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Index by author

October 01, 2010; Volume 38,Issue 10

A

  1. Annaert, Pieter P.

    1. In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats
      Souzan B. Yanni, Patrick F. Augustijns, Daniel K. Benjamin, Kim L. R. Brouwer, Dhiren R. Thakker and Pieter P. Annaert
      Drug Metabolism and Disposition October 2010, 38 (10) 1848-1856; DOI: https://doi.org/10.1124/dmd.110.033811

  2. Ariano, John M.

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

  3. Artur, Yves

    1. Effects of Typical Inducers on Olfactory Xenobiotic-Metabolizing Enzyme, Transporter, and Transcription Factor Expression in Rats
      Nicolas Thiebaud, Maud Sigoillot, Joëlle Chevalier, Yves Artur, Jean-Marie Heydel and Anne-Marie Le Bon
      Drug Metabolism and Disposition October 2010, 38 (10) 1865-1875; DOI: https://doi.org/10.1124/dmd.110.035014

  4. Asano, Masahide

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  5. Augustijns, Patrick F.

    1. In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats
      Souzan B. Yanni, Patrick F. Augustijns, Daniel K. Benjamin, Kim L. R. Brouwer, Dhiren R. Thakker and Pieter P. Annaert
      Drug Metabolism and Disposition October 2010, 38 (10) 1848-1856; DOI: https://doi.org/10.1124/dmd.110.033811

  6. Augustine, Lisa M.

    1. Drug Transporter Expression and Localization in Rat Nasal Respiratory and Olfactory Mucosa and Olfactory Bulb
      Mary Beth Genter, Mansi Krishan, Lisa M. Augustine and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2010, 38 (10) 1644-1647; DOI: https://doi.org/10.1124/dmd.110.034611

  7. Avula, Bharathi

    1. Interaction between Topically and Systemically Coadministered P-Glycoprotein Substrates/Inhibitors: Effect on Vitreal Kinetics
      Ketan Hippalgaonkar, Ramesh Srirangam, Bharathi Avula, Ikhlas A. Khan and Soumyajit Majumdar
      Drug Metabolism and Disposition October 2010, 38 (10) 1790-1797; DOI: https://doi.org/10.1124/dmd.110.032672

B

  1. Beck, Melissa J.

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

  2. Bellemare, Judith

    1. Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro
      Judith Bellemare, Mélanie Rouleau, Hugo Girard, Mario Harvey and Chantal Guillemette
      Drug Metabolism and Disposition October 2010, 38 (10) 1785-1789; DOI: https://doi.org/10.1124/dmd.110.034835

  3. Benjamin, Daniel K.

    1. In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats
      Souzan B. Yanni, Patrick F. Augustijns, Daniel K. Benjamin, Kim L. R. Brouwer, Dhiren R. Thakker and Pieter P. Annaert
      Drug Metabolism and Disposition October 2010, 38 (10) 1848-1856; DOI: https://doi.org/10.1124/dmd.110.033811

  4. Biesemeier, John A.

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

  5. Bodle, Eric S.

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

  6. Bompart, Jacques

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  7. Bonnet, Pierre-Antoine

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  8. Bordini, Ellenia

    1. Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs
      Lidia Miraglia, Sabrina Pagliarusco, Ellenia Bordini, Silvia Martinucci and Mario Pellegatti
      Drug Metabolism and Disposition October 2010, 38 (10) 1876-1891; DOI: https://doi.org/10.1124/dmd.110.033092

  9. Boyer, James L.

    1. Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis
      Albert Mennone, Carol J. Soroka, Kathy M. Harry and James L. Boyer
      Drug Metabolism and Disposition October 2010, 38 (10) 1673-1678; DOI: https://doi.org/10.1124/dmd.110.034512

  10. Bressolle, Françoise M. M.

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  11. Brocker, Chad

    1. Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme
      Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou
      Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678

  12. Brouwer, Kim L. R.

    1. In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats
      Souzan B. Yanni, Patrick F. Augustijns, Daniel K. Benjamin, Kim L. R. Brouwer, Dhiren R. Thakker and Pieter P. Annaert
      Drug Metabolism and Disposition October 2010, 38 (10) 1848-1856; DOI: https://doi.org/10.1124/dmd.110.033811

  13. Brown, Dean G.

    1. In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism
      Jian Yu, Dean G. Brown and Doug Burdette
      Drug Metabolism and Disposition October 2010, 38 (10) 1767-1778; DOI: https://doi.org/10.1124/dmd.110.033910

  14. Burdette, Doug

    1. In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism
      Jian Yu, Dean G. Brown and Doug Burdette
      Drug Metabolism and Disposition October 2010, 38 (10) 1767-1778; DOI: https://doi.org/10.1124/dmd.110.033910

  15. Bushby, Nick

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

C

  1. Cai, May Xiaoxin

    1. O-Methylation of Catechol Estrogens by Human Placental Catechol-O-Methyltransferase: Interindividual Differences in Sensitivity to Heat Inactivation and to Inhibition by Dietary Polyphenols
      Bao Ting Zhu, Karen Y. Wu, Pan Wang, May Xiaoxin Cai and Allan H. Conney
      Drug Metabolism and Disposition October 2010, 38 (10) 1892-1899; DOI: https://doi.org/10.1124/dmd.110.033548

  2. Chen, Chien-Kuang

    1. Metabolism of Dicentrine: Identification of the Phase I and Phase II Metabolites in Miniature Pig Urine
      Yi-Chun Lai, Tzong-Fu Kuo, Chien-Kuang Chen, Han-Ju Tsai and Shoei-Sheng Lee
      Drug Metabolism and Disposition October 2010, 38 (10) 1714-1722; DOI: https://doi.org/10.1124/dmd.110.033795

  3. Chen, Ying

    1. Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme
      Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou
      Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678

  4. Cherrington, Nathan J.

    1. Drug Transporter Expression and Localization in Rat Nasal Respiratory and Olfactory Mucosa and Olfactory Bulb
      Mary Beth Genter, Mansi Krishan, Lisa M. Augustine and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2010, 38 (10) 1644-1647; DOI: https://doi.org/10.1124/dmd.110.034611

  5. Chevalier, Joëlle

    1. Effects of Typical Inducers on Olfactory Xenobiotic-Metabolizing Enzyme, Transporter, and Transcription Factor Expression in Rats
      Nicolas Thiebaud, Maud Sigoillot, Joëlle Chevalier, Yves Artur, Jean-Marie Heydel and Anne-Marie Le Bon
      Drug Metabolism and Disposition October 2010, 38 (10) 1865-1875; DOI: https://doi.org/10.1124/dmd.110.035014

  6. Conney, Allan H.

    1. O-Methylation of Catechol Estrogens by Human Placental Catechol-O-Methyltransferase: Interindividual Differences in Sensitivity to Heat Inactivation and to Inhibition by Dietary Polyphenols
      Bao Ting Zhu, Karen Y. Wu, Pan Wang, May Xiaoxin Cai and Allan H. Conney
      Drug Metabolism and Disposition October 2010, 38 (10) 1892-1899; DOI: https://doi.org/10.1124/dmd.110.033548

  7. Cooper, Jean-François

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

D

  1. Dai, Chen

    1. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

  2. Dejam, André

    1. Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation
      Yuen Yi Hon, He Sun, André Dejam and Mark T. Gladwin
      Drug Metabolism and Disposition October 2010, 38 (10) 1707-1713; DOI: https://doi.org/10.1124/dmd.110.034355

  3. Dekant, Wolfgang

    1. Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats
      Carolin Hamberger, Marco Kellert, Ute M. Schauer, Wolfgang Dekant and Angela Mally
      Drug Metabolism and Disposition October 2010, 38 (10) 1698-1706; DOI: https://doi.org/10.1124/dmd.109.031781

  4. Deleuze-Masquéfa, Carine

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  5. Donald, Elizabeth

    1. Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme
      Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou
      Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678

  6. Duan, Haichuan

    1. Adenosine Transport by Plasma Membrane Monoamine Transporter: Reinvestigation and Comparison with Organic Cations
      Mingyan Zhou, Haichuan Duan, Karen Engel, Li Xia and Joanne Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1798-1805; DOI: https://doi.org/10.1124/dmd.110.032987

  7. Duignan, David B.

    1. Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
      Wendy WeiWei Wang, Salman R. Khetani, Stacy Krzyzewski, David B. Duignan and R. Scott Obach
      Drug Metabolism and Disposition October 2010, 38 (10) 1900-1905; DOI: https://doi.org/10.1124/dmd.110.034876

E

  1. El Messaoudi, Safia

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  2. Endo, Ryuta

    1. Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method
      Ran Okada, Yuri Ishizu, Ryuta Endo, Alexander Lezhava, Ichiro Ieiri, Hiroyuki Kusuhara, Yuichi Sugiyama and Yoshihide Hayashizaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1636-1639; DOI: https://doi.org/10.1124/dmd.110.034652

  3. Endo, Yoshio

    1. Influence of Cytidine Deaminase on Antitumor Activity of 2′-Deoxycytidine Analogs In Vitro and In Vivo
      Takahiro Yoshida, Yoshio Endo, Tohru Obata, Yuri Kosugi, Kazuki Sakamoto and Takuma Sasaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1814-1819; DOI: https://doi.org/10.1124/dmd.110.034397

  4. Engel, Karen

    1. Adenosine Transport by Plasma Membrane Monoamine Transporter: Reinvestigation and Comparison with Organic Cations
      Mingyan Zhou, Haichuan Duan, Karen Engel, Li Xia and Joanne Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1798-1805; DOI: https://doi.org/10.1124/dmd.110.032987

G

  1. Gattacceca, Florence

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  2. Genter, Mary Beth

    1. Drug Transporter Expression and Localization in Rat Nasal Respiratory and Olfactory Mucosa and Olfactory Bulb
      Mary Beth Genter, Mansi Krishan, Lisa M. Augustine and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2010, 38 (10) 1644-1647; DOI: https://doi.org/10.1124/dmd.110.034611

  3. Girard, Hugo

    1. Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro
      Judith Bellemare, Mélanie Rouleau, Hugo Girard, Mario Harvey and Chantal Guillemette
      Drug Metabolism and Disposition October 2010, 38 (10) 1785-1789; DOI: https://doi.org/10.1124/dmd.110.034835

  4. Gladwin, Mark T.

    1. Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation
      Yuen Yi Hon, He Sun, André Dejam and Mark T. Gladwin
      Drug Metabolism and Disposition October 2010, 38 (10) 1707-1713; DOI: https://doi.org/10.1124/dmd.110.034355

  5. Gong, Ping

    1. Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
      Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845

  6. Goto, Yuma

    1. Regulatory Xenobiotic Responsive Elements in the Distal 5′-Flanking Region of the Mouse Cyp1a2 Gene Required for Transcriptional Activation by 3-Methylcholanthrene and 2,3,7,8-Tetrachlorodibenzo-p-dioxin
      Yuki Kawasaki, Tsutomu Sakuma, Yuma Goto and Nobuo Nemoto
      Drug Metabolism and Disposition October 2010, 38 (10) 1640-1643; DOI: https://doi.org/10.1124/dmd.109.031856

  7. Guillemette, Chantal

    1. Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro
      Judith Bellemare, Mélanie Rouleau, Hugo Girard, Mario Harvey and Chantal Guillemette
      Drug Metabolism and Disposition October 2010, 38 (10) 1785-1789; DOI: https://doi.org/10.1124/dmd.110.034835

H

  1. Hamberger, Carolin

    1. Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats
      Carolin Hamberger, Marco Kellert, Ute M. Schauer, Wolfgang Dekant and Angela Mally
      Drug Metabolism and Disposition October 2010, 38 (10) 1698-1706; DOI: https://doi.org/10.1124/dmd.109.031781

  2. Hao, Hai-Ping

    1. Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats
      Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936

  3. Hao, Haiping

    1. Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
      Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845
    2. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

  4. Hao, Kun

    1. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

  5. Hardy, Marcia

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

  6. Harrison, Mike

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

  7. Harry, Kathy M.

    1. Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis
      Albert Mennone, Carol J. Soroka, Kathy M. Harry and James L. Boyer
      Drug Metabolism and Disposition October 2010, 38 (10) 1673-1678; DOI: https://doi.org/10.1124/dmd.110.034512

  8. Harvey, Mario

    1. Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro
      Judith Bellemare, Mélanie Rouleau, Hugo Girard, Mario Harvey and Chantal Guillemette
      Drug Metabolism and Disposition October 2010, 38 (10) 1785-1789; DOI: https://doi.org/10.1124/dmd.110.034835

  9. Hayashizaki, Yoshihide

    1. Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method
      Ran Okada, Yuri Ishizu, Ryuta Endo, Alexander Lezhava, Ichiro Ieiri, Hiroyuki Kusuhara, Yuichi Sugiyama and Yoshihide Hayashizaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1636-1639; DOI: https://doi.org/10.1124/dmd.110.034652

  10. Heydel, Jean-Marie

    1. Effects of Typical Inducers on Olfactory Xenobiotic-Metabolizing Enzyme, Transporter, and Transcription Factor Expression in Rats
      Nicolas Thiebaud, Maud Sigoillot, Joëlle Chevalier, Yves Artur, Jean-Marie Heydel and Anne-Marie Le Bon
      Drug Metabolism and Disposition October 2010, 38 (10) 1865-1875; DOI: https://doi.org/10.1124/dmd.110.035014

  11. Hippalgaonkar, Ketan

    1. Interaction between Topically and Systemically Coadministered P-Glycoprotein Substrates/Inhibitors: Effect on Vitreal Kinetics
      Ketan Hippalgaonkar, Ramesh Srirangam, Bharathi Avula, Ikhlas A. Khan and Soumyajit Majumdar
      Drug Metabolism and Disposition October 2010, 38 (10) 1790-1797; DOI: https://doi.org/10.1124/dmd.110.032672

  12. Hisaka, Akihiro

    1. Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide
      Yusuke Masuo, Kousei Ito, Takehito Yamamoto, Akihiro Hisaka, Masashi Honma and Hiroshi Suzuki
      Drug Metabolism and Disposition October 2010, 38 (10) 1828-1835; DOI: https://doi.org/10.1124/dmd.110.034231

  13. Hofmann, Alan F.

    1. Hepatobiliary Disposition of 3α,6α,7α,12α-Tetrahydroxy-Cholanoyl Taurine: A Substrate for Multiple Canalicular Transporters
      Vandana Megaraj, Takashi Iida, Paiboon Jungsuwadee, Alan F. Hofmann and Mary Vore
      Drug Metabolism and Disposition October 2010, 38 (10) 1723-1730; DOI: https://doi.org/10.1124/dmd.110.033480

  14. Hon, Yuen Yi

    1. Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation
      Yuen Yi Hon, He Sun, André Dejam and Mark T. Gladwin
      Drug Metabolism and Disposition October 2010, 38 (10) 1707-1713; DOI: https://doi.org/10.1124/dmd.110.034355

  15. Honma, Hidehito

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  16. Honma, Masashi

    1. Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide
      Yusuke Masuo, Kousei Ito, Takehito Yamamoto, Akihiro Hisaka, Masashi Honma and Hiroshi Suzuki
      Drug Metabolism and Disposition October 2010, 38 (10) 1828-1835; DOI: https://doi.org/10.1124/dmd.110.034231

  17. Hu, Yongjun

    1. Significance and Regional Dependency of Peptide Transporter (PEPT) 1 in the Intestinal Permeability of Glycylsarcosine: In Situ Single-Pass Perfusion Studies in Wild-Type and Pept1 Knockout Mice
      Dilara Jappar, Shu-Pei Wu, Yongjun Hu and David E. Smith
      Drug Metabolism and Disposition October 2010, 38 (10) 1740-1746; DOI: https://doi.org/10.1124/dmd.110.034025

I

  1. Ieiri, Ichiro

    1. Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method
      Ran Okada, Yuri Ishizu, Ryuta Endo, Alexander Lezhava, Ichiro Ieiri, Hiroyuki Kusuhara, Yuichi Sugiyama and Yoshihide Hayashizaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1636-1639; DOI: https://doi.org/10.1124/dmd.110.034652

  2. Iida, Takashi

    1. Hepatobiliary Disposition of 3α,6α,7α,12α-Tetrahydroxy-Cholanoyl Taurine: A Substrate for Multiple Canalicular Transporters
      Vandana Megaraj, Takashi Iida, Paiboon Jungsuwadee, Alan F. Hofmann and Mary Vore
      Drug Metabolism and Disposition October 2010, 38 (10) 1723-1730; DOI: https://doi.org/10.1124/dmd.110.033480

  3. Ikari, Akira

    1. Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats
      Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Shin-ichi Ikushiro, Toshiyuki Sakaki, Akira Ikari and Masao Miwa
      Drug Metabolism and Disposition October 2010, 38 (10) 1655-1664; DOI: https://doi.org/10.1124/dmd.110.034090

  4. Ikushiro, Shin-ichi

    1. Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats
      Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Shin-ichi Ikushiro, Toshiyuki Sakaki, Akira Ikari and Masao Miwa
      Drug Metabolism and Disposition October 2010, 38 (10) 1655-1664; DOI: https://doi.org/10.1124/dmd.110.034090

  5. Iseki, Shoichi

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  6. Ishizu, Yuri

    1. Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method
      Ran Okada, Yuri Ishizu, Ryuta Endo, Alexander Lezhava, Ichiro Ieiri, Hiroyuki Kusuhara, Yuichi Sugiyama and Yoshihide Hayashizaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1636-1639; DOI: https://doi.org/10.1124/dmd.110.034652

  7. Ito, Kousei

    1. Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide
      Yusuke Masuo, Kousei Ito, Takehito Yamamoto, Akihiro Hisaka, Masashi Honma and Hiroshi Suzuki
      Drug Metabolism and Disposition October 2010, 38 (10) 1828-1835; DOI: https://doi.org/10.1124/dmd.110.034231

  8. Iwata, Daisuke

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

J

  1. Jackson, Brian C.

    1. Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme
      Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou
      Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678

  2. Jacobi, Sylvia

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

  3. Jappar, Dilara

    1. Significance and Regional Dependency of Peptide Transporter (PEPT) 1 in the Intestinal Permeability of Glycylsarcosine: In Situ Single-Pass Perfusion Studies in Wild-Type and Pept1 Knockout Mice
      Dilara Jappar, Shu-Pei Wu, Yongjun Hu and David E. Smith
      Drug Metabolism and Disposition October 2010, 38 (10) 1740-1746; DOI: https://doi.org/10.1124/dmd.110.034025

  4. Jordan, Angela

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

  5. Jungsuwadee, Paiboon

    1. Hepatobiliary Disposition of 3α,6α,7α,12α-Tetrahydroxy-Cholanoyl Taurine: A Substrate for Multiple Canalicular Transporters
      Vandana Megaraj, Takashi Iida, Paiboon Jungsuwadee, Alan F. Hofmann and Mary Vore
      Drug Metabolism and Disposition October 2010, 38 (10) 1723-1730; DOI: https://doi.org/10.1124/dmd.110.033480

K

  1. Kang, An

    1. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

  2. Kato, Sayaka

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  3. Kato, Yukio

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  4. Kawasaki, Yuki

    1. Regulatory Xenobiotic Responsive Elements in the Distal 5′-Flanking Region of the Mouse Cyp1a2 Gene Required for Transcriptional Activation by 3-Methylcholanthrene and 2,3,7,8-Tetrachlorodibenzo-p-dioxin
      Yuki Kawasaki, Tsutomu Sakuma, Yuma Goto and Nobuo Nemoto
      Drug Metabolism and Disposition October 2010, 38 (10) 1640-1643; DOI: https://doi.org/10.1124/dmd.109.031856

  5. Kellert, Marco

    1. Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats
      Carolin Hamberger, Marco Kellert, Ute M. Schauer, Wolfgang Dekant and Angela Mally
      Drug Metabolism and Disposition October 2010, 38 (10) 1698-1706; DOI: https://doi.org/10.1124/dmd.109.031781

  6. Khan, Ikhlas A.

    1. Interaction between Topically and Systemically Coadministered P-Glycoprotein Substrates/Inhibitors: Effect on Vitreal Kinetics
      Ketan Hippalgaonkar, Ramesh Srirangam, Bharathi Avula, Ikhlas A. Khan and Soumyajit Majumdar
      Drug Metabolism and Disposition October 2010, 38 (10) 1790-1797; DOI: https://doi.org/10.1124/dmd.110.032672

  7. Khetani, Salman R.

    1. Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
      Wendy WeiWei Wang, Salman R. Khetani, Stacy Krzyzewski, David B. Duignan and R. Scott Obach
      Drug Metabolism and Disposition October 2010, 38 (10) 1900-1905; DOI: https://doi.org/10.1124/dmd.110.034876

  8. Khier, Sonia

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  9. Knych, Heather K. DiMaio

    1. Molecular Cloning, Expression, and Initial Characterization of Members of the CYP3A Family in Horses
      Heather K. DiMaio Knych, Daniel S. McKemie and Scott D. Stanley
      Drug Metabolism and Disposition October 2010, 38 (10) 1820-1827; DOI: https://doi.org/10.1124/dmd.110.032953

  10. Kobayashi, Yoshimasa

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  11. Kosugi, Yuri

    1. Influence of Cytidine Deaminase on Antitumor Activity of 2′-Deoxycytidine Analogs In Vitro and In Vivo
      Takahiro Yoshida, Yoshio Endo, Tohru Obata, Yuri Kosugi, Kazuki Sakamoto and Takuma Sasaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1814-1819; DOI: https://doi.org/10.1124/dmd.110.034397

  12. Kozakai, Kazumasa

    1. Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys
      Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume
      Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656

  13. Krishan, Mansi

    1. Drug Transporter Expression and Localization in Rat Nasal Respiratory and Olfactory Mucosa and Olfactory Bulb
      Mary Beth Genter, Mansi Krishan, Lisa M. Augustine and Nathan J. Cherrington
      Drug Metabolism and Disposition October 2010, 38 (10) 1644-1647; DOI: https://doi.org/10.1124/dmd.110.034611

  14. Krzyzewski, Stacy

    1. Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
      Wendy WeiWei Wang, Salman R. Khetani, Stacy Krzyzewski, David B. Duignan and R. Scott Obach
      Drug Metabolism and Disposition October 2010, 38 (10) 1900-1905; DOI: https://doi.org/10.1124/dmd.110.034876

  15. Kubo, Yoshiyuki

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  16. Kume, Toshiyuki

    1. Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys
      Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume
      Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656

  17. Kuo, Tzong-Fu

    1. Metabolism of Dicentrine: Identification of the Phase I and Phase II Metabolites in Miniature Pig Urine
      Yi-Chun Lai, Tzong-Fu Kuo, Chien-Kuang Chen, Han-Ju Tsai and Shoei-Sheng Lee
      Drug Metabolism and Disposition October 2010, 38 (10) 1714-1722; DOI: https://doi.org/10.1124/dmd.110.033795

  18. Kurihara, Atsushi

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  19. Kurosawa, Masatoshi

    1. Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats
      Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Shin-ichi Ikushiro, Toshiyuki Sakaki, Akira Ikari and Masao Miwa
      Drug Metabolism and Disposition October 2010, 38 (10) 1655-1664; DOI: https://doi.org/10.1124/dmd.110.034090

  20. Kusuhara, Hiroyuki

    1. Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method
      Ran Okada, Yuri Ishizu, Ryuta Endo, Alexander Lezhava, Ichiro Ieiri, Hiroyuki Kusuhara, Yuichi Sugiyama and Yoshihide Hayashizaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1636-1639; DOI: https://doi.org/10.1124/dmd.110.034652

L

  1. Lafaille, Florian

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  2. Lai, Li

    1. Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
      Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845
    2. Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats
      Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936

  3. Lai, Yi-Chun

    1. Metabolism of Dicentrine: Identification of the Phase I and Phase II Metabolites in Miniature Pig Urine
      Yi-Chun Lai, Tzong-Fu Kuo, Chien-Kuang Chen, Han-Ju Tsai and Shoei-Sheng Lee
      Drug Metabolism and Disposition October 2010, 38 (10) 1714-1722; DOI: https://doi.org/10.1124/dmd.110.033795

  4. Le Bon, Anne-Marie

    1. Effects of Typical Inducers on Olfactory Xenobiotic-Metabolizing Enzyme, Transporter, and Transcription Factor Expression in Rats
      Nicolas Thiebaud, Maud Sigoillot, Joëlle Chevalier, Yves Artur, Jean-Marie Heydel and Anne-Marie Le Bon
      Drug Metabolism and Disposition October 2010, 38 (10) 1865-1875; DOI: https://doi.org/10.1124/dmd.110.035014

  5. Lecoeur, Sylvaine

    1. The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies
      Caroline Prouillac and Sylvaine Lecoeur
      Drug Metabolism and Disposition October 2010, 38 (10) 1623-1635; DOI: https://doi.org/10.1124/dmd.110.033571

  6. Lee, Shoei-Sheng

    1. Metabolism of Dicentrine: Identification of the Phase I and Phase II Metabolites in Miniature Pig Urine
      Yi-Chun Lai, Tzong-Fu Kuo, Chien-Kuang Chen, Han-Ju Tsai and Shoei-Sheng Lee
      Drug Metabolism and Disposition October 2010, 38 (10) 1714-1722; DOI: https://doi.org/10.1124/dmd.110.033795

  7. Lezhava, Alexander

    1. Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method
      Ran Okada, Yuri Ishizu, Ryuta Endo, Alexander Lezhava, Ichiro Ieiri, Hiroyuki Kusuhara, Yuichi Sugiyama and Yoshihide Hayashizaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1636-1639; DOI: https://doi.org/10.1124/dmd.110.034652

  8. Liang, Yan

    1. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

  9. Liu, Chang-Xiao

    1. Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats
      Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936

  10. Liu, Yi-Tong

    1. Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats
      Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936

M

  1. Majumdar, Soumyajit

    1. Interaction between Topically and Systemically Coadministered P-Glycoprotein Substrates/Inhibitors: Effect on Vitreal Kinetics
      Ketan Hippalgaonkar, Ramesh Srirangam, Bharathi Avula, Ikhlas A. Khan and Soumyajit Majumdar
      Drug Metabolism and Disposition October 2010, 38 (10) 1790-1797; DOI: https://doi.org/10.1124/dmd.110.032672

  2. Mally, Angela

    1. Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats
      Carolin Hamberger, Marco Kellert, Ute M. Schauer, Wolfgang Dekant and Angela Mally
      Drug Metabolism and Disposition October 2010, 38 (10) 1698-1706; DOI: https://doi.org/10.1124/dmd.109.031781

  3. Martinucci, Silvia

    1. Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs
      Lidia Miraglia, Sabrina Pagliarusco, Ellenia Bordini, Silvia Martinucci and Mario Pellegatti
      Drug Metabolism and Disposition October 2010, 38 (10) 1876-1891; DOI: https://doi.org/10.1124/dmd.110.033092

  4. Masuda, Kayoko

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  5. Masuo, Yusuke

    1. Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide
      Yusuke Masuo, Kousei Ito, Takehito Yamamoto, Akihiro Hisaka, Masashi Honma and Hiroshi Suzuki
      Drug Metabolism and Disposition October 2010, 38 (10) 1828-1835; DOI: https://doi.org/10.1124/dmd.110.034231

  6. McKemie, Daniel S.

    1. Molecular Cloning, Expression, and Initial Characterization of Members of the CYP3A Family in Horses
      Heather K. DiMaio Knych, Daniel S. McKemie and Scott D. Stanley
      Drug Metabolism and Disposition October 2010, 38 (10) 1820-1827; DOI: https://doi.org/10.1124/dmd.110.032953

  7. Megaraj, Vandana

    1. Hepatobiliary Disposition of 3α,6α,7α,12α-Tetrahydroxy-Cholanoyl Taurine: A Substrate for Multiple Canalicular Transporters
      Vandana Megaraj, Takashi Iida, Paiboon Jungsuwadee, Alan F. Hofmann and Mary Vore
      Drug Metabolism and Disposition October 2010, 38 (10) 1723-1730; DOI: https://doi.org/10.1124/dmd.110.033480

  8. Mennone, Albert

    1. Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis
      Albert Mennone, Carol J. Soroka, Kathy M. Harry and James L. Boyer
      Drug Metabolism and Disposition October 2010, 38 (10) 1673-1678; DOI: https://doi.org/10.1124/dmd.110.034512

  9. Miraglia, Lidia

    1. Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs
      Lidia Miraglia, Sabrina Pagliarusco, Ellenia Bordini, Silvia Martinucci and Mario Pellegatti
      Drug Metabolism and Disposition October 2010, 38 (10) 1876-1891; DOI: https://doi.org/10.1124/dmd.110.033092

  10. Miwa, Masao

    1. Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats
      Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Shin-ichi Ikushiro, Toshiyuki Sakaki, Akira Ikari and Masao Miwa
      Drug Metabolism and Disposition October 2010, 38 (10) 1655-1664; DOI: https://doi.org/10.1124/dmd.110.034090

  11. Murai, Takahiro

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  12. Myers, Nicole R.

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

N

  1. Nakamichi, Noritaka

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  2. Nemoto, Nobuo

    1. Regulatory Xenobiotic Responsive Elements in the Distal 5′-Flanking Region of the Mouse Cyp1a2 Gene Required for Transcriptional Activation by 3-Methylcholanthrene and 2,3,7,8-Tetrachlorodibenzo-p-dioxin
      Yuki Kawasaki, Tsutomu Sakuma, Yuma Goto and Nobuo Nemoto
      Drug Metabolism and Disposition October 2010, 38 (10) 1640-1643; DOI: https://doi.org/10.1124/dmd.109.031856

O

  1. Obach, R. Scott

    1. Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
      Wendy WeiWei Wang, Salman R. Khetani, Stacy Krzyzewski, David B. Duignan and R. Scott Obach
      Drug Metabolism and Disposition October 2010, 38 (10) 1900-1905; DOI: https://doi.org/10.1124/dmd.110.034876

  2. Obata, Tohru

    1. Influence of Cytidine Deaminase on Antitumor Activity of 2′-Deoxycytidine Analogs In Vitro and In Vivo
      Takahiro Yoshida, Yoshio Endo, Tohru Obata, Yuri Kosugi, Kazuki Sakamoto and Takuma Sasaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1814-1819; DOI: https://doi.org/10.1124/dmd.110.034397

  3. Ohnuki, Takashi

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  4. Ohtsuka, Tatsuyuki

    1. Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys
      Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume
      Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656

  5. Okada, Ran

    1. Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method
      Ran Okada, Yuri Ishizu, Ryuta Endo, Alexander Lezhava, Ichiro Ieiri, Hiroyuki Kusuhara, Yuichi Sugiyama and Yoshihide Hayashizaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1636-1639; DOI: https://doi.org/10.1124/dmd.110.034652

  6. Okazaki, Osamu

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  7. Okudaira, Noriko

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  8. Orlicky, David J.

    1. Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme
      Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou
      Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678

P

  1. Pagliarusco, Sabrina

    1. Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs
      Lidia Miraglia, Sabrina Pagliarusco, Ellenia Bordini, Silvia Martinucci and Mario Pellegatti
      Drug Metabolism and Disposition October 2010, 38 (10) 1876-1891; DOI: https://doi.org/10.1124/dmd.110.033092

  2. Pattison, Christine

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

  3. Pellegatti, Mario

    1. Metabolic Disposition of Casopitant, a Potent Neurokinin-1 Receptor Antagonist, in Mice, Rats, and Dogs
      Lidia Miraglia, Sabrina Pagliarusco, Ellenia Bordini, Silvia Martinucci and Mario Pellegatti
      Drug Metabolism and Disposition October 2010, 38 (10) 1876-1891; DOI: https://doi.org/10.1124/dmd.110.033092

  4. Petrovic, Vanja

    1. Impact of Polyinosinic/Polycytidylic Acid on Placental and Hepatobiliary Drug Transporters in Pregnant Rats
      Vanja Petrovic and Micheline Piquette-Miller
      Drug Metabolism and Disposition October 2010, 38 (10) 1760-1766; DOI: https://doi.org/10.1124/dmd.110.034470

  5. Pinguet, Frédéric

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  6. Piquette-Miller, Micheline

    1. Impact of Polyinosinic/Polycytidylic Acid on Placental and Hepatobiliary Drug Transporters in Pregnant Rats
      Vanja Petrovic and Micheline Piquette-Miller
      Drug Metabolism and Disposition October 2010, 38 (10) 1760-1766; DOI: https://doi.org/10.1124/dmd.110.034470

  7. Pollard, Christopher R. J.

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

  8. Prouillac, Caroline

    1. The Role of the Placenta in Fetal Exposure to Xenobiotics: Importance of Membrane Transporters and Human Models for Transfer Studies
      Caroline Prouillac and Sylvaine Lecoeur
      Drug Metabolism and Disposition October 2010, 38 (10) 1623-1635; DOI: https://doi.org/10.1124/dmd.110.033571

R

  1. Rollison, Helen

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

  2. Rouleau, Mélanie

    1. Alternatively Spliced Products of the UGT1A Gene Interact with the Enzymatically Active Proteins to Inhibit Glucuronosyltransferase Activity In Vitro
      Judith Bellemare, Mélanie Rouleau, Hugo Girard, Mario Harvey and Chantal Guillemette
      Drug Metabolism and Disposition October 2010, 38 (10) 1785-1789; DOI: https://doi.org/10.1124/dmd.110.034835

S

  1. Sadamitsu, Satoshi

    1. Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats
      Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Shin-ichi Ikushiro, Toshiyuki Sakaki, Akira Ikari and Masao Miwa
      Drug Metabolism and Disposition October 2010, 38 (10) 1655-1664; DOI: https://doi.org/10.1124/dmd.110.034090

  2. Sakaki, Toshiyuki

    1. Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats
      Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Shin-ichi Ikushiro, Toshiyuki Sakaki, Akira Ikari and Masao Miwa
      Drug Metabolism and Disposition October 2010, 38 (10) 1655-1664; DOI: https://doi.org/10.1124/dmd.110.034090

  3. Sakamoto, Kazuki

    1. Influence of Cytidine Deaminase on Antitumor Activity of 2′-Deoxycytidine Analogs In Vitro and In Vivo
      Takahiro Yoshida, Yoshio Endo, Tohru Obata, Yuri Kosugi, Kazuki Sakamoto and Takuma Sasaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1814-1819; DOI: https://doi.org/10.1124/dmd.110.034397

  4. Sakuma, Tsutomu

    1. Regulatory Xenobiotic Responsive Elements in the Distal 5′-Flanking Region of the Mouse Cyp1a2 Gene Required for Transcriptional Activation by 3-Methylcholanthrene and 2,3,7,8-Tetrachlorodibenzo-p-dioxin
      Yuki Kawasaki, Tsutomu Sakuma, Yuma Goto and Nobuo Nemoto
      Drug Metabolism and Disposition October 2010, 38 (10) 1640-1643; DOI: https://doi.org/10.1124/dmd.109.031856

  5. Sarda, Sunil

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

  6. Sasaki, Takuma

    1. Influence of Cytidine Deaminase on Antitumor Activity of 2′-Deoxycytidine Analogs In Vitro and In Vivo
      Takahiro Yoshida, Yoshio Endo, Tohru Obata, Yuri Kosugi, Kazuki Sakamoto and Takuma Sasaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1814-1819; DOI: https://doi.org/10.1124/dmd.110.034397

  7. Sawamura, Ryoko

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  8. Schauer, Ute M.

    1. Hepatobiliary Toxicity of Furan: Identification of Furan Metabolites in Bile of Male F344/N Rats
      Carolin Hamberger, Marco Kellert, Ute M. Schauer, Wolfgang Dekant and Angela Mally
      Drug Metabolism and Disposition October 2010, 38 (10) 1698-1706; DOI: https://doi.org/10.1124/dmd.109.031781

  9. Schulz-Utermoehl, Timothy

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

  10. Sheng, Longsheng

    1. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

  11. Shimizu, Takuya

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  12. Sigoillot, Maud

    1. Effects of Typical Inducers on Olfactory Xenobiotic-Metabolizing Enzyme, Transporter, and Transcription Factor Expression in Rats
      Nicolas Thiebaud, Maud Sigoillot, Joëlle Chevalier, Yves Artur, Jean-Marie Heydel and Anne-Marie Le Bon
      Drug Metabolism and Disposition October 2010, 38 (10) 1865-1875; DOI: https://doi.org/10.1124/dmd.110.035014

  13. Silberberg, Hanna

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

  14. Smith, David E.

    1. Significance and Regional Dependency of Peptide Transporter (PEPT) 1 in the Intestinal Permeability of Glycylsarcosine: In Situ Single-Pass Perfusion Studies in Wild-Type and Pept1 Knockout Mice
      Dilara Jappar, Shu-Pei Wu, Yongjun Hu and David E. Smith
      Drug Metabolism and Disposition October 2010, 38 (10) 1740-1746; DOI: https://doi.org/10.1124/dmd.110.034025

  15. Soga, Tomoyoshi

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  16. Solassol, Isabelle

    1. Metabolism and Pharmacokinetics of EAPB0203 and EAPB0503, Two Imidazoquinoxaline Compounds Previously Shown to Have Antitumoral Activity on Melanoma and T-Lymphomas
      Sonia Khier, Florence Gattacceca, Safia El Messaoudi, Florian Lafaille, Carine Deleuze-Masquéfa, Jacques Bompart, Jean-François Cooper, Isabelle Solassol, Frédéric Pinguet, Pierre-Antoine Bonnet and Françoise M. M. Bressolle
      Drug Metabolism and Disposition October 2010, 38 (10) 1836-1847; DOI: https://doi.org/10.1124/dmd.110.034579

  17. Soroka, Carol J.

    1. Role of Breast Cancer Resistance Protein in the Adaptive Response to Cholestasis
      Albert Mennone, Carol J. Soroka, Kathy M. Harry and James L. Boyer
      Drug Metabolism and Disposition October 2010, 38 (10) 1673-1678; DOI: https://doi.org/10.1124/dmd.110.034512

  18. Spear, Michael

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

  19. Srirangam, Ramesh

    1. Interaction between Topically and Systemically Coadministered P-Glycoprotein Substrates/Inhibitors: Effect on Vitreal Kinetics
      Ketan Hippalgaonkar, Ramesh Srirangam, Bharathi Avula, Ikhlas A. Khan and Soumyajit Majumdar
      Drug Metabolism and Disposition October 2010, 38 (10) 1790-1797; DOI: https://doi.org/10.1124/dmd.110.032672

  20. Stagos, Dimitrios

    1. Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme
      Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou
      Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678

  21. Stanley, Scott D.

    1. Molecular Cloning, Expression, and Initial Characterization of Members of the CYP3A Family in Horses
      Heather K. DiMaio Knych, Daniel S. McKemie and Scott D. Stanley
      Drug Metabolism and Disposition October 2010, 38 (10) 1820-1827; DOI: https://doi.org/10.1124/dmd.110.032953

  22. Stedeford, Todd

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

  23. Stump, Donald G.

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

  24. Sugatani, Junko

    1. Nutritional Status Affects Fluvastatin-Induced Hepatotoxicity and Myopathy in Rats
      Junko Sugatani, Satoshi Sadamitsu, Masatoshi Kurosawa, Shin-ichi Ikushiro, Toshiyuki Sakaki, Akira Ikari and Masao Miwa
      Drug Metabolism and Disposition October 2010, 38 (10) 1655-1664; DOI: https://doi.org/10.1124/dmd.110.034090

  25. Sugiura, Tomoko

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  26. Sugiyama, Yuichi

    1. Direct and Rapid Genotyping of Glutathione-S-transferase M1 and T1 from Human Blood Specimens Using the SmartAmp2 Method
      Ran Okada, Yuri Ishizu, Ryuta Endo, Alexander Lezhava, Ichiro Ieiri, Hiroyuki Kusuhara, Yuichi Sugiyama and Yoshihide Hayashizaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1636-1639; DOI: https://doi.org/10.1124/dmd.110.034652

  27. Sun, He

    1. Characterization of Erythrocytic Uptake and Release and Disposition Pathways of Nitrite, Nitrate, Methemoglobin, and Iron-Nitrosyl Hemoglobin in the Human Circulation
      Yuen Yi Hon, He Sun, André Dejam and Mark T. Gladwin
      Drug Metabolism and Disposition October 2010, 38 (10) 1707-1713; DOI: https://doi.org/10.1124/dmd.110.034355

  28. Suzuki, Hiroshi

    1. Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide
      Yusuke Masuo, Kousei Ito, Takehito Yamamoto, Akihiro Hisaka, Masashi Honma and Hiroshi Suzuki
      Drug Metabolism and Disposition October 2010, 38 (10) 1828-1835; DOI: https://doi.org/10.1124/dmd.110.034231

  29. Suzuki, Kazuhiro

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  30. Sved, Daniel W.

    1. Effects of Dose, Administration Route, and/or Vehicle on Decabromodiphenyl Ether Concentrations in Plasma of Maternal, Fetal, and Neonatal Rats and in Milk of Maternal Rats
      John A. Biesemeier, Melissa J. Beck, Hanna Silberberg, Nicole R. Myers, John M. Ariano, Eric S. Bodle, Daniel W. Sved, Sylvia Jacobi, Donald G. Stump, Marcia Hardy and Todd Stedeford
      Drug Metabolism and Disposition October 2010, 38 (10) 1648-1654; DOI: https://doi.org/10.1124/dmd.110.033431

T

  1. Tachibana, Masaya

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  2. Tamai, Ikumi

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  3. Thakker, Dhiren R.

    1. In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats
      Souzan B. Yanni, Patrick F. Augustijns, Daniel K. Benjamin, Kim L. R. Brouwer, Dhiren R. Thakker and Pieter P. Annaert
      Drug Metabolism and Disposition October 2010, 38 (10) 1848-1856; DOI: https://doi.org/10.1124/dmd.110.033811

  4. Thiebaud, Nicolas

    1. Effects of Typical Inducers on Olfactory Xenobiotic-Metabolizing Enzyme, Transporter, and Transcription Factor Expression in Rats
      Nicolas Thiebaud, Maud Sigoillot, Joëlle Chevalier, Yves Artur, Jean-Marie Heydel and Anne-Marie Le Bon
      Drug Metabolism and Disposition October 2010, 38 (10) 1865-1875; DOI: https://doi.org/10.1124/dmd.110.035014

  5. Thompson, David C.

    1. Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme
      Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou
      Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678

  6. Tsai, Han-Ju

    1. Metabolism of Dicentrine: Identification of the Phase I and Phase II Metabolites in Miniature Pig Urine
      Yi-Chun Lai, Tzong-Fu Kuo, Chien-Kuang Chen, Han-Ju Tsai and Shoei-Sheng Lee
      Drug Metabolism and Disposition October 2010, 38 (10) 1714-1722; DOI: https://doi.org/10.1124/dmd.110.033795

  7. Tsuji, Akira

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  8. Tsuneto, Yumi

    1. Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys
      Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume
      Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656

U

  1. Uno, Yasuhiro

    1. Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys
      Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume
      Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656

  2. Utoh, Masahiro

    1. Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys
      Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume
      Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656

V

  1. Vasiliou, Vasilis

    1. Aldehyde Dehydrogenase 1B1: Molecular Cloning and Characterization of a Novel Mitochondrial Acetaldehyde-Metabolizing Enzyme
      Dimitrios Stagos, Ying Chen, Chad Brocker, Elizabeth Donald, Brian C. Jackson, David J. Orlicky, David C. Thompson and Vasilis Vasiliou
      Drug Metabolism and Disposition October 2010, 38 (10) 1679-1687; DOI: https://doi.org/10.1124/dmd.110.034678

  2. Vore, Mary

    1. Hepatobiliary Disposition of 3α,6α,7α,12α-Tetrahydroxy-Cholanoyl Taurine: A Substrate for Multiple Canalicular Transporters
      Vandana Megaraj, Takashi Iida, Paiboon Jungsuwadee, Alan F. Hofmann and Mary Vore
      Drug Metabolism and Disposition October 2010, 38 (10) 1723-1730; DOI: https://doi.org/10.1124/dmd.110.033480

W

  1. Wakayama, Tomohiko

    1. Functional Expression of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Mouse Small Intestine and Liver
      Tomoko Sugiura, Sayaka Kato, Takuya Shimizu, Tomohiko Wakayama, Noritaka Nakamichi, Yoshiyuki Kubo, Daisuke Iwata, Kazuhiro Suzuki, Tomoyoshi Soga, Masahide Asano, Shoichi Iseki, Ikumi Tamai, Akira Tsuji and Yukio Kato
      Drug Metabolism and Disposition October 2010, 38 (10) 1665-1672; DOI: https://doi.org/10.1124/dmd.110.032763

  2. Wang, Guang-Ji

    1. Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats
      Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936

  3. Wang, Guangji

    1. Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
      Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845
    2. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

  4. Wang, Joanne

    1. Adenosine Transport by Plasma Membrane Monoamine Transporter: Reinvestigation and Comparison with Organic Cations
      Mingyan Zhou, Haichuan Duan, Karen Engel, Li Xia and Joanne Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1798-1805; DOI: https://doi.org/10.1124/dmd.110.032987

  5. Wang, Pan

    1. O-Methylation of Catechol Estrogens by Human Placental Catechol-O-Methyltransferase: Interindividual Differences in Sensitivity to Heat Inactivation and to Inhibition by Dietary Polyphenols
      Bao Ting Zhu, Karen Y. Wu, Pan Wang, May Xiaoxin Cai and Allan H. Conney
      Drug Metabolism and Disposition October 2010, 38 (10) 1892-1899; DOI: https://doi.org/10.1124/dmd.110.033548

  6. Wang, Qiong

    1. Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
      Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845
    2. Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats
      Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936

  7. Wang, Wendy WeiWei

    1. Assessment of a Micropatterned Hepatocyte Coculture System to Generate Major Human Excretory and Circulating Drug Metabolites
      Wendy WeiWei Wang, Salman R. Khetani, Stacy Krzyzewski, David B. Duignan and R. Scott Obach
      Drug Metabolism and Disposition October 2010, 38 (10) 1900-1905; DOI: https://doi.org/10.1124/dmd.110.034876

  8. Ward, Michelle

    1. In Vitro Hepatic Metabolism of Cediranib, a Potent Vascular Endothelial Growth Factor Tyrosine Kinase Inhibitor: Interspecies Comparison and Human Enzymology
      Timothy Schulz-Utermoehl, Michael Spear, Christopher R. J. Pollard, Christine Pattison, Helen Rollison, Sunil Sarda, Michelle Ward, Nick Bushby, Angela Jordan and Mike Harrison
      Drug Metabolism and Disposition October 2010, 38 (10) 1688-1697; DOI: https://doi.org/10.1124/dmd.110.033159

  9. Watanabe, Kengo

    1. Predictability of Idiosyncratic Drug Toxicity Risk for Carboxylic Acid-Containing Drugs Based on the Chemical Stability of Acyl Glucuronide
      Ryoko Sawamura, Noriko Okudaira, Kengo Watanabe, Takahiro Murai, Yoshimasa Kobayashi, Masaya Tachibana, Takashi Ohnuki, Kayoko Masuda, Hidehito Honma, Atsushi Kurihara and Osamu Okazaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1857-1864; DOI: https://doi.org/10.1124/dmd.110.034173

  10. Wu, Karen Y.

    1. O-Methylation of Catechol Estrogens by Human Placental Catechol-O-Methyltransferase: Interindividual Differences in Sensitivity to Heat Inactivation and to Inhibition by Dietary Polyphenols
      Bao Ting Zhu, Karen Y. Wu, Pan Wang, May Xiaoxin Cai and Allan H. Conney
      Drug Metabolism and Disposition October 2010, 38 (10) 1892-1899; DOI: https://doi.org/10.1124/dmd.110.033548

  11. Wu, Liang

    1. Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
      Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845

  12. Wu, Shu-Pei

    1. Significance and Regional Dependency of Peptide Transporter (PEPT) 1 in the Intestinal Permeability of Glycylsarcosine: In Situ Single-Pass Perfusion Studies in Wild-Type and Pept1 Knockout Mice
      Dilara Jappar, Shu-Pei Wu, Yongjun Hu and David E. Smith
      Drug Metabolism and Disposition October 2010, 38 (10) 1740-1746; DOI: https://doi.org/10.1124/dmd.110.034025

X

  1. Xia, Li

    1. Adenosine Transport by Plasma Membrane Monoamine Transporter: Reinvestigation and Comparison with Organic Cations
      Mingyan Zhou, Haichuan Duan, Karen Engel, Li Xia and Joanne Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1798-1805; DOI: https://doi.org/10.1124/dmd.110.032987

  2. Xie, Hong-Guang

    1. Extensive Intestinal First-Pass Elimination and Predominant Hepatic Distribution of Berberine Explain Its Low Plasma Levels in Rats
      Yi-Tong Liu, Hai-Ping Hao, Hong-Guang Xie, Li Lai, Qiong Wang, Chang-Xiao Liu and Guang-Ji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1779-1784; DOI: https://doi.org/10.1124/dmd.110.033936

  3. Xie, Lin

    1. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

  4. Xie, Tong

    1. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

Y

  1. Yamamoto, Takehito

    1. Characterization of Inhibitory Effect of Carbapenem Antibiotics on the Deconjugation of Valproic Acid Glucuronide
      Yusuke Masuo, Kousei Ito, Takehito Yamamoto, Akihiro Hisaka, Masashi Honma and Hiroshi Suzuki
      Drug Metabolism and Disposition October 2010, 38 (10) 1828-1835; DOI: https://doi.org/10.1124/dmd.110.034231

  2. Yamazaki, Hiroshi

    1. Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys
      Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume
      Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656

  3. Yanni, Souzan B.

    1. In Vitro Investigation of the Hepatobiliary Disposition Mechanisms of the Antifungal Agent Micafungin in Humans and Rats
      Souzan B. Yanni, Patrick F. Augustijns, Daniel K. Benjamin, Kim L. R. Brouwer, Dhiren R. Thakker and Pieter P. Annaert
      Drug Metabolism and Disposition October 2010, 38 (10) 1848-1856; DOI: https://doi.org/10.1124/dmd.110.033811

  4. Yoshida, Takahiro

    1. Influence of Cytidine Deaminase on Antitumor Activity of 2′-Deoxycytidine Analogs In Vitro and In Vivo
      Takahiro Yoshida, Yoshio Endo, Tohru Obata, Yuri Kosugi, Kazuki Sakamoto and Takuma Sasaki
      Drug Metabolism and Disposition October 2010, 38 (10) 1814-1819; DOI: https://doi.org/10.1124/dmd.110.034397

  5. Yoshikawa, Takahiro

    1. Alprazolam as an In Vivo Probe for Studying Induction of CYP3A in Cynomolgus Monkeys
      Tatsuyuki Ohtsuka, Takahiro Yoshikawa, Kazumasa Kozakai, Yumi Tsuneto, Yasuhiro Uno, Masahiro Utoh, Hiroshi Yamazaki and Toshiyuki Kume
      Drug Metabolism and Disposition October 2010, 38 (10) 1806-1813; DOI: https://doi.org/10.1124/dmd.110.032656

  6. Yu, Guo

    1. Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
      Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845

  7. Yu, Jian

    1. In Vitro Metabolism Studies of Nomifensine Monooxygenation Pathways: Metabolite Identification, Reaction Phenotyping, and Bioactivation Mechanism
      Jian Yu, Dean G. Brown and Doug Burdette
      Drug Metabolism and Disposition October 2010, 38 (10) 1767-1778; DOI: https://doi.org/10.1124/dmd.110.033910

Z

  1. Zheng, Chaonan

    1. Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
      Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845

  2. Zheng, Xiao

    1. Development of a Systematic Approach to Identify Metabolites for Herbal Homologs Based on Liquid Chromatography Hybrid Ion Trap Time-of-Flight Mass Spectrometry: Gender-Related Difference in Metabolism of Schisandra Lignans in Rats
      Yan Liang, Haiping Hao, Lin Xie, An Kang, Tong Xie, Xiao Zheng, Chen Dai, Kun Hao, Longsheng Sheng and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1747-1759; DOI: https://doi.org/10.1124/dmd.110.033373

  3. Zhou, Mingyan

    1. Adenosine Transport by Plasma Membrane Monoamine Transporter: Reinvestigation and Comparison with Organic Cations
      Mingyan Zhou, Haichuan Duan, Karen Engel, Li Xia and Joanne Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1798-1805; DOI: https://doi.org/10.1124/dmd.110.032987

  4. Zhou, Xueyan

    1. Microsomal Cytochrome P450-Mediated Metabolism of Protopanaxatriol Ginsenosides: Metabolite Profile, Reaction Phenotyping, and Structure-Metabolism Relationship
      Haiping Hao, Li Lai, Chaonan Zheng, Qiong Wang, Guo Yu, Xueyan Zhou, Liang Wu, Ping Gong and Guangji Wang
      Drug Metabolism and Disposition October 2010, 38 (10) 1731-1739; DOI: https://doi.org/10.1124/dmd.110.033845

  5. Zhu, Bao Ting

    1. O-Methylation of Catechol Estrogens by Human Placental Catechol-O-Methyltransferase: Interindividual Differences in Sensitivity to Heat Inactivation and to Inhibition by Dietary Polyphenols
      Bao Ting Zhu, Karen Y. Wu, Pan Wang, May Xiaoxin Cai and Allan H. Conney
      Drug Metabolism and Disposition October 2010, 38 (10) 1892-1899; DOI: https://doi.org/10.1124/dmd.110.033548
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