposition October 2010, 38 (10) 1865-1875; DOI: https://doi.org/10.1124/dmd.110.035014
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  Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs

  Lidia Miraglia, Sabrina Pagliarusco, Ellenia Bordini, Silvia Martinucci and Mario Pellegatti

  Drug Metabolism and Disposition October 2010, 38 (10) 1876-1891; DOI: https://doi.org/10.1124/dmd.110.033092
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  O-Methylation of Catechol Estrogens by Human Placental Catechol-O-Methyltransferase: Interindividual Differences in Sensitivity to Heat Inactivation and to Inhibition by Dietary Polyphenols

  Bao Ting Zhu, Karen Y. Wu, Pan Wang, May Xiaoxin Cai and Allan H. Conney

  Drug Metabolism and Disposition October 2010, 38 (10) 1892-1899; DOI: https://doi.org/10.1124/dmd.110.033548