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Drug Metabolism & Disposition

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Table of Contents

October 01, 2010; Volume 38,Issue 10

MINIREVIEW

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    The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies
    Caroline Prouillac and Sylvaine Lecoeur
    Drug Metabolism and Disposition October 2010, 38 (10) 1623-1635; DOI: https://doi.org/10.1124/dmd.110.033571

Short Communications

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    Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method
    Ran Okada, Yuri Ishizu, Ryuta Endo, Alexander Lezhava, Ichiro Ieiri, Hiroyuki Kusuhara, Yuichi Sugiyama and Yoshihide Hayashizaki
    Drug Metabolism and Disposition October 2010, 38 (10) 1636-1639; DOI: https://doi.org/10.1124/dmd.110.034652
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    Regulatory Xenobiotic Responsive Elements in the Distal 5′-Flanking Region of the Mouse Cyp1a2 Gene Required for Transcriptional Activation by 3-Methylcholanthrene and 2,3,7,8-Tetrachlorodibenzo-p-dioxin
    Yuki Kawasaki, Tsutomu Sakuma, Yuma Goto and Nobuo Nemoto
    Drug Metabolism and Disposition October 2010, 38 (10) 1640-1643; DOI: https://doi.org/10.1124/dmd.109.031856
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    Drug Transporter Expression and Localization in Rat Nasal Respiratory and Olfactory Mucosa and Olfactory Bulb
    Mary Beth Genter, Mansi Krishan, Lisa M. Augustine and Nathan J. Cherrington
    Drug Metabolism and Disposition October 2010, 38 (10) 1644-1647; DOI: https://doi.org/10.1124/dmd.110.034611

Articles

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    Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
    John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
    Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431
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    Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats
    Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Shin-ichi Ikushiro, Toshiyuki Sakaki, Akira Ikari and Masao Miwa
    Drug Metabolism and Disposition October 2010, 38 (10) 1655-1664; DOI: https://doi.org/10.1124/dmd.110.034090
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    Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
    Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
    Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763
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    Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis
    Albert Mennone, Carol J. Soroka, Kathy M. Harry and James L. Boyer
    Drug Metabolism and Disposition October 2010, 38 (10) 1673-1678; DOI: https://doi.org/10.1124/dmd.110.034512
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    Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme
    Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou
    Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678
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    In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
    Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
    Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159
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    Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats
    Carolin Hamberger, Marco Kellert, Ute M. Schauer, Wolfgang Dekant and Angela Mally
    Drug Metabolism and Disposition October 2010, 38 (10) 1698-1706; DOI: https://doi.org/10.1124/dmd.109.031781
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    Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation
    Yuen Yi Hon, He Sun, André Dejam and Mark T. Gladwin
    Drug Metabolism and Disposition October 2010, 38 (10) 1707-1713; DOI: https://doi.org/10.1124/dmd.110.034355
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    Metabolism of Dicentrine: Identification of the Phase I and Phase II Metabolites in Miniature Pig Urine
    Yi-Chun Lai, Tzong-Fu Kuo, Chien-Kuang Chen, Han-Ju Tsai and Shoei-Sheng Lee
    Drug Metabolism and Disposition October 2010, 38 (10) 1714-1722; DOI: https://doi.org/10.1124/dmd.110.033795
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    Hepatobiliary Disposition of 3α,6α,7α,12α-Tetrahydroxy-Cholanoyl Taurine: A Substrate for Multiple Canalicular Transporters
    Vandana Megaraj, Takashi Iida, Paiboon Jungsuwadee, Alan F. Hofmann and Mary Vore
    Drug Metabolism and Disposition October 2010, 38 (10) 1723-1730; DOI: https://doi.org/10.1124/dmd.110.033480
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    Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
    Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
    Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845
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    Significance and Regional Dependency of Peptide Transporter (PEPT) 1 in the Intestinal Permeability of Glycylsarcosine: In Situ Single-Pass Perfusion Studies in Wild-Type and Pept1 Knockout Mice
    Dilara Jappar, Shu-Pei Wu, Yongjun Hu and David E. Smith
    Drug Metabolism and Disposition October 2010, 38 (10) 1740-1746; DOI: https://doi.org/10.1124/dmd.110.034025
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    Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
    Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
    Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373
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    Impact of Polyinosinic/Polycytidylic Acid on Placental and Hepatobiliary Drug Transporters in Pregnant Rats
    Vanja Petrovic and Micheline Piquette-Miller
    Drug Metabolism and Disposition October 2010, 38 (10) 1760-1766; DOI: https://doi.org/10.1124/dmd.110.034470
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    In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism
    Jian Yu, Dean G. Brown and Doug Burdette
    Drug Metabolism and Disposition October 2010, 38 (10) 1767-1778; DOI: https://doi.org/10.1124/dmd.110.033910
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    Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats
    Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
    Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936
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    Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro
    Judith Bellemare, Mélanie Rouleau, Hugo Girard, Mario Harvey and Chantal Guillemette
    Drug Metabolism and Disposition October 2010, 38 (10) 1785-1789; DOI: https://doi.org/10.1124/dmd.110.034835
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    Interaction between Topically and Systemically Coadministered P-Glycoprotein Substrates/Inhibitors: Effect on Vitreal Kinetics
    Ketan Hippalgaonkar, Ramesh Srirangam, Bharathi Avula, Ikhlas A. Khan and Soumyajit Majumdar
    Drug Metabolism and Disposition October 2010, 38 (10) 1790-1797; DOI: https://doi.org/10.1124/dmd.110.032672
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    Adenosine Transport by Plasma Membrane Monoamine Transporter: Reinvestigation and Comparison with Organic Cations
    Mingyan Zhou, Haichuan Duan, Karen Engel, Li Xia and Joanne Wang
    Drug Metabolism and Disposition October 2010, 38 (10) 1798-1805; DOI: https://doi.org/10.1124/dmd.110.032987
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    Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys
    Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume
    Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656
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    Influence of Cytidine Deaminase on Antitumor Activity of 2′-Deoxycytidine Analogs In Vitro and In Vivo
    Takahiro Yoshida, Yoshio Endo, Tohru Obata, Yuri Kosugi, Kazuki Sakamoto and Takuma Sasaki
    Drug Metabolism and Disposition October 2010, 38 (10) 1814-1819; DOI: https://doi.org/10.1124/dmd.110.034397
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    Molecular Cloning, Expression, and Initial Characterization of Members of the CYP3A Family in Horses
    Heather K. DiMaio Knych, Daniel S. McKemie and Scott D. Stanley
    Drug Metabolism and Disposition October 2010, 38 (10) 1820-1827; DOI: https://doi.org/10.1124/dmd.110.032953
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    Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide
    Yusuke Masuo, Kousei Ito, Takehito Yamamoto, Akihiro Hisaka, Masashi Honma and Hiroshi Suzuki
    Drug Metabolism and Disposition October 2010, 38 (10) 1828-1835; DOI: https://doi.org/10.1124/dmd.110.034231
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    Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
    Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
    Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579
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    In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats
    Souzan B. Yanni, Patrick F. Augustijns, Daniel K. Benjamin, Kim L. R. Brouwer, Dhiren R. Thakker and Pieter P. Annaert
    Drug Metabolism and Disposition October 2010, 38 (10) 1848-1856; DOI: https://doi.org/10.1124/dmd.110.033811
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    Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
    Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
    Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173
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    Effects of Typical Inducers on Olfactory Xenobiotic-Metabolizing Enzyme, Transporter, and Transcription Factor Expression in Rats
    Nicolas Thiebaud, Maud Sigoillot, Joëlle Chevalier, Yves Artur, Jean-Marie Heydel and Anne-Marie Le Bon
    Drug Metabolism and Disposition October 2010, 38 (10) 1865-1875; DOI: https://doi.org/10.1124/dmd.110.035014
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    Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs
    Lidia Miraglia, Sabrina Pagliarusco, Ellenia Bordini, Silvia Martinucci and Mario Pellegatti
    Drug Metabolism and Disposition October 2010, 38 (10) 1876-1891; DOI: https://doi.org/10.1124/dmd.110.033092
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    O-Methylation of Catechol Estrogens by Human Placental Catechol-O-Methyltransferase: Interindividual Differences in Sensitivity to Heat Inactivation and to Inhibition by Dietary Polyphenols
    Bao Ting Zhu, Karen Y. Wu, Pan Wang, May Xiaoxin Cai and Allan H. Conney
    Drug Metabolism and Disposition October 2010, 38 (10) 1892-1899; DOI: https://doi.org/10.1124/dmd.110.033548

Accelerated Communication

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    Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
    Wendy WeiWei Wang, Salman R. Khetani, Stacy Krzyzewski, David B. Duignan and R. Scott Obach
    Drug Metabolism and Disposition October 2010, 38 (10) 1900-1905; DOI: https://doi.org/10.1124/dmd.110.034876
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Drug Metabolism and Disposition: 38 (10)
Drug Metabolism and Disposition
Vol. 38, Issue 10
1 Oct 2010
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  • Cytochrome P450 inhibitors. Evaluation of specificities in the in vitrometabolism of therapeutic agents by human liver microsomes.
  • Prediction of Human Clearance of Twenty-Nine Drugs from Hepatic Microsomal Intrinsic Clearance Data: An Examination of In Vitro Half-Life Approach and Nonspecific Binding to Microsomes
  • THE HUMAN INTESTINAL CYTOCHROME P450 “PIE”
  • DRUG-DRUG INTERACTIONS FOR UDP-GLUCURONOSYLTRANSFERASE SUBSTRATES: A PHARMACOKINETIC EXPLANATION FOR TYPICALLY OBSERVED LOW EXPOSURE (AUCI/AUC) RATIOS
  • In Vitro-In Vivo Scaling of CYP Kinetic Data Not Consistent with the Classical Michaelis-Menten Model
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